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MX2010010871A - Compuesto de indolinona. - Google Patents

Compuesto de indolinona.

Info

Publication number
MX2010010871A
MX2010010871A MX2010010871A MX2010010871A MX2010010871A MX 2010010871 A MX2010010871 A MX 2010010871A MX 2010010871 A MX2010010871 A MX 2010010871A MX 2010010871 A MX2010010871 A MX 2010010871A MX 2010010871 A MX2010010871 A MX 2010010871A
Authority
MX
Mexico
Prior art keywords
alkyl
constipation
pharmaceutical composition
activation activity
channel activation
Prior art date
Application number
MX2010010871A
Other languages
English (en)
Inventor
Hidetaka Kaku
Michihito Kageyama
Tomofumi Takuwa
Katsura Nozawa
Hitoshi Doihara
Original Assignee
Astellas Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astellas Pharma Inc filed Critical Astellas Pharma Inc
Publication of MX2010010871A publication Critical patent/MX2010010871A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/38—Oxygen atoms in positions 2 and 3, e.g. isatin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

Se proporciona un compuesto A, que es útil como un ingrediente activo para una composición farmacéutica, por ejemplo una composición farmacéutica para tratar el síndrome de intestino irritable de tipo estreñimiento, estreñimiento atónico y/o trastorno gastrointestinal funcional. Los presentes inventores han estudiado ampliamente los compuestos que tienen actividad de activación del canal de TRPA1, y han confirmado que un compuesto de indolinona tiene una actividad de activación del canal de TRPA1, y así completaron la presente invención. El compuesto de indolinona de la presente invención tiene una actividad de activación del canal de TRPA1 y puede utilizarse como un ingrediente activo de una composición farmacéutica para prevenir y/o tratar el síndrome de intestino irritable de tipo estreñimiento, estreñimiento atónico y/o trastorno gastrointestinal funcional o similares.
MX2010010871A 2008-04-01 2009-03-30 Compuesto de indolinona. MX2010010871A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2008095040 2008-04-01
PCT/JP2009/056431 WO2009123080A1 (ja) 2008-04-01 2009-03-30 インドリノン化合物

Publications (1)

Publication Number Publication Date
MX2010010871A true MX2010010871A (es) 2010-10-26

Family

ID=41135456

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010010871A MX2010010871A (es) 2008-04-01 2009-03-30 Compuesto de indolinona.

Country Status (13)

Country Link
US (1) US20110009379A1 (es)
EP (1) EP2261206A4 (es)
JP (1) JPWO2009123080A1 (es)
KR (1) KR20100135248A (es)
CN (1) CN101983188A (es)
AU (1) AU2009232836A1 (es)
BR (1) BRPI0909209A2 (es)
CA (1) CA2720275A1 (es)
IL (1) IL208164A0 (es)
MX (1) MX2010010871A (es)
RU (1) RU2010144548A (es)
WO (1) WO2009123080A1 (es)
ZA (1) ZA201006623B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012012498A2 (en) 2010-07-20 2012-01-26 Pulmatrix, Inc. Use of trp channel agonists to treat infections
WO2012078519A2 (en) * 2010-12-06 2012-06-14 Numerate, Inc. 3-acylidene-2-oxoindole derivatives for inhibition of transglutaminase 2
US9182233B2 (en) * 2012-05-17 2015-11-10 Robert Bosch Gmbh System and method for autocompletion and alignment of user gestures
US10482265B2 (en) * 2015-12-30 2019-11-19 International Business Machines Corporation Data-centric monitoring of compliance of distributed applications
KR102620902B1 (ko) * 2020-04-24 2024-01-04 가천대학교 산학협력단 신규 알파-시누클레인 방사성 리간드 및 이를 포함하는 신경퇴행성 질환 진단용 조성물
CN113545316B (zh) * 2020-04-24 2022-05-17 中国科学院上海药物研究所 血根碱在制备trpa1通道激动剂中的应用
WO2023090313A1 (ja) 2021-11-16 2023-05-25 京都府公立大学法人 摂食量亢進用及び／又は食欲不振改善用組成物並びに一過性受容器電位アンキリン１を活性化するための組成物
WO2024096014A1 (ja) 2022-10-31 2024-05-10 京都府公立大学法人 一過性受容器電位アンキリン１を活性化するための組成物並びに摂食量亢進用及び／又は食欲不振改善用組成物

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1239553A (es) * 1967-08-16 1971-07-21
US3428649A (en) 1968-01-23 1969-02-18 Mcneilab Inc Oxindole derivatives
WO1999057100A1 (en) * 1998-05-01 1999-11-11 Eli Lilly And Company Spla2 inhibitor compounds for treatment of disease
TWI270545B (en) * 2000-05-24 2007-01-11 Sugen Inc Mannich base prodrugs of 3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives
US7244721B2 (en) 2000-07-21 2007-07-17 Schering Corporation Peptides as NS3-serine protease inhibitors of hepatitis C virus
CA2508290C (en) * 2002-12-20 2017-02-28 Ciba Specialty Chemicals Holding Inc. Synthesis of amines and intermediates for the synthesis thereof
WO2006105796A1 (en) * 2005-04-08 2006-10-12 Leo Pharma A/S Novel indolinone derivatives
EP1872795A4 (en) * 2005-04-21 2009-07-22 Astellas Pharma Inc THERAPEUTIC AGENT AGAINST IRRITATION SYNDROME
JP2007047770A (ja) * 2005-07-13 2007-02-22 Fujifilm Corp 感光性組成物
EP1744212B1 (en) * 2005-07-13 2012-01-11 FUJIFILM Corporation Photosensitive composition
JP5460054B2 (ja) * 2005-11-23 2014-04-02 ザ ボード オブ リージェンツ オブ ザ ユニバーシティー オブ テキサス システム 腫瘍形成性ｒａｓ特異的細胞障害性化合物およびその使用法
NZ596024A (en) * 2006-08-07 2013-07-26 Ironwood Pharmaceuticals Inc Indole compounds
JP4591599B2 (ja) * 2006-10-06 2010-12-01 アステラス製薬株式会社 消化管運動改善剤スクリーニング法
TW201242961A (en) * 2007-06-20 2012-11-01 Ironwood Pharmaceuticals Inc FAAH inhibitors

Also Published As

Publication number Publication date
US20110009379A1 (en) 2011-01-13
ZA201006623B (en) 2011-11-30
KR20100135248A (ko) 2010-12-24
EP2261206A4 (en) 2011-08-17
CN101983188A (zh) 2011-03-02
CA2720275A1 (en) 2009-10-08
AU2009232836A1 (en) 2009-10-08
BRPI0909209A2 (pt) 2015-08-25
JPWO2009123080A1 (ja) 2011-07-28
WO2009123080A1 (ja) 2009-10-08
EP2261206A1 (en) 2010-12-15
IL208164A0 (en) 2010-12-30
RU2010144548A (ru) 2012-05-10

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Legal Events

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