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CR20220675A - Análogos de nucleósido de 1´- ciano y usos de los mismos - Google Patents

Análogos de nucleósido de 1´- ciano y usos de los mismos

Info

Publication number
CR20220675A
CR20220675A CR20220675A CR20220675A CR20220675A CR 20220675 A CR20220675 A CR 20220675A CR 20220675 A CR20220675 A CR 20220675A CR 20220675 A CR20220675 A CR 20220675A CR 20220675 A CR20220675 A CR 20220675A
Authority
CR
Costa Rica
Prior art keywords
nucleoside analogs
compounds
cyano nucleoside
cyano
singly
Prior art date
Application number
CR20220675A
Other languages
English (en)
Inventor
Richard L Mackman
Thao D Perry
Daniel H Byun
Scott P Simonovich
Byoung-Kwon Chun
Dustin S Siegel
Rao V Kalla
Michael O Clarke
Petr Jansa
Dmitry Koltun
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Publication of CR20220675A publication Critical patent/CR20220675A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Se divulgan compuestos y métodos para usar dichos compuestos, solos o en combinación con agentes adicionales, y composiciones farmacéuticas de dichos compuestos para el tratamiento de infecciones virales.
CR20220675A 2020-06-24 2021-06-23 Análogos de nucleósido de 1´- ciano y usos de los mismos CR20220675A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063043349P 2020-06-24 2020-06-24
US202163139648P 2021-01-20 2021-01-20
PCT/US2021/038645 WO2021262826A2 (en) 2020-06-24 2021-06-23 1'-cyano nucleoside analogs and uses thereof

Publications (1)

Publication Number Publication Date
CR20220675A true CR20220675A (es) 2023-02-15

Family

ID=76959096

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20220675A CR20220675A (es) 2020-06-24 2021-06-23 Análogos de nucleósido de 1´- ciano y usos de los mismos

Country Status (18)

Country Link
US (2) US11939347B2 (es)
EP (1) EP4172160A2 (es)
JP (1) JP2023531524A (es)
KR (1) KR20230028486A (es)
CN (1) CN115996928A (es)
AU (1) AU2021296841B2 (es)
BR (1) BR112022026321A2 (es)
CA (1) CA3187821A1 (es)
CL (1) CL2022003733A1 (es)
CO (1) CO2022018715A2 (es)
CR (1) CR20220675A (es)
DO (1) DOP2022000293A (es)
IL (1) IL299202A (es)
MX (1) MX2022016405A (es)
PE (1) PE20230618A1 (es)
PH (1) PH12022553530A1 (es)
TW (2) TWI819321B (es)
WO (1) WO2021262826A2 (es)

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CN117982682A (zh) 2017-07-11 2024-05-07 吉利德科学公司 用于治疗病毒感染的包含rna聚合酶抑制剂和环糊精的组合物
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CN118994170A (zh) 2020-03-12 2024-11-22 吉利德科学公司 制备1'-氰基核苷的方法
CA3179226A1 (en) 2020-05-29 2021-12-02 Tomas Cihlar Remdesivir treatment methods
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WO2022166581A1 (zh) * 2021-02-07 2022-08-11 石家庄迪斯凯威医药科技有限公司 一种核苷酸衍生物及其药物组合物和用途
IL315102A (en) 2022-03-02 2024-10-01 Gilead Sciences Inc COMPOSITIONS AND METHODS FOR THE TREATMENT OF VIRAL INFECTIONS
CN118165034A (zh) * 2022-12-09 2024-06-11 深圳市塔吉瑞生物医药有限公司 核苷酸类化合物及其组合物及用途
CN116410228A (zh) * 2023-05-04 2023-07-11 南京颐媛生物医学研究院有限公司 一种抗冠状病毒核苷类化合物的制备方法及其应用
CN116284135B (zh) * 2023-05-04 2025-03-21 南京颐媛生物医学研究院有限公司 抗冠状病毒核苷类化合物的制备方法及其应用
CN116332996B (zh) * 2023-05-04 2025-04-01 南京颐媛生物医学研究院有限公司 L-呋喃核糖型抗冠状病毒化合物及其制备方法和应用

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