CN102370145A - Automatic nerve regulating agent with asparagus leaf as effective ingredient - Google Patents
Automatic nerve regulating agent with asparagus leaf as effective ingredient Download PDFInfo
- Publication number
- CN102370145A CN102370145A CN2011100792609A CN201110079260A CN102370145A CN 102370145 A CN102370145 A CN 102370145A CN 2011100792609 A CN2011100792609 A CN 2011100792609A CN 201110079260 A CN201110079260 A CN 201110079260A CN 102370145 A CN102370145 A CN 102370145A
- Authority
- CN
- China
- Prior art keywords
- asparagus
- leaf
- substances
- disposed
- food
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 235000005340 Asparagus officinalis Nutrition 0.000 title claims abstract description 75
- 210000005036 nerve Anatomy 0.000 title abstract description 8
- 230000001105 regulatory effect Effects 0.000 title abstract description 4
- 239000004615 ingredient Substances 0.000 title abstract 2
- 244000003416 Asparagus officinalis Species 0.000 title description 62
- 235000013305 food Nutrition 0.000 claims abstract description 42
- 239000000463 material Substances 0.000 claims abstract description 28
- 235000013376 functional food Nutrition 0.000 claims abstract description 15
- 241000234427 Asparagus Species 0.000 claims abstract description 14
- 210000000467 autonomic pathway Anatomy 0.000 claims description 43
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 38
- 206010003840 Autonomic nervous system imbalance Diseases 0.000 claims description 34
- 230000003750 conditioning effect Effects 0.000 claims description 26
- 239000004480 active ingredient Substances 0.000 claims description 20
- 230000002265 prevention Effects 0.000 claims description 13
- 238000004519 manufacturing process Methods 0.000 claims description 10
- 238000000034 method Methods 0.000 abstract description 9
- 238000001035 drying Methods 0.000 abstract description 6
- 238000005520 cutting process Methods 0.000 abstract description 5
- 238000007710 freezing Methods 0.000 abstract description 2
- 230000008014 freezing Effects 0.000 abstract description 2
- 239000000126 substance Substances 0.000 abstract 10
- 239000003795 chemical substances by application Substances 0.000 description 39
- 208000024891 symptom Diseases 0.000 description 25
- 239000000843 powder Substances 0.000 description 22
- 239000003814 drug Substances 0.000 description 18
- 230000036528 appetite Effects 0.000 description 15
- 235000019789 appetite Nutrition 0.000 description 15
- 239000000203 mixture Substances 0.000 description 14
- 230000001734 parasympathetic effect Effects 0.000 description 9
- 206010012735 Diarrhoea Diseases 0.000 description 7
- 244000269722 Thea sinensis Species 0.000 description 7
- 239000000284 extract Substances 0.000 description 7
- 239000000546 pharmaceutical excipient Substances 0.000 description 7
- 235000013616 tea Nutrition 0.000 description 7
- AHOUBRCZNHFOSL-UHFFFAOYSA-N 3-(1,3-benzodioxol-5-yloxymethyl)-4-(4-fluorophenyl)piperidine Chemical compound C1=CC(F)=CC=C1C1C(COC=2C=C3OCOC3=CC=2)CNCC1 AHOUBRCZNHFOSL-UHFFFAOYSA-N 0.000 description 6
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 6
- 235000020965 cold beverage Nutrition 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 230000036541 health Effects 0.000 description 6
- 206010022437 insomnia Diseases 0.000 description 6
- 238000002360 preparation method Methods 0.000 description 6
- JMGZEFIQIZZSBH-UHFFFAOYSA-N Bioquercetin Natural products CC1OC(OCC(O)C2OC(OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5)C(O)C2O)C(O)C(O)C1O JMGZEFIQIZZSBH-UHFFFAOYSA-N 0.000 description 5
- 201000010099 disease Diseases 0.000 description 5
- IVTMALDHFAHOGL-UHFFFAOYSA-N eriodictyol 7-O-rutinoside Natural products OC1C(O)C(O)C(C)OC1OCC1C(O)C(O)C(O)C(OC=2C=C3C(C(C(O)=C(O3)C=3C=C(O)C(O)=CC=3)=O)=C(O)C=2)O1 IVTMALDHFAHOGL-UHFFFAOYSA-N 0.000 description 5
- 238000009472 formulation Methods 0.000 description 5
- FDRQPMVGJOQVTL-UHFFFAOYSA-N quercetin rutinoside Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 FDRQPMVGJOQVTL-UHFFFAOYSA-N 0.000 description 5
- IKGXIBQEEMLURG-BKUODXTLSA-N rutin Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@@H]1OC[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 IKGXIBQEEMLURG-BKUODXTLSA-N 0.000 description 5
- ALABRVAAKCSLSC-UHFFFAOYSA-N rutin Natural products CC1OC(OCC2OC(O)C(O)C(O)C2O)C(O)C(O)C1OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5 ALABRVAAKCSLSC-UHFFFAOYSA-N 0.000 description 5
- 235000005493 rutin Nutrition 0.000 description 5
- 229960004555 rutoside Drugs 0.000 description 5
- 239000002002 slurry Substances 0.000 description 5
- 229940088594 vitamin Drugs 0.000 description 5
- 239000011782 vitamin Substances 0.000 description 5
- GUBGYTABKSRVRQ-PICCSMPSSA-N D-Maltose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 4
- 235000013361 beverage Nutrition 0.000 description 4
- 239000012141 concentrate Substances 0.000 description 4
- 235000009508 confectionery Nutrition 0.000 description 4
- 238000003745 diagnosis Methods 0.000 description 4
- 235000016709 nutrition Nutrition 0.000 description 4
- 230000035764 nutrition Effects 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- 235000011888 snacks Nutrition 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 206010000087 Abdominal pain upper Diseases 0.000 description 3
- 208000019901 Anxiety disease Diseases 0.000 description 3
- 240000008620 Fagopyrum esculentum Species 0.000 description 3
- 235000009419 Fagopyrum esculentum Nutrition 0.000 description 3
- 206010019233 Headaches Diseases 0.000 description 3
- 206010022998 Irritability Diseases 0.000 description 3
- 230000006806 disease prevention Effects 0.000 description 3
- 208000035475 disorder Diseases 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 230000003203 everyday effect Effects 0.000 description 3
- 206010016256 fatigue Diseases 0.000 description 3
- 239000000835 fiber Substances 0.000 description 3
- 230000006870 function Effects 0.000 description 3
- 231100000869 headache Toxicity 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 235000013336 milk Nutrition 0.000 description 3
- 239000008267 milk Substances 0.000 description 3
- 210000004080 milk Anatomy 0.000 description 3
- 230000001053 orthosympathetic effect Effects 0.000 description 3
- 229960005183 paroxetine hydrochloride Drugs 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- 239000002994 raw material Substances 0.000 description 3
- 235000013599 spices Nutrition 0.000 description 3
- 241000251468 Actinopterygii Species 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- 208000018522 Gastrointestinal disease Diseases 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 2
- DATAGRPVKZEWHA-YFKPBYRVSA-N N(5)-ethyl-L-glutamine Chemical compound CCNC(=O)CC[C@H]([NH3+])C([O-])=O DATAGRPVKZEWHA-YFKPBYRVSA-N 0.000 description 2
- 241000237502 Ostreidae Species 0.000 description 2
- 229930006000 Sucrose Natural products 0.000 description 2
- 240000002657 Thymus vulgaris Species 0.000 description 2
- 235000007303 Thymus vulgaris Nutrition 0.000 description 2
- 235000010724 Wisteria floribunda Nutrition 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 229940009098 aspartate Drugs 0.000 description 2
- 235000012970 cakes Nutrition 0.000 description 2
- 150000001720 carbohydrates Chemical class 0.000 description 2
- 235000014633 carbohydrates Nutrition 0.000 description 2
- 235000015218 chewing gum Nutrition 0.000 description 2
- 229940112822 chewing gum Drugs 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- CTQMJYWDVABFRZ-UHFFFAOYSA-N cloxiquine Chemical compound C1=CN=C2C(O)=CC=C(Cl)C2=C1 CTQMJYWDVABFRZ-UHFFFAOYSA-N 0.000 description 2
- 229950003660 cloxiquine Drugs 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 230000001276 controlling effect Effects 0.000 description 2
- 235000012495 crackers Nutrition 0.000 description 2
- 235000021185 dessert Nutrition 0.000 description 2
- 208000010643 digestive system disease Diseases 0.000 description 2
- 208000002173 dizziness Diseases 0.000 description 2
- 230000035622 drinking Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 235000019688 fish Nutrition 0.000 description 2
- 239000000796 flavoring agent Substances 0.000 description 2
- 235000019634 flavors Nutrition 0.000 description 2
- 238000004108 freeze drying Methods 0.000 description 2
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 2
- 208000018685 gastrointestinal system disease Diseases 0.000 description 2
- 235000021552 granulated sugar Nutrition 0.000 description 2
- 239000012535 impurity Substances 0.000 description 2
- 235000015110 jellies Nutrition 0.000 description 2
- 239000008274 jelly Substances 0.000 description 2
- 239000000845 maltitol Substances 0.000 description 2
- 235000010449 maltitol Nutrition 0.000 description 2
- VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 description 2
- 229940035436 maltitol Drugs 0.000 description 2
- 235000012054 meals Nutrition 0.000 description 2
- 230000003340 mental effect Effects 0.000 description 2
- 239000004570 mortar (masonry) Substances 0.000 description 2
- 230000008035 nerve activity Effects 0.000 description 2
- 210000000653 nervous system Anatomy 0.000 description 2
- 235000015097 nutrients Nutrition 0.000 description 2
- 235000020636 oyster Nutrition 0.000 description 2
- 210000005037 parasympathetic nerve Anatomy 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 238000010298 pulverizing process Methods 0.000 description 2
- 239000001397 quillaja saponaria molina bark Substances 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 239000004576 sand Substances 0.000 description 2
- 229930182490 saponin Natural products 0.000 description 2
- 150000007949 saponins Chemical class 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 235000011496 sports drink Nutrition 0.000 description 2
- 239000004575 stone Substances 0.000 description 2
- 239000005720 sucrose Substances 0.000 description 2
- 235000000346 sugar Nutrition 0.000 description 2
- 239000002562 thickening agent Substances 0.000 description 2
- 239000001585 thymus vulgaris Substances 0.000 description 2
- 210000001835 viscera Anatomy 0.000 description 2
- PVXPPJIGRGXGCY-DJHAAKORSA-N 6-O-alpha-D-glucopyranosyl-alpha-D-fructofuranose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@](O)(CO)O1 PVXPPJIGRGXGCY-DJHAAKORSA-N 0.000 description 1
- 241000451942 Abutilon sonneratianum Species 0.000 description 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- 244000247812 Amorphophallus rivieri Species 0.000 description 1
- 235000001206 Amorphophallus rivieri Nutrition 0.000 description 1
- 108010085443 Anserine Proteins 0.000 description 1
- 208000006820 Arthralgia Diseases 0.000 description 1
- 241000605422 Asparagus asparagoides Species 0.000 description 1
- 244000248539 Asparagus cochinchinensis Species 0.000 description 1
- 241000432767 Asparagus setaceus Species 0.000 description 1
- 241000972773 Aulopiformes Species 0.000 description 1
- 235000017166 Bambusa arundinacea Nutrition 0.000 description 1
- 235000017491 Bambusa tulda Nutrition 0.000 description 1
- 206010004542 Bezoar Diseases 0.000 description 1
- UMSGKTJDUHERQW-UHFFFAOYSA-N Brotizolam Chemical compound C1=2C=C(Br)SC=2N2C(C)=NN=C2CN=C1C1=CC=CC=C1Cl UMSGKTJDUHERQW-UHFFFAOYSA-N 0.000 description 1
- QRYRORQUOLYVBU-VBKZILBWSA-N Carnosic acid Natural products CC([C@@H]1CC2)(C)CCC[C@]1(C(O)=O)C1=C2C=C(C(C)C)C(O)=C1O QRYRORQUOLYVBU-VBKZILBWSA-N 0.000 description 1
- 108010087806 Carnosine Proteins 0.000 description 1
- 206010008479 Chest Pain Diseases 0.000 description 1
- 235000005979 Citrus limon Nutrition 0.000 description 1
- 244000131522 Citrus pyriformis Species 0.000 description 1
- 206010010774 Constipation Diseases 0.000 description 1
- 229920001353 Dextrin Polymers 0.000 description 1
- 239000004375 Dextrin Substances 0.000 description 1
- LFMYNZPAVPMEGP-PIDGMYBPSA-N Fluvoxamine maleate Chemical compound OC(=O)\C=C/C(O)=O.COCCCC\C(=N/OCCN)C1=CC=C(C(F)(F)F)C=C1 LFMYNZPAVPMEGP-PIDGMYBPSA-N 0.000 description 1
- 241000287828 Gallus gallus Species 0.000 description 1
- 235000018958 Gardenia augusta Nutrition 0.000 description 1
- 235000010469 Glycine max Nutrition 0.000 description 1
- 244000068988 Glycine max Species 0.000 description 1
- SQUHHTBVTRBESD-UHFFFAOYSA-N Hexa-Ac-myo-Inositol Natural products CC(=O)OC1C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C1OC(C)=O SQUHHTBVTRBESD-UHFFFAOYSA-N 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 235000010254 Jasminum officinale Nutrition 0.000 description 1
- 240000005385 Jasminum sambac Species 0.000 description 1
- 229920002752 Konjac Polymers 0.000 description 1
- SLRNWACWRVGMKD-UHFFFAOYSA-N L-anserine Natural products CN1C=NC(CC(NC(=O)CCN)C(O)=O)=C1 SLRNWACWRVGMKD-UHFFFAOYSA-N 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 240000008415 Lactuca sativa Species 0.000 description 1
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 1
- XNCDYJFPRPDERF-PBCQUBLHSA-N Milnacipran hydrochloride Chemical compound [Cl-].C=1C=CC=CC=1[C@@]1(C(=O)N(CC)CC)C[C@@H]1C[NH3+] XNCDYJFPRPDERF-PBCQUBLHSA-N 0.000 description 1
- 244000294411 Mirabilis expansa Species 0.000 description 1
- 235000015429 Mirabilis expansa Nutrition 0.000 description 1
- CQOVPNPJLQNMDC-UHFFFAOYSA-N N-beta-alanyl-L-histidine Natural products NCCC(=O)NC(C(O)=O)CC1=CN=CN1 CQOVPNPJLQNMDC-UHFFFAOYSA-N 0.000 description 1
- 240000004371 Panax ginseng Species 0.000 description 1
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 1
- 235000003140 Panax quinquefolius Nutrition 0.000 description 1
- 241000286209 Phasianidae Species 0.000 description 1
- 244000082204 Phyllostachys viridis Species 0.000 description 1
- 235000015334 Phyllostachys viridis Nutrition 0.000 description 1
- 235000008331 Pinus X rigitaeda Nutrition 0.000 description 1
- 235000011613 Pinus brutia Nutrition 0.000 description 1
- 241000018646 Pinus brutia Species 0.000 description 1
- 241001529246 Platymiscium Species 0.000 description 1
- 241000210053 Potentilla elegans Species 0.000 description 1
- 206010041349 Somnolence Diseases 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 239000004376 Sucralose Substances 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 206010042434 Sudden death Diseases 0.000 description 1
- 235000006468 Thea sinensis Nutrition 0.000 description 1
- 208000009205 Tinnitus Diseases 0.000 description 1
- 235000021307 Triticum Nutrition 0.000 description 1
- 244000098338 Triticum aestivum Species 0.000 description 1
- KGEKLUUHTZCSIP-HOSYDEDBSA-N [(1s,4s,6r)-1,7,7-trimethyl-6-bicyclo[2.2.1]heptanyl] acetate Chemical compound C1C[C@]2(C)[C@H](OC(=O)C)C[C@H]1C2(C)C KGEKLUUHTZCSIP-HOSYDEDBSA-N 0.000 description 1
- 235000010489 acacia gum Nutrition 0.000 description 1
- 239000001785 acacia senegal l. willd gum Substances 0.000 description 1
- JAZBEHYOTPTENJ-JLNKQSITSA-N all-cis-5,8,11,14,17-icosapentaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O JAZBEHYOTPTENJ-JLNKQSITSA-N 0.000 description 1
- MYYIAHXIVFADCU-QMMMGPOBSA-N anserine Chemical compound CN1C=NC=C1C[C@H](NC(=O)CC[NH3+])C([O-])=O MYYIAHXIVFADCU-QMMMGPOBSA-N 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 229940125713 antianxiety drug Drugs 0.000 description 1
- 230000036506 anxiety Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 230000037424 autonomic function Effects 0.000 description 1
- 239000011425 bamboo Substances 0.000 description 1
- 235000013527 bean curd Nutrition 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 235000008429 bread Nutrition 0.000 description 1
- 229960003051 brotizolam Drugs 0.000 description 1
- 235000014121 butter Nutrition 0.000 description 1
- 229940041514 candida albicans extract Drugs 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 210000000748 cardiovascular system Anatomy 0.000 description 1
- 229940044199 carnosine Drugs 0.000 description 1
- CQOVPNPJLQNMDC-ZETCQYMHSA-N carnosine Chemical compound [NH3+]CCC(=O)N[C@H](C([O-])=O)CC1=CNC=N1 CQOVPNPJLQNMDC-ZETCQYMHSA-N 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 235000010980 cellulose Nutrition 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 235000013351 cheese Nutrition 0.000 description 1
- 230000009194 climbing Effects 0.000 description 1
- 235000016213 coffee Nutrition 0.000 description 1
- 235000013353 coffee beverage Nutrition 0.000 description 1
- 238000004040 coloring Methods 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000010411 cooking Methods 0.000 description 1
- 230000002354 daily effect Effects 0.000 description 1
- 230000000994 depressogenic effect Effects 0.000 description 1
- 235000019425 dextrin Nutrition 0.000 description 1
- 239000008121 dextrose Substances 0.000 description 1
- AAOVKJBEBIDNHE-UHFFFAOYSA-N diazepam Chemical compound N=1CC(=O)N(C)C2=CC=C(Cl)C=C2C=1C1=CC=CC=C1 AAOVKJBEBIDNHE-UHFFFAOYSA-N 0.000 description 1
- 229960003529 diazepam Drugs 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 235000021186 dishes Nutrition 0.000 description 1
- 239000002270 dispersing agent Substances 0.000 description 1
- 238000002651 drug therapy Methods 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 235000013601 eggs Nutrition 0.000 description 1
- 229960005135 eicosapentaenoic acid Drugs 0.000 description 1
- JAZBEHYOTPTENJ-UHFFFAOYSA-N eicosapentaenoic acid Natural products CCC=CCC=CCC=CCC=CCC=CCCCC(O)=O JAZBEHYOTPTENJ-UHFFFAOYSA-N 0.000 description 1
- 235000020673 eicosapentaenoic acid Nutrition 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 235000013312 flour Nutrition 0.000 description 1
- 229960002107 fluvoxamine maleate Drugs 0.000 description 1
- 235000015203 fruit juice Nutrition 0.000 description 1
- 229960003692 gamma aminobutyric acid Drugs 0.000 description 1
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 description 1
- 210000004392 genitalia Anatomy 0.000 description 1
- 235000008434 ginseng Nutrition 0.000 description 1
- 210000004907 gland Anatomy 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 230000009931 harmful effect Effects 0.000 description 1
- 235000013402 health food Nutrition 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 235000008216 herbs Nutrition 0.000 description 1
- 230000013632 homeostatic process Effects 0.000 description 1
- 238000000265 homogenisation Methods 0.000 description 1
- 235000015243 ice cream Nutrition 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 229960000367 inositol Drugs 0.000 description 1
- CDAISMWEOUEBRE-GPIVLXJGSA-N inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-GPIVLXJGSA-N 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 230000003871 intestinal function Effects 0.000 description 1
- 239000000252 konjac Substances 0.000 description 1
- 235000010485 konjac Nutrition 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 210000002429 large intestine Anatomy 0.000 description 1
- 210000000867 larynx Anatomy 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 239000008204 material by function Substances 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 235000010746 mayonnaise Nutrition 0.000 description 1
- 239000008268 mayonnaise Substances 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 1
- 239000008108 microcrystalline cellulose Substances 0.000 description 1
- 229940016286 microcrystalline cellulose Drugs 0.000 description 1
- 230000027939 micturition Effects 0.000 description 1
- 229960000638 milnacipran hydrochloride Drugs 0.000 description 1
- 235000013536 miso Nutrition 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 210000000214 mouth Anatomy 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 239000005445 natural material Substances 0.000 description 1
- 230000001537 neural effect Effects 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 235000012149 noodles Nutrition 0.000 description 1
- 235000020333 oolong tea Nutrition 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000016046 other dairy product Nutrition 0.000 description 1
- 239000005022 packaging material Substances 0.000 description 1
- 230000029553 photosynthesis Effects 0.000 description 1
- 238000010672 photosynthesis Methods 0.000 description 1
- 229940126532 prescription medicine Drugs 0.000 description 1
- 235000020991 processed meat Nutrition 0.000 description 1
- 230000004952 protein activity Effects 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 238000001671 psychotherapy Methods 0.000 description 1
- 235000011962 puddings Nutrition 0.000 description 1
- 238000012797 qualification Methods 0.000 description 1
- 208000012802 recumbency Diseases 0.000 description 1
- 235000012045 salad Nutrition 0.000 description 1
- 235000019515 salmon Nutrition 0.000 description 1
- 235000013580 sausages Nutrition 0.000 description 1
- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 description 1
- 235000014102 seafood Nutrition 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 235000014214 soft drink Nutrition 0.000 description 1
- 235000014347 soups Nutrition 0.000 description 1
- 235000013322 soy milk Nutrition 0.000 description 1
- 235000013555 soy sauce Nutrition 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 238000001256 steam distillation Methods 0.000 description 1
- 235000013547 stew Nutrition 0.000 description 1
- BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 description 1
- 235000019408 sucralose Nutrition 0.000 description 1
- -1 sucrose fatty ester Chemical class 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000035900 sweating Effects 0.000 description 1
- 235000011270 sweet biscuits Nutrition 0.000 description 1
- 235000019605 sweet taste sensations Nutrition 0.000 description 1
- 230000002889 sympathetic effect Effects 0.000 description 1
- 210000002820 sympathetic nervous system Anatomy 0.000 description 1
- 238000002636 symptomatic treatment Methods 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 229940026510 theanine Drugs 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 231100000886 tinnitus Toxicity 0.000 description 1
- 230000003867 tiredness Effects 0.000 description 1
- 208000016255 tiredness Diseases 0.000 description 1
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 1
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 235000014101 wine Nutrition 0.000 description 1
- 239000012138 yeast extract Substances 0.000 description 1
- 235000008924 yoghurt drink Nutrition 0.000 description 1
- 235000013618 yogurt Nutrition 0.000 description 1
Images
Landscapes
- Medicines Containing Plant Substances (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
The present invention provides an automatic nerve regulating agent for safely and effectively adjusting automatic nerves, preventing or improving automatic nerve disharmony and effectively improving sleeping state; functional food or food material for preventing or improving automatic nerve disharmony; and a using method of the functional food or the food materials for preventing or improving automatic nerve disharmony, and improving sleep through adding the automatic nerve regulating agent in food or food materials. Asparagus leaves and disposed substances (apart from grinding disposed substances, cutting disposed substances, drying disposed substances, baking disposed substances, extracting disposed substances, ultrasonic homogenizing disposed substances freezing disposed substances, and substances formed by combing the above disposed substances) are used, and dried power is selectively used as effective ingredients.
Description
Technical field
The present invention relates to a kind of is the autonomic nerve conditioning agent of active ingredient with asparagus plan leaf; In more detail, relate to this asparagus intend autonomic nerve conditioning agent that leaf or its handled thing are active ingredient, autonomic imbalance disease prevention or improver, sleep-improving agent, be used to prevent or improve functional food or the food material of autonomic imbalance disease and the method for using that asparagus is intended leaf or its handled thing.
Background technology
Autonomic nerves system is to be distributed widely in various internal organ, blood vessel, body of gland etc.; Regulate each internal organs through the property followed ground; Bringing into play for external, internal environment thus and reasonably keeping the nervous system that steady state is the function of stable state (homeostasis), be also referred to as automatic nervous system.Autonomic nerves system has sympathetic nervous system these the two kinds of systems of parasympathetic that unify, and autonomic nerves system is to control through both balances.That is, orthosympathetic activity is dominant during body movement, and whole body becomes nervous state.On the contrary, the anxiety of health was eliminated when parasympathetic activity was dominant, and became comfortable state.It is well-known producing various health obstacles when in addition, pressure causes long-term the continuing of the movable disorder of autonomic nerve.The movable disorder of autonomic nerve is meant the state that state that SA is dominant or parasympathetic activity are dominant, yet particularly in modern society, the healthy obstacle that continues to cause of the state that is dominant of SA is regarded as a kind of problem.
Neural and the parasympathetic balance of known exchange also with people's psychological condition close association.For example, under melancholy state, its movable parasympathetic movable reduction that should be hyperfunction when loosening is if but recovery from illness then returns to the be dominant normal equilibrium of work of parasympathetic nerve when loosening.In addition, when being exposed to excess pressure, parasympathetic nerve still can not be brought into play function smoothly, and it is hyperfunction that orthosympathetic activity continues, and causes that bad condition such as insomnia also is well-known.As other symptom, headache, dizzy, sense of fatigue arranged, shake, coldness of extremities, parahidrosis, palpitaition, breathe hard, colourful symptom such as uncomfortable in chest, chest pain, poor appetite, gasteremphraxis, constipation, diarrhoea.In recent years, pointed out that it is the important risk factor of coronary cardiopathy or sudden death that parasympathetic activity reduces.Autonomic function reduces caused various private prosecution symptom and is called autonomic imbalance disease, brings significant harmful effect in the raising normal keeping of daily life.
Actual state is that each above-mentioned each symptom or disease are carried out symptomatic treatment, does not have to adopt the method for self controlling as the autonomic nerve activity of basic reason.Heteropathy can temporarily be improved its state of an illness self; But recurrence when ending to take medicine; And when continuing to take medicine,, also produce under many circumstances by disorder or movable other disease that causes that reduces of autonomic nerve as the autonomic nerve of basic reason even improve a kind of disease.For this reason, require pharmaceuticals or the health food of control as the autonomic nerve activity self of basic reason.Promptly; As long as can obtain having active ingredient compound, material or the natural goods of following effect; Consider that from the aspect of the prevention of various diseases value is also high; It act as as follows: through suppressing because of hyperfunction SA or the parasympathetic activity of some principal element or promote lowered SA or parasympathetic activity, recover state that SA is dominant, state that parasympathetic activity is dominant, the state of the hyperactive state of autonomic nerve or reduction on the whole.
In the past, proposed to use the various schemes of the active ingredient compound in autonomic imbalance disease, anxiety disorder, hypochondriacal prevention, the therapeutic agent, and come from crude and give the sense of feeling at ease, known most crude drug in the past to the people.As coming from vegeto-animal material; Known have: with the thick saponin(e of ginseng for medicinal use be active ingredient the pressure symptom of following autonomic imbalance disease restorative (for example; Referring to patent documentation 1) or contain the orthosympathetic excited inhibitor of phosphatide as active ingredient; It is that highly unsaturated fatty acid is as constituent (for example, referring to patent documentation 2) that this phosphatide contains through extracting n-3 such as the DHA obtain and/or eicosapentaenoic acid with usual way from natural material.
In addition; Known contain select in the group of forming by theanine (from the extract of tealeaves), medicinal herbs, GABA and palatinose one or more the composition that is used for resistance to compression and loosens (for example; Referring to patent documentation 3) or contain the chicken extract that comprises carnosine and anserine (for example have functional food that learning functionality improves effect and anti-uneasy effect; Referring to patent documentation 4) or with select in the steam distillation thing by extract, 3-methyloctanoic acid-4-lactone, borneolacetate and the thyme (thymus vulgaris) of Jasmine (jasmin sambac) one or more be the autonomic nerve conditioning agent (for example, referring to patent documentation 5) of active ingredient.
In addition, as the beverage that relaxation effect is arranged, knownly contain the beverage with relaxation effect (for example, referring to patent documentation 6) that hardness is 60～2000 water.
On the other hand; Technology as the stem that has utilized asparagus, plan leaf; Known with dry, pulverize, cure asparagus that the green asparagus stem portion forms be the powder tea of raw material or the tea blend that in this powder tea, has mixed the powder leaf tea that likewise drying, pulverizing, Grilled Asparagus with Butter and Cheese plan leaf form (for example; Referring to patent documentation 7); Or contain the dried powder (for example, referring to patent documentation 8) of plan leaf texture that rutin and every 1g dry weight contain lucid asparagus (Asparagus) platymiscium of 100mg carbohydrate at least.
On the other hand, unknown is the autonomic nerve conditioning agent of active ingredient, prevention or improver, the sleep-improving agent etc. of autonomic imbalance disease with asparagus plan leaf.
The prior art document
Patent documentation
Patent documentation 1: the special public clear 62-44526 communique of Japan
Patent documentation 2: TOHKEMY 2004-67537 communique
Patent documentation 3: TOHKEMY 2005-232045 communique
Patent documentation 4: International Publication 2007-116987 communique
Patent documentation 5: TOHKEMY 2009-235015 communique
Patent documentation 6: TOHKEMY 2009-274980 communique
Patent documentation 7: japanese kokai publication sho 63-273462 communique
Patent documentation 8: International Publication 2006-22338 communique
Summary of the invention
The present invention provides and can securely and effectively adjust autonomic nerve, prevention or improve autonomic imbalance disease, can improve dormant autonomic nerve conditioning agent effectively, be used to prevent or improve the functional food or the food material of autonomic imbalance disease; In food or food material, contain above-mentioned autonomic nerve conditioning agent as the method for using that is used to prevent or improves autonomic imbalance disease and the food or the food material that are used to improve sleep; And in the use that is used for preventing or improves the autonomic imbalance disease and the manufacturing of food that is used to improve sleep or food material.
The inventor notices, in Hokkaido that asparagus cultivation rises, after the asparagus results; A large amount of discarded from the green asparagus of stem below the front end 25cm and growth leaf (plan leaf) in great numbers; Known in the past in above-mentioned plan leaf the content of rutin more, intend the effective use of leaf for further exploitation asparagus and further investigate, the result finds; With asparagus intend leaf or its handled thing be diagnosed as minor depression the people, the people of indefinite private prosecution symptom is arranged, he when tells the people etc. of insomnia; Improved above-mentioned symptom, further studied, the result finds; Effective in the prevention of the disease in autonomic nerves systems such as autonomic imbalance disease, insomnia, the improvement, thus the present invention accomplished.
That is, the present invention relates to: (1) a kind of autonomic nerve conditioning agent is characterized in that intending leaf with asparagus is active ingredient; (2) a kind of prevention of autonomic imbalance disease or improver is characterized in that, intending leaf with asparagus is active ingredient; (3) a kind of sleep-improving agent is characterized in that, intending leaf with asparagus is active ingredient.
In addition, the present invention relates to: (4) a kind of being used to prevents or improves functional food or the food material that autonomic imbalance disease perhaps is used to improve sleep, it is characterized in that, contains asparagus and intends leaf as active ingredient; (5) asparagus is intended leaf and is being used for preventing or is improving autonomic imbalance disease or be used to improve the application of manufacturing of functional food or the food material of sleep.
The prevention of autonomic nerve conditioning agent of the present invention, autonomic imbalance disease or improver, sleep-improving agent, be used for preventing or the functional food or the food material that improve autonomic imbalance disease has no side effect in its use; And autonomic nerve can be regulated imperturbably and not by about the sensitivity of individuality or hobby property; Be in the people of the state that excessively is dominant for the collapse of the balance of autonomic nerve and sympathetic nerve, various symptoms that can securely and effectively improve poor appetite, hypertension, headache, shoulder acid (shoulder こ り), get angry, irritability etc. caused by autonomic imbalance or insomnia etc.In addition, intend effective utilization of leaf discarded object and the aspect consideration that discarded object reduces from asparagus, the present invention can not bring any influence on natural environment, help environmental protection on the contrary.
Description of drawings
WA sleep sense numerical value when Fig. 1 representes to take sample at every turn, sample A representes the dextrin as comparative example, sample B representes to intend the leaf powder as the asparagus of autonomic nerve conditioning agent of the present invention.
The specific embodiment
As prevention or the improver and the sleep-improving agent of autonomic nerve conditioning agent of the present invention, autonomic imbalance disease, be active ingredient as long as intend leaf with asparagus, just not special restriction; As the effect in above-mentioned autonomic nerve conditioning agent; Though physical symptoms such as sense of fatigue, taediumvitae, insomnia, carebaria, sweating are arranged, almost there are not mental symptoms such as uneasy sense, be to improve for the symptom of the degree that is not to use antianxiety drug; Though and in autonomic imbalance disease, individual difference is arranged; But the balance of autonomic nerve is disorderly, in autonomic nerves system (the for example autonomic nerves system in each organ in head, ear, mouth, larynx, cardiovascular system, respirator, digester, hand, foot, skin, uropoiesis device, genitals, muscle and joint), multiple subjective symptoms is arranged, specifically; Except headache, tinnitus, palpitaition, choke, feel sick, hidrosis, hand fiber crops, foot are cold, frequent micturition, shoulder acid, the arthralgia; As constitutional symptom, have taediumvitae, fatiguability, dizzy, get angry, symptom such as poor appetite, as mental symptom; Become uneasy; The symptom that, irritability frightened, irritable, depressed by the terrified heart, no concentrated force, no passion, memory or notice reduce, for these symptoms, the present invention has carried out prevention or has improved.In addition, sleep-improving agent improves symptoms such as the misery of can not sleeping, wake up immediately, get up.
Asparagus is intended leaf after the tender stem of edible part stretches out, and can replace leaf to utilize photosynthesis to make nutrient on the stem of branch.During outdoor cropping 5, the most of tender stem of results about June, but in order in root, to accumulate nutrient, directly stay a part of tender stem as usefulness in the coming year, make and intend leaf and grow up.Utilization in the present invention becomes the asparagus plan leaf of the such shape of pine needle to liking the front end that occurs through growing up.
Asparagus plant is liliaceous perennial plant, from southern Europe to Ukraine, is the original producton location, except Europe, is distributed widely in Africa, Asia etc.Generally referred to as "asparagus", as food plants are asparagus (Asparagus? Officinalis, Japanese name is Alan Tuo pheasant withhold any), but in addition, eggs Ye aspartate (A.asparagoides), aspartate (A. cochinchinensis), asparagus (A.plumosus), Matsuba Wu bamboo (A.myrioclaudus), also make use of the food, foliage, medicine, etc..Intend leaf as the asparagus among the present invention, can be fit to enumerate asparagus and intend leaf.
In the tender stem of asparagus, contain functional materials such as rutin, saponin(e, FOS and food fiber.Known in these materials Wheat Protein and antitumor activity etc.In addition; The rutin content that known asparagus is intended leaf is up to being 100～200 times of general buck wheat; And do not have the irritated worry of buckwheat, have the shallow asparagus local flavor of smearing the such beautiful green of tea and having a little sweet taste,, can be used as the drink and food material from these situation.
Asparagus among the present invention is intended leaf and comprises plan leaf self or its handled thing.As its handled thing, except asparagus intend leaf the pulverization process thing, fritter handled thing, dried thing, cure handled thing, extract handled thing, ultrasonic wave homogenization processing thing, the freezing processing thing, can enumerate the handled thing that the combination by these processing obtains.For example; The manufacturing approach of asparagus slurry mud is roughly as follows: clean plan leaf that the summer in cultivation to evening produced with the native sand that removes attachment removal, dust etc. after; Fritter with cutting machine through food; Fritter at this and to add water in thing, grind up to becoming prescribed particle size, concentrate resulting pulp-like solution with the low temperature thickener with electronic stone mortar etc.This concentrate (slurry mud) demonstrates bottle-green congee shape; Directly or mix other excipient etc., can be suitable as autonomic nerve conditioning agent of the present invention, autonomic imbalance disease prevention or improver, sleep-improving agent, or be used to prevent or improve the functional food or the food material of autonomic imbalance disease.
In addition; The manufacturing approach that asparagus is intended the drying and crushing handled thing of leaf is roughly as follows: fritter asparagus through food with cutting machine and intend leaf; Utilization makes the plan leaf that fritters dry under temperate condition by the drying machine of selecting in freeze drier, drying under reduced pressure machine, the throughcirculation dryer etc., utilizes the pulverizer that satisfies purposes that resulting dried asparagus is intended leaf and carries out powdered.In addition, for example also can use turbine type pulverizer atomizers such as (タ one ボ Industrial Co., Ltd) carry out micropowderization.Dried powder; Directly or mix other excipient etc., can be suitable as autonomic nerve conditioning agent of the present invention or autonomic imbalance disease prevention or improver, be used to prevent or improve the functional food of autonomic imbalance disease or the raw material of food material.Compare with above-mentioned slurry mud, dried powder can be applied to multiple field.
Intend the handled thing of leaf as other asparagus; Can enumerate the handled thing or its dry thing that fritter asparagus and intend leaf, asparagus is intended leaf become liquid handled thing (juice) or its dry thing etc.; These materials directly or mix other excipient etc. can be as the prevention or the improver of autonomic nerve conditioning agent of the present invention or autonomic imbalance disease, be used to prevent or improve the functional food or the food material of autonomic imbalance disease.
Formulation as the prevention of autonomic nerve conditioning agent of the present invention, autonomic imbalance disease or improver, sleep-improving agent; Can enumerate pulvis, tablet, capsule, granule, powder, liquor etc., common mode oral administration with replenishers or medical composition.In addition, these formulations can be utilized known in the past common formulation method manufacturing.For example, with the manufacturing of preparation on carrier, excipient, spices, emulsifying agent, anticorrisive agent, dispersant of allowing etc. mix aftershaping.In addition, also can further mix other active ingredient as required.As the example of above-mentioned excipient, can enumerate lactose, dextrose, cellulose, methylcellulose, starch etc.
Be used to prevent or improve autonomic imbalance disease or be used to improve the functional food or the food material of sleep as of the present invention; The handled thing that contains asparagus plan leaf self or above-mentioned asparagus plan leaf is as active ingredient; Consider from the aspect that is used to prevent or improve autonomic imbalance disease or be used to improve sleep; As long as can separate as product zone with other the food or the food material that contain asparagus plan leaf; Whether just not special restriction, can enumerate and on the packaging material of food or food material, indicate and be used to prevent or improve autonomic imbalance disease or be used to improve the content etc. of the function of sleep as the example that can separate as product zone at this.Preparation method as such functional food or food material; For example; Can enumerate frittering handled thing that asparagus intends leaf or its dry thing, asparagus is intended leaf becoming liquid handled thing (slurry mud, juice etc.) or its dry thing, asparagus is intended the handled thing that leaf carries out powdered add in food or the food material, perhaps add, method of mixing in manufacturing process or after making.As the food object is not particularly limited, specifically includes small sweet biscuits, bread, cakes, crackers and other baked snacks; lemon dessert (ra Rousseau Neko fruit) and other pieces snacks; jelly and other Japanese sweets; pudding, jelly , ice cream and other frozen dessert category; chewing gum, candy and other snacks; crackers, pieces (chips) and other snacks; Udon (ぅ ど san), soba noodles; fish cake, ham, fish sausage and other processed meat products ; cheese, butter and other dairy products; miso, soy sauce, mayonnaise, sweet spices and other spices; tofu, konjac (ko san ni ゃ ku), the other into the cooking seafood, dumplings, croquettes, salads, soups, stews, etc. a variety of dishes; yogurt, yogurt drinks, fruit juices, milk, soy milk, wine, coffee, tea, Sencha, Oolong tea, sports drinks and other beverages.
The dosage of the prevention of autonomic nerve conditioning agent of the present invention, autonomic imbalance disease or improver, sleep-improving agent is because of the different of age, result of treatment and the state of an illness etc. and not special the qualification; But, make to absorb 1～300g asparagus every day and intend leaf, be preferably 2～10g and get final product in dry weight as long as regulate combined amount etc.As stated; Asparagus is intended leaf and can take with various formulations; Take after can adding in various food, the beverage etc. in addition; But under the situation of particularly taking with drink form, become when together taking and smear the tea local flavor, but also can together take according to hobby and sports drink, milk, soya-bean milk etc. with water.
Below, specify the present invention through embodiment, but technical scope of the present invention is not limited to these examples.
Embodiment 1
(asparagus is intended the preparation of leaf slurry mud)
The asparagus of removing results is intended the impurity of leaf, after the cleaning, dewaters, and fritters into 2～3cm with food with cutting machine (ス ラ ィ サ one OV type, ァ one シ ェ Le society make).Fritter in the thing water that adds 3 times of amounts at this, grind 2 times up to becoming prescribed particle size with electronic stone mortar (マ ス コ ロ ィ ダ one, increase the manufacturing of good fortune Industry Co., Ltd).In low temperature thickener (ェ バ Port one Le, the former making manufacturing in great river), add pulp-like solution, under 35 ℃ liquid temperature, be concentrated into about Bx15, further 55 ℃ of heating 15 minutes, the preparation asparagus is intended the leaf concentrate.Product demonstrates bottle-green congee shape, contains the rutin, the sugar that conform to contained humidity.Yield is 150%.This concentrate directly perhaps is filled in bottle, jar, the paper container etc., can be used as autonomic nerve conditioning agent of the present invention.In addition, can mix as the food or the food material that are used to prevent or improve autonomic imbalance disease and be used to improve sleep with the raw material mode of food or food material.Also can freezingly preserve.
Embodiment 2
(asparagus is intended the preparation of leaf freeze drying powder)
The asparagus of removing results is intended the impurity of leaf, after the cleaning, dewaters, and fritters into 2～3cm with food with cutting machine (ス ラ ィ サ one OV type, ァ one シ ェ Le society make).This fritters thing-40 ℃ of following precoolings, further uses vacuum freeze drier (consonance vacuum technique (strain) system), under 30 ℃ canopy heating-up temperature, drying time of 48 hours, carries out freeze drying when dry.Yield is 24%.Pulverize dry asparagus with turbine type pulverizer (タ one ボ Industrial Co., Ltd) and intend leaf, become powder.This powder directly perhaps is filled in bottle, jar, the paper container etc., can be used as autonomic nerve conditioning agent of the present invention, in addition, can in the autonomic nerve conditioning agent of various formulations, use.
Embodiment 3
[particle (below, mixed proportion is represented with quality %)]
(1) Sucralose 0.1
(2) autonomic nerve conditioning agent (dried powder of embodiment 2) 0.5
(3) flavoring 5.0
(4) excipient (microcrystalline cellulose) 10.0
(5) maltitol surplus
Embodiment 4
[tablet (masticatory pattern)]
(1) inositol 11.0
(2) maltitol 15.0
(3) sucrose 0.5
(4) salmon essence extract (DNA Na) 0.1
(5) yeast extract 0.1
(6) autonomic nerve conditioning agent (dried powder of embodiment 2) 0.5
(7) flavoring 5.0
(8) excipient surplus
[tablet]
(1) lubricant (sucrose fatty ester etc.) 1.0
(2) the Arabic gum aqueous solution (5%) 2.0
(3) acidulant 1.0
(4) colouring agent is an amount of
(5) autonomic nerve conditioning agent (dried powder of embodiment 2) 1.0
(6) carbohydrate (flour sand sugar or sorbierite etc.) surplus
Embodiment 6
[candy]
(1) granulated sugar 57.5
(2) malt sugar 40.0
(3) organic acid 2.0
(4) autonomic nerve conditioning agent (dried powder of embodiment 2) 0.5
Embodiment 7
[chewing gum]
(1) granulated sugar 33.0
(2) matrix 30.0
(3) glucose 10.0
(4) malt sugar 16.0
(5) autonomic nerve conditioning agent (dried powder of embodiment 2) 1.0
Embodiment 8
(symptom; Minor depression, 28 years old, women)
Be diagnosed as minor depression, carried out drug therapy, and just treated at present in nearly 2 years with the commercially available paroxetine hydrochloride of 1 slice/day of 20mg.About 3 weeks, take the medicine rather than the regulation dose of 2 all components, also be hopeful to end this human hope of taking medicine, intend leaf, observation situation so share asparagus.As the instructions of taking of asparagus plan leaf, the asparagus of dissolving suspension 2g/ day is drunk after intending leaf (dried powder of embodiment 2) in 500ml cold drink (soft drink).The back health is very comfortable about 1 week, from weak unusually, tiredness occurring when drinking commercially available paroxetine hydrochloride after about 2 weeks, so end taking of commercially available paroxetine hydrochloride, the observation process.Roughly end fully after 1 month to take medicine, taking at present and containing 6 in the tablet that asparagus is intended leaf and oyster extract, the sign of recovery occurred.
Embodiment 9
(symptom; Insomnia, anxiety disorder, poor appetite, 33 years old, the male sex)
Before 2 years or 3 years; Have and to sleep, unexpected uneasiness sense, do not have the symptom of appetite; Accept the diagnosis of psychotherapy internal medicine, taking at present the commercially available milnacipran hydrochloride of 2 slices/day of 15mg, 1 slice/day the commercially available cloxiquine of 1 slice/day of commercially available brotizolam, 1mg, corresponding stable; But also has the uneasiness sense on daytime, so once use the diazepam of 0.3g/ day in case of necessity.Asparagus through 1-2 time on the 1st picked-up 2g/ day that dissolving suspends in the 500ml cold drink is intended leaf (dried powder of embodiment 2) and the commercially available nutrition multi-vitamin agent of 4g; The situation that not have daydream about 1 week in the back sleep is fully felt the appetite of nature about 2 weeks.Intend drinking of leaf and vitamin preparation through about 2 months asparagus, although almost do not take medicine, condition, sleep state are also good.
(symptom; Poor appetite, melancholy state, 32 years old, women)
Taking the commercially available De cloxiquine of 1 slice/day of commercially available fluvoxamine maleate, the 1mg of 2 slices/day of 25mg; But the asparagus of the picked-up 2g/ day that dissolving suspends in the 500ml cold drink is intended leaf (dried powder of embodiment 2); The result has recovered appetite, passion; Reduce dose, refused to obey medication at present.
Embodiment 11
(symptom; Diarrhoea, poor appetite, 38 years old, the male sex)
Be in that poor appetite, health are weak, the state of no any passion, think some gastrointestinal disease and accept the internal medicine diagnosis, but be diagnosed as not unusually, accepted the psychiatric department diagnosis.Can not improve and just feel sleepy even drink the prescription medicine of psychiatric department, though every day and with 6 of ERABU and 6 in the commercially available agent of nutrition multi-vitamin, Chinese medicine (sleep, stabilizing agent), work every day misery is lived the date that ordered about by uneasiness.Take the asparagus of the 2g/ day that dissolving suspends in the 500ml cold drink when offeing medicine and intend leaf (dried powder of embodiment 2), the result becomes comfortable with 1 all healths.
Embodiment 12
(symptom; Diarrhoea, poor appetite, 26 years old, women)
The pressure that is caused by the company management between siblings becomes reason, and irritability between 1 day, poor appetite, health be weak, have no worry.Think some gastrointestinal disease and accept the internal medicine diagnosis, but be diagnosed as not unusual.But; In any case think Fuji after 1 week and the college days friends who mountain-climbing, diet is the amount of 1 day 1 meal and picked-up congee degree during this 1 week, has taken commercially available nutrition multi-vitamin potus before this, has contained 6 in the tablet of oyster extract etc.; But before 1 week of mountain-climbing; Add the asparagus of taking in the 500ml cold drink 2g/ day that dissolving suspends and intend leaf (dried powder of embodiment 2) and 3/4 Chinese medicine (cow-bezoar is unit meticulously), the result has had appetite immediately, in climbing the mountain in the Fuji because of the bad weather no return; A people can crest a hill only, has recovered energy.
Embodiment 13
(symptom; Diarrhoea, poor appetite, one's late 30s, the male sex)
Because of diarrhoea, stomachache, stomachache etc., accepted the inspection of gastroscope and large intestine fiber etc., but be diagnosed as not unusual fully.Also have difficulty in going to sleep night, and be the state of recumbency for a long time morning all the time.And with commercially available nutrition multi-vitamin agent and the asparagus of the 2g/ day that dissolving suspends in 500ml cold drink plan leaf (dried powder of embodiment 2) and the commercially available drug for controlling intestinal function of 3 bag/days, the result becomes energetic with 1 time-of-week.Diarrhoea also becomes soft stool, and number of times also is reduced to about 1 time.Stomachache also reduces, and appetite has also been arranged.Night, can have a meal morning as long as note just sleeping.
Claims (5)
1. an autonomic nerve conditioning agent is characterized in that, intending leaf with asparagus is active ingredient.
2. the prevention of an autonomic imbalance disease or improver is characterized in that, intending leaf with asparagus is active ingredient.
3. a sleep-improving agent is characterized in that, intending leaf with asparagus is active ingredient.
4. one kind is used to prevent or improve functional food or the food material that autonomic imbalance disease perhaps is used to improve sleep, it is characterized in that, contains asparagus and intends leaf as active ingredient.
5. asparagus is intended leaf and is being used for preventing or is improving autonomic imbalance disease or be used to improve the application of manufacturing of functional food or the food material of sleep.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2010-183967 | 2010-08-19 | ||
| JP2010183967A JP4669077B1 (en) | 2009-12-28 | 2010-08-19 | Autonomic nerve regulator containing asparagus pseudo-leaf as active ingredient |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102370145A true CN102370145A (en) | 2012-03-14 |
Family
ID=45793813
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2011100792609A Pending CN102370145A (en) | 2010-08-19 | 2011-03-29 | Automatic nerve regulating agent with asparagus leaf as effective ingredient |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102370145A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104146246A (en) * | 2014-07-17 | 2014-11-19 | 秦皇岛长胜营养健康科技有限公司 | Application of instant asparagus powder in food, medicine and healthcare product |
| CN115104730A (en) * | 2022-06-28 | 2022-09-27 | 北京姿美堂生物技术股份有限公司 | Composition for improving sleep, sparrow leucomelas-asparagus sleep improvement liquid and tea powder preparation method and application |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1840067A (en) * | 2006-01-17 | 2006-10-04 | 山东轻工业学院 | Asparagus chewable tablet and its production process |
| JP2006296213A (en) * | 2005-04-15 | 2006-11-02 | Unitika Ltd | Composition obtained from asparagus |
| JP2009137913A (en) * | 2007-12-10 | 2009-06-25 | S Net:Kk | Lipid metabolism improver |
| CN101653223A (en) * | 2009-08-25 | 2010-02-24 | 济南博恒实业有限公司 | Preparation method of asparagus health care product for both eating and drinking |
| CN101715859A (en) * | 2009-11-04 | 2010-06-02 | 李青峰 | Method for preparing asparagus health care tea |
-
2011
- 2011-03-29 CN CN2011100792609A patent/CN102370145A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006296213A (en) * | 2005-04-15 | 2006-11-02 | Unitika Ltd | Composition obtained from asparagus |
| CN1840067A (en) * | 2006-01-17 | 2006-10-04 | 山东轻工业学院 | Asparagus chewable tablet and its production process |
| JP2009137913A (en) * | 2007-12-10 | 2009-06-25 | S Net:Kk | Lipid metabolism improver |
| CN101653223A (en) * | 2009-08-25 | 2010-02-24 | 济南博恒实业有限公司 | Preparation method of asparagus health care product for both eating and drinking |
| CN101715859A (en) * | 2009-11-04 | 2010-06-02 | 李青峰 | Method for preparing asparagus health care tea |
Non-Patent Citations (2)
| Title |
|---|
| 苏茜•格兰特: "《活力充沛48小时》", 31 August 2003, 中央编译出版社 * |
| 铃木平光: "《鱼の神奇药效》", 31 January 2003, 中国农业出版社 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104146246A (en) * | 2014-07-17 | 2014-11-19 | 秦皇岛长胜营养健康科技有限公司 | Application of instant asparagus powder in food, medicine and healthcare product |
| CN115104730A (en) * | 2022-06-28 | 2022-09-27 | 北京姿美堂生物技术股份有限公司 | Composition for improving sleep, sparrow leucomelas-asparagus sleep improvement liquid and tea powder preparation method and application |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR102076459B1 (en) | Composition containing enzyme treatmented Tenebrio molitor for muscle mass enhancement and restorative rejuvenation of recovering patients or elderly patients | |
| KR101738912B1 (en) | Composition For Anti-obesity And Diet | |
| US6171635B1 (en) | Coffee substitute | |
| CN111053190A (en) | Light-weight food composition for weight-losing meal replacement and preparation method thereof | |
| KR101184666B1 (en) | Composition for improving physiological activity of positive constitution | |
| WO2006132042A1 (en) | Nutritional supplement powder and fat for food or medicine | |
| JP5685752B2 (en) | Blood flow promoting agent | |
| CN105661521A (en) | Composition with functions of reducing hypertension, hyperglycemia and hyperlipidemia and preparation method of composition | |
| JP6463504B2 (en) | Health supplements for hair growth promotion, hair loss relief and improvement, blood sugar control, gastrointestinal symptom relief and improvement | |
| CN101828678A (en) | Highland barley-sesame paste and preparation method thereof | |
| JPWO2004112817A1 (en) | Celery family-derived extract and method for producing the same | |
| CN103988911A (en) | Black potato buffalo milk dairy product and preparation method thereof | |
| KR102487651B1 (en) | A composition for preventing, improving or treating sarcopenia comprising extracts of wheat sprout | |
| JP2018070570A (en) | Chromoji extract | |
| CN107613998A (en) | Medicinal composition or health functional food for prevention and treatment of metabolic diseases containing Ferula ferulae water extract as an active ingredient | |
| KR101834638B1 (en) | The method of functional korea traditional cracker using the jujube | |
| KR101930433B1 (en) | manufacturing method of sweet jelly containing mealworm and sweet jelly containing mealworm made by the same | |
| KR101115450B1 (en) | Cereal composition for portion packaging with tea and porridge functions and preparation thereof | |
| JP4669077B1 (en) | Autonomic nerve regulator containing asparagus pseudo-leaf as active ingredient | |
| CN102370145A (en) | Automatic nerve regulating agent with asparagus leaf as effective ingredient | |
| KR101439792B1 (en) | Oriental medicine composition for children's underweight and respiratory organ, and oriental medicine extracts derived therefrom, and method of preparing the same | |
| JP4768105B2 (en) | Oral composition | |
| TWI294284B (en) | ||
| CN100444878C (en) | Enhancing sexual desire and performance with meal from plants containing protein-bound tryptophan | |
| KR20110124444A (en) | Composition for enhancing physiological activity of cold constitution |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| ASS | Succession or assignment of patent right |
Owner name: LIFENICS CO., LTD. RED HORSE HEALTH CO., LTD. Effective date: 20150217 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20150217 Address after: Hokkaido Japan Applicant after: Nissei Biological Co., Ltd. Applicant after: Life Nics Co., Ltd. Applicant after: The Red Horse Health Corporation Address before: Hokkaido Japan Applicant before: Nissei Biological Co., Ltd. |
|
| C12 | Rejection of a patent application after its publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20120314 |