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CY1111225T1 - Νεα πεπτιδια ως αναστολεις πρωτεασης νs3-σερινης ιου ηπατiτιδας c - Google Patents

Νεα πεπτιδια ως αναστολεις πρωτεασης νs3-σερινης ιου ηπατiτιδας c

Info

Publication number
CY1111225T1
CY1111225T1 CY20101100797T CY101100797T CY1111225T1 CY 1111225 T1 CY1111225 T1 CY 1111225T1 CY 20101100797 T CY20101100797 T CY 20101100797T CY 101100797 T CY101100797 T CY 101100797T CY 1111225 T1 CY1111225 T1 CY 1111225T1
Authority
CY
Cyprus
Prior art keywords
protease inhibitors
serine protease
inhibitors inhibit
new peptides
compounds
Prior art date
Application number
CY20101100797T
Other languages
English (en)
Inventor
Anil K Saksena
Viyyoor M Girijavallabhn
Raymond G Lovey
Edwin Jao
Frank Bennett
Cormick Jinping L Mc
Haiyan Wang
Russell E Pike
Stephane L Bogen
Tin-Yau Chan
Yi-Tsung Liu
Zhaoning Zhu
George F Njoroge
Ashok Arasappan
Tejal Parekh
Ashit K Ganguly
Kevin X Chen
Srikanth Venkatraman
Henry A Vaccaro
Patrick A Pinto
Bama Santhanam
Scott Jeffrey Kemp
Odile Esther Levy
Marguerita Lim-Wilby
Susan Y Tamura
Wanli Wu
Siska Hendrata
Yuhua Huang
Jesse K Wong
Latha G Nair
Original Assignee
Schering Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corporation filed Critical Schering Corporation
Publication of CY1111225T1 publication Critical patent/CY1111225T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Η παρούσα εφεύρεση αποκαλύπτει νέες ενώσεις οι οποίες έχουν ανασταλτική δραστικότητα πρωτεάσης HCV καθώς και μεθόδους παρασκευής τέτοιων ενώσεων. Σε άλλη πραγματοποίηση η εφεύρεση αποκαλύπτει φαρμακευτικές συνθέσεις που περιλαμβάνουν τέτοιες ενώσεις, καθώς και μεθόδους χρήσης αυτών για την θεραπεία διαταραχών που σχετίζονται με την πρωτεάση HCV.
CY20101100797T 2002-01-18 2010-09-01 Νεα πεπτιδια ως αναστολεις πρωτεασης νs3-σερινης ιου ηπατiτιδας c CY1111225T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/052,386 US7244721B2 (en) 2000-07-21 2002-01-18 Peptides as NS3-serine protease inhibitors of hepatitis C virus
EP03731956A EP1481000B1 (en) 2002-01-18 2003-01-16 Novel peptides as ns3-serine protease inhibitors of hepatitis c virus

Publications (1)

Publication Number Publication Date
CY1111225T1 true CY1111225T1 (el) 2015-06-11

Family

ID=27609106

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20101100797T CY1111225T1 (el) 2002-01-18 2010-09-01 Νεα πεπτιδια ως αναστολεις πρωτεασης νs3-σερινης ιου ηπατiτιδας c

Country Status (28)

Country Link
US (2) US7244721B2 (el)
EP (1) EP1481000B1 (el)
JP (1) JP4563033B2 (el)
KR (1) KR101020355B1 (el)
CN (2) CN1633446A (el)
AR (1) AR038183A1 (el)
AT (1) ATE469914T1 (el)
AU (1) AU2009210423B2 (el)
BR (1) BR0306931A (el)
CA (1) CA2473032A1 (el)
CO (1) CO5650168A2 (el)
CY (1) CY1111225T1 (el)
DE (1) DE60332814D1 (el)
DK (1) DK1481000T3 (el)
EC (1) ECSP045191A (el)
IL (1) IL162815A0 (el)
MX (1) MXPA04006934A (el)
MY (1) MY140710A (el)
NO (1) NO20042792L (el)
NZ (1) NZ571073A (el)
PE (1) PE20030852A1 (el)
PL (1) PL372747A1 (el)
PT (1) PT1481000E (el)
RU (1) RU2404189C9 (el)
SI (1) SI1481000T1 (el)
TW (1) TWI334872B (el)
WO (1) WO2003062265A2 (el)
ZA (1) ZA200405304B (el)

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* Cited by examiner, † Cited by third party
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