CN1840067A - Asparagus chewable tablet and its production process - Google Patents
Asparagus chewable tablet and its production process Download PDFInfo
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- CN1840067A CN1840067A CNA2006100420361A CN200610042036A CN1840067A CN 1840067 A CN1840067 A CN 1840067A CN A2006100420361 A CNA2006100420361 A CN A2006100420361A CN 200610042036 A CN200610042036 A CN 200610042036A CN 1840067 A CN1840067 A CN 1840067A
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- 238000004519 manufacturing process Methods 0.000 title claims description 13
- 229940068682 chewable tablet Drugs 0.000 title description 6
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- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention provides an asparagus spear chewing tablet and preparing process, which comprises using asparagus spear as raw materials, separating effective portions and concentrating concrete, charging prescription amount of powered auxiliary materials, mixing homogenously, using water-containing ethanol as wetting agent, sieving and granulating, drying, compressing into chewing tablets which can be used for the subsidiary treatment of cancer.
Description
Technical field
The present invention relates to a kind of new product of Chinese medicine and preparation technology thereof, especially extraction separation effective site from the Chinese medicine Germinatus Phragmitis through concentrating under reduced pressure, adds suitable adjuvant, makes the production technology of chewable tablet.
Background technology
Germinatus Phragmitis is the underground tender stem of liliaceous plant asparagus Asparagus officinalis L, digs tuber in spring, autumn.Germinatus Phragmitis chemical constituent, Pharmacological action study are more deep.Germinatus Phragmitis mainly contains flavone compound, free amino acid, multiple steroidal saponin, vitamin, trace element and other active substance.Flavone compound mainly comprises Quercetin, Fructus Citri element, kaempferol and rutin etc.The content of free amino acid is also quite high, asparagine most importantly, content accounts for more than 48% of total amount, the content of glutamic acid is up to 28%, except that tryptophan, Radix Asparagi, third, silk, dried meat, Guang, rely, arginine and glutamine also have high level.Contained vitamin mainly contains VitA, B, B2, B6 and VitC etc., contains various trace elements such as sodium, potassium, calcium, magnesium, ferrum, selenium, phosphorus, sulfur, zinc and protein, fat, cellulose, carbohydrate etc. in addition.Pharmacological research shows that Germinatus Phragmitis has antitumor action, promotes immunologic function, endurance effect, resisting oxygen lack, the acquisition of promotion mouse memory, analgesic activity, anti-aging effects, effect for reducing blood fat, effect in increasing leukocyte, protecting liver and detoxication effect.(Li Fengqin, Deng. STUDIES ON THE ANTITUMOUR ACTIVITIES OF LUSUN EXTRACTS [J]. cancer, 1993,12 (3): 200 ponds of refined buying, Deng. the Germinatus Phragmitis treatment is to the influence [J] of malignant tumor patient T cell subsets. Henan Medical Univ.'s journal, 1994,29 (3): 261 leaves wood is flourish, Deng. the pharmacological research of asparagus juice [J]. CHINA JOURNAL OF CHINESE MATERIA MEDICA, 1994,19 (4): 240 Wus are carefully big etc. Germinatus Phragmitis research overview [J]. traditional Chinese medical science research, 1996,9 (4): 54 civilian duckweeds. Germinatus Phragmitis chemical constituent and pharmacological research progress [J]. Chinese herbal medicine, 1996,27 (12): 746).Claim that according to " international cancer ward mate association circular " Germinatus Phragmitis is almost all effective in cure to various types of cancers.It has the function that prevents the cancerous cell diffusion, and effective in cure to lymphoma, bladder cancer, pulmonary carcinoma, skin carcinoma and renal calculus etc., Germinatus Phragmitis is to hypertension, heart disease, tachycardias, and diseases such as fatigue, edema, cystitis, dysuria all have certain curative effect.
Chewable tablet is a kind of quick-effective preparation that development in recent years is got up, because its distinctive advantage more and more is subjected to people's attention.2000 editions two radicals by which characters are arranged in traditional Chinese dictionaries of Chinese Pharmacopoeia have recorded this dosage form.Comparing chewable tablet with conventional tablet has the following advantages: good dispersing state, disintegration time are lacked, the medicine stripping is rapid; Absorb fast, bioavailability is high, taking convenience can be swallowed, chew to contain and suck or with taking after the aqueous dispersion, the patient who especially is fit to the old man and the difficulty of swallowing takes.Compare with granule, chewable tablet has little, delicately packed, the easy to carry advantage of volume, improved go out, granule needs the inconvenience that boiled water takes in the travelling process.
The present invention has developed a kind of new product of Chinese medicine---chewing tablet of asparagus, it has overcome the deficiency of the existing dosage form of Germinatus Phragmitis preparation, have that good dispersing state, disintegration time are short, the medicine stripping rapidly, absorb fast, advantages such as bioavailability is high, taking convenience, and its production technology carried out careful research, can directly declare production.Chewing tablet of asparagus can be used for the dry mouth and tougue that causes after the auxiliary treatment, chemotherapy of cancer, inappetence, general lassitude person clinically.
Summary of the invention
The present invention is directed to the deficiency of the existing dosage form of Germinatus Phragmitis preparation, make good dispersing state, disintegration time is short, the medicine stripping is rapid; Absorb fast, bioavailability is high, taking convenience can be swallowed, chew to contain and suck or with the novel form of taking after the aqueous dispersion, and its production technology has been carried out careful research, particular content is as follows:
Take by weighing clean Germinatus Phragmitis by recipe quantity, separate effective site and concentrate extractum, add other adjuvant fine powders (all crossing 80 mesh sieves) of recipe quantity, mixing is made wetting agent with aquiferous ethanol, 16 mesh sieves are granulated, drying is pressed into chewable tablet.
Preferably, medical material is aquatic foods product or the dry product of Germinatus Phragmitis, and recipe quantity is 100～10000g.
Preferably, separate the extraction of 0～70% aquiferous ethanol or squeeze juice and the centrifugal or filtration that effective site can adopt 8～15 times of amounts.
Modes such as preferred, the simmer down to normal pressure concentrates, concentrating under reduced pressure, membrance separation, spray drying are condensed into clear extractum or the dry extract or the dry powder of relative density 1.0～1.30 (25 ℃).
Preferred, optional mannitol, Icing Sugar, the A Siba with recipe quantity of other adjuvants is sweet, lactose, dextrin, stevioside.
Preferred, the wetting agent that adopts is 0～70% aquiferous ethanol.
Preferred, granulation can be used in method or wet granulation, and prill drying can adopt oven dry, drying under reduced pressure or other drying means, and baking temperature is 50～100 ℃, and be 0.5～10 hour drying time.
Preferred, made chewing tablet of asparagus sheet weighs 0.5～5g.
According to appended chewing tablet of asparagus total nitrogen and total amino acids assay method, the chewing tablet of asparagus that this law makes contains total nitrogen 1.0～15mg/ sheet, is reference substance with the Aspartic Acid, total amino acids 2.0～30mg/ sheet that this method makes.
The present invention has prepared a kind of new product of Chinese medicine, and it has overcome the deficiency of the existing dosage form of Germinatus Phragmitis preparation, have that good dispersing state, disintegration time are short, the medicine stripping rapidly, absorb fast, advantages such as bioavailability is high, taking convenience.Can be used for the dry mouth and tougue that causes after the auxiliary treatment, chemotherapy of cancer, inappetence, general lassitude person clinically.
The specific embodiment
Embodiment 1
Take by weighing 4 kilograms of Germinatus Phragmitis medical materials (dry product), with the water extraction of 8 times of amounts, extracting liquid filtering.Concentrating under reduced pressure becomes the clear extractum of relative density 1.1 (25 ℃), add mannitol 100g, the sweet 50g of Icing Sugar 1000g, A Siba, dextrin 200g, adopt 70% aquiferous ethanol as wetting agent, 16 mesh sieve wet granulations, in 80 ℃ of dryings 2 hours, suppress 95 of the chewing tablet of asparagus of heavy 5g in blocks, yield rate (95.0%).Finished product is tested according to appended chewing tablet of asparagus quality standard draft, and the every index of result is all up to specification.
| Character | The sundown sheet, it is sweet to distinguish the flavor of |
| Differentiate | In the test sample chromatograph, with the corresponding position of aspartic acid reference substance chromatograph on, show the speckle of same color | |
| Check | Weight differential microbial limit moisture (%) | Escherichia coli up to specification, the demodicid mite that lives all do not detect, and antibacterial and mycete number average are less than 10/g 5.8 |
| Assay | Total nitrogen (mg/ sheet) total amino acids (mg/ sheet) | 4.2 6.4 |
Embodiment 2
Take by weighing 8.12 kilograms of Germinatus Phragmitis medical materials (bright product), squeeze juice, filter the clear extractum that the back concentrating under reduced pressure becomes relative density 1.1 (25 ℃), add mannitol 100g, the sweet 50g of Icing Sugar 1000g, A Siba, dextrin 200g adopts water as wetting agent, 16 mesh sieve wet granulations, in 60 ℃ of dryings 3 hours, suppress 490 of the chewing tablet of asparagus of heavy 2.5g in blocks, yield rate (98.0%).Finished product is tested according to appended chewing tablet of asparagus quality standard draft, and the every index of result is all up to specification.
| Character | The sundown sheet, it is sweet to distinguish the flavor of | |
| Differentiate | In the test sample chromatograph, with the corresponding position of aspartic acid reference substance chromatograph on, show the speckle of same color | |
| Check | Weight differential microbial limit moisture (%) | Escherichia coli up to specification, the demodicid mite that lives all do not detect, and antibacterial and mycete number average are less than 10/g 5.9 |
| Assay | Total nitrogen (mg/ sheet) total amino acids (mg/ sheet) | 1.5 3.5 |
Embodiment 3
Take by weighing 7.86 kilograms of Germinatus Phragmitis medical materials (bright product), squeeze juice, filter the back concentrating under reduced pressure and become into dry extract, after dry extract is pulverized, add mannitol 100g, the sweet 50g of Icing Sugar 1000g, A Siba, dextrin 200g, adopt water as wetting agent, 16 mesh sieve wet granulations were in 90 ℃ of dryings 1.5 hours, suppress 475 of the chewing tablet of asparagus of heavy 2g in blocks, yield rate (95.0%).Finished product is tested according to appended chewing tablet of asparagus quality standard draft, and the every index of result is all up to specification.
| Character | The sundown sheet, it is sweet to distinguish the flavor of | |
| Differentiate | In the test sample chromatograph, with the corresponding position of aspartic acid reference substance chromatograph on, show the speckle of same color | |
| Check | Weight differential microbial limit moisture (%) | Escherichia coli up to specification, the demodicid mite that lives all do not detect, and antibacterial and mycete number average are less than 10/g 5.3 |
| Assay | Total nitrogen (mg/ sheet) total amino acids (mg/ sheet) | 3 6.8 |
Attached total nitrogen and total amino acids assay method
Total nitrogen is got 10 of this product, and accurate the title decides, porphyrize, and precision takes by weighing in right amount, measures according to N2 method (2005 editions one appendix IX L of Chinese Pharmacopoeia, second method), promptly.
Total amino acids
The preparation precision of reference substance solution takes by weighing the Aspartic Acid reference substance and puts in right amount in the measuring bottle, adds water and makes the reference substance solution that every 1mL contains 15 μ g.
The preparation precision of standard curve is measured reference substance solution 0,0.2,0.4,0.6,0.8,1.0mL, put respectively in the 10mL tool plug test tube, respectively add water and make into 1.0mL, add the acetate buffer solution 1.0mL of the 2mol/L of pH value 5.4, add 1.0mL 1,2,3-indantrione monohydrate colour developing liquid again, fully behind the mixing, cover the test tube mouth, in 100 ℃ of water-baths, heat 15min, take out, with the tap water cooling, behind the placement 5min, add 1.5mL 60% ethanol dilution, fully shake up, measure absorbance at 570nm according to spectrophotography (an appendix V of Chinese Pharmacopoeia version in 2000 A).With the absorbance A is vertical coordinate, and amino acid content is an abscissa, the drawing standard curve.
Algoscopy is got 10 of this product, the accurate title, decide, porphyrize, and precision takes by weighing in right amount, precision adds water supersound extraction 30min, precision is measured subsequent filtrate 1mL, puts in the 10mL tool plug test tube method under the sighting target directrix curve preparation, measure trap from " the acetate buffer solution 1.0mL that adds the 2mol/L of pH value 5.4 " in accordance with the law, from the weight (μ g) that standard curve is read need testing solution Mid-Heaven Gate winter propylhomoserin, calculate, promptly.
Claims (8)
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| CNA2006100420361A CN1840067A (en) | 2006-01-17 | 2006-01-17 | Asparagus chewable tablet and its production process |
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| CN102133352A (en) * | 2011-03-12 | 2011-07-27 | 合肥七星医药科技有限公司 | Asparagus oral liquid for preventing and curing tumor disease and preparation method thereof |
| CN102258193A (en) * | 2011-07-19 | 2011-11-30 | 江西省农业科学院 | Production method of asparagus chewable tablets |
| CN102370145A (en) * | 2010-08-19 | 2012-03-14 | 日生生物股份有限公司 | Automatic nerve regulating agent with asparagus leaf as effective ingredient |
| CN101589804B (en) * | 2008-05-26 | 2012-11-21 | 北京星昊嘉宇医药科技有限公司 | Asparagus composition |
| CN102965224A (en) * | 2012-11-02 | 2013-03-13 | 南昌大学 | Preparation method of asparagus beer |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101589804B (en) * | 2008-05-26 | 2012-11-21 | 北京星昊嘉宇医药科技有限公司 | Asparagus composition |
| CN102370145A (en) * | 2010-08-19 | 2012-03-14 | 日生生物股份有限公司 | Automatic nerve regulating agent with asparagus leaf as effective ingredient |
| CN102133352A (en) * | 2011-03-12 | 2011-07-27 | 合肥七星医药科技有限公司 | Asparagus oral liquid for preventing and curing tumor disease and preparation method thereof |
| CN102133352B (en) * | 2011-03-12 | 2012-09-05 | 合肥七星医药科技有限公司 | Asparagus oral liquid for preventing and curing tumor disease and preparation method thereof |
| CN102258193A (en) * | 2011-07-19 | 2011-11-30 | 江西省农业科学院 | Production method of asparagus chewable tablets |
| CN102965224A (en) * | 2012-11-02 | 2013-03-13 | 南昌大学 | Preparation method of asparagus beer |
| CN103271958A (en) * | 2013-05-28 | 2013-09-04 | 严斯文 | Method for processing coriander moss |
| CN107375757A (en) * | 2017-08-30 | 2017-11-24 | 四川汇诚药业有限公司 | A kind of asparagus tablet and preparation method thereof |
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