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CY1124852T1 - Φαρμακευτικες συνθεσεις 3-(6-(1-(2,2-διφθοροβενζο[d][1,3]διοξολ-5-υλ) κυκλοπροπανοκαρβοξαμιδο)-3-μεθυλπυριδιν-2-υλ)βενζοϊκου οξεος και χορηγηση αυτων - Google Patents

Φαρμακευτικες συνθεσεις 3-(6-(1-(2,2-διφθοροβενζο[d][1,3]διοξολ-5-υλ) κυκλοπροπανοκαρβοξαμιδο)-3-μεθυλπυριδιν-2-υλ)βενζοϊκου οξεος και χορηγηση αυτων

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Publication number
CY1124852T1
CY1124852T1 CY20211101061T CY211101061T CY1124852T1 CY 1124852 T1 CY1124852 T1 CY 1124852T1 CY 20211101061 T CY20211101061 T CY 20211101061T CY 211101061 T CY211101061 T CY 211101061T CY 1124852 T1 CY1124852 T1 CY 1124852T1
Authority
CY
Cyprus
Prior art keywords
cyclopropanecarboxamido
difluorobenzo
dioxol
methylpyridin
benzoic acid
Prior art date
Application number
CY20211101061T
Other languages
English (en)
Inventor
Marinus Jacobus Verwijs
Rossitza Gueorguieva Alargova
Ritu Rohit Kaushik
Irina Nikolaevna Kadiyala
Christopher Ryan Young
Original Assignee
Vertex Pharmaceuticals Incorporated
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47075277&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1124852(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Vertex Pharmaceuticals Incorporated filed Critical Vertex Pharmaceuticals Incorporated
Publication of CY1124852T1 publication Critical patent/CY1124852T1/el

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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/443—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
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Abstract

Φαρμακευτική σύνθεση περιλαμβάνουσα Ένωση 1, (3-(6-(1-(2,2- διφθοροβενζο[d][1,3]διοξολ-5-υλ)κυκλοπροπανοκαρβοξαμιδο)-3-μεθυλπυριδιν-2-υλ)βενζοϊκό οξύ), και τουλάχιστον ένα έκδοχο που επιλέγεται από: πληρωτικό, αραιωτικό, αποσαθρωτικό, επιφανειοδραστικό, συνδετικό, ολισθητικό και λιπαντικό, η δε σύνθεση είναι κατάλληλη για χορήγηση από του στόματος σε έναν ασθενή που έχει ανάγκη αυτής για να θεραπεύεται προκαλούμενη από CFTR ασθένεια όπως Κυστική Ίνωση. Μέθοδοι για θεραπεία ασθενούς που έχει ανάγκη αυτής περιλαμβάνουν χορήγηση από του στόματος φαρμακευτικού σκευάσματος της Ένωσης 1 στον ασθενή.
CY20211101061T 2010-04-07 2021-12-03 Φαρμακευτικες συνθεσεις 3-(6-(1-(2,2-διφθοροβενζο[d][1,3]διοξολ-5-υλ) κυκλοπροπανοκαρβοξαμιδο)-3-μεθυλπυριδιν-2-υλ)βενζοϊκου οξεος και χορηγηση αυτων CY1124852T1 (el)

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PCT/US2011/031519 WO2011127241A2 (en) 2010-04-07 2011-04-07 Pharmaceutical compositions of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyriodin-2-yl)benzoic acid and administration thereof

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