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BRPI0510498A - sistema de modulação da expressão de genes; polinucleotìdeo isolado que codifica um domìnio de ligação a ligante de receptor nuclear do grupo h compreendendo pelo menos uma mutação; vetor de expressão; célula hospedeira isolada; polipeptìdio isolado que compreende um domìnio de ligação a ligante do receptor nuclear do grupo h que compreende pelo menos uma mutação; método para a modulação da expressão de um gene em uma célula hospedeira; célula hospedeira isolada; e organismo não humano - Google Patents

sistema de modulação da expressão de genes; polinucleotìdeo isolado que codifica um domìnio de ligação a ligante de receptor nuclear do grupo h compreendendo pelo menos uma mutação; vetor de expressão; célula hospedeira isolada; polipeptìdio isolado que compreende um domìnio de ligação a ligante do receptor nuclear do grupo h que compreende pelo menos uma mutação; método para a modulação da expressão de um gene em uma célula hospedeira; célula hospedeira isolada; e organismo não humano

Info

Publication number
BRPI0510498A
BRPI0510498A BRPI0510498-0A BRPI0510498A BRPI0510498A BR PI0510498 A BRPI0510498 A BR PI0510498A BR PI0510498 A BRPI0510498 A BR PI0510498A BR PI0510498 A BRPI0510498 A BR PI0510498A
Authority
BR
Brazil
Prior art keywords
host cell
isolated
mutation
group
gene
Prior art date
Application number
BRPI0510498-0A
Other languages
English (en)
Inventor
Subba Reddy Palli
Mohan Basavaraju Kumar
Original Assignee
Rheogene Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rheogene Inc filed Critical Rheogene Inc
Priority to BR122015016288-2A priority Critical patent/BR122015016288B1/pt
Publication of BRPI0510498A publication Critical patent/BRPI0510498A/pt
Publication of BRPI0510498B1 publication Critical patent/BRPI0510498B1/pt

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4
    • C07D215/44—Nitrogen atoms attached in position 4 with aryl radicals attached to said nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43536—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from worms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/635—Externally inducible repressor mediated regulation of gene expression, e.g. tetR inducible by tetracyline
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/855—Proteins from animals other than mammals or birds
    • Y10S530/858—Proteins from animals other than mammals or birds insects; venom

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

SISTEMA DE MODULAçãO DA EXPRESSãO DE GENES; POLINUCLEOTìDEO ISOLADO QUE CODIFICA UM DOMìNIO DE LIGAçãO A LIGANTE DE RECEPTOR NUCLEAR DO GRUPO H COMPREENDENDO PELO MENOS UMA MUTAçãO; VETOR DE EXPRESSãO; CéLULA HOSPEDEIRA ISOLADA; POLIPEPTìDIO ISOLADO QUE COMPREENDE UM DOMìNIO DE LIGAçãO A LIGANTE DO RECEPTOR NUCLEAR DO GRUPO H QUE COMPREENDE PELO MENOS UMA MUTAçãO; MéTODO PARA A MODULAçãO DA EXPRESSãO DE UM GENE EM UMA CéLULA HOSPEDEIRA; CéLULA HOSPEDEIRA ISOLADA; E ORGANISMO NãO HUMANO. A presente invenção refere-se à área da biotecnologia ou da engenharia genética. Especificamente, esta invenção se refere à área da expressão genética. Mais especificamente, a invenção em questão se refere a receptores mutantes por substituição inusitados e ao uso dos mesmos em um sistema de expressão genética induzível com base no receptor nuclear e a métodos de modulação da expressão genética em uma célula hospedeira para aplicações tais como terapia genética, produção de proteínas e anticorpos em larga escala,ensaios de peneiramento de produção ultra-alta baseada em célula, genómicos funcionais e regulagem das peculiaridades dos organismos transgênicos.
BRPI0510498-0A 2004-04-30 2005-05-02 Sistema de modulação da expressão de genes, vetor de expressão, célula hospedeira e organismo não humano, bem como método de modulação da expressão de gene em célula hospedeira BRPI0510498B1 (pt)

Priority Applications (1)

Application Number Priority Date Filing Date Title
BR122015016288-2A BR122015016288B1 (pt) 2004-04-30 2005-05-02 Sistemas de modulação da expressão de genes, polinucleotídeo isolado e vetor de expressão

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US56729404P 2004-04-30 2004-04-30
US60/567,294 2004-04-30
US60942404P 2004-09-13 2004-09-13
US60/609,424 2004-09-13
US11/118,855 2005-04-29
US11/118,855 US7935510B2 (en) 2004-04-30 2005-04-29 Mutant receptors and their use in a nuclear receptor-based inducible gene expression system
PCT/US2005/015089 WO2005108617A2 (en) 2004-04-30 2005-05-02 Mutant receptors and their use in a nuclear receptor-based inducible gene expression system

Publications (2)

Publication Number Publication Date
BRPI0510498A true BRPI0510498A (pt) 2007-11-20
BRPI0510498B1 BRPI0510498B1 (pt) 2018-02-06

Family

ID=35320809

Family Applications (2)

Application Number Title Priority Date Filing Date
BRPI0510498-0A BRPI0510498B1 (pt) 2004-04-30 2005-05-02 Sistema de modulação da expressão de genes, vetor de expressão, célula hospedeira e organismo não humano, bem como método de modulação da expressão de gene em célula hospedeira
BR122015016288-2A BR122015016288B1 (pt) 2004-04-30 2005-05-02 Sistemas de modulação da expressão de genes, polinucleotídeo isolado e vetor de expressão

Family Applications After (1)

Application Number Title Priority Date Filing Date
BR122015016288-2A BR122015016288B1 (pt) 2004-04-30 2005-05-02 Sistemas de modulação da expressão de genes, polinucleotídeo isolado e vetor de expressão

Country Status (14)

Country Link
US (6) US7935510B2 (pt)
EP (4) EP3000317B1 (pt)
JP (2) JP4950032B2 (pt)
KR (1) KR101005735B1 (pt)
CN (3) CN105018509B (pt)
AU (2) AU2005241051B2 (pt)
BR (2) BRPI0510498B1 (pt)
CA (2) CA2979456A1 (pt)
DK (3) DK2292088T3 (pt)
HK (2) HK1094521A1 (pt)
MX (1) MXPA06012594A (pt)
NZ (2) NZ551657A (pt)
RU (1) RU2539036C2 (pt)
WO (1) WO2005108617A2 (pt)

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