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CO4890856A1 - CICATRIZACION DE FRACTURAS USANDO ANALOGOS DE PTHrP - Google Patents

CICATRIZACION DE FRACTURAS USANDO ANALOGOS DE PTHrP

Info

Publication number
CO4890856A1
CO4890856A1 CO98051174A CO98051174A CO4890856A1 CO 4890856 A1 CO4890856 A1 CO 4890856A1 CO 98051174 A CO98051174 A CO 98051174A CO 98051174 A CO98051174 A CO 98051174A CO 4890856 A1 CO4890856 A1 CO 4890856A1
Authority
CO
Colombia
Prior art keywords
healing
fractures
pthrp
pthrp analogs
analogs
Prior art date
Application number
CO98051174A
Other languages
English (en)
Inventor
Brian Henry Vickery
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of CO4890856A1 publication Critical patent/CO4890856A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/635—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/29—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Un análogo polipeptídico del péptido relacionado con la hormonaparatiroidea (PTHrP) y de sales del mismo, en el cual los residuos aminoacídicos 22-31 de dicho análogo de PTHrP forman una hélice a anfifática, para ser utilizado en la cicatrización de hueso y reparación de fracturas.
CO98051174A 1997-09-09 1998-09-07 CICATRIZACION DE FRACTURAS USANDO ANALOGOS DE PTHrP CO4890856A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US5832497P 1997-09-09 1997-09-09

Publications (1)

Publication Number Publication Date
CO4890856A1 true CO4890856A1 (es) 2000-02-28

Family

ID=22016113

Family Applications (1)

Application Number Title Priority Date Filing Date
CO98051174A CO4890856A1 (es) 1997-09-09 1998-09-07 CICATRIZACION DE FRACTURAS USANDO ANALOGOS DE PTHrP

Country Status (32)

Country Link
US (1) US6583114B2 (es)
EP (1) EP1005359B1 (es)
JP (1) JP2002509854A (es)
KR (1) KR100679778B1 (es)
CN (1) CN1210059C (es)
AR (1) AR015435A1 (es)
AT (1) ATE297754T1 (es)
AU (1) AU752925B2 (es)
BR (1) BR9812068A (es)
CA (1) CA2302255C (es)
CO (1) CO4890856A1 (es)
CZ (1) CZ298701B6 (es)
DE (1) DE69830591T2 (es)
ES (1) ES2244090T3 (es)
HK (1) HK1030753A1 (es)
HR (1) HRP20000109A2 (es)
HU (1) HU226866B1 (es)
IL (2) IL134719A0 (es)
MA (1) MA26545A1 (es)
MY (1) MY121291A (es)
NO (1) NO323740B1 (es)
NZ (1) NZ502970A (es)
PE (1) PE117399A1 (es)
PL (1) PL195703B1 (es)
RS (1) RS49707B (es)
RU (1) RU2224539C2 (es)
SA (1) SA98190565B1 (es)
TR (1) TR200000649T2 (es)
TW (1) TW552139B (es)
UY (1) UY25172A1 (es)
WO (1) WO1999012561A2 (es)
ZA (1) ZA988030B (es)

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DZ2873A1 (fr) * 1998-08-19 2003-12-15 Lilly Co Eli Procédé pour augmenter la dureté et la rigidité osseuse.
EP1136076A1 (en) * 1998-08-19 2001-09-26 Eli Lilly And Company Method of increasing bone toughness and stiffness and reducing fractures
EP1769804B1 (en) * 1998-08-19 2012-09-19 Eli Lilly And Company hPTH(1-34) for use in preventing or reducing the incidence or severity of vertebral and / or non vertebral fracture in a male human
US20040033950A1 (en) 2000-09-26 2004-02-19 Hock Janet M. Method of increasing bone toughness and stiffness and reducing fractures
CA2245903A1 (en) * 1998-09-28 2000-03-28 Mcgill University Use of pex in the treatment of metabolic bone diseases
DE60015508T2 (de) 1999-03-05 2005-04-21 Univ Durham C-16 ungesätigte fp-selektive prostaglandin analoge
US20020013294A1 (en) 2000-03-31 2002-01-31 Delong Mitchell Anthony Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives
US20020172693A1 (en) 2000-03-31 2002-11-21 Delong Michell Anthony Compositions and methods for treating hair loss using non-naturally occurring prostaglandins
US6393328B1 (en) * 2000-05-08 2002-05-21 International Rehabilitative Sciences, Inc. Multi-functional portable electro-medical device
US6560487B1 (en) * 2000-05-08 2003-05-06 International Rehabilitative Sciences, Inc. Electro-medical device for use with biologics
US6675048B2 (en) * 2000-05-08 2004-01-06 International Rehabilitative Sciences, Inc. Electro-medical device for use with biologics
MXPA04006728A (es) * 2002-01-10 2005-08-19 Osteotrophin Llc Tratamiento de desordenes oseos con medicamentos anabolicos esqueleticos.
WO2005041998A1 (en) 2003-10-02 2005-05-12 Ali Sadat M Peptide for promoting healing of fractures
WO2006042152A2 (en) * 2004-10-08 2006-04-20 Forbes Medi-Tech (Research) Inc. Vasoactive intestinal polypeptide pharmaceuticals
JP2009515535A (ja) * 2005-11-10 2009-04-16 ボード オブ コントロール オブ ミシガン テクノロジカル ユニヴァーシティー クロクマの副甲状腺ホルモン及びクロクマの副甲状腺ホルモンを使用する方法
US20090022684A1 (en) * 2006-05-09 2009-01-22 Paul Morley Methods for hematopoietic stimulation
USRE49444E1 (en) 2006-10-03 2023-03-07 Radius Health, Inc. Method of treating osteoporosis comprising administration of PTHrP analog
KR101512377B1 (ko) 2006-10-03 2015-04-28 라디우스 헬쓰, 인코포레이티드 골 아나볼릭 단백질을 위한 약물 전달 방법
US7803770B2 (en) * 2006-10-03 2010-09-28 Radius Health, Inc. Method of treating osteoporosis comprising administration of PTHrP analog
EP1961765A1 (en) * 2006-12-08 2008-08-27 Zealand Pharma A/S Truncated PTH peptides with a cyclic conformation
JP5564167B2 (ja) * 2008-05-22 2014-07-30 日本たばこ産業株式会社 苦味マスキング剤及び苦味低減方法
US8870876B2 (en) 2009-02-13 2014-10-28 Tarsus Medical Inc. Methods and devices for treating hallux valgus
US8563513B2 (en) 2009-03-27 2013-10-22 Van Andel Research Institute Parathyroid hormone peptides and parathyroid hormone-related protein peptides and methods of use
US8277459B2 (en) 2009-09-25 2012-10-02 Tarsus Medical Inc. Methods and devices for treating a structural bone and joint deformity
US8987201B2 (en) 2009-12-07 2015-03-24 Michigan Technological University Black bear parathyroid hormone and methods of using black bear parathyroid hormone
US8652141B2 (en) 2010-01-21 2014-02-18 Tarsus Medical Inc. Methods and devices for treating hallux valgus
US8696719B2 (en) 2010-06-03 2014-04-15 Tarsus Medical Inc. Methods and devices for treating hallux valgus
CN104146961B (zh) * 2014-07-04 2018-02-27 深圳职业技术学院 一种薄膜蒸发法制备载细胞因子和骨蛋白微球的方法
MX2017013801A (es) 2015-04-29 2018-08-15 Radius Pharmaceuticals Inc Métodos para tratar el cáncer.
CN108025042A (zh) * 2015-07-06 2018-05-11 董正欣 PTHrP类似物的新型制剂
EP3481414B1 (en) 2016-04-18 2021-11-03 Radius Health, Inc. Formulations of abaloparatide, transdermal patches thereof, and uses thereof
IL292245B1 (en) 2017-01-05 2024-12-01 Radius Pharmaceuticals Inc Polymorphic forms of rad1901-2hcl
US10996208B2 (en) 2017-04-28 2021-05-04 Radius Health, Inc. Abaloparatide formulations and methods of testing, storing, modifying, and using same
WO2020010216A1 (en) 2018-07-04 2020-01-09 Radius Pharmaceuticals, Inc. Polymorphic forms of rad 1901-2hcl
EP4027899A4 (en) * 2019-09-12 2023-08-16 Radius Health, Inc. METHODS OF ENHANCING SPINE FUSION USING ABALOPARATIDE
CN112646042A (zh) * 2019-10-10 2021-04-13 陕西麦科奥特科技有限公司 活性多肽化合物
WO2022149066A1 (en) * 2021-01-05 2022-07-14 Radius Health, Inc. Treatment of long bone fractures with abaloparatide

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DE3935738A1 (de) * 1989-10-27 1991-05-08 Forssmann Wolf Georg Arzneimittel, enthaltend das humane parathormon-fragment (1-37) als aktiven wirkstoff
US5821225A (en) * 1992-07-14 1998-10-13 Syntex (U.S.A.) Inc. Method for the treatment of corticosteroid induced osteopenia comprising administration of modified PTH or PTHrp
US5977070A (en) * 1992-07-14 1999-11-02 Piazza; Christin Teresa Pharmaceutical compositions for the nasal delivery of compounds useful for the treatment of osteoporosis
US5589452A (en) * 1992-07-14 1996-12-31 Syntex (U.S.A.) Inc. Analogs of parathyroid hormone and parathyroid hormone related peptide: synthesis and use for the treatment of osteoporosis
AU672790B2 (en) * 1992-07-15 1996-10-17 Novartis Ag Variants of parathyroid hormone and its fragments
WO1995002610A1 (en) * 1993-07-13 1995-01-26 Syntex (U.S.A.) Inc. Analogs of parathyroid hormone and parathyroid hormone related peptide: synthesis and use for the treatment of osteoporosis
TW273513B (es) * 1993-10-27 1996-04-01 Chugai Pharmaceutical Co Ltd
JPH08310965A (ja) * 1995-05-16 1996-11-26 Chugai Pharmaceut Co Ltd 骨癒合促進剤
US5717062A (en) * 1995-06-07 1998-02-10 Beth Israel Hospital Association Cyclic analogs of PTH and PTHrP
US5723577A (en) * 1995-07-13 1998-03-03 Biomeasure Inc. Analogs of parathyroid hormone
US5955574A (en) * 1995-07-13 1999-09-21 Societe De Conseils De Recherches Et D'applications Scientifiques, S.A. Analogs of parathyroid hormone

Also Published As

Publication number Publication date
ATE297754T1 (de) 2005-07-15
KR100679778B1 (ko) 2007-02-07
PE117399A1 (es) 1999-11-20
WO1999012561A2 (en) 1999-03-18
IL134719A0 (en) 2001-04-30
WO1999012561A9 (en) 2000-03-16
DE69830591D1 (de) 2005-07-21
AR015435A1 (es) 2001-05-02
NZ502970A (en) 2002-03-01
PL339449A1 (en) 2000-12-18
TW552139B (en) 2003-09-11
CZ2000862A3 (cs) 2000-09-13
ES2244090T3 (es) 2005-12-01
IL134719A (en) 2010-04-29
US20020077281A1 (en) 2002-06-20
NO323740B1 (no) 2007-07-02
AU9740698A (en) 1999-03-29
CA2302255A1 (en) 1999-03-18
WO1999012561A3 (en) 1999-05-14
HUP0004560A3 (en) 2005-11-28
HU226866B1 (en) 2009-12-28
AU752925B2 (en) 2002-10-03
HK1030753A1 (en) 2001-05-18
JP2002509854A (ja) 2002-04-02
EP1005359B1 (en) 2005-06-15
CA2302255C (en) 2011-11-08
ZA988030B (en) 1999-03-09
UY25172A1 (es) 2001-01-31
NO20001195L (no) 2000-03-08
NO20001195D0 (no) 2000-03-08
PL195703B1 (pl) 2007-10-31
CN1269726A (zh) 2000-10-11
TR200000649T2 (tr) 2000-09-21
HRP20000109A2 (en) 2001-02-28
DE69830591T2 (de) 2006-05-04
KR20010023795A (ko) 2001-03-26
SA98190565B1 (ar) 2006-07-30
HUP0004560A2 (hu) 2001-04-28
YU12700A (sh) 2004-09-03
RU2224539C2 (ru) 2004-02-27
MA26545A1 (fr) 2004-12-20
CZ298701B6 (cs) 2007-12-27
RS49707B (sr) 2007-12-31
MY121291A (en) 2006-01-28
EP1005359A2 (en) 2000-06-07
US6583114B2 (en) 2003-06-24
BR9812068A (pt) 2000-09-26
CN1210059C (zh) 2005-07-13

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