[go: up one dir, main page]

UY24651A1 - Método para la síntesis de analogos de la hormona paratiroidea y del peptido relacionado con la hormona paratiroidea. - Google Patents

Método para la síntesis de analogos de la hormona paratiroidea y del peptido relacionado con la hormona paratiroidea.

Info

Publication number
UY24651A1
UY24651A1 UY24651A UY24651A UY24651A1 UY 24651 A1 UY24651 A1 UY 24651A1 UY 24651 A UY24651 A UY 24651A UY 24651 A UY24651 A UY 24651A UY 24651 A1 UY24651 A1 UY 24651A1
Authority
UY
Uruguay
Prior art keywords
parathyroid hormone
synthesis
analogs
peptide related
peptide
Prior art date
Application number
UY24651A
Other languages
English (en)
Inventor
Humberto Bartolome Arzeno
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of UY24651A1 publication Critical patent/UY24651A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/635—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • A61P5/12—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH for decreasing, blocking or antagonising the activity of the posterior pituitary hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
    • C07K1/026—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution by fragment condensation in solution
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Se proporciona un proceso de condensación de fragmentos para la síntesis de análogos de la hormona paratiroidea y del péptido relacionado con la hormona paratiroidea, en el que los residuos aminoácidos forman una hélice alfa anfipática sintética.
UY24651A 1996-07-30 1997-07-29 Método para la síntesis de analogos de la hormona paratiroidea y del peptido relacionado con la hormona paratiroidea. UY24651A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US2332296P 1996-07-30 1996-07-30

Publications (1)

Publication Number Publication Date
UY24651A1 true UY24651A1 (es) 2000-12-29

Family

ID=21814418

Family Applications (1)

Application Number Title Priority Date Filing Date
UY24651A UY24651A1 (es) 1996-07-30 1997-07-29 Método para la síntesis de analogos de la hormona paratiroidea y del peptido relacionado con la hormona paratiroidea.

Country Status (30)

Country Link
US (1) US6849710B1 (es)
EP (1) EP0822200B1 (es)
JP (1) JP4229992B2 (es)
KR (1) KR100518982B1 (es)
CN (1) CN1293096C (es)
AR (2) AR008094A1 (es)
AT (1) ATE277080T1 (es)
AU (1) AU731160B2 (es)
BR (1) BR9704138A (es)
CA (1) CA2206008C (es)
CO (1) CO4650046A1 (es)
CZ (1) CZ239697A3 (es)
DE (1) DE69730787T2 (es)
DK (1) DK0822200T3 (es)
ES (1) ES2227639T3 (es)
HR (1) HRP970416A2 (es)
HU (1) HUP9701277A3 (es)
IL (1) IL121391A0 (es)
MA (1) MA24353A1 (es)
MX (1) MX9705719A (es)
NO (1) NO973482L (es)
NZ (1) NZ328411A (es)
PE (1) PE91998A1 (es)
PL (1) PL321391A1 (es)
SG (1) SG67408A1 (es)
TR (1) TR199700714A2 (es)
TW (1) TW505654B (es)
UY (1) UY24651A1 (es)
YU (1) YU32197A (es)
ZA (1) ZA976555B (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA04006728A (es) 2002-01-10 2005-08-19 Osteotrophin Llc Tratamiento de desordenes oseos con medicamentos anabolicos esqueleticos.
US7378495B2 (en) * 2002-10-21 2008-05-27 Pevion Biotech, Ltd. PTH-rP related peptide cancer therapeutics
JP2009515535A (ja) * 2005-11-10 2009-04-16 ボード オブ コントロール オブ ミシガン テクノロジカル ユニヴァーシティー クロクマの副甲状腺ホルモン及びクロクマの副甲状腺ホルモンを使用する方法
DK1979370T3 (da) * 2006-01-17 2010-06-28 Organon Nv Selektiv enzymatisk hydrolyse af C-terminale tert-butyl-ester peptider
USRE49444E1 (en) 2006-10-03 2023-03-07 Radius Health, Inc. Method of treating osteoporosis comprising administration of PTHrP analog
US7803770B2 (en) * 2006-10-03 2010-09-28 Radius Health, Inc. Method of treating osteoporosis comprising administration of PTHrP analog
KR101512377B1 (ko) 2006-10-03 2015-04-28 라디우스 헬쓰, 인코포레이티드 골 아나볼릭 단백질을 위한 약물 전달 방법
US8563513B2 (en) 2009-03-27 2013-10-22 Van Andel Research Institute Parathyroid hormone peptides and parathyroid hormone-related protein peptides and methods of use
US8987201B2 (en) 2009-12-07 2015-03-24 Michigan Technological University Black bear parathyroid hormone and methods of using black bear parathyroid hormone
CN102731643A (zh) * 2012-06-26 2012-10-17 深圳翰宇药业股份有限公司 一种治疗骨质疏松多肽的制备方法
CN102993293B (zh) * 2012-12-05 2014-05-07 深圳翰宇药业股份有限公司 一种特立帕肽醋酸盐的纯化方法
HUE033371T2 (en) 2013-03-21 2017-11-28 Sanofi Aventis Deutschland Process for the preparation of peptide products containing a ring imide
ES2623979T3 (es) 2013-03-21 2017-07-12 Sanofi-Aventis Deutschland Gmbh Síntesis de productos peptídicos que contienen hidantoína
CN104530198B (zh) * 2014-12-09 2017-09-15 兰州大学 一种片段缩合制备醋酸去氨加压素的方法
MX2017013801A (es) 2015-04-29 2018-08-15 Radius Pharmaceuticals Inc Métodos para tratar el cáncer.
IL292245B1 (en) 2017-01-05 2024-12-01 Radius Pharmaceuticals Inc Polymorphic forms of rad1901-2hcl
US10996208B2 (en) 2017-04-28 2021-05-04 Radius Health, Inc. Abaloparatide formulations and methods of testing, storing, modifying, and using same
WO2019175173A1 (en) * 2018-03-12 2019-09-19 Fresenius Kabi Ipsum S.R.L. Process for the manufacture of pthrp analogue
WO2020010216A1 (en) 2018-07-04 2020-01-09 Radius Pharmaceuticals, Inc. Polymorphic forms of rad 1901-2hcl
CN111057139B (zh) * 2018-10-17 2023-12-22 南京华威医药科技集团有限公司 一种制备特立帕肽的新工艺

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3886132A (en) * 1972-12-21 1975-05-27 Us Health Human parathyroid hormone
FR2550204B1 (fr) * 1983-08-05 1987-11-13 Toyo Jozo Kk Derives peptidiques de (nle8,nle1b, tyr34)-h-pth
EP0539491A1 (en) * 1990-07-13 1993-05-05 The Regents Of The University Of California PARATHYROID HORMONE ANALOGUES MODIFIED AT POSITIONS 3, 6 or 9
GB9020544D0 (en) * 1990-09-20 1990-10-31 Sandoz Ltd Improvements in or relating to organic compounds
US5589452A (en) * 1992-07-14 1996-12-31 Syntex (U.S.A.) Inc. Analogs of parathyroid hormone and parathyroid hormone related peptide: synthesis and use for the treatment of osteoporosis
WO1995002610A1 (en) * 1993-07-13 1995-01-26 Syntex (U.S.A.) Inc. Analogs of parathyroid hormone and parathyroid hormone related peptide: synthesis and use for the treatment of osteoporosis
CO4410206A1 (es) * 1994-07-28 1997-01-09 Sandoz Ag DERIVADOS DE PTH o PTHrP, SU PREPARACION Y COMPOSICIONES FARMACEUTICAS QUE LAS COMPRENDEN

Also Published As

Publication number Publication date
CN1293096C (zh) 2007-01-03
NZ328411A (en) 1998-12-23
PL321391A1 (en) 1998-02-02
DK0822200T3 (da) 2005-01-31
AU3236297A (en) 1998-02-05
HRP970416A2 (en) 1998-08-31
DE69730787T2 (de) 2005-10-13
MA24353A1 (fr) 1998-07-01
AU731160B2 (en) 2001-03-22
JPH1077295A (ja) 1998-03-24
ES2227639T3 (es) 2005-04-01
EP0822200A1 (en) 1998-02-04
TW505654B (en) 2002-10-11
IL121391A0 (en) 1998-01-04
ZA976555B (en) 1998-01-30
NO973482D0 (no) 1997-07-29
EP0822200B1 (en) 2004-09-22
NO973482L (no) 1998-02-02
PE91998A1 (es) 1998-12-31
HUP9701277A3 (en) 2001-02-28
CA2206008C (en) 2008-09-23
CA2206008A1 (en) 1998-01-30
CO4650046A1 (es) 1998-09-03
BR9704138A (pt) 1998-12-29
AR016981A2 (es) 2001-08-01
ATE277080T1 (de) 2004-10-15
HU9701277D0 (en) 1997-09-29
US6849710B1 (en) 2005-02-01
JP4229992B2 (ja) 2009-02-25
CN1174845A (zh) 1998-03-04
CZ239697A3 (cs) 1998-04-15
MX9705719A (es) 1998-02-28
YU32197A (sh) 1999-07-28
KR100518982B1 (ko) 2006-05-29
HUP9701277A2 (hu) 1998-11-30
KR980009282A (ko) 1998-04-30
AR008094A1 (es) 1999-12-09
TR199700714A2 (xx) 1998-02-21
DE69730787D1 (de) 2004-10-28
SG67408A1 (en) 1999-09-21

Similar Documents

Publication Publication Date Title
UY24651A1 (es) Método para la síntesis de analogos de la hormona paratiroidea y del peptido relacionado con la hormona paratiroidea.
EA199901025A1 (ru) Пептидные аналоги паратиреоидного гормона
ES2185770T3 (es) Anticuerpo monoclonal especifico para 4-1bb humano y linea celular que lo produce.
ES535125A0 (es) Un procedimiento para la preparacion de un peptido en forma sustancialmente pura.
ES2115838T3 (es) Procedimiento para la purificacion de acido (met)acrilico en bruto.
ES548388A0 (es) Un procedimiento para la preparacion de un peptido.
PT81991B (pt) Processo para a preparacao de derivados peptidicos, analogos a pepestatina, inibidores darenina e das proteases acidas
EA200001071A1 (ru) Способ получения полимер-связанных циклических пептидов
ES552093A0 (es) Un procedimiento para sintetizar una secuencia de aminoacidos que contienen la totalidad o parte de la secuencia de aminoacidos de la preprorrelaxina -h2 humana.
ES548617A0 (es) Procedimiento para disociar peptidos y proteinas en el enla-ce metionilo
AR026063A1 (es) Metodo para la preparacion de 5-carboxiftalida.
ES2103921T3 (es) Nuevos peptidos de union.
PE20030849A1 (es) Agonistas del receptor 2 del factor liberador de la corticotropina
ES2003075A4 (es) Sintesis de peptidos en fase solida.
AR013618A1 (es) Metodo y composiciones para la distribucion y expresion de acidos nucleicos de interferon
ES2054256T3 (es) Fragmentos de peptido de hiv.
ECSP972207A (es) Metodo para la sintesis de analogos de la hormona paratiroidea y del peptido relacionado con la hormona paratiroidea (caso ran 4105/190)
DE3364838D1 (en) Process for the conversion of preproinsulin analogues into insulins
ES2099287T3 (es) Procedimiento de separacion de un peptido de una resina.
ES501321A0 (es) Un metodo de preparacion de un peptido inhibidor de la liberacion de gonadotropinas por la glandula pituitaria en mamiferos.
ES522559A0 (es) Un procedimiento para la preparacion de un derivado de un peptido ciclico a-21978c.
ES2112921T3 (es) Peptidos y anticuerpos para el tratamiento de la artritis reumatoide.
ES2060650T3 (es) Peptidos de rinovirus humanos.
ES2138363T3 (es) Procedimiento para la obtencion de dolastatina 15 y sus productos intermedios.
AR021576A1 (es) Analogos del peptido 1-similar al glucagon, uso de los mismos para la manufactura de un medicamento y composiciones farmaceuticas que los contienen.

Legal Events

Date Code Title Description
109 Application deemed to be withdrawn

Effective date: 20130301