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PE20160561A1 - Anticuerpos conjugados contra ly75 para el tratamiento de cancer - Google Patents

Anticuerpos conjugados contra ly75 para el tratamiento de cancer

Info

Publication number
PE20160561A1
PE20160561A1 PE2016000466A PE2016000466A PE20160561A1 PE 20160561 A1 PE20160561 A1 PE 20160561A1 PE 2016000466 A PE2016000466 A PE 2016000466A PE 2016000466 A PE2016000466 A PE 2016000466A PE 20160561 A1 PE20160561 A1 PE 20160561A1
Authority
PE
Peru
Prior art keywords
cancer
antibodies
treatment
antibodies against
conjugated antibodies
Prior art date
Application number
PE2016000466A
Other languages
English (en)
Inventor
Jonathan Alexander Terrett
James Edward Ackroyd
Original Assignee
Oxford Biotherapeutics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oxford Biotherapeutics Ltd filed Critical Oxford Biotherapeutics Ltd
Publication of PE20160561A1 publication Critical patent/PE20160561A1/es

Links

Classifications

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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
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    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/68033—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a maytansine
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    • A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
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Abstract

La invencion proporciona anticuerpos que se unen a LY75. Tambien se proporcionan moleculas de acido nucleico que codifican los anticuerpos, vectores de expresion, celulas hospedadoras y procedimientos para expresar los anticuerpos. Los anticuerpos se pueden usar para el tratamiento del cancer, incluyendo cancer de pancreas, cancer de ovario, cancer de mama, cancer colorrectal, cancer de esofago, cancer de piel, cancer de tiroides, cancer de pulmon, cancer de vejiga, mieloma multiple y linfoma
PE2016000466A 2013-10-11 2014-10-10 Anticuerpos conjugados contra ly75 para el tratamiento de cancer PE20160561A1 (es)

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