[go: up one dir, main page]

DE3852539D1 - Ribozyme. - Google Patents

Ribozyme.

Info

Publication number
DE3852539D1
DE3852539D1 DE3852539T DE3852539T DE3852539D1 DE 3852539 D1 DE3852539 D1 DE 3852539D1 DE 3852539 T DE3852539 T DE 3852539T DE 3852539 T DE3852539 T DE 3852539T DE 3852539 D1 DE3852539 D1 DE 3852539D1
Authority
DE
Germany
Prior art keywords
ribozymes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE3852539T
Other languages
English (en)
Other versions
DE3852539T2 (de
DE3852539T3 (de
Inventor
Wayne Lyle Gerlach
James Phillip Haseloff
Philip Anthony Jennings
Fiona Helen Cameron
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gene Shears Pty Ltd
Original Assignee
Gene Shears Pty Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27507391&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE3852539(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Gene Shears Pty Ltd filed Critical Gene Shears Pty Ltd
Application granted granted Critical
Publication of DE3852539D1 publication Critical patent/DE3852539D1/de
Publication of DE3852539T2 publication Critical patent/DE3852539T2/de
Publication of DE3852539T3 publication Critical patent/DE3852539T3/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N57/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds
    • A01N57/10—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having phosphorus-to-oxygen bonds or phosphorus-to-sulfur bonds
    • A01N57/16—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having phosphorus-to-oxygen bonds or phosphorus-to-sulfur bonds containing heterocyclic radicals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N63/00—Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N63/00—Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
    • A01N63/60—Isolated nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
    • C12N15/8218—Antisense, co-suppression, viral induced gene silencing [VIGS], post-transcriptional induced gene silencing [PTGS]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/12—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/12—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes
    • C12N2310/121—Hammerhead
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/12—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes
    • C12N2310/124—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes based on group I or II introns

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Dentistry (AREA)
  • Agronomy & Crop Science (AREA)
  • Environmental Sciences (AREA)
  • Pest Control & Pesticides (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
DE3852539T 1987-12-15 1988-12-14 Ribozyme. Expired - Lifetime DE3852539T3 (de)

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
AUPI591187 1987-12-15
AU5911/87 1987-12-15
AUPI995088 1988-08-19
AU9950/88 1988-08-19
AU353/88 1988-09-09
AUPJ035388 1988-09-09
AUPJ130488 1988-11-04
AU1304/88 1988-11-04
AU1333/88 1988-11-07
AUPJ133388 1988-11-07

Publications (3)

Publication Number Publication Date
DE3852539D1 true DE3852539D1 (de) 1995-02-02
DE3852539T2 DE3852539T2 (de) 1995-05-04
DE3852539T3 DE3852539T3 (de) 2005-08-04

Family

ID=27507391

Family Applications (1)

Application Number Title Priority Date Filing Date
DE3852539T Expired - Lifetime DE3852539T3 (de) 1987-12-15 1988-12-14 Ribozyme.

Country Status (19)

Country Link
EP (2) EP0640688A1 (de)
JP (1) JP3046318B2 (de)
KR (1) KR970010758B1 (de)
CN (1) CN1102174C (de)
AR (1) AR243935A1 (de)
AT (1) ATE115999T1 (de)
AU (1) AU632993B2 (de)
CA (1) CA1340831C (de)
DE (1) DE3852539T3 (de)
DK (1) DK175956B1 (de)
ES (1) ES2065919T5 (de)
FI (1) FI104562B (de)
GR (1) GR3015374T3 (de)
HU (2) HUT54407A (de)
MC (1) MC2115A1 (de)
NO (2) NO308610B1 (de)
NZ (1) NZ227332A (de)
RO (1) RO114469B1 (de)
WO (1) WO1989005852A1 (de)

Families Citing this family (188)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5019556A (en) * 1987-04-14 1991-05-28 President And Fellows Of Harvard College Inhibitors of angiogenin
CA1340323C (en) * 1988-09-20 1999-01-19 Arnold E. Hampel Rna catalyst for cleaving specific rna sequences
US5866701A (en) * 1988-09-20 1999-02-02 The Board Of Regents For Northern Illinois University Of Dekalb HIV targeted hairpin ribozymes
US5624824A (en) * 1989-03-24 1997-04-29 Yale University Targeted cleavage of RNA using eukaryotic ribonuclease P and external guide sequence
US5168053A (en) * 1989-03-24 1992-12-01 Yale University Cleavage of targeted RNA by RNAase P
DE4091533T (de) * 1989-08-31 1992-01-30
US5225337A (en) * 1989-09-25 1993-07-06 Innovir Laboratories, Inc. Ribozyme compositions and methods for use
US5225347A (en) * 1989-09-25 1993-07-06 Innovir Laboratories, Inc. Therapeutic ribozyme compositions and expression vectors
DE3933384A1 (de) * 1989-10-06 1991-04-18 Hoechst Ag Multifunktionelle rna mit selbstprozessierungsaktivitaet, ihre herstellung und ihre verwendung
DE3935473A1 (de) * 1989-10-25 1991-05-02 Hoechst Ag Rna mit endonuclease- und antisense-aktivitaet, ihre herstellung und ihre verwendung
ATE271064T1 (de) * 1990-01-11 2004-07-15 Isis Pharmaceuticals Inc Oligonukleotidderivate zur detektieren und modulation von rna aktivität und genexpression
US5519164A (en) * 1990-02-01 1996-05-21 Hoechst Aktiengesellschaft Expression of a multigene RNA having self-splicing activity
DE4002885A1 (de) * 1990-02-01 1991-08-08 Hoechst Ag Expression einer multigen rna mit self-splicing aktivitaet
US5180818A (en) * 1990-03-21 1993-01-19 The University Of Colorado Foundation, Inc. Site specific cleavage of single-stranded dna
WO1991018913A1 (en) * 1990-06-07 1991-12-12 City Of Hope Ribozyme mediated reversal of transformation by cleavage of the hras oncogene rna
WO1991018625A1 (en) * 1990-06-07 1991-12-12 City Of Hope Ribozyme mediated reversal of transformation by cleavage of the hras oncogene rna
US6008343A (en) * 1990-06-19 1999-12-28 Gene Shears Pty. Ltd. Nucleotide based endonucleases
JPH05509224A (ja) * 1990-06-19 1993-12-22 コモンウェルス　サイエンティフィク　アンド　インダストリアル　リサーチ　オーガナイゼイション エンドヌクレアーゼ
US5246921A (en) * 1990-06-26 1993-09-21 The Wistar Institute Of Anatomy And Biology Method for treating leukemias
WO1992000080A1 (en) * 1990-06-26 1992-01-09 The Wistar Institute Of Anatomy & Biology Method for treating leukemias
WO1992001786A1 (en) * 1990-07-26 1992-02-06 Foundation For Research And Technology - Hellas (Fo.R.T.H.) Institute Of Molecular Biology & Biotechnology Portable ribozyme cassettes, dna sequences containing them, ribozymes encoded by these dna sequences, and compositions containing these ribozymes
JP3257675B2 (ja) * 1990-10-12 2002-02-18 マックス−プランク−ゲゼルシャフト ツール フェルデルング デル ビッセンシャフテン エー．ファウ． 修飾リボザイム
NZ314630A (en) * 1991-01-17 2000-11-24 Harvard College Use of trans-splicing ribozymes for genetic modification and cell ablation in a host cell
NZ314629A (en) * 1991-01-17 2000-08-25 Gen Hospital Corp Use trans-splicing ribozymes to prepare medicaments for gene therapies
FR2675803B1 (fr) * 1991-04-25 1996-09-06 Genset Sa Oligonucleotides fermes, antisens et sens et leurs applications.
FI913197A0 (fi) 1991-07-01 1991-07-01 Xyrofin Oy Nya jaeststammar med reducerad foermaoga att metabolisera xylitol, foerfarande foer bildande av dessa och deras anvaendning vid framstaellning av xylitol.
JPH07502898A (ja) * 1992-01-13 1995-03-30 デューク・ユニバーシティー 酵素ｒｎａ分子
DE69331216T2 (de) * 1992-04-17 2002-07-25 Kirin Beer K.K., Tokio/Tokyo Planze resistent gegen mindestens zwei viren und dessen preparation
DE69333937T2 (de) * 1992-06-29 2006-08-31 Gene Shears Pty. Ltd. Nukleinsäuren und sie verwendende verfahren zur bekämpfung viraler pathogene
ATE236975T1 (de) * 1992-07-02 2003-04-15 Sankyo Co Haarnadelförmiges ribozym
US5409823A (en) * 1992-09-24 1995-04-25 Ciba-Geigy Corporation Methods for the production of hybrid seed
US5864028A (en) * 1992-11-03 1999-01-26 Gene Shears Pty. Limited Degradation resistant mRNA derivatives linked to TNF-α ribozymes
WO1994010301A1 (en) * 1992-11-03 1994-05-11 Gene Shears Pty. Limited TNF-α RIBOZYMES AND DEGRADATION RESISTANT mRNA DERIVATIVES LINKED TO TNF-α RIBOZYMES
JP3595841B2 (ja) * 1992-12-04 2004-12-02 サーナ セラピューティクス，インコーポレイテッド リボザイム増幅診断用薬
WO1994013791A1 (en) * 1992-12-04 1994-06-23 Innovir Laboratories, Inc. Regulatable nucleic acid therapeutic and methods of use thereof
EP0674707A4 (de) * 1992-12-04 1998-01-14 Apollon Inc Verbindungen und methoden zur behandlung von leukämien.
FR2701960B1 (fr) * 1993-02-26 2002-09-13 Gene Shears Pty Ltd Polyribozyme apte à conférer, aux plantes, une résistance aux virus et plantes résistantes produisant ce polyribozyme.
US5817635A (en) * 1993-08-09 1998-10-06 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Modified ribozymes
AU5334294A (en) * 1993-10-15 1995-05-04 Dkfz Deutsches Krebsforschungszentrum Stiftung Des Offentlichen Rechts Asymmetric hammerhead ribozymes and nucleotide sequences for their construction
US5869248A (en) * 1994-03-07 1999-02-09 Yale University Targeted cleavage of RNA using ribonuclease P targeting and cleavage sequences
US5998193A (en) * 1994-06-24 1999-12-07 Gene Shears Pty., Ltd. Ribozymes with optimized hybridizing arms, stems, and loops, tRNA embedded ribozymes and compositions thereof
US6350934B1 (en) 1994-09-02 2002-02-26 Ribozyme Pharmaceuticals, Inc. Nucleic acid encoding delta-9 desaturase
US6057153A (en) * 1995-01-13 2000-05-02 Yale University Stabilized external guide sequences
US5683873A (en) * 1995-01-13 1997-11-04 Innovir Laboratories, Inc. EGS-mediated inactivation of target RNA
FR2730637B1 (fr) 1995-02-17 1997-03-28 Rhone Poulenc Rorer Sa Composition pharmaceutique contenant des acides nucleiques, et ses utilisations
IL122428A0 (en) * 1995-06-07 1998-06-15 Commw Scient Ind Res Org Minizymes and minribozymes and uses thereof
US6010904A (en) * 1995-06-07 2000-01-04 The General Hospital Corporation Cell ablation using trans-splicing ribozymes
US6004806A (en) * 1995-06-07 1999-12-21 Commonwealth Scientific And Industrial Research Organization Optimized minizymes and miniribozymes and uses thereof
WO1997010328A2 (en) * 1995-07-13 1997-03-20 Ribozyme Pharmaceuticals, Inc. Compositions and method for modulation of gene expression in plants
US5824519A (en) * 1995-11-08 1998-10-20 Medical University Of South Carolina Tissue-specific and target RNA-specific ribozymes
US6620805B1 (en) 1996-03-14 2003-09-16 Yale University Delivery of nucleic acids by porphyrins
US5877162A (en) * 1996-03-14 1999-03-02 Innovir Laboratories, Inc. Short external guide sequences
US6610478B1 (en) 1996-08-16 2003-08-26 Yale University Phenotypic conversion of cells mediated by external guide sequences
US5976874A (en) * 1996-08-16 1999-11-02 Yale University Phenotypic conversion of drug-resistant bacteria to drug-sensitivity
US6884430B1 (en) 1997-02-10 2005-04-26 Aventis Pharma S.A. Formulation of stabilized cationic transfection agent(s) /nucleic acid particles
US6969601B2 (en) 1997-04-03 2005-11-29 Jensenius Jens Chr MASP-2, a complement-fixing enzyme, and uses for it
US7589253B2 (en) 1997-04-15 2009-09-15 Commonwealth Scientific And Industrial Research Organisation Fatty acid epoxygenase genes from plants and uses therefor in modifying fatty acid metabolism
IL132393A0 (en) 1997-04-15 2001-03-19 Commw Scient Ind Res Org Plant fatty acid epoxygenase genes and uses therefor
IL133710A0 (en) 1997-06-30 2001-04-30 Rhone Poulence Rorer S A Improved method for transferring nucleic acid into the striped muscle and combination thereof
WO1999014331A2 (en) 1997-09-16 1999-03-25 Cropdesign Nv Cyclin-dependent kinase inhibitors and uses thereof
DE19741375C2 (de) * 1997-09-19 1999-10-21 Max Planck Gesellschaft Transgene Pflanzen, deren oberirdische Teile früher reifen und vollständig absterben
JP4891477B2 (ja) 1997-10-02 2012-03-07 マックス−プランク−ゲゼルシャフト ツール フォーデルング デル ヴィッセンシャフテン エー．ヴェー． 血管新生及び／または既存細動脈網から側枝動脈及び／または他の動脈の発達の調節に関する方法
JP4749541B2 (ja) 1997-11-18 2011-08-17 マックス−プランク−ゲゼルシャフト・ツア・フェルデルング・デア・ヴィッセンシャフテン・エー・ファオ レスポンダー表現型に関わる核酸およびその適用
US6013447A (en) * 1997-11-21 2000-01-11 Innovir Laboratories, Inc. Random intracellular method for obtaining optimally active nucleic acid molecules
AUPP249298A0 (en) 1998-03-20 1998-04-23 Ag-Gene Australia Limited Synthetic genes and genetic constructs comprising same I
CZ295108B6 (cs) 1998-03-20 2005-05-18 Benitec Australia Ltd Syntetický gen obsahující dispergovanou nebo cizorodou deoxyribonukleovou molekulu a genový konstrukt obsahující tento syntetický gen
US6248525B1 (en) 1998-03-30 2001-06-19 Yale University Method for identifying essential or functional genes
WO1999067400A1 (en) 1998-06-24 1999-12-29 Musc Foundation For Research Development Tissue-specific and target rna-specific ribozymes
DE19836098A1 (de) 1998-07-31 2000-02-03 Hoechst Schering Agrevo Gmbh Pflanzen, die eine modifizierte Stärke synthetisieren, Verfahren zur Herstellung der Pflanzen, ihre Verwendung sowie die modifizierte Stärke
WO2000022130A2 (en) 1998-10-15 2000-04-20 Chiron Corporation Metastatic breast and colon cancer regulated genes
AU773808B2 (en) * 1998-11-09 2004-06-10 Bayer Cropscience Aktiengesellschaft Nucleic acid molecules from rice and their use for the production of modified starch
EP1637607B1 (de) 1998-11-12 2014-04-23 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Chimäre promotoren zur vermittlung der genexpression in pflanzen durch pathogeninfektion und deren anwendungen
ATE519840T1 (de) 1998-12-16 2011-08-15 Novartis Vaccines & Diagnostic Menschliche cyclin-abhängige kinase (hpnqalre)
CA2365901A1 (en) 1999-04-14 2000-10-19 Musc Foundation For Research Development Tissue-specific and pathogen-specific toxic agents and ribozymes
US6271359B1 (en) 1999-04-14 2001-08-07 Musc Foundation For Research Development Tissue-specific and pathogen-specific toxic agents and ribozymes
AUPQ005299A0 (en) 1999-04-29 1999-05-27 Commonwealth Scientific And Industrial Research Organisation Novel genes encoding wheat starch synthases and uses therefor
DE60023006T2 (de) 1999-07-20 2006-07-06 GVS Gesellschaft für Erwerb und Verwertung von Schutzrechten mbH Neues verfahren zur herstellung und auswahl von transgenen flachspflanzen und leinsamen
US6423885B1 (en) 1999-08-13 2002-07-23 Commonwealth Scientific And Industrial Research Organization (Csiro) Methods for obtaining modified phenotypes in plant cells
AU8466501A (en) 2000-07-21 2002-02-05 Essentia Biosystems Inc Multi-component biological transport systems
AU1480402A (en) 2000-11-09 2002-05-21 Commw Scient Ind Res Org Barley with reduced SSII activity and starch containing products with a reduced amylopectin content
ITMI20011364A1 (it) * 2001-06-28 2002-12-28 Metapontum Agrobios S C R L Robozima hammerhead specifico per la stearoyl-acp desaturesi di piante oleaginose differenti
AU2002316640C1 (en) 2001-07-10 2009-01-29 Johnson & Johnson Research Pty Limited Methods for genetic modification of hematopoietic progenitor cells and uses of the modified cells
ES2358187T3 (es) 2001-07-10 2011-05-06 JOHNSON & JOHNSON RESEARCH PTY LIMITED Procedimientos para la modificación genética de las células progenitoras hematopoyéticas y utilizaciones de las células modificadas.
US8022272B2 (en) 2001-07-13 2011-09-20 Sungene Gmbh & Co. Kgaa Expression cassettes for transgenic expression of nucleic acids
FR2829136B1 (fr) 2001-08-29 2006-11-17 Aventis Pharma Sa Derives lipidiques d'aminoglycosides
US7456335B2 (en) 2001-09-03 2008-11-25 Basf Plant Science Gmbh Nucleic acid sequences and their use in methods for achieving pathogen resistance in plants
US20070136825A1 (en) 2001-09-18 2007-06-14 Wolf-Bernd Frommer Fusion proteins useful for detecting analytes
AU2002359761A1 (en) 2001-12-18 2003-06-30 Invenux, Inc. Antibiotic compounds
US7432371B2 (en) 2002-02-07 2008-10-07 Covalent Partners, Llc Nanofilm and membrane compositions
US20040005546A1 (en) 2002-02-28 2004-01-08 Oncolytics Biotech Inc. Use of ribozymes in the detection of adventitious agents
DE10212892A1 (de) 2002-03-20 2003-10-09 Basf Plant Science Gmbh Konstrukte und Verfahren zur Regulation der Genexpression
EP1900827A3 (de) 2002-05-21 2008-04-16 Bayer HealthCare AG Verfahren und Zusammensetzungen zur Vorhersage, Diagnose, Prognose, Verhinderung und Behandlung maligner Neoplasien
CA2542171C (en) 2002-06-26 2015-12-15 Abbott Gmbh & Co. Kg Modulators and modulation of the interaction between rgm and neogenin
EP2036984B1 (de) 2002-07-26 2012-02-22 BASF Plant Science GmbH Revertierung der negativ-selektiven Wirkung von negativen Markerproteinen als Selektionsverfahren
ATE481422T1 (de) 2002-11-21 2010-10-15 Celltech R & D Inc Modulieren von immunantworten
CN1726282B (zh) 2002-12-19 2012-09-26 拜尔作物科学股份公司 合成终粘度增加的淀粉的植物细胞及植物
WO2006032707A2 (en) 2004-09-24 2006-03-30 Basf Plant Science Gmbh Plant cells and plants with increased tolerance to environmental stress
PT2374819T (pt) 2003-05-12 2017-07-04 Helion Biotech Aps Anticorpos para masp-2
EP2290084A3 (de) 2003-06-30 2011-10-12 Commonwealth Scientific and Industrial Research Organization Weizen mit veränderter Verzweigungsenzymaktivität und daraus abgeleitete Stärke-haltige Produkte
EP1892306A3 (de) 2003-10-06 2008-06-11 Bayer HealthCare AG Verfahren und Kit zur Untersuchung von Krebs
EP1602926A1 (de) 2004-06-04 2005-12-07 University of Geneva Neue Mittel und Verfahren zur Behandlung von Gehörverlust oder Tinnitus
US7604947B2 (en) 2004-06-09 2009-10-20 Cornell Research Foundation, Inc. Detection and modulation of cancer stem cells
US8840893B2 (en) 2004-06-10 2014-09-23 Omeros Corporation Methods for treating conditions associated with MASP-2 dependent complement activation
US7919094B2 (en) 2004-06-10 2011-04-05 Omeros Corporation Methods for treating conditions associated with MASP-2 dependent complement activation
EP2446902A1 (de) 2004-06-10 2012-05-02 Omeros Corporation Verfahren zur Behandlung von Leiden in Zusammenhang mit MASP-2-abhängiger Komplementaktivierung
DK1763582T3 (en) 2004-07-08 2015-01-12 Dlf Trifolium As Means and method of controlling the flowering of plants
AU2005268917B2 (en) 2004-08-02 2010-05-20 Basf Plant Science Gmbh Method for isolation of transcription termination sequences
WO2006069422A1 (en) 2004-12-30 2006-07-06 Commonwealth Scientific And Industrial Research Organisation Method and means for improving bowel health
EP1707632A1 (de) 2005-04-01 2006-10-04 Bayer CropScience GmbH Phosphorylierte waxy-Kartoffelstärke
CN101277974A (zh) 2005-09-30 2008-10-01 阿伯特有限及两合公司 排斥性引导分子(rgm)蛋白质家族的蛋白质的结合结构域及其功能性片段和它们的用途
EP1948806A2 (de) 2005-11-08 2008-07-30 BASF Plant Science GmbH Verwendung von armadillo-repeat (arm1)-polynukleotiden zum erreichen einer pathogenresistenz in pflanzen
ES2464315T3 (es) 2006-01-12 2014-06-02 Basf Plant Science Gmbh Uso de polinucleótidos de estomatina (STM1) para alcanzar una resistencia a patógenos en plantas
WO2008034648A1 (en) 2006-04-05 2008-03-27 Metanomics Gmbh Process for the production of a fine chemical
WO2007134818A2 (en) 2006-05-18 2007-11-29 Univ Muenchen L Maximilians Method for diagnosing mitochondrial dysfunction
US8383597B2 (en) 2006-05-25 2013-02-26 Cornell Research Foundation, Inc. G proteins in tumor growth and angiogenesis
WO2008040095A1 (en) 2006-10-06 2008-04-10 Johnson & Johnson Research Pty Limited Molecular switches and methods for their use
EP2057273A2 (de) 2007-01-15 2009-05-13 BASF Plant Science GmbH Verwendung von subtilisin (rnr9)-polynukleotiden zur erzielung von resistenz gegen krankheitserreger in pflanzen
KR20090119910A (ko) 2007-02-16 2009-11-20 바스프 플랜트 사이언스 게엠베하 외떡잎 식물에서 배-특이적 발현의 조절을 위한 핵산 서열
WO2008119057A2 (en) 2007-03-27 2008-10-02 Omeros Corporation The use of pde7 inhibitors for the treatment of movement disorders
AU2008252998A1 (en) 2007-05-22 2008-11-27 Basf Plant Science Gmbh Plant cells and plants with increased tolerance and/or resistance to environmental stress and increased biomass production-KO
CL2008002775A1 (es) 2007-09-17 2008-11-07 Amgen Inc Uso de un agente de unión a esclerostina para inhibir la resorción ósea.
EP2040075A1 (de) 2007-09-24 2009-03-25 Julius-Maximilians-Universität Würzburg Verbindungen und Marker für oberflächenverstärkte Raman-Streuung
JP2011506483A (ja) 2007-12-14 2011-03-03 アムジエン・インコーポレーテツド 抗スクレロスチン抗体を用いた骨折の治療方法
DE112008003433T5 (de) 2007-12-21 2010-11-04 Basf Plant Science Gmbh Pflanzen mit erhöhtem Ertrag (KO NUE)
US8962803B2 (en) 2008-02-29 2015-02-24 AbbVie Deutschland GmbH & Co. KG Antibodies against the RGM A protein and uses thereof
EP2100962A1 (de) 2008-03-12 2009-09-16 Biogemma Pflanzen mit verbesserter Widerstandsfähigkeit gegen Pathogene
US10517839B2 (en) 2008-06-09 2019-12-31 Cornell University Mast cell inhibition in diseases of the retina and vitreous
EP2331071A1 (de) 2008-09-05 2011-06-15 Institut National De La Sante Et De La Recherche Medicale Neue multimodulare anordnung zur intrazellulären abgabe
EP2184351A1 (de) 2008-10-30 2010-05-12 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Polynukleotid-kondierende Caryophyllen-Synthase und ihre Verwendung
ES2363358B1 (es) 2009-04-03 2012-06-21 FUNDACIÓ INSTITUT DE RECERCA HOSPITAL UNIVERSITARI VALL D'HEBRON (Titular al Agentes terapéuticos para el tratamiento de enfermedades asociadas con una proliferación celular indeseable.
DE112010003162T5 (de) 2009-04-22 2012-08-16 Basf Plant Science Company Gmbh Gesamtsamen-spezifischer Promotor
WO2011030312A1 (en) 2009-09-10 2011-03-17 Institut National De La Sante Et De La Recherche Medicale (Inserm) NOVEL INHIBITORS OF STEAROYL-CoA-DESATURASE-1 AND THEIR USES
EP2305285A1 (de) 2009-09-29 2011-04-06 Julius-Maximilians-Universität Würzburg Mittel und Verfahren zur Behandlung von ischämischen Erkrankungen
PT2488203T (pt) 2009-10-16 2017-03-10 Univ Leicester Métodos para tratamento de coagulação intravascular disseminada através da inibição da activação do complemento dependente de masp-2
CN102812014B (zh) 2009-10-30 2016-01-20 多美恩医疗公司 新颖的肟衍生物及其作为代谢型谷氨酸受体的别构调节剂的用途
EP2322149A1 (de) 2009-11-03 2011-05-18 Universidad del Pais Vasco Verfahren und Zusammensetzung zur Behandlung von Ischämie
US9175075B2 (en) 2009-12-08 2015-11-03 AbbVie Deutschland GmbH & Co. KG Methods of treating retinal nerve fiber layer degeneration with monoclonal antibodies against a retinal guidance molecule (RGM) protein
EP2338492A1 (de) 2009-12-24 2011-06-29 Universidad del Pais Vasco Verfahren und Zusammensetzung zur Behandlung von Alzheimer
US8476485B2 (en) 2010-06-24 2013-07-02 Academia Sinica Non-human animal model for amyotrophic lateral sclerosis (ALS) with loss-of-TDP-43 function
US9220715B2 (en) 2010-11-08 2015-12-29 Omeros Corporation Treatment of addiction and impulse-control disorders using PDE7 inhibitors
KR102385359B1 (ko) 2010-11-08 2022-04-11 오메로스 코포레이션 Pde7 억제제를 사용한 중독 및 충동-조절 장애의 치료
MX355648B (es) 2011-04-08 2018-04-26 Univ Leicester El uso de un agente inhibidor de masp-2 para tratar condiciones asociadas con la activacion del complemento dependiente de masp-2.
US9644035B2 (en) 2011-04-08 2017-05-09 Omeros Corporation Methods for treating conditions associated with MASP-2 dependent complement activation
WO2013066438A2 (en) 2011-07-22 2013-05-10 President And Fellows Of Harvard College Evaluation and improvement of nuclease cleavage specificity
US20150017091A1 (en) 2011-08-18 2015-01-15 Cornell University Detection and treatment of metastatic disease
WO2013039880A1 (en) 2011-09-12 2013-03-21 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Biomarkers and therapeutic targets of hepatocellular cancer
WO2013090814A2 (en) 2011-12-16 2013-06-20 Board Of Trustees Of Michigan State University p-Coumaroyl-CoA:Monolignol Transferase
IL297229A (en) 2012-01-27 2022-12-01 Abbvie Inc The composition and method for the diagnosis and treatment of diseases related to the degeneration of nerve cells
US9408832B2 (en) 2012-03-14 2016-08-09 University Of Central Florida Research Foundation, Inc. LIM kinasemodulating agents for neurofibromatoses therapy and methods for screening for same
EP2666775A1 (de) 2012-05-21 2013-11-27 Domain Therapeutics Substituierte Pyrazolochinazolinone und Pyrrolochinazolinone als allosterische Modulatoren von metabotropen Glutamatrezeptoren der Gruppe II
WO2014127835A1 (en) 2013-02-22 2014-08-28 Christian-Albrechts-Universität Zu Kiel Plant-derived resistance gene
US9163284B2 (en) 2013-08-09 2015-10-20 President And Fellows Of Harvard College Methods for identifying a target site of a Cas9 nuclease
RS61351B1 (sr) 2013-10-17 2021-02-26 Omeros Corp Postupci za lečenje stanja udruženih sa aktivacijom komplementa zavisnom od masp-2
US20150166985A1 (en) 2013-12-12 2015-06-18 President And Fellows Of Harvard College Methods for correcting von willebrand factor point mutations
WO2015196250A1 (en) 2014-06-27 2015-12-30 Commonwealth Scientific And Industrial Research Organisation Lipid comprising docosapentaenoic acid
KR102535223B1 (ko) 2013-12-18 2023-05-30 커먼웰쓰 사이언티픽 앤 인더스트리알 리서치 오거니제이션 장쇄 다중불포화 지방산을 포함하는 지질
EP3000814A1 (de) 2014-09-26 2016-03-30 Domain Therapeutics Substituierte Pyrazolochinazolinone und Pyrrolochinazolinone als allosterische Modulatoren von metabotropen Glutamatrezeptoren der Gruppe II
JP7067793B2 (ja) 2015-10-23 2022-05-16 プレジデント アンド フェローズ オブ ハーバード カレッジ 核酸塩基編集因子およびその使用
BR112018009311A8 (pt) 2015-11-09 2019-02-26 Omeros Corporation E Univ Of Leicester ?método para tratar um sujeito humano sofrendo de tma persistente associada com transplante de célula tronco hematopoiética?
KR102564616B1 (ko) 2016-01-05 2023-08-08 유니버시티 오브 레스터 필요로 하는 대상체에서 섬유증의 억제 방법
CN109152834A (zh) 2016-03-31 2019-01-04 奥默罗斯公司 抑制有需要的受试者的血管发生的方法
MA44031B1 (fr) 2016-05-26 2021-06-30 Nunhemes B V Plantes produisant des fruits sans graines
GB2568182A (en) 2016-08-03 2019-05-08 Harvard College Adenosine nucleobase editors and uses thereof
EP3497214B1 (de) 2016-08-09 2023-06-28 President and Fellows of Harvard College Programmierbare cas9-rekombinase-fusionsproteine und verwendungen davon
WO2018039438A1 (en) 2016-08-24 2018-03-01 President And Fellows Of Harvard College Incorporation of unnatural amino acids into proteins using base editing
US10745677B2 (en) 2016-12-23 2020-08-18 President And Fellows Of Harvard College Editing of CCR5 receptor gene to protect against HIV infection
US11873496B2 (en) 2017-01-09 2024-01-16 Whitehead Institute For Biomedical Research Methods of altering gene expression by perturbing transcription factor multimers that structure regulatory loops
EP3592853A1 (de) 2017-03-09 2020-01-15 President and Fellows of Harvard College Unterdrückung von schmerzen durch geneditierung
US10883089B2 (en) 2017-04-04 2021-01-05 Wisconsin Alumni Research Foundation Feruloyl-CoA:monolignol transferases
US10883090B2 (en) 2017-04-18 2021-01-05 Wisconsin Alumni Research Foundation P-coumaroyl-CoA:monolignol transferases
CN111447940A (zh) 2017-07-17 2020-07-24 科罗拉多大学评议会 预防或治疗由辐射或放射疗法引起的辐射诱发的旁观者效应的组合物和方法
CN111801345A (zh) 2017-07-28 2020-10-20 哈佛大学的校长及成员们 使用噬菌体辅助连续进化(pace)的进化碱基编辑器的方法和组合物
TWI818919B (zh) 2017-08-15 2023-10-21 美商歐米諾斯公司 用於治療和／ 或預防與造血幹細胞移植有關的移植物抗宿主病和／ 或瀰漫性肺泡出血和／ 或靜脈閉塞性病的方法
WO2019139645A2 (en) 2017-08-30 2019-07-18 President And Fellows Of Harvard College High efficiency base editors comprising gam
EP3697906A1 (de) 2017-10-16 2020-08-26 The Broad Institute, Inc. Verwendungen von adenosinbasiseditoren
EP3797160A1 (de) 2018-05-23 2021-03-31 The Broad Institute Inc. Baseneditoren und verwendungen davon
US11584714B2 (en) 2018-05-29 2023-02-21 Omeros Corporation MASP-2 inhibitors and methods of use
CN119350433A (zh) 2018-05-29 2025-01-24 奥默罗斯公司 Masp-2抑制剂和使用方法
US11291176B2 (en) 2018-06-15 2022-04-05 Nunhems B.V. Seedless watermelon plants comprising modifications in an ABC transporter gene
BR112021007864A2 (pt) 2018-11-09 2021-08-10 Wisconsin Alumni Research Foundation ácido nucleico recombinante, métodos e vegetal transgênico fértil
WO2020191248A1 (en) 2019-03-19 2020-09-24 The Broad Institute, Inc. Method and compositions for editing nucleotide sequences
US12030853B2 (en) 2019-12-04 2024-07-09 Omeros Corporation MASP-2 inhibitors and methods of use
KR20220110530A (ko) 2019-12-04 2022-08-08 오메로스 코포레이션 Masp-2 억제자 및 사용 방법
IL293588A (en) 2019-12-04 2022-08-01 Omeros Corp Masp-2 inhibitor compounds, compositions comprising same and uses thereof
EP4146804A1 (de) 2020-05-08 2023-03-15 The Broad Institute Inc. Verfahren und zusammensetzungen zur gleichzeitigen bearbeitung beider stränge einer doppelsträngigen zielnukleotidsequenz
US20240011030A1 (en) 2020-08-10 2024-01-11 Novartis Ag Treatments for retinal degenerative diseases
WO2024038090A1 (en) 2022-08-18 2024-02-22 Mitodicure Gmbh Use of substituted benzoxazole and benzofuran compounds for the treatment and prevention of diseases associated with chronic fatigue, exhaustion and/or exertional intolerance
WO2024042160A1 (en) 2022-08-26 2024-02-29 Mitodicure Gmbh Use of a therapeutic agent with sodium-hydrogen antiporter 1 inhibitory activity for the treatment and prevention of diseases associated with chronic fatigue, exhaustion and/or exertional intolerance

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5116742A (en) * 1986-12-03 1992-05-26 University Patents, Inc. RNA ribozyme restriction endoribonucleases and methods
US4987071A (en) * 1986-12-03 1991-01-22 University Patents, Inc. RNA ribozyme polymerases, dephosphorylases, restriction endoribonucleases and methods
DE3642623A1 (de) * 1986-12-13 1988-06-23 Burbach & Bender Ohg Gasspuelstein fuer metallurgische gefaesse
DE3939771A1 (de) * 1989-12-01 1991-06-06 Behringwerke Ag Verfahren zur biologischen inaktivierung von nukleinsaeuren

Also Published As

Publication number Publication date
FI902923A0 (fi) 1990-06-12
HU211891A9 (en) 1995-12-28
JPH03502638A (ja) 1991-06-20
NZ227332A (en) 1991-08-27
KR970010758B1 (ko) 1997-06-30
EP0321201A3 (en) 1990-01-10
JP3046318B2 (ja) 2000-05-29
NO902661L (no) 1990-08-14
CN1102174C (zh) 2003-02-26
ATE115999T1 (de) 1995-01-15
CA1340831C (en) 1999-11-30
CN1033838A (zh) 1989-07-12
DK175956B1 (da) 2005-08-22
ES2065919T5 (es) 2005-06-16
RO114469B1 (ro) 1999-04-30
MC2115A1 (fr) 1991-07-05
GR3015374T3 (en) 1995-06-30
AR243935A1 (es) 1993-09-30
EP0321201B2 (de) 2004-11-24
NO312105B1 (no) 2002-03-18
DK143390D0 (da) 1990-06-12
AU632993B2 (en) 1993-01-21
NO20000369D0 (no) 2000-01-25
DE3852539T2 (de) 1995-05-04
EP0321201B1 (de) 1994-12-21
KR900700603A (ko) 1990-08-16
EP0321201A2 (de) 1989-06-21
DK143390A (da) 1990-08-14
ES2065919T3 (es) 1995-03-01
NO20000369L (no) 1990-08-14
FI104562B (fi) 2000-02-29
EP0640688A1 (de) 1995-03-01
DE3852539T3 (de) 2005-08-04
WO1989005852A1 (en) 1989-06-29
AU2800789A (en) 1989-07-19
NO902661D0 (no) 1990-06-14
NO308610B1 (no) 2000-10-02
HUT54407A (en) 1991-02-28

Similar Documents

Publication Publication Date Title
DE3852539D1 (de) Ribozyme.
DE3880632D1 (de) Kuevette.
DE3876304D1 (de) Polysilacylobutasilazane.
ES2019689B3 (es) Caudalimetro.
FI831659L (fi) Tvaodelad ask.
FI884125L (fi) Vaermeaoterhaemtningsbart alster.
IT8421396A0 (it) Vaglio.
FI86994B (fi) Korrosionsfasta vismut innehaollande zirkoniumlegeringar.
FI883691A0 (fi) Spel.
FI882776A0 (fi) Nytt foerfarande.
NO880953D0 (no) 4-benzyl-piperazinyl-hydrazoner.
FI871618L (fi) Givarestruktur.
FI871465A0 (fi) Sjaelvdrivande trumfilter.
FI871816A0 (fi) Betningsaggregat foer en automatisk potatissaettningsmaskin.
ES2019679B3 (es) Mejoras en burletes.
FI881520A0 (fi) Klorfluorkolvaetekompositioner.
FI872670A0 (fi) Spel.
NO875149D0 (no) Maaletrommel-system.
ES269598Y (es) Juguete.
IT8321724V0 (it) Struttura di giocattolo passatempo.
ES521579A0 (es) Mejoras introducidas en arados.
FI78607B (fi) Traenaeste.
FI833621A (fi) Tvaodelad ask.
FI871973L (fi) Lie.
FI870318A0 (fi) Andningsmask foer haest.

Legal Events

Date Code Title Description
8363 Opposition against the patent
8328 Change in the person/name/address of the agent

Free format text: DERZEIT KEIN VERTRETER BESTELLT

8327 Change in the person/name/address of the patent owner

Owner name: GENE SHEARS PTY LTD., NORTH RYDE, NEUSUEDWALES, AU

8328 Change in the person/name/address of the agent

Free format text: UEXKUELL & STOLBERG, 22607 HAMBURG

8327 Change in the person/name/address of the patent owner

Owner name: GENE SHEARS PTY. LTD., CANBERRA, AU

8366 Restricted maintained after opposition proceedings