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CO2022018715A2 - Análogos de nucleósido de 1’-ciano y usos de los mismos - Google Patents

Análogos de nucleósido de 1’-ciano y usos de los mismos

Info

Publication number
CO2022018715A2
CO2022018715A2 CONC2022/0018715A CO2022018715A CO2022018715A2 CO 2022018715 A2 CO2022018715 A2 CO 2022018715A2 CO 2022018715 A CO2022018715 A CO 2022018715A CO 2022018715 A2 CO2022018715 A2 CO 2022018715A2
Authority
CO
Colombia
Prior art keywords
nucleoside analogues
compounds
cyano nucleoside
cyano
alone
Prior art date
Application number
CONC2022/0018715A
Other languages
English (en)
Inventor
Rao V Kalla
Thao D Perry
Michael O Clarke
Richard L Mackman
Dustin S Siegel
Daniel H Byun
Byoung-Kwon Chun
Petr Jansa
Dmitry Koltun
Scott P Simonovich
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Publication of CO2022018715A2 publication Critical patent/CO2022018715A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Se divulgan compuestos y métodos para usar dichos compuestos, solos o en combinación con agentes adicionales, y composiciones farmacéuticas de dichos compuestos para el tratamiento de infecciones virales.
CONC2022/0018715A 2020-06-24 2022-12-22 Análogos de nucleósido de 1’-ciano y usos de los mismos CO2022018715A2 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063043349P 2020-06-24 2020-06-24
US202163139648P 2021-01-20 2021-01-20
PCT/US2021/038645 WO2021262826A2 (en) 2020-06-24 2021-06-23 1'-cyano nucleoside analogs and uses thereof

Publications (1)

Publication Number Publication Date
CO2022018715A2 true CO2022018715A2 (es) 2022-12-30

Family

ID=76959096

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2022/0018715A CO2022018715A2 (es) 2020-06-24 2022-12-22 Análogos de nucleósido de 1’-ciano y usos de los mismos

Country Status (18)

Country Link
US (2) US11939347B2 (es)
EP (1) EP4172160A2 (es)
JP (1) JP2023531524A (es)
KR (1) KR20230028486A (es)
CN (1) CN115996928A (es)
AU (1) AU2021296841B2 (es)
BR (1) BR112022026321A2 (es)
CA (1) CA3187821A1 (es)
CL (1) CL2022003733A1 (es)
CO (1) CO2022018715A2 (es)
CR (1) CR20220675A (es)
DO (1) DOP2022000293A (es)
IL (1) IL299202A (es)
MX (1) MX2022016405A (es)
PE (1) PE20230618A1 (es)
PH (1) PH12022553530A1 (es)
TW (2) TW202417008A (es)
WO (1) WO2021262826A2 (es)

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CN114641299A (zh) 2020-01-27 2022-06-17 吉利德科学公司 用于治疗SARS CoV-2感染的方法
CN118994170A (zh) 2020-03-12 2024-11-22 吉利德科学公司 制备1'-氰基核苷的方法
TW202203941A (zh) 2020-05-29 2022-02-01 美商基利科學股份有限公司 瑞德西韋之治療方法
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WO2024120464A1 (zh) * 2022-12-09 2024-06-13 深圳市塔吉瑞生物医药有限公司 核苷酸类似物及其组合物及用途
CN116410228A (zh) * 2023-05-04 2023-07-11 南京颐媛生物医学研究院有限公司 一种抗冠状病毒核苷类化合物的制备方法及其应用
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