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CR20150493A - Composiciones de amri contra el componente c5 del complemento y métodos para su uso - Google Patents

Composiciones de amri contra el componente c5 del complemento y métodos para su uso

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Publication number
CR20150493A
CR20150493A CR20150493A CR20150493A CR20150493A CR 20150493 A CR20150493 A CR 20150493A CR 20150493 A CR20150493 A CR 20150493A CR 20150493 A CR20150493 A CR 20150493A CR 20150493 A CR20150493 A CR 20150493A
Authority
CR
Costa Rica
Prior art keywords
methods
complement
amri
compositions against
against component
Prior art date
Application number
CR20150493A
Other languages
English (en)
Inventor
Kallanthottathil G Rajeev
Kevin Fitzgerald
Muthiah Manoharan
Martin Maier
Satyanarayana Kuchimanchi
James Butler
Brian Bettencourt
Anna Borodovsky
Klaus Charisse
Donald Foster
Original Assignee
Alnylam Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alnylam Pharmaceuticals Inc filed Critical Alnylam Pharmaceuticals Inc
Publication of CR20150493A publication Critical patent/CR20150493A/es

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    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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Abstract

La invención se relaciona con ARNi, por ejemplo, composiciones de ácido ribonucleico de hebra doble (ARNhd), dirigidas al gen del componente C5 del complemento, y métodos para usar dicho ARNi.
CR20150493A 2013-03-14 2015-09-16 Composiciones de amri contra el componente c5 del complemento y métodos para su uso CR20150493A (es)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201361782531P 2013-03-14 2013-03-14
US201361837399P 2013-06-20 2013-06-20
US201361904579P 2013-11-15 2013-11-15
US201361912777P 2013-12-06 2013-12-06
US201461942367P 2014-02-20 2014-02-20
PCT/US2014/025882 WO2014160129A2 (en) 2013-03-14 2014-03-13 Complement component c5 irna compositions and methods of use thereof

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Publication Number Publication Date
CR20150493A true CR20150493A (es) 2016-03-28

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CR20150493A CR20150493A (es) 2013-03-14 2015-09-16 Composiciones de amri contra el componente c5 del complemento y métodos para su uso

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EP (2) EP2970974B1 (es)
JP (4) JP6524060B2 (es)
KR (4) KR102234620B1 (es)
CN (2) CN105324485B (es)
AU (3) AU2014244116B9 (es)
BR (1) BR112015022876B1 (es)
CA (2) CA3216595A1 (es)
CL (4) CL2015002710A1 (es)
CR (1) CR20150493A (es)
CY (1) CY1120289T1 (es)
DK (1) DK2970974T3 (es)
DO (1) DOP2015000234A (es)
EA (1) EA201591707A1 (es)
ES (1) ES2649490T3 (es)
GT (1) GT201500293A (es)
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US9228186B2 (en) 2002-11-14 2016-01-05 Thermo Fisher Scientific Inc. Methods and compositions for selecting siRNA of improved functionality
JP2015502931A (ja) 2011-11-18 2015-01-29 アルナイラム ファーマシューティカルズ, インコーポレイテッドAlnylam Pharmaceuticals, Inc. 修飾RNAi剤
BR112015022876B1 (pt) * 2013-03-14 2022-03-15 Alnylam Pharmaceuticals, Inc Agente de rna fita dupla, composição farmacêutica e método para inibição da expressão do componente do complemento c5 em uma célula
CA2897334A1 (en) 2013-03-29 2014-10-02 Alexion Pharmaceuticals, Inc. Compositions and methods for increasing the serum half-life of a therapeutic agent targeting complement c5
WO2015168635A2 (en) 2014-05-01 2015-11-05 Isis Pharmaceuticals, Inc. Compositions and methods for modulating complement factor b expression
IL316808A (en) 2014-08-20 2025-01-01 Alnylam Pharmaceuticals Inc Modified double-stranded RNA materials and their uses
WO2016040589A1 (en) * 2014-09-12 2016-03-17 Alnylam Pharmaceuticals, Inc. Polynucleotide agents targeting complement component c5 and methods of use thereof
WO2016044419A1 (en) * 2014-09-16 2016-03-24 Alnylam Pharmaceuticals, Inc. Complement component c5 irna compositions and methods of use thereof
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SG10201700239UA (en) 2017-02-27
EP3312281A3 (en) 2018-06-27
JP2019142944A (ja) 2019-08-29
NZ751385A (en) 2021-05-28
CN105324485B (zh) 2021-11-23
MX366660B (es) 2019-07-18
DK2970974T3 (en) 2017-12-04

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