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CY1108896T1 - ΔΙΠΛΟΚΛΩΝΟ RNA (dsRNA) ΓΙΑ ΤΗΝ ΑΝΑΣΤΟΛΗ ΤΗΣ ΕΚΦΡΑΣΗΣ ΠΡΟΚΑΘΟΡΙΣΜΕΝΟΥ ΓΟΝΙΔΙΟΥ - Google Patents

ΔΙΠΛΟΚΛΩΝΟ RNA (dsRNA) ΓΙΑ ΤΗΝ ΑΝΑΣΤΟΛΗ ΤΗΣ ΕΚΦΡΑΣΗΣ ΠΡΟΚΑΘΟΡΙΣΜΕΝΟΥ ΓΟΝΙΔΙΟΥ

Info

Publication number
CY1108896T1
CY1108896T1 CY20091100310T CY091100310T CY1108896T1 CY 1108896 T1 CY1108896 T1 CY 1108896T1 CY 20091100310 T CY20091100310 T CY 20091100310T CY 091100310 T CY091100310 T CY 091100310T CY 1108896 T1 CY1108896 T1 CY 1108896T1
Authority
CY
Cyprus
Prior art keywords
dsrna
expression
inhibit
stranded rna
double
Prior art date
Application number
CY20091100310T
Other languages
English (en)
Inventor
Roland Kreutzer
Stefan Limmer
Original Assignee
Alnylam Europe Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26051592&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1108896(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Alnylam Europe Ag filed Critical Alnylam Europe Ag
Publication of CY1108896T1 publication Critical patent/CY1108896T1/el

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/111—General methods applicable to biologically active non-coding nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/11—Antisense
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    • C12N2330/30—Production chemically synthesised
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    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Η εφεύρεση αφορά ολιγοριβονουκλεοτίδιο με διπλόκλωνη δομή (dsRNA) για την αναστολή της έκφρασης ενός προκαθορισμένου γονιδίου-στόχου εντός κυττάρων θηλαστικών, στην οποία περίπτωση το dsRNA περιλαμβάνει 15 έως 49 ζεύγη βάσεων και ένας κλώνος του dsRNA περιλαμβάνει περιοχή I περιλαμβάνουσα το πολύ 49 διαδοχικά ζεύγη νουκλεοτιδίων και τουλάχιστον κατά τμήματα συμπληρωματική προς το γονίδιο-στόχος, και συμπληρωματική περιοχή II εσωτερικά της διπλόκλωνης δομής είναι σχηματισμένη από δύο ξεχωριστούς RNA-μονοκλώνους.
CY20091100310T 1999-01-30 2009-03-20 ΔΙΠΛΟΚΛΩΝΟ RNA (dsRNA) ΓΙΑ ΤΗΝ ΑΝΑΣΤΟΛΗ ΤΗΣ ΕΚΦΡΑΣΗΣ ΠΡΟΚΑΘΟΡΙΣΜΕΝΟΥ ΓΟΝΙΔΙΟΥ CY1108896T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19903713 1999-01-30
DE19956568A DE19956568A1 (de) 1999-01-30 1999-11-24 Verfahren und Medikament zur Hemmung der Expression eines vorgegebenen Gens
EP05002454A EP1550719B1 (de) 1999-01-30 2000-01-29 Doppelsträngige RNA (dsRNA) zur Hemmung der Expression eines vorgegebenen Gens

Publications (1)

Publication Number Publication Date
CY1108896T1 true CY1108896T1 (el) 2014-07-02

Family

ID=26051592

Family Applications (3)

Application Number Title Priority Date Filing Date
CY20091100310T CY1108896T1 (el) 1999-01-30 2009-03-20 ΔΙΠΛΟΚΛΩΝΟ RNA (dsRNA) ΓΙΑ ΤΗΝ ΑΝΑΣΤΟΛΗ ΤΗΣ ΕΚΦΡΑΣΗΣ ΠΡΟΚΑΘΟΡΙΣΜΕΝΟΥ ΓΟΝΙΔΙΟΥ
CY20161101011T CY1118264T1 (el) 1999-01-30 2016-10-12 Ολιγονουκλεοτιδio για την αναστολη της εκφρασης προκαθορισμενου γονιδιου
CY20171100634T CY1119221T1 (el) 1999-01-30 2017-06-15 Μεθοδος και φαρμακο για αναστολη της εκφρασης ενος προκαθορισμενου γονιδιου

Family Applications After (2)

Application Number Title Priority Date Filing Date
CY20161101011T CY1118264T1 (el) 1999-01-30 2016-10-12 Ολιγονουκλεοτιδio για την αναστολη της εκφρασης προκαθορισμενου γονιδιου
CY20171100634T CY1119221T1 (el) 1999-01-30 2017-06-15 Μεθοδος και φαρμακο για αναστολη της εκφρασης ενος προκαθορισμενου γονιδιου

Country Status (14)

Country Link
US (17) US8119608B2 (el)
EP (6) EP1798285B1 (el)
JP (14) JP2003502012A (el)
AT (3) ATE418610T1 (el)
AU (2) AU778474B2 (el)
CA (1) CA2359180C (el)
CY (3) CY1108896T1 (el)
DE (7) DE19956568A1 (el)
DK (4) DK2363479T3 (el)
ES (5) ES2182791T3 (el)
HK (1) HK1160487A1 (el)
PT (4) PT2363479T (el)
WO (1) WO2000044895A1 (el)
ZA (1) ZA200105909B (el)

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