CN100455300C - Wild kiwifruit compound swallow tablet and preparation method thereof - Google Patents

Abstract

The invention discloses a compound swallowing tablet of wild kiwi fruit and a preparation method thereof. The tablet is made of the following raw materials in weight ratio: 30-120 parts of wild kiwi fruit (cat ginseng), 5-20 parts of angelica, 10-40 parts of astragalus, 10-30 parts of poria cocos and 1-5 parts of American ginseng. Mix the five-flavored ingredients evenly according to the weight distribution, add water and decoct 2-3 times, 1-3 hours each time, combine the decoction, filter, and concentrate the filtrate into a thick paste, which is spray-dried, vacuum-dried or vacuum-freeze-dried to dry paste, crushed and sieved to make uniform powder, added auxiliary materials, mixed evenly, granulated, dried, compressed into tablets, coated, and obtained. The invention adopts advanced technology to make the health food which is portable, convenient to take and high in curative effect with low cost and high quality. It has the functions of nourishing qi, nourishing blood and improving the body's immunity. It is suitable for immunocompromised people who are weak, recover from long-term illness, and recover from cancer. At the same time, it also plays a preventive and health-care role in improving immunity for people with normal physiques.

Description

Wild kiwifruit compound swallow tablet and preparation method thereof

technical field

The present invention relates to a compound swallowing tablet, Ai Neng tablet, which has the functions of anti-tumor, supporting healthy energy and enhancing immunity, and uses a wild kiwi fruit (commonly known as cat ginseng) as the main raw material, and the preparation method and use of the tablet .

Background technique

The sub-health state refers to a state in which the human body has reduced vitality and adaptability, although there is no definite disease. It is a state of reduced physiological function between health and disease. According to a global survey by the World Health Organization (WHO), only 5% of people in the world are truly healthy, 20% are diagnosed with diseases, and 75% are in a sub-health state. Sub-health has become the number one invisible killer that endangers human health today, and it is also one of the difficult problems facing modern medicine. With the development of our country's national economy and the continuous enhancement of the public's awareness of health care, people are calling for health-enhancing, natural health food with definite curative effects, and inquiring about effective drugs that can stay away from sub-health and keep youth forever. However, at present, people consume too much animal food and refined processed food, coupled with the tense pace of work and high pressure, resulting in "modern civilization diseases", such as lack of energy, depression, insomnia and dreaminess. Furthermore, with the development of modern industry, people's living environment is deteriorating day by day. Air, water, food, fruits, vegetables and other substances closely related to human life are surrounded by harmful substances, which has brought many serious damages to people. , such as gene mutations, cell aging (increased free radicals), weakened immune response, etc., such as the increase in tumor patients and the generalization of sub-healthy states. Therefore, effective health food for anti-tumor and immunity enhancement is favored. However, most of the nourishing products currently on the market are medicines for symptoms of yang and dryness, which are suitable for non-chronic patients and those with weak constitutions; there is an urgent need to research and develop a pure natural preparation that can improve immune function, enhance physical resistance to disease, and promote physical recovery. .

Cat ginseng is a kind of wild kiwi fruit resource, which is commonly used in folk herbal medicine. According to the Chinese Medicine Dictionary, it has the functions of detoxification, detumescence, wind and dampness, and it is clinically used to treat deep abscess, osteomyelitis, rheumatic arthralgia, sore swelling, liver cirrhosis, icteric ascites, etc.; Tumor efficacy has also been widely recognized. In recent years, it has been found that this wild kiwi fruit has a unique effect in inhibiting tumor growth and improving vital signs, and has become another source of anticancer drugs from the genus Actinidia after the root of vine pear (Actinidia sinensis). Nevertheless, up to now, also do not see the report of the relevant health food of this plant. We apply modern pharmaceutical technology to overcome the shortcomings of many dosage forms and make swallow tablets, which are not only convenient to produce, but also reduce the loss of heat-sensitive and volatile components in the prescription, ensuring the curative effect, and are convenient to take and carry. This is of great significance for inheriting and carrying forward the medical heritage of the motherland.

Citations:

①. Zhao Ruiqin, Song Zhenfeng, 2002: Research progress on sub-health problems, Foreign Medicine and Social Medicine Volume, 19(1): 10-13;

②. He Jing, 2004: Get out of sub-health, stay away from "grey" life, Science and Technology Literature, 7: 82-87;

③. Zhou Xingzhao, 2000; Tang Fuan on the syndrome and treatment of lung cancer, Journal of Zhejiang University of Traditional Chinese Medicine, 24(2): 45;

④. Jin Ruizhi, Wang Guoqiang, 1998; Maorenshen Decoction in the treatment of swelling, Zhejiang Journal of Traditional Chinese Medicine, 33(1): 35;

⑤. Lai Pingfan, Zhang Hongyan, 2002; Research progress of traditional Chinese medicine cat ginseng in Zhejiang, Journal of Zhejiang University of Traditional Chinese Medicine, 26(1): 77-78.

Contents of the invention

The purpose of the present invention is to overcome the deficiencies of the above technologies, and to provide a wild kiwi fruit compound swallow tablet and a preparation method thereof which are small in dosage and easy to produce, take and carry.

The present invention is achieved through the following measures:

1. Wild kiwifruit compound swallowing tablet (Ai Neng tablet) and its preparation method comprise the following steps:

1.1 The formula composition of wild kiwi fruit compound swallow tablet (Ai Neng tablet)

The formula of the wild kiwi fruit compound swallowing tablet is calculated in parts by weight:

Wild kiwi 30-120 parts

Angelica 5-20 servings

Astragalus 10-40 parts

Poria cocos 10-30 parts

American ginseng 1-5 parts.

Its preferred formula is calculated in parts by weight:

Wild kiwi 60 servings

Angelica 10 servings

Astragalus 20 servings

Poria cocos 15 parts

American ginseng 1-5 parts.

1.2 Preparation process of wild kiwifruit compound swallow tablet (Ai Neng tablet)

Take the prescribed Chinese herbal medicines, extract and prepare them into tablets for swallowing by a suitable process, and the preparation process can adopt the following process or other suitable processes.

Process 1 Mix the five herbs evenly according to the distribution, add water and decoct 2-3 times, 1-3 hours each time, combine the decoction, filter, and concentrate the filtrate into a thick paste, which is spray-dried/vacuum-dried/vacuum-freeze-dried into Dry paste, and crushed and sieved to make a uniform powder. Add appropriate amount of auxiliary materials, mix evenly, granulate, dry, compress into tablets, and coat.

Process 2: Extract wild kiwi fruit with 60-95% edible alcohol for 2-3 times, each time for 1.5-2 hours, combine the extracts, filter, recover ethanol, and obtain the extract for later use; add water to extract the poria cocos, filter the extract, The filtrate is used for later use; Chinese angelica, astragalus, and western ginseng are added to the above-mentioned wild kiwi fruit dregs and decocted with water for 2-3 times, 1-3 hours each time, the decoction is combined, filtered, and the filtrate is mixed with wild kiwi fruit extract and Poria cocos filtrate, and concentrated to thicken Paste, thick paste is spray-dried, vacuum-dried or vacuum-freeze-dried into a dry paste, crushed and sieved to make a uniform powder, added with auxiliary materials, mixed evenly, granulated, dried, compressed into tablets, coated, and obtained.

1.3 Excipients and specific process for preparing wild kiwifruit compound swallow tablet (Ai Neng tablet)

The medicinal materials in the process are crushed into coarse powder/cut into decoction pieces, usually coarse powder over 5-50 mesh/cut into decoction pieces, preferably coarse powder over 20-40 mesh.

In the process, the thick paste is finally pulverized into a fine powder of 80-160 mesh before adding auxiliary materials, and it is best to be superfinely pulverized into a fine powder of 200-300 mesh.

The alcohol extraction method adopted in the process, the alcohol extraction conditions are: use 60-95% edible alcohol as solvent, and can be extracted by heating reflux method or infiltration method or other suitable methods, the best is heating with 70% edible alcohol Reflux extraction 2 times, 2 hours each time.

The water extraction method adopted in the process, the water extraction conditions are: after warm soaking (50°C-90°C) for 5-12 hours, decocting 2-3 times, the amount of water added for the first time is 6-15 times the amount of medicine, The second and third times are 4-12 times the amount of medicine, 0.5-4 hours each time; the best is 8 times the amount of water boiled, soaked at 80 ° C for 5 hours, decocted 3 times, and the amount of water added is respectively the amount of medicine 10, 8, 8 times, the time is 2, 2, 1 hour respectively. When the medicinal dregs are added to the same decoction, they can be added during the second decoction.

The drying of the extract in the process can adopt vacuum drying or spray drying or other suitable methods. The vacuum drying temperature is controlled at 50°C-80°C; the optimum is 60°C. Spray drying is to concentrate the extract into a concentrated solution with a relative density of 1.05-1.15 (60°C), spray drying, the inlet air temperature is 100°C-200°C, and the outlet air temperature is 50°C-150°C; the best relative density is 1.08-1.10 (60°C), the inlet air temperature is 150°C-170°C, and the outlet air temperature is 80°C-100°C.

Concentration in the process adopts vacuum concentration/film concentration/vacuum film concentration or other suitable methods.

Filtration in the process can adopt conventional filtration, centrifugation, ultrafiltration or other suitable methods.

The tablets obtained in the process can be coated with suitable coating materials, such as gastric-soluble film coating premix (Opadry), hydroxypropyl cellulose or other suitable materials.

The auxiliary materials used in the process can be one or more of lecithin, xylitol, sucrose, β-cyclodextrin, hydroxypropyl-β-cyclodextrin, sorbitol, magnesium stearate or other suitable auxiliary materials Mixed use, accounting for about 15% to 45% of the total formula.

2. The quality standard control of Wild Kiwi Fruit Compound Swallow Tablets (Ai Neng Tablets) includes functional component testing, stability testing, hygienic testing, toxicological testing and pharmacological evaluation.

In the detection of functional components, it is required that the content of crude polysaccharides is ≥ 3%, and the content of total saponins is ≥ 2%; in the stability test, the samples are required to be kept at a temperature of 37°C-40°C and a relative humidity of 75% for 3 months. It complies with the relevant regulations of the national health food; in the hygienic inspection, each index of the sample is required to meet the relevant regulations of the national health food; the toxicology experiment shows that the Ames test, mouse micronucleus test and sperm abnormality test of the Aineng tablet are all It was negative; no toxic reaction was seen in the acute toxicity and long-term toxicity experiments of rats and mice; in the pharmacological evaluation, the wild kiwi fruit compound swallowing tablet (Ai Neng tablet) can significantly affect the normal constitution and the defective constitution with low immunity. To provide the body's immune function.

3. The efficacy of wild kiwifruit compound swallowing tablet (Ai Neng tablet)

The wild kiwifruit compound swallow tablet (Ai Neng tablet) of the present invention is used in combination with several medicines to have the effects of anti-tumor and enhancing immunity.

Wild kiwifruit (cat ginseng), as an endemic herb in southeastern my country, has a long history of medicinal use among the people. For this reason, this medicine has been included in the "Local Medicinal Material Standards" (Zhejiang Provincial Department of Health, 1994), which has laid a foundation for the development, research and comprehensive utilization of this medicine. Experimental studies have shown that cat ginseng-based prescriptions can be used to treat various digestive tract tumors mainly liver cancer, and the clinical curative effect is obvious. Cat ginseng can improve the quality of life and prolong the survival period of patients.

Wild kiwi fruit has a long history in my country as a folk herbal medicine for nourishing the body and preventing and treating diseases. It has the functions of invigorating the stomach, treating indigestion, detoxifying, reducing swelling, expelling wind and dehumidification; it is clinically used to treat deep abscess, osteomyelitis, rheumatic arthralgia, sores and swelling, liver cirrhosis, jaundice and ascites, etc. Gastrointestinal tumors. In recent years, it has been found that it also has unique effects in inhibiting tumor growth and improving vital signs. It can cure a variety of diseases, reduce swelling and expel silt, dissolve dead cells, and decompose chlorine nitrite carcinogens in the human body, adjust the middle and regulate Qi, so it can relieve heat and annoyance, promote body fluid and moisten dryness, maintain health and longevity, and treat digestion Bad, loss of appetite and other diseases. In recent years, many scholars have studied the pharmacological activity of various parts of wild kiwifruit plants, and found that some ingredients such as kiwifruit polysaccharides have the effects of lowering blood fat, resisting lipid peroxidation, scavenging active oxygen free radicals, inhibiting tumor cells, and improving immune function. Pharmacological activity, is an effective immunomodulator.

In addition, astragalus in the formula has the effect of invigorating qi and strengthening the body; poria cocos can strengthen the spleen and stomach, calm the mind and calm the nerves; angelica can nourish blood and blood, moisturize dryness and smooth the intestines; According to the principles of traditional Chinese medicine prescriptions, reasonable and scientific compatibility is carried out, so that the whole prescription can clear away heat and detoxify, relieve throat and relieve stagnation, nourish qi and blood, moisten and nourish bone marrow, and regulate the immune function of the body.

Therefore, the wild kiwifruit compound swallow tablet (Ai Neng tablet) of the present invention has the following advantages: it has certain anti-tumor and immunity-enhancing effects, is safe and has no side effects, and is suitable for weak health, long-term illness recovery, cancer recovery and immunity. People with low function, at the same time, also play a preventive and health-care role in improving immunity for people with normal physique; and the preparation method is simple, suitable for industrial production without loss of drug ingredients, overcomes the shortcomings of cumbersome and frequent taking methods, and the oral dosage is relatively low. Small and works quickly.

Detailed ways

Following example is in order to further illustrate the present invention, for reference, but does not limit the scope of the present invention thus.

Embodiment 1: The five kinds of medicinal materials are cleaned separately, remove impurities, and pass the test for later use; weigh 12.0 kg of wild kiwi fruit (cat ginseng), 2.0 kg of angelica, 4.0 kg of astragalus, 3.0 kg of poria cocos, and 0.5 kg of American ginseng, and grind them into coarse powder respectively , mixed evenly for later use; after soaking the coarse powder of medicinal materials in water (60°C) for 12 hours, decocting in water three times, the amount of water added was 10, 8, and 8 times of the amount of medicine, and the time was 2, 2, and 1 hour respectively; the decoction was combined , filter, and the filtrate is concentrated to a concentrated solution with a relative density of 1.05-1.15 (60° C.), spray-dried, and collects 2.9 kilograms of dry cream powder, which is superfinely pulverized into a uniform fine powder of 200 meshes; adding 20% xylitol powder, Spray with pure water, boil to granulate (air inlet temperature 75°C; water spray volume 5R/MIN; drying end point 50°C); Temperature 70～75 ℃, exhaust air temperature 45～55 ℃); That is to get the tablet of the present invention, tablet weight control 0.5g±5%/tablet.

Usage and dosage: Take orally, 3 times a day, 1-2 tablets each time.

Embodiment 2: The five kinds of medicinal materials are cleaned separately, remove impurities, and pass the test for later use; weigh 3.0 kg of wild kiwi fruit (cat ginseng), 0.5 kg of angelica, 1.0 kg of astragalus, 1.0 kg of poria cocos, and 0.1 kg of American ginseng, and grind them into coarse powder respectively , mixed evenly for later use; after soaking the coarse powder of medicinal materials in water (60°C) for 12 hours, decocting in water three times, the amount of water added was 10, 8, and 8 times of the amount of medicine, and the time was 2, 2, and 1 hour respectively; the decoction was combined , filter, and the filtrate is concentrated to a concentrated solution with a relative density of 1.05-1.15 (60° C.), spray-dried, and collects 2.9 kilograms of dry cream powder, which is superfinely pulverized into a uniform fine powder of 200 meshes; add 35% mannitol powder, fully Mix well, use 2% PVP _k30 (50% ethanol solution) to make soft material, spray with pure water, boil and granulate (inlet air temperature 75°C; water spray volume 5R/MIN; drying end point 50°C); add 2.5% of the granules Magnesium stearate, mixing, granulation, tabletting, coating (inlet air temperature 70～75 ℃, exhaust air temperature 45～55 ℃); obtain the tablet of the present invention, tablet weight control 0.5g±5%/ piece.

Usage and dosage: Take orally, 3 times a day, 1-2 tablets each time.

Embodiment 3: The five kinds of medicinal materials are cleaned separately, remove impurities, and pass the test for later use; Weigh 10.0 kg of wild kiwi fruit (cat ginseng), 1.8 kg of angelica, 3.5 kg of astragalus, 3.0 kg of poria cocos, and 0.5 kg of American ginseng, and grind them into coarse powder respectively Standby; take cat ginseng coarse powder, heat and reflux with 70% edible alcohol to extract twice, each time for 2 hours, combine the extracts, filter, recover ethanol, and obtain the extract for later use; soak the coarse powder of Poria cocos in warm water, and filter the extract , the filtrate is ready for use; the coarse powder of angelica, astragalus, American ginseng and the above-mentioned cat ginseng dregs are decocted with water for 3 times, the time is 2, 2, and 1 hour respectively, and the decoction is combined, filtered, and the filtrate is mixed with the above-mentioned cat ginseng extract and Poria cocos The filtrates were combined, concentrated to a concentrated solution with a relative density of 1.05-1.15 (60°C), vacuum freeze-dried to obtain a dry paste of 1.5 kg, and ultrafinely pulverized to 200 mesh; add 35% mannitol powder, mix well, and use 2% PVP _K30 (50% ethanol solution) made of soft material, sprayed with pure water, boiling granulation (inlet air temperature 75°C; water spray volume 5R/MIN; drying end point 50°C); add 2.5% magnesium stearate to the granules, mix, Sizing, tableting, coating (inlet air temperature 70-75°C, exhaust air temperature 45-55°C); that is, the tablet of the present invention is obtained, and the tablet weight is controlled at 0.5g±5%/tablet.

Usage and dosage: Take orally, 3 times a day, 1-2 tablets each time.

Embodiment 4: The five kinds of medicinal materials are cleaned separately, remove impurities, and pass the inspection for later use; Weigh 4.0 kg of wild kiwi fruit (cat ginseng), 0.6 kg of angelica, 1.5 kg of astragalus, 1.0 kg of poria cocos, and 0.3 kg of American ginseng, and grind them into coarse powder respectively Standby; take cat ginseng coarse powder, heat and reflux with 70% edible alcohol to extract twice, each time for 2 hours, combine the extracts, filter, recover ethanol, and obtain the extract for later use; soak the coarse powder of Poria cocos in warm water, and filter the extract , the filtrate is ready for use; the coarse powder of angelica, astragalus, American ginseng and the above-mentioned cat ginseng dregs are decocted with water for 3 times, the time is 2, 2, and 1 hour respectively, and the decoction is combined, filtered, and the filtrate is mixed with the above-mentioned cat ginseng extract and Poria cocos The filtrates are combined, concentrated to a concentrated solution with a relative density of 1.05-1.15 (60°C), vacuum freeze-dried to obtain 1.5 kg of dry paste, and ultrafinely pulverized to 200 mesh; add 20% xylitol powder, spray with pure water, and boil to prepare grains (inlet air temperature 75°C; water spray volume 5R/MIN; drying end point 50°C). The granules are added with 0.5% magnesium stearate, mixed, granulated, tabletted and coated (inlet air temperature 70-75°C, exhaust air temperature 45-55°C). Promptly get the tablet of the present invention, tablet weight control 0.5g ± 5%/tablet.

Usage and dosage: Take orally, 3 times a day, 1-2 tablets each time.

The wild kiwi fruit compound swallow tablet (Ai Neng tablet) that makes with above-mentioned method carries out quality standard control, and the result is as follows:

1. Testing, Stability and Hygienic Testing of Functional Components of Wild Kiwi Fruit Compound Swallow Tablets (Ai Neng Tablets)

According to the requirements of "Chinese Pharmacopoeia" (2000 edition) and "Health Food Inspection and Evaluation Technical Specifications" (2003 edition) of the Ministry of Health, relevant tests were carried out. 3%, the total saponin content ≥ 2%; in the stability test, the samples were kept at 37°C-40°C and 75% relative humidity for 3 months, and the indicators (functional ingredients, moisture, ash, protein, heavy metal and Microorganisms, etc.) are in line with the relevant regulations of the national health food; in the hygienic inspection, the indicators of the sample (functional ingredients, moisture, ash, protein, heavy metals and microorganisms, etc.) are in line with the relevant regulations of the national health food.

2. Toxicology experiment of wild kiwifruit compound swallow tablet (Ai Neng tablet)

The first and second stage toxicity test

In accordance with the requirements of the "Technical Specifications for Health Food Inspection and Evaluation" (version 2003) issued by the Ministry of Health, the first and second stages of toxicity tests were carried out on wild kiwifruit compound swallow tablets (Ai Neng tablets). The test results show that: in the first stage, the median lethal dose (LD ₅₀ ) of acute oral toxicity in rats and mice was greater than 1000 mg/kg body weight for both sexes, and judged by the acute toxicity grading standard, the sample was actually non-toxic; in the second stage The results of Ames test were negative; the results of mouse bone marrow cell micronucleus test and mouse sperm abnormality test were negative. This shows that wild kiwifruit compound swallowing tablet (Ai Neng tablet) does not show mutagenicity.

30-day feeding test in rats

In accordance with the requirements of the "Technical Specifications for Health Food Inspection and Evaluation" (2003 edition) issued by the Ministry of Health, a 30-day feeding test was carried out on wild kiwi fruit compound swallow tablets (Ai Neng tablets). The test results show that: there are three dose groups of wild kiwifruit compound swallow tablet (Ai Neng tablet), which are respectively 25 times, 50 times and 100 times the recommended human intake, and the rats were fed for 30 days. There was no obvious toxic reaction in each index in the dosage group.

3. Pharmacological experiment of wild kiwifruit compound swallow tablet (Ai Neng tablet)

According to the requirements of the "Technical Specifications for Health Food Inspection and Evaluation" (2003 edition) issued by the Ministry of Health, the pharmacological evaluation of wild kiwi fruit compound swallow tablets (Ai Neng tablets) in normal mice was tested as follows: ConA-induced mice spleen Lymphocyte transformation test, determination of mouse serum hemolysin, detection of antibody-producing cells (number of hemolytic plaques), and determination of NK cell activity. Set wild kiwifruit compound swallowing tablet (Ai Neng tablet) three dosage groups to feed continuously for 30 days, which are respectively equivalent to 5 times, 10 times and 30 times of human recommended intake, and set negative control group ( distilled water). The test results showed that, compared with the negative control group, both the middle and high dose groups could improve the proliferation ability of ConA-induced mouse spleen lymphocytes, and the difference was significant (q test, p<0.05); the high dose group could improve the NK Cell viability, significant difference (q test, p＜0.05); middle dose group can improve mouse hemolytic plaque number, difference has significance (q test, p＜0.05); middle dose group can improve mouse serum hemolysin, The difference was significant (q test, p<0.05). Therefore, it is believed that wild kiwifruit compound swallowing tablet (Ai Neng tablet) has the function of enhancing immunity to normal constitution. (See Table 1)

According to the requirements of the Ministry of Health "Technical Specifications for Health Food Inspection and Evaluation" (2003 edition), the pharmacological evaluation of wild kiwifruit compound swallow tablets (Ai Neng tablets) in deficient mice was carried out as follows: ConA induced mouse spleen T lymphocyte transformation test, mouse serum hemolysin assay, and macrophage phagocytosis assay. Set wild kiwifruit compound swallowing tablet (Ai Neng tablet) three dosage groups to feed continuously for 30 days, which are respectively equivalent to 5 times, 10 times and 30 times of human recommended intake, and set negative control group ( distilled water). The test results showed that, compared with the tumor control group, both the low and middle dose groups could significantly improve the proliferation ability of ConA-induced mouse splenic T lymphocytes (q test, p<0.001～0.01); the low, medium and high dose groups Both can significantly increase serum hemolysin in mice, the difference is significant (q test, p<0.001); the low dose group can improve the phagocytic activity of mouse macrophages, the difference is significant (q test, p<0.05). Therefore, it is believed that wild kiwi fruit compound swallowing tablet (Ai Neng tablet) has the function of enhancing immunity for those with low immunity. (See Table 2)

Table 1

Pharmacological Evaluation of Wild Kiwi Fruit Compound Swallow Tablet (Ai Neng Tablet) on Normal Mice

^* indicates q test, p<0.05 compared with the negative control.

Table 2

Pharmacological Experiment of Wild Kiwi Fruit Compound Swallow Tablet (Ai Neng Tablet) on S ₁₈₀ Tumor-bearing Mice

^* , ^** , ^*** represent q test, p<0.05, 0.01, 0.001 compared with tumor control.

The above results were verified by Zhejiang Provincial Center for Disease Control and Prevention and Zhejiang Provincial Academy of Traditional Chinese Medicine. The results show that: wild kiwi fruit compound swallow tablet (Ai Neng tablet) has good pharmacological activity, has the effect of improving human immunity, and is safe and has no side effects.

Claims (6)

1. a wild kiwi fruit compound swallowing tablet is characterized in that its bulk drug is calculated in parts by weight: Wild kiwi fruit 30-120 servings Angelica 5-20 servings Astragalus 10-40 servings Poria cocos 10-30 parts American ginseng 1-5 servings. 2. a kind of wild kiwifruit compound swallowing tablet according to claim 1 is characterized in that its crude drug is calculated in parts by weight: 60 servings of wild kiwi Angelica 10 servings Astragalus 20 servings Poria cocos 15 parts American ginseng 1-5 servings. 3. a preparation method of wild kiwi fruit compound swallowing tablet as claimed in claim 1, is characterized in that, the five flavor materials are uniformly mixed according to the formula, add water and decoct 2-3 times, each 1-3 hour, merge the decoction, Filtration, the filtrate is concentrated into a thick paste, the thick paste is spray-dried, vacuum-dried or vacuum-freeze-dried into a dry paste, and crushed and sieved to make a uniform powder, adding auxiliary materials, mixing, granulating, drying, tableting, coating, Instantly. 4. the preparation method of a kind of wild kiwifruit compound swallowing tablet according to claim 3 is characterized in that described auxiliary material is lecithin, xylitol, sucrose, β-cyclodextrin, hydroxypropyl-β-cyclodextrin One or more of dextrin, sorbitol or magnesium stearate are used in combination, accounting for 15% to 45% of the total formula. 5. a preparation method of wild kiwi fruit compound swallowing tablet as claimed in claim 1, is characterized in that, wild kiwi fruit is extracted 2-3 times with 60-95% edible alcohol, each 1.5-2 hour, merges extract , filter, recover ethanol, and obtain the extract for later use; Poria cocos is extracted with water, the leaching solution is filtered, and the filtrate is for later use; angelica, astragalus, and western kiwi participate in the above-mentioned wild kiwi fruit dregs and decoct for 2-3 times, each time for 1-3 hours , combined decoction, filtered, the filtrate was mixed with wild kiwi fruit extract and poria cocos filtrate, concentrated into a thick paste, the thick paste was spray-dried, vacuum-dried or vacuum-freeze-dried into a dry paste, and crushed and sieved to make a uniform powder, adding auxiliary materials, Mix evenly, granulate, dry, compress into tablets, coat, and obtain. 6. the preparation method of a kind of wild kiwi fruit compound swallowing tablet according to claim 5 is characterized in that described auxiliary material is lecithin, xylitol, sucrose, β-cyclodextrin, hydroxypropyl-β-cyclodextrin One or more of dextrin, sorbitol or magnesium stearate are used in combination, accounting for 15% to 45% of the total formula.