BR9907683A - Composições farmacêuticas na forma de nanopartìculas, compreendendo substâncias lipìdicas e substâncias anfifìlicas e processo de preparação correlacionado - Google Patents
Composições farmacêuticas na forma de nanopartìculas, compreendendo substâncias lipìdicas e substâncias anfifìlicas e processo de preparação correlacionadoInfo
- Publication number
- BR9907683A BR9907683A BR9907683-7A BR9907683A BR9907683A BR 9907683 A BR9907683 A BR 9907683A BR 9907683 A BR9907683 A BR 9907683A BR 9907683 A BR9907683 A BR 9907683A
- Authority
- BR
- Brazil
- Prior art keywords
- substances
- nanoparticles
- pharmaceutical compositions
- correlated
- preparation process
- Prior art date
Links
- 239000000126 substance Substances 0.000 abstract 4
- 239000002131 composite material Substances 0.000 abstract 2
- 150000002632 lipids Chemical class 0.000 abstract 2
- 239000002105 nanoparticle Substances 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 230000002596 correlated effect Effects 0.000 abstract 1
- 238000010348 incorporation Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/5123—Organic compounds, e.g. fats, sugars
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/23—Calcitonins
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nanotechnology (AREA)
- Optics & Photonics (AREA)
- Physics & Mathematics (AREA)
- Biomedical Technology (AREA)
- Endocrinology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
<B>"COMPOSIçõES FARMACêUTICAS NA FORMA DE NANOPARTìCULAS, COMPREENDENDO SUBSTâNCIAS LIPìDICAS E SUBSTâNCIAS ANFIFìLICAS E PROCESSO DE PREPARAçãO CORRELACIONADO"<D>. A presente invenção se refere à composições farmacêuticas na forma de nanopartículas, compreendendo um material compósito, consistindo de pelo menos uma substância lipídica e pelo menos uma substância anfifílica e um princípio farmaceuticamente ativo. As ditas composições, graças às propriedades de superfície e massa do dito material compósito, mostram um melhoramento na incorporação dos princípios ativos e aumento da biodisponibilidade dos princípios ativos fracamente absorvíveis.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT98MI000234A IT1298575B1 (it) | 1998-02-06 | 1998-02-06 | Composizioni farmaceutiche in forma di nanoparticelle comprendenti sostanze lipidiche e sostanze antifiliche e relativo processo di |
PCT/EP1999/000782 WO1999039700A1 (en) | 1998-02-06 | 1999-02-05 | Pharmaceutical compositions in form of nanoparticles comprising lipidic substances and amphiphilic substances and related preparation process |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9907683A true BR9907683A (pt) | 2000-11-14 |
Family
ID=11378856
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9907683-7A BR9907683A (pt) | 1998-02-06 | 1999-02-05 | Composições farmacêuticas na forma de nanopartìculas, compreendendo substâncias lipìdicas e substâncias anfifìlicas e processo de preparação correlacionado |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP1051160A1 (pt) |
JP (1) | JP2002502813A (pt) |
KR (1) | KR20010040726A (pt) |
AU (1) | AU747129B2 (pt) |
BR (1) | BR9907683A (pt) |
CA (1) | CA2319565A1 (pt) |
IT (1) | IT1298575B1 (pt) |
WO (1) | WO1999039700A1 (pt) |
Families Citing this family (78)
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CA2377301C (en) | 1999-06-14 | 2009-05-12 | Cosmo S.P.A. | Controlled release and taste masking oral pharmaceutical compositions |
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US6309663B1 (en) * | 1999-08-17 | 2001-10-30 | Lipocine Inc. | Triglyceride-free compositions and methods for enhanced absorption of hydrophilic therapeutic agents |
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US20060003012A9 (en) * | 2001-09-26 | 2006-01-05 | Sean Brynjelsen | Preparation of submicron solid particle suspensions by sonication of multiphase systems |
US9308220B2 (en) | 2001-12-11 | 2016-04-12 | Cosmo Technologies Limited | Pharmaceutical compositions for the oral administration of heparin or derivatives thereof |
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MXPA04005783A (es) * | 2001-12-14 | 2004-09-13 | Jagotec Ag | Formulacion farmaceutica que comprende ciclosporina y uso de la misma. |
SE0104421D0 (sv) | 2001-12-21 | 2001-12-21 | Ponsus Pharma Ab | New composition |
KR100422763B1 (ko) * | 2002-01-17 | 2004-03-12 | 주식회사 태평양 | 경피흡수 촉진 능력이 우수한 식물성 나노입자의 제조 및이를 함유하는 화장료 및 의약용 외용제 조성물 |
JP2003342196A (ja) * | 2002-05-31 | 2003-12-03 | Mukku:Kk | 静脈注射用組成物、その製造法およびその製剤 |
ITMI20022323A1 (it) * | 2002-10-31 | 2004-05-01 | Maria Rosa Gasco | Composizioni farmaceutiche atte al trattamento di malattie oftalmiche. |
KR100507771B1 (ko) * | 2002-11-08 | 2005-08-17 | 한미약품 주식회사 | 난용성 감기약 활성 성분의 경구투여용 조성물 및 그의제조 방법 |
US7731947B2 (en) | 2003-11-17 | 2010-06-08 | Intarcia Therapeutics, Inc. | Composition and dosage form comprising an interferon particle formulation and suspending vehicle |
KR20040084240A (ko) * | 2003-03-27 | 2004-10-06 | (주) 코스메디 | 고형지질나노입자, 이를 함유하는 활성성분 전달용약학조성물 및 이의 제조방법 |
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EP1674077A1 (en) * | 2004-12-27 | 2006-06-28 | Université de Liège | Mucoadhesive pharmaceutical compositions comprising chemoattractants |
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US11246913B2 (en) | 2005-02-03 | 2022-02-15 | Intarcia Therapeutics, Inc. | Suspension formulation comprising an insulinotropic peptide |
US8252326B2 (en) | 2005-06-01 | 2012-08-28 | Catalent Australia Pty Ltd. | Self-microemulsifying dosage forms of low solubility active ingredients such as co-enzyme Q10 |
CA2663558C (en) * | 2006-09-26 | 2013-05-28 | Samyang Corporation | Submicron nanoparticle of poorly water soluble camptothecin derivatives and process for preparation thereof |
PL2157967T3 (pl) | 2007-04-23 | 2013-06-28 | Intarcia Therapeutics Inc | Formulacje zawiesinowe peptydów insulinotropowych i ich zastosowania |
JP2010529142A (ja) | 2007-06-08 | 2010-08-26 | アドレネクス・ファーマシューティカルズ,インコーポレイテッド | アドレナリン調節異常症を治療する徐放性の製剤および方法 |
CA2726861C (en) | 2008-02-13 | 2014-05-27 | Intarcia Therapeutics, Inc. | Devices, formulations, and methods for delivery of multiple beneficial agents |
FR2943545B1 (fr) * | 2009-03-31 | 2011-06-03 | Univ Claude Bernard Lyon | Nanoparticules lipidiques solides encapsulant du minoxidil et suspension aqueuse les contenant. |
HUE035862T2 (en) | 2009-09-28 | 2018-05-28 | Intarcia Therapeutics Inc | Rapid establishment and/or termination of substantial steady-state drug delivery |
FR2958150B1 (fr) | 2010-04-01 | 2012-06-15 | Univ Claude Bernard Lyon | Elements orthodontiques elastiques aptes a liberer de la chlorhexidine faiblement soluble dans la salive |
CN102247320B (zh) * | 2010-05-21 | 2013-03-13 | 天津药物研究院 | 一种依托泊苷长循环乳剂及其制备方法 |
BRPI1002601E2 (pt) * | 2010-06-01 | 2020-06-30 | Embrapa Pesquisa Agropecuaria | composição nanoestruturada de uso veterinário para administração de fármacos |
CN101912363A (zh) * | 2010-07-29 | 2010-12-15 | 蔡海德 | 溶解超滤-喷雾干燥-分子分散包衣-水化制粒-冷冻干燥生产脂质体组合药物 |
US20120208755A1 (en) | 2011-02-16 | 2012-08-16 | Intarcia Therapeutics, Inc. | Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers |
US10154964B2 (en) | 2011-09-07 | 2018-12-18 | Cosmo Technologies Limited | Controlled release and taste masking oral pharmaceutical composition |
EP2782584B1 (en) | 2011-11-23 | 2021-06-09 | TherapeuticsMD, Inc. | Natural combination hormone replacement formulations and therapies |
US9301920B2 (en) | 2012-06-18 | 2016-04-05 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
US20150196640A1 (en) | 2012-06-18 | 2015-07-16 | Therapeuticsmd, Inc. | Progesterone formulations having a desirable pk profile |
US20130338122A1 (en) | 2012-06-18 | 2013-12-19 | Therapeuticsmd, Inc. | Transdermal hormone replacement therapies |
US10806740B2 (en) | 2012-06-18 | 2020-10-20 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
US10806697B2 (en) | 2012-12-21 | 2020-10-20 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
FR2995222B1 (fr) | 2012-09-11 | 2016-05-20 | Creathes | Procede alternatif de microencapsulation de principe actif |
ES2802050T3 (es) * | 2012-11-14 | 2021-01-15 | Abon Pharmaceuticals Llc | Sistema de administración de fármacos por vía transmucosa oral |
CN102988285B (zh) * | 2012-12-13 | 2014-02-19 | 哈药集团技术中心 | 一种多西他赛注射液组合物及其制备方法 |
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US9180091B2 (en) | 2012-12-21 | 2015-11-10 | Therapeuticsmd, Inc. | Soluble estradiol capsule for vaginal insertion |
US10471072B2 (en) | 2012-12-21 | 2019-11-12 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
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SI3174535T1 (sl) * | 2014-08-01 | 2019-06-28 | Glenmark Pharmaceuticals S.A. | Formulacija nanodelcev, obsegajoča MPGES-1 inhibitor |
KR20170054429A (ko) | 2014-09-03 | 2017-05-17 | 제네세규스 인코포레이티드 | 치료용 나노입자 및 관련 조성물, 방법, 및 시스템 |
US9889085B1 (en) | 2014-09-30 | 2018-02-13 | Intarcia Therapeutics, Inc. | Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c |
MX2017015504A (es) | 2015-06-03 | 2018-05-15 | Intarcia Therapeutics Inc | Sistemas de colocacion y remoción de implante. |
US10328087B2 (en) | 2015-07-23 | 2019-06-25 | Therapeuticsmd, Inc. | Formulations for solubilizing hormones |
US10286077B2 (en) | 2016-04-01 | 2019-05-14 | Therapeuticsmd, Inc. | Steroid hormone compositions in medium chain oils |
KR20180126582A (ko) | 2016-04-01 | 2018-11-27 | 쎄러퓨틱스엠디, 인코퍼레이티드 | 스테로이드 호르몬 약제학적 조성물 |
CA3024479A1 (en) | 2016-05-16 | 2017-11-23 | Intarcia Therapeutics, Inc. | Glucagon-receptor selective polypeptides and methods of use thereof |
USD840030S1 (en) | 2016-06-02 | 2019-02-05 | Intarcia Therapeutics, Inc. | Implant placement guide |
USD860451S1 (en) | 2016-06-02 | 2019-09-17 | Intarcia Therapeutics, Inc. | Implant removal tool |
CN110225762A (zh) | 2017-01-03 | 2019-09-10 | 因塔西亚制药公司 | 包括glp-1受体激动剂的连续施用和药物的共同施用的方法 |
WO2021016134A1 (en) * | 2019-07-19 | 2021-01-28 | Spi Pharma, Inc. | Preparation of lipophilic active ingredients |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3421468A1 (de) * | 1984-06-08 | 1985-12-19 | Dr. Rentschler Arzneimittel Gmbh & Co, 7958 Laupheim | Lipidnanopellets als traegersystem fuer arzneimittel zur peroralen anwendung |
US5250236A (en) * | 1991-08-05 | 1993-10-05 | Gasco Maria R | Method for producing solid lipid microspheres having a narrow size distribution |
CA2091152C (en) * | 1993-03-05 | 2005-05-03 | Kirsten Westesen | Solid lipid particles, particles of bioactive agents and methods for the manfuacture and use thereof |
-
1998
- 1998-02-06 IT IT98MI000234A patent/IT1298575B1/it active IP Right Grant
-
1999
- 1999-02-05 EP EP99907510A patent/EP1051160A1/en not_active Withdrawn
- 1999-02-05 BR BR9907683-7A patent/BR9907683A/pt not_active IP Right Cessation
- 1999-02-05 WO PCT/EP1999/000782 patent/WO1999039700A1/en not_active Application Discontinuation
- 1999-02-05 JP JP2000530200A patent/JP2002502813A/ja active Pending
- 1999-02-05 AU AU27238/99A patent/AU747129B2/en not_active Ceased
- 1999-02-05 KR KR1020007008610A patent/KR20010040726A/ko not_active Application Discontinuation
- 1999-02-05 CA CA002319565A patent/CA2319565A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
AU2723899A (en) | 1999-08-23 |
JP2002502813A (ja) | 2002-01-29 |
KR20010040726A (ko) | 2001-05-15 |
EP1051160A1 (en) | 2000-11-15 |
AU747129B2 (en) | 2002-05-09 |
CA2319565A1 (en) | 1999-08-12 |
ITMI980234A1 (it) | 1999-08-06 |
IT1298575B1 (it) | 2000-01-12 |
WO1999039700A1 (en) | 1999-08-12 |
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