DD285354A5 - Verfahren zur herstellung von 2-oxo-benzimidazolin-1-carbonsaeurederivate - Google Patents

Verfahren zur herstellung von 2-oxo-benzimidazolin-1-carbonsaeurederivate Download PDF

Info

Publication number: DD285354A5
Authority: DD; German Democratic Republic
Prior art keywords: methyl; endo; alkyl; azabicyclo; compound
Prior art date: 1987-09-23

Application number

DD88319929A

Other languages

German (de)

English (en)

Inventor

Marco Turconi

Arturo Donetti

Rosamaria Micheletti

Annamaria Uberti

Massimo Nicola

Antonio Giachetti

Ernesto Montagna

Original Assignee

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Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-09-23

Filing date

1988-09-19

Publication date

1990-12-12

1988-09-19 Application filed by ��@��@��@�K@�K@�Kk�� filed Critical ��@��@��@�K@�K@�Kk��

1990-12-12 Publication of DD285354A5 publication Critical patent/DD285354A5/de

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
- C07D451/12—Oxygen atoms acylated by aromatic or heteroaromatic carboxylic acids, e.g. cocaine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/14—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/06—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing isoquinuclidine ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Anesthesiology (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Otolaryngology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

DD88319929A 1987-09-23 1988-09-19 Verfahren zur herstellung von 2-oxo-benzimidazolin-1-carbonsaeurederivate DD285354A5 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT8721997A IT1231413B (it)	1987-09-23	1987-09-23	Derivati dell'acido benzimidazolin-2-osso-1-carbossilico utili come antagonisti dei recettori 5-ht

Publications (1)

Publication Number	Publication Date
DD285354A5 true DD285354A5 (de)	1990-12-12

Family

ID=11189966

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DD88319929A DD285354A5 (de)	1987-09-23	1988-09-19	Verfahren zur herstellung von 2-oxo-benzimidazolin-1-carbonsaeurederivate

Country Status (28)

Country	Link
EP (1)	EP0309423B1 (da)
JP (1)	JPH0631225B2 (da)
KR (1)	KR960003604B1 (da)
AT (1)	ATE107305T1 (da)
BR (1)	BR1100514A (da)
CA (1)	CA1337347C (da)
CZ (1)	CZ279864B6 (da)
DD (1)	DD285354A5 (da)
DE (1)	DE3850203T2 (da)
DK (1)	DK172226B1 (da)
ES (1)	ES2054872T3 (da)
FI (1)	FI89920C (da)
HK (1)	HK142195A (da)
HU (2)	HU200770B (da)
IE (1)	IE63234B1 (da)
IL (1)	IL87795A (da)
IT (1)	IT1231413B (da)
LV (1)	LV11035B (da)
MX (1)	MX9203249A (da)
NO (1)	NO169286C (da)
NZ (1)	NZ226291A (da)
PH (1)	PH29923A (da)
PL (2)	PL152951B1 (da)
SK (1)	SK278812B6 (da)
SU (1)	SU1676451A3 (da)
UA (1)	UA8022A1 (da)
YU (1)	YU46925B (da)
ZA (1)	ZA887083B (da)

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IT1230881B (it) *	1989-06-20	1991-11-08	Angeli Inst Spa	Derivati del r(-) 3-chinuclidinolo
CA2030051C (en) *	1989-11-17	2001-08-07	Haruhiko Kikuchi	Indole derivatives
EP0436245A1 (en) *	1989-12-27	1991-07-10	Duphar International Research B.V	Substituted 3,4-annelated benzimidazol-2(1H)-ones
JP3122671B2 (ja) *	1990-05-23	2001-01-09	協和醗酵工業株式会社	複素環式化合物
US5192770A (en) *	1990-12-07	1993-03-09	Syntex (U.S.A.) Inc.	Serotonergic alpha-oxoacetamides
JP3026845B2 (ja) *	1991-02-20	2000-03-27	日清製粉株式会社	ピペリジン誘導体
IT1250629B (it) *	1991-07-04	1995-04-21	Boehringer Ingelheim Italia	Uso dei derivati dell'acido benzimidazolin-2-oxo-1-carbossilico.
GB9204565D0 (en) *	1992-03-03	1992-04-15	Smithkline Beecham Plc	Pharmaceuticals
JP2699794B2 (ja) *	1992-03-12	1998-01-19	三菱化学株式会社	チエノ〔３，２−ｂ〕ピリジン誘導体
JPH05310732A (ja) *	1992-03-12	1993-11-22	Mitsubishi Kasei Corp	シンノリン−３−カルボン酸誘導体
US5763459A (en) *	1992-05-23	1998-06-09	Smithkline Beecham P.L.C.	Medicaments for the treatment of anxiety
US5521193A (en) *	1992-06-24	1996-05-28	G. D. Searle & Co.	Benzimidazole compounds
US5300512A (en) *	1992-06-24	1994-04-05	G. D. Searle & Co.	Benzimidazole compounds
US5280028A (en) *	1992-06-24	1994-01-18	G. D. Searle & Co.	Benzimidazole compounds
WO1994000113A2 (en) *	1992-06-27	1994-01-06	Smithkline Beecham Plc	Medicaments containing 5-ht4 receptor antagonists
FR2694292B1 (fr) *	1992-07-29	1994-10-21	Esteve Labor Dr	Dérivés de benzimidazole-2-thione-, leur préparation et leur application en tant que médicament.
US5534521A (en) *	1993-06-23	1996-07-09	G. D. Searle & Co.	Benzimidazole compounds
GB9502582D0 (en) *	1995-02-10	1995-03-29	Smithkline Beecham Plc	Novel process
AU755117B2 (en) *	1999-05-12	2002-12-05	Sydney Gordon Low	A message processing system
TW200533348A (en)	2004-02-18	2005-10-16	Theravance Inc	Indazole-carboxamide compounds as 5-ht4 receptor agonists
TWI351282B (en)	2004-04-07	2011-11-01	Theravance Inc	Quinolinone-carboxamide compounds as 5-ht4 recepto
US7728006B2 (en)	2004-04-07	2010-06-01	Theravance, Inc.	Quinolinone-carboxamide compounds as 5-HT4 receptor agonists
US8309575B2 (en)	2004-04-07	2012-11-13	Theravance, Inc.	Quinolinone-carboxamide compounds as 5-HT4 receptor agonists
JP4129445B2 (ja) *	2004-06-15	2008-08-06	ファイザー・インク	ベンズイミダゾロンカルボン酸誘導体
DE602005014566D1 (de)	2004-11-05	2009-07-02	Theravance Inc	Chinolinon-carboxamid-verbindungen
JP5086091B2 (ja)	2004-11-05	2012-11-28	セラヴァンス，インコーポレーテッド	５−ｈｔ４受容体アゴニスト化合物
AU2005319190A1 (en)	2004-12-22	2006-06-29	Theravance, Inc.	Indazole-carboxamide compounds
EA013567B1 (ru)	2005-03-02	2010-06-30	Тереванс, Инк.	Хинолиноновые соединения в качестве агонистов рецептора 5-ht
US7317022B2 (en)	2005-06-07	2008-01-08	Theravance, Inc.	Benzoimidazolone-carboxamide compounds as 5-HT4 receptors agonists
MY143574A (en)	2005-11-22	2011-05-31	Theravance Inc	Carbamate compounds as 5-ht4 receptor agonists
WO2009016564A2 (en) *	2007-07-27	2009-02-05	Actelion Pharmaceuticals Ltd	2-aza-bicyclo[3.3.0]octane derivatives
EP2253316B1 (en)	2009-05-20	2013-08-14	INSERM (Institut National de la Santé et de la Recherche Médicale)	Serotonin 5-HT3 receptor antagonists for use in the treatment or prevention of an inner ear pathology with vestibular deficits
DK2432467T3 (da)	2009-05-20	2018-04-16	Inst Nat Sante Rech Med	Serotonin 5-ht3-receptorantagonister til anvendelse i behandling af vestibulære læsionsforstyrrelser
CA2834548C (en)	2011-04-28	2021-06-01	The Broad Institute, Inc.	Inhibitors of histone deacetylase
CA2880117C (en)	2012-07-27	2021-04-06	The Broad Institute, Inc.	Inhibitors of histone deacetylase
US9914717B2 (en)	2012-12-20	2018-03-13	The Broad Institute, Inc.	Cycloalkenyl hydroxamic acid derivatives and their use as histone deacetylase inhibitors
US20170166561A1 (en) *	2014-07-11	2017-06-15	Alpharmagen, Llc	Quinuclidine compounds for modulating alpha7-nicotinic acetylcholine receptor activity
US12128018B2 (en)	2018-01-12	2024-10-29	KDAc Therapeutics, Inc.	Combination of a selective histone deacetylase 3 (HDAC3) inhibitor and an immunotherapy agent for the treatment of cancer

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US4250176A (en) *	1976-12-21	1981-02-10	Janssen Pharmaceutica N.V.	Piperazine derivatives
EP0093488A3 (en) *	1982-03-18	1984-05-23	Beecham Group Plc	Nortropyl benzopyrrolinone compounds, process for their preparation and pharmaceutical compositions containing them
EP0247266B1 (en) *	1986-01-07	1993-03-10	Beecham Group Plc	Indole derivatives having an azabicyclic side chain, process for their preparation, intermediates, and pharmaceutical compositions

1987
- 1987-09-23 IT IT8721997A patent/IT1231413B/it active
1988
- 1988-09-19 PL PL1988279346A patent/PL152951B1/pl unknown
- 1988-09-19 PL PL1988274751A patent/PL151434B1/pl unknown
- 1988-09-19 DE DE3850203T patent/DE3850203T2/de not_active Expired - Lifetime
- 1988-09-19 EP EP88830375A patent/EP0309423B1/en not_active Expired - Lifetime
- 1988-09-19 ES ES88830375T patent/ES2054872T3/es not_active Expired - Lifetime
- 1988-09-19 AT AT88830375T patent/ATE107305T1/de not_active IP Right Cessation
- 1988-09-19 DD DD88319929A patent/DD285354A5/de not_active IP Right Cessation
- 1988-09-19 IL IL87795A patent/IL87795A/xx active Protection Beyond IP Right Term
- 1988-09-20 CA CA000577840A patent/CA1337347C/en not_active Expired - Lifetime
- 1988-09-20 JP JP63236179A patent/JPH0631225B2/ja not_active Expired - Lifetime
- 1988-09-21 YU YU177888A patent/YU46925B/sh unknown
- 1988-09-21 NZ NZ226291A patent/NZ226291A/xx unknown
- 1988-09-22 ZA ZA887083A patent/ZA887083B/xx unknown
- 1988-09-22 NO NO884202A patent/NO169286C/no not_active IP Right Cessation
- 1988-09-22 UA UA4356601A patent/UA8022A1/uk unknown
- 1988-09-22 SU SU884356601A patent/SU1676451A3/ru active
- 1988-09-22 IE IE286988A patent/IE63234B1/en not_active IP Right Cessation
- 1988-09-22 DK DK526188A patent/DK172226B1/da not_active IP Right Cessation
- 1988-09-22 HU HU884970A patent/HU200770B/hu not_active IP Right Cessation
- 1988-09-22 PH PH37579A patent/PH29923A/en unknown
- 1988-09-22 SK SK6307-88A patent/SK278812B6/sk unknown
- 1988-09-22 CZ CS886307A patent/CZ279864B6/cs not_active IP Right Cessation
- 1988-09-22 FI FI884350A patent/FI89920C/fi not_active IP Right Cessation
- 1988-09-23 KR KR88012299A patent/KR960003604B1/ko not_active IP Right Cessation
1992
- 1992-06-24 MX MX9203249A patent/MX9203249A/es unknown
1995
- 1995-02-17 LV LVP-95-33A patent/LV11035B/en unknown
- 1995-06-30 HU HU95P/P00691P patent/HU211566A9/hu unknown
- 1995-09-07 HK HK142195A patent/HK142195A/xx not_active IP Right Cessation
1997
- 1997-05-13 BR BR1100514-9A patent/BR1100514A/pt active IP Right Grant

Also Published As

Publication number	Publication date
FI89920B (fi)	1993-08-31
UA8022A1 (uk)	1995-12-26
DK172226B1 (da)	1998-01-12
PL152951B1 (en)	1991-02-28
CZ279864B6 (cs)	1995-07-12
EP0309423A2 (en)	1989-03-29
SK630788A3 (en)	1998-03-04
IT1231413B (it)	1991-12-04
HU200770B (en)	1990-08-28
HU211566A9 (en)	1995-12-28
PL274751A1 (en)	1989-09-04
NO169286C (no)	1992-06-03
NZ226291A (en)	1991-05-28
IL87795A (en)	1993-02-21
IE63234B1 (en)	1995-04-05
KR960003604B1 (en)	1996-03-20
CZ630788A3 (en)	1995-04-12
FI884350A (fi)	1989-03-24
DE3850203D1 (de)	1994-07-21
NO884202L (no)	1989-03-28
DE3850203T2 (de)	1994-09-22
SU1676451A3 (ru)	1991-09-07
CA1337347C (en)	1995-10-17
HK142195A (en)	1995-09-15
JPH01106882A (ja)	1989-04-24
KR890005105A (ko)	1989-05-11
FI884350A0 (fi)	1988-09-22
JPH0631225B2 (ja)	1994-04-27
PL151434B1 (en)	1990-09-28
NO884202D0 (no)	1988-09-22
NO169286B (no)	1992-02-24
YU46925B (sh)	1994-06-24
ATE107305T1 (de)	1994-07-15
PH29923A (en)	1996-09-16
AU2237888A (en)	1989-03-23
IE882869L (en)	1989-03-23
DK526188A (da)	1989-03-24
FI89920C (fi)	1993-12-10
ZA887083B (en)	1990-05-30
PL279346A1 (en)	1990-01-08
HUT48250A (en)	1989-05-29
LV11035B (en)	1996-08-20
EP0309423B1 (en)	1994-06-15
LV11035A (lv)	1996-02-20
SK278812B6 (sk)	1998-03-04
BR1100514A (pt)	2002-04-02
MX9203249A (es)	1992-07-01
DK526188D0 (da)	1988-09-22
IL87795A0 (en)	1989-03-31
ES2054872T3 (es)	1994-08-16
AU610040B2 (en)	1991-05-09
IT8721997A0 (it)	1987-09-23
EP0309423A3 (en)	1989-11-29
YU177888A (en)	1990-06-30

Publication	Publication Date	Title
DD285354A5 (de)	1990-12-12	Verfahren zur herstellung von 2-oxo-benzimidazolin-1-carbonsaeurederivate
DE69024381T2 (de)	1996-05-15	Benzo-annellierte-N-enthaltende heterocyclische Derivate
DE69025621T2 (de)	1996-07-04	Heterozyklische verbindungen
DE69020694T2 (de)	1996-01-18	Tricyclische Verbindungen.
DE3850255T2 (de)	1994-09-22	Heterocyclische Verbindungen.
US5358954A (en)	1994-10-25	Benzimidazoline-2-oxo-1-carboxylic acid derivatives useful as 5-HT receptor antagonists
EP0504679A1 (en)	1992-09-23	New imidazopyridines as serotonergic 5-HT3 antagonists
EP0528922B1 (de)	1999-06-16	Neue sulfonylverbindungen
DE69009195T2 (de)	1994-10-06	Isoxazol-Derivate mit Anti-Serotonin-Aktivität, deren Herstellungsverfahren und diese enthaltende Zusammensetzungen.
DD284013A5 (de)	1990-10-31	Verfahren zur herstellung von amidin- und guanidinderivaten
DE69022965T2 (de)	1996-04-04	Aminopiperazinderivate.
DE69232473T2 (de)	2002-11-21	Amid-Analoge-Derivate von bestimmten methanoverbrückten Chinolizinen
DE69205312T2 (de)	1996-03-14	Substituierte Imidazol-2-one Derivate und Verfahren zu deren Herstellung.
EP0288431B1 (de)	1992-08-19	3H-1,2,3-Triazolo[4,5-d]pyrimidine
WO1992014465A1 (de)	1992-09-03	Verwendung von anellierten tetrahydropyridinessigsäurederivaten für die behandlung neurologischer erkrankungen
DE60026883T2 (de)	2006-11-23	Methoden und zusammensetzungen zur behandlung von schmerzen
DE69514315T2 (de)	2000-07-27	AZABICYCLOALKYLDERIVATE VON IMIDAZO[1,5-a]INDOL-3-ONE ALS 5HT3 ANTAGONISTEN
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1994-03-17	RPI	Change in the person, name or address of the patentee (searches according to art. 11 and 12 extension act)
1995-06-08	ENJ	Ceased due to non-payment of renewal fee