CO5550460A2 - Moduladores de receptores ampa alostericos naftotiazina positivos (paarm) - Google Patents
Moduladores de receptores ampa alostericos naftotiazina positivos (paarm)Info
- Publication number
- CO5550460A2 CO5550460A2 CO03105591A CO03105591A CO5550460A2 CO 5550460 A2 CO5550460 A2 CO 5550460A2 CO 03105591 A CO03105591 A CO 03105591A CO 03105591 A CO03105591 A CO 03105591A CO 5550460 A2 CO5550460 A2 CO 5550460A2
- Authority
- CO
- Colombia
- Prior art keywords
- alkyl
- nr6r7
- so2h
- group
- optionally substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/02—1,2-Thiazines; Hydrogenated 1,2-thiazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychiatry (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Abstract
1.- Compuestos de la fórmula general (I) en dondeR1 significa un radical elegido del grupo consistente en hidrógeno, un grupo alquilo C1-C6 eventualmente sustituido con uno o varios átomos de halógeno, -SO2H, -SO2- -alquilo C1-C6, -SO-alquilo C1-C6, -CO-alquilo C1-C6, -O, fenil-alquilo C1-C4, -alquil C1-C4-NR6R7 y -alquil C1-C4-O-alquilo C1-C4, y cicloalquilo C3-C6, R2, R3, iguales o diferentes, significan un radical elegido del grupo consistente en hidrógeno, un grupo alquilo C1-C6 eventualmente sustituido con uno o varios átomos de halógeno, halógeno, -NO2, -SO2H, -SO2-alquilo C1-C6, -SO-alquilo C1-C6, -CO-alquilo C1-C6, -OH, -O-alquiloC1-C6, -S-alquilo C1-C6, alquil C1-C4-NR6R7 y -alquil C1-C4-O-alquilo C1-C4, y cicloalquilo C3-C6, oR1 y R2, juntos, significan un puente de alquileno C4-C6 ,R6, R7, iguales o diferentes, significan hidrógeno, alquilo C1-C4 o -CO-alquilo C1-C4, R4, iguales o diferentes, significa un radical elegido del grupo consistente en un grupo alquilo C1-C6 eventualmente sustituido con uno o varios átomos de halógeno, fenil-alquilo C1-C4, halógeno, -CN, -NO2, -SO2H, -SO3H, -SO2-alquilo C1-C6, -SO-alquilo C1-C6, -SO2-NR6R7, -COOH, -CO-alquilo C1-C6, TO-CO-alquilo C1-C4, -CO-O-alquilo C1-C4, -O-CO-O-alquilo C1-C4, -CO-NR6R7, -OH, -O-alquilo C1-C6, -S-alquilo C1-C6, -NR6R7 yun radical arilo, eventualmente sustituido, una vez o varias veces, con átomos de halógeno, -NO2, -SO2H o alquilo C1-C4, R5, iguales o diferentes, significa un radical elegido del grupo consistente en un grupo alquilo C1-C6 eventualmente sustituido con uno o varios átomos de halógeno, fenil-alquilo C1-C4, halógeno, -CN, -NO2, -SO2H, -SO3H, -SO2-alquilo C1-C6, -SO-alquilo C1-C6, -SO2-NR6R7, -COOH, -CO-alquilo C1-C6, -O-CO-alquilo C1-C4, -CO-O-alquilo C1-C4, -O-CO-O-alquilo C1-C4, -CO-NR6R7, -OH, -O-alquilo C1-C6, -S-alquilo C1-C6, -NR6R7 y un radical arilo, eventualmente sustituido, una vez o varias veces, con átomos de halógeno, -NO2, -SO2H o alquilo C1-C4, yn, m, iguales o diferentes, significan 0, 1, 2 o 3,con la condición de que esté excluida nafto[1,8-de]-2,3-dihidro-1,1-dióxido-1,2-tiazina, eventualmente en forma de sus distintos enantiómeros y diastereoisómeros, así como de sus sales fármacológicamente inocuas.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10123952A DE10123952A1 (de) | 2001-05-17 | 2001-05-17 | Neue positive allosterische AMPA-Rezeptor Modulatoren (PAARM), Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO5550460A2 true CO5550460A2 (es) | 2005-08-31 |
Family
ID=7685080
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO03105591A CO5550460A2 (es) | 2001-05-17 | 2003-12-01 | Moduladores de receptores ampa alostericos naftotiazina positivos (paarm) |
Country Status (26)
| Country | Link |
|---|---|
| EP (1) | EP1404340A1 (es) |
| JP (1) | JP2004529980A (es) |
| KR (1) | KR20040007572A (es) |
| CN (1) | CN1533278A (es) |
| AR (1) | AR036332A1 (es) |
| BG (1) | BG108324A (es) |
| BR (1) | BR0209796A (es) |
| CA (1) | CA2449189A1 (es) |
| CO (1) | CO5550460A2 (es) |
| CZ (1) | CZ20033112A3 (es) |
| DE (1) | DE10123952A1 (es) |
| EA (1) | EA006608B1 (es) |
| EC (1) | ECSP034852A (es) |
| EE (1) | EE200300566A (es) |
| HR (1) | HRP20030933A2 (es) |
| HU (1) | HUP0401273A3 (es) |
| IL (1) | IL158642A0 (es) |
| MX (1) | MXPA03010373A (es) |
| NO (1) | NO20035088L (es) |
| NZ (1) | NZ530154A (es) |
| PL (1) | PL364053A1 (es) |
| SK (1) | SK14222003A3 (es) |
| UY (1) | UY27290A1 (es) |
| WO (1) | WO2002100411A1 (es) |
| YU (1) | YU90403A (es) |
| ZA (1) | ZA200308466B (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20090047534A (ko) * | 2006-08-31 | 2009-05-12 | 더 거버너스 오브 더 유니버시티 오브 앨버타 | 양성 알로스테릭 ａｍｐａ 수용체 조절인자를 사용하여 호흡 저하를 억제하는 방법 |
| CN111518058B (zh) * | 2020-05-29 | 2021-03-09 | 四川大学华西医院 | 一种噁噻嗪类化合物及其用途 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU4345297A (en) * | 1996-09-17 | 1998-04-14 | Regents Of The University Of California, The | Benzothiadiazide derivatives and their use as allosteric up-modulators of the ampa receptor |
| WO1999067242A1 (en) * | 1998-06-25 | 1999-12-29 | Merck & Co., Inc. | Naphtho[1,8-de]thiasin-2-yl methyl carbapenem antibacterials |
| DE10004572A1 (de) * | 2000-02-02 | 2001-08-09 | Boehringer Ingelheim Pharma | Neue positive allosterische AMPA-Rezeptor Modulatoren (PAARM), Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel |
-
2001
- 2001-05-17 DE DE10123952A patent/DE10123952A1/de not_active Withdrawn
-
2002
- 2002-05-15 EP EP02750931A patent/EP1404340A1/en not_active Withdrawn
- 2002-05-15 JP JP2003503232A patent/JP2004529980A/ja not_active Abandoned
- 2002-05-15 IL IL15864202A patent/IL158642A0/xx unknown
- 2002-05-15 BR BR0209796-6A patent/BR0209796A/pt not_active Expired - Fee Related
- 2002-05-15 EE EEP200300566A patent/EE200300566A/xx unknown
- 2002-05-15 KR KR10-2003-7014965A patent/KR20040007572A/ko not_active Application Discontinuation
- 2002-05-15 MX MXPA03010373A patent/MXPA03010373A/es unknown
- 2002-05-15 PL PL02364053A patent/PL364053A1/xx not_active Application Discontinuation
- 2002-05-15 YU YU90403A patent/YU90403A/sh unknown
- 2002-05-15 WO PCT/EP2002/005338 patent/WO2002100411A1/en not_active Application Discontinuation
- 2002-05-15 CN CNA028100832A patent/CN1533278A/zh active Pending
- 2002-05-15 UY UY27290A patent/UY27290A1/es not_active Application Discontinuation
- 2002-05-15 CZ CZ20033112A patent/CZ20033112A3/cs unknown
- 2002-05-15 HU HU0401273A patent/HUP0401273A3/hu unknown
- 2002-05-15 NZ NZ530154A patent/NZ530154A/en unknown
- 2002-05-15 SK SK1422-2003A patent/SK14222003A3/sk unknown
- 2002-05-15 CA CA002449189A patent/CA2449189A1/en not_active Abandoned
- 2002-05-15 EA EA200301167A patent/EA006608B1/ru not_active IP Right Cessation
- 2002-05-17 AR ARP020101827A patent/AR036332A1/es not_active Suspension/Interruption
-
2003
- 2003-10-30 ZA ZA200308466A patent/ZA200308466B/en unknown
- 2003-11-07 BG BG108324A patent/BG108324A/bg active Pending
- 2003-11-14 NO NO20035088A patent/NO20035088L/no not_active Application Discontinuation
- 2003-11-14 HR HR20030933A patent/HRP20030933A2/xx not_active Application Discontinuation
- 2003-11-17 EC EC2003004852A patent/ECSP034852A/es unknown
- 2003-12-01 CO CO03105591A patent/CO5550460A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EE200300566A (et) | 2004-02-16 |
| EA200301167A1 (ru) | 2004-06-24 |
| AR036332A1 (es) | 2004-09-01 |
| BG108324A (bg) | 2004-12-30 |
| NO20035088D0 (no) | 2003-11-14 |
| CA2449189A1 (en) | 2002-12-19 |
| PL364053A1 (en) | 2004-12-13 |
| IL158642A0 (en) | 2004-05-12 |
| EA006608B1 (ru) | 2006-02-24 |
| CZ20033112A3 (en) | 2004-03-17 |
| WO2002100411A1 (en) | 2002-12-19 |
| SK14222003A3 (sk) | 2004-05-04 |
| EP1404340A1 (en) | 2004-04-07 |
| YU90403A (sh) | 2006-05-25 |
| ECSP034852A (es) | 2003-12-24 |
| DE10123952A1 (de) | 2002-11-21 |
| JP2004529980A (ja) | 2004-09-30 |
| HUP0401273A2 (hu) | 2004-10-28 |
| KR20040007572A (ko) | 2004-01-24 |
| ZA200308466B (en) | 2004-05-24 |
| HRP20030933A2 (en) | 2004-04-30 |
| MXPA03010373A (es) | 2004-03-16 |
| NO20035088L (no) | 2003-11-14 |
| UY27290A1 (es) | 2002-12-31 |
| HUP0401273A3 (en) | 2006-11-28 |
| NZ530154A (en) | 2005-09-30 |
| CN1533278A (zh) | 2004-09-29 |
| BR0209796A (pt) | 2004-06-01 |
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