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CY1124006T1 - Συζευγμενα αντισωματα κατα toy ly75 για τη θεραπεια του καρκινου - Google Patents

Συζευγμενα αντισωματα κατα toy ly75 για τη θεραπεια του καρκινου

Info

Publication number
CY1124006T1
CY1124006T1 CY20211100272T CY211100272T CY1124006T1 CY 1124006 T1 CY1124006 T1 CY 1124006T1 CY 20211100272 T CY20211100272 T CY 20211100272T CY 211100272 T CY211100272 T CY 211100272T CY 1124006 T1 CY1124006 T1 CY 1124006T1
Authority
CY
Cyprus
Prior art keywords
cancer
antibodies
treatment
conjugated antibodies
lymphoma
Prior art date
Application number
CY20211100272T
Other languages
English (en)
Inventor
Jonathan Alexander Terrett
James Edward ACKROYD
Original Assignee
Oxford Bio Therapeutics Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oxford Bio Therapeutics Limited filed Critical Oxford Bio Therapeutics Limited
Publication of CY1124006T1 publication Critical patent/CY1124006T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2851—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
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    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/68033—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a maytansine
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    • A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
    • A61K47/6855—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell the tumour determinant being from breast cancer cell
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    • A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
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Abstract

Η εφεύρεση παρέχει αντισώματα που δεσμεύονται με το LY75. Παρέχονται επίσης μόρια νουκλεϊκού οξέος που κωδικοποιούν τα αντισώματα, φορείς έκφρασης, κύτταρα-ξενιστές και μεθόδους έκφρασης των αντισωμάτων. Τα αντισώματα μπορούν να χρησιμοποιηθούν για τη θεραπεία του καρκίνου, συμπεριλαμβανομένου του καρκίνου του παγκρέατος, του καρκίνου των ωοθηκών, του καρκίνου του μαστού, του καρκίνου του παχέος εντέρου, του καρκίνου του οισοφάγου, του καρκίνου του δέρματος, του καρκίνου του θυρεοειδούς, του καρκίνου του πνεύμονα, του καρκίνου της ουροδόχου κύστης, πολλαπλού μυελώματος και λεμφώματος.
CY20211100272T 2013-10-11 2021-03-26 Συζευγμενα αντισωματα κατα toy ly75 για τη θεραπεια του καρκινου CY1124006T1 (el)

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PCT/GB2014/053057 WO2015052537A1 (en) 2013-10-11 2014-10-10 Conjugated antibodies against ly75 for the treatment of cancer

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