RU2001116085A - Фосфолипидные комплексы проантоцианидина а2 в качестве антиатеросклеротических агентов - Google Patents
Фосфолипидные комплексы проантоцианидина а2 в качестве антиатеросклеротических агентовInfo
- Publication number
- RU2001116085A RU2001116085A RU2001116085/14A RU2001116085A RU2001116085A RU 2001116085 A RU2001116085 A RU 2001116085A RU 2001116085/14 A RU2001116085/14 A RU 2001116085/14A RU 2001116085 A RU2001116085 A RU 2001116085A RU 2001116085 A RU2001116085 A RU 2001116085A
- Authority
- RU
- Russia
- Prior art keywords
- complexes
- proanthocyanidin
- manufacture
- phospholipid
- atherosclerotic agents
- Prior art date
Links
- 150000003904 phospholipids Chemical class 0.000 title claims 5
- NSEWTSAADLNHNH-TXZJYACMSA-N Proanthocyanidin A-2 Natural products C1([C@H]2OC3=C4[C@H]5C6=C(O)C=C(O)C=C6O[C@]([C@@H]5O)(OC4=CC(O)=C3C[C@@H]2O)C=2C=C(O)C(O)=CC=2)=CC=C(O)C(O)=C1 NSEWTSAADLNHNH-TXZJYACMSA-N 0.000 title claims 3
- 229920002982 Procyanidin A2 Polymers 0.000 title claims 3
- NSEWTSAADLNHNH-UHFFFAOYSA-N pavetannin A-2 Natural products OC1CC2=C(O)C=C3OC(C4O)(C=5C=C(O)C(O)=CC=5)OC5=CC(O)=CC(O)=C5C4C3=C2OC1C1=CC=C(O)C(O)=C1 NSEWTSAADLNHNH-UHFFFAOYSA-N 0.000 title claims 3
- NSEWTSAADLNHNH-LSBOWGMISA-N proanthocyanidin A2 Chemical compound C1([C@H]2OC3=C4[C@H]5C6=C(O)C=C(O)C=C6O[C@]([C@@H]5O)(OC4=CC(O)=C3C[C@H]2O)C=2C=C(O)C(O)=CC=2)=CC=C(O)C(O)=C1 NSEWTSAADLNHNH-LSBOWGMISA-N 0.000 title claims 3
- 230000000879 anti-atherosclerotic effect Effects 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 claims 4
- 239000004480 active ingredient Substances 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 229940126601 medicinal product Drugs 0.000 claims 2
- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 claims 2
- TZCPCKNHXULUIY-RGULYWFUSA-N 1,2-distearoyl-sn-glycero-3-phosphoserine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@H](N)C(O)=O)OC(=O)CCCCCCCCCCCCCCCCC TZCPCKNHXULUIY-RGULYWFUSA-N 0.000 claims 1
- 201000001320 Atherosclerosis Diseases 0.000 claims 1
- JZNWSCPGTDBMEW-UHFFFAOYSA-N Glycerophosphorylethanolamin Natural products NCCOP(O)(=O)OCC(O)CO JZNWSCPGTDBMEW-UHFFFAOYSA-N 0.000 claims 1
- ZWZWYGMENQVNFU-UHFFFAOYSA-N Glycerophosphorylserin Natural products OC(=O)C(N)COP(O)(=O)OCC(O)CO ZWZWYGMENQVNFU-UHFFFAOYSA-N 0.000 claims 1
- 210000004556 brain Anatomy 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000007903 gelatin capsule Substances 0.000 claims 1
- 235000010445 lecithin Nutrition 0.000 claims 1
- 239000000787 lecithin Substances 0.000 claims 1
- 208000010125 myocardial infarction Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 150000008104 phosphatidylethanolamines Chemical class 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
Claims (9)
1. Фосфолипидные комплексы проантоцианидина А2.
2. Комплексы по п. 1, в которых фосфолипиды выбирают из лецитинов, фосфатидилхолина, фосфатидилэтаноламина, фосфати-дилсерина.
3. Комплексы по п. 2, в которых фосфолипид представляет собой фосфатидилхолин.
4. Комплексы по любому из пп. 1-3, в которых массовое соотношение масс проантоцианидина А2 и фосфолипида находится в интервале от 2: 1 до 1: 2.
5. Комплексы по любому из пп. 1-4, для изготовления лекарственных средств для профилактики или лечения атеросклероза и инфаркта миокарда и головного мозга.
6. Комплексы по п. 5, для изготовления лекарственного средства со стандартной дозой в интервале от 50 до 500 мг активного ингредиента.
7. Комплексы по п. 5 или 6, для изготовления лекарственного средства, которое вводят пероральным путем.
8. Комплексы по п. 7, для изготовления лекарственного средства в форме мягких или твердых желатиновых капсул или таблеток.
9. Фармацевтические композиции, содержащие в качестве активного ингредиента комплекс по пп. 1-4.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI98A002732 | 1998-12-18 | ||
| IT1998MI002732A IT1304183B1 (it) | 1998-12-18 | 1998-12-18 | Complessi di proantocianidina a2 con fosfolipidi come agentiantiaterosclerotici. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2001116085A true RU2001116085A (ru) | 2003-03-20 |
| RU2248798C2 RU2248798C2 (ru) | 2005-03-27 |
Family
ID=11381268
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2001116085/15A RU2248798C2 (ru) | 1998-12-18 | 1999-12-13 | Фосфолипидные комплексы проантоцианидина а2 в качестве антиатеросклеротических агентов |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US6429202B1 (ru) |
| EP (1) | EP1140115B1 (ru) |
| JP (1) | JP4842436B2 (ru) |
| KR (1) | KR100694907B1 (ru) |
| CN (1) | CN1146429C (ru) |
| AT (1) | ATE238803T1 (ru) |
| AU (1) | AU763907B2 (ru) |
| CA (1) | CA2355776C (ru) |
| CZ (1) | CZ301495B6 (ru) |
| DE (1) | DE69907509T2 (ru) |
| DK (1) | DK1140115T3 (ru) |
| ES (1) | ES2197708T3 (ru) |
| HK (1) | HK1042430B (ru) |
| HU (1) | HU228928B1 (ru) |
| IL (2) | IL143751A0 (ru) |
| IT (1) | IT1304183B1 (ru) |
| NO (1) | NO328733B1 (ru) |
| PL (1) | PL197153B1 (ru) |
| PT (1) | PT1140115E (ru) |
| RU (1) | RU2248798C2 (ru) |
| SK (1) | SK284884B6 (ru) |
| WO (1) | WO2000037062A2 (ru) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8507018B2 (en) * | 1998-03-12 | 2013-08-13 | Mars, Incorporated | Products containing polyphenol(s) and L-arginine and methods of use thereof |
| CA2475630C (en) * | 2002-02-12 | 2011-01-18 | Hunza Di Pistolesi Elvira & C. S.A.S. | N-acyl-phosphatidyl-ethanolamines and/or mixtures of n-acyl-ethanolamines with phosphatidic acids or lysophosphatidic acids |
| ITMI20020756A1 (it) * | 2002-04-09 | 2003-10-09 | Sinclair Pharma S R L | Composizioni farmaceutiche topiche per il trattamento delle dermatiti |
| GB0321996D0 (en) * | 2003-09-19 | 2003-10-22 | Novartis Nutrition Ag | Organic compounds |
| EP1713467B1 (en) * | 2004-01-28 | 2012-08-01 | Mars, Incorporated | Compositions and methods of use of a-type procyanidins |
| EP1837030A1 (en) | 2006-03-09 | 2007-09-26 | INDENA S.p.A. | Phospholipid complexes of curcumin having improved bioavailability |
| WO2009104556A1 (ja) * | 2008-02-19 | 2009-08-27 | 株式会社岐阜セラツク製造所 | 組成物 |
| IT1398624B1 (it) * | 2009-02-02 | 2013-03-08 | Dermogyn S R L | Uso cosmetico della proantocianidina a2 |
| RU2456674C1 (ru) * | 2011-05-31 | 2012-07-20 | Тагир Уралович Гафаров | Способ моделирования атрофического рубца кожи |
| CN102688501A (zh) * | 2012-06-20 | 2012-09-26 | 浙江萧山医院 | 原花青素b2磷脂复合物及其制备方法和用途 |
| CN103120798A (zh) * | 2013-01-10 | 2013-05-29 | 施冬云 | 一种具有抗氧化应激作用的磷脂复合物制备方法及其应用 |
| CN103467778B (zh) * | 2013-09-06 | 2015-09-30 | 天津大学 | 细菌纤维素/卵磷脂复合材料及制备和应用 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4698360B1 (en) * | 1985-04-09 | 1997-11-04 | D Investigations Pharmacologiq | Plant extract with a proanthocyanidins content as therapeutic agent having radical scavenger effect and use thereof |
| GB8518289D0 (en) * | 1985-07-19 | 1985-08-29 | Inverni Della Beffa Spa | Obtaining proanthocyanidine a2 |
| IT1201151B (it) * | 1987-01-14 | 1989-01-27 | Indena Spa | Complessi fosfolipidici con estratti da vitis vinifera,procedimento per la loro preparazione e composizioni che li cntengono |
| IT1201149B (it) * | 1987-01-14 | 1989-01-27 | Indena Spa | Complessi di bioflavonoidi con fosfolipidi,loro preparazione,uso e composizioni farmaceutici e cosmetiche |
| CA2088994C (en) * | 1990-08-20 | 2002-08-13 | Gerhard Ohlenschlaeger | Therapeutically active mixture of glutathion and anthocyan compounds |
| IT1265312B1 (it) * | 1993-12-21 | 1996-10-31 | Indena Spa | Formulazioni contenenti carotenoidi e procarotenoidi associati a polifenoli nella prevenzione dei danni da abnorme produzione di |
| US5648377A (en) | 1993-12-21 | 1997-07-15 | Indena S.P.A. | Formulations containing carotenoids an procarotenoids combined with polyphenols in the prevention of the damages due to an abnormal production of free radicals |
| IT1270999B (it) * | 1994-07-26 | 1997-05-26 | Indena Spa | Formulazioni a base di cumarine e loro uso in campo farmaceutico e cosmetico |
| FI955691A7 (fi) * | 1994-11-28 | 1996-05-29 | Suntory Ltd | Lipoproteiini(a):ta alentava aine, kolesterolia alentava aine ja näitä aineita sisältävät lääkkeet |
| IT1296920B1 (it) * | 1997-12-04 | 1999-08-03 | Indena Spa | Uso di complessi di estratti vitis vinifera con fosfolipidi come agenti anti-aterosclerotici |
| JP2003509898A (ja) | 1999-09-08 | 2003-03-11 | シーメンス アクチエンゲゼルシヤフト | 光情報伝送装置および方法 |
-
1998
- 1998-12-18 IT IT1998MI002732A patent/IT1304183B1/it active
-
1999
- 1999-12-13 DE DE69907509T patent/DE69907509T2/de not_active Expired - Lifetime
- 1999-12-13 KR KR1020017007374A patent/KR100694907B1/ko not_active Expired - Fee Related
- 1999-12-13 CA CA002355776A patent/CA2355776C/en not_active Expired - Fee Related
- 1999-12-13 CZ CZ20012134A patent/CZ301495B6/cs not_active IP Right Cessation
- 1999-12-13 DK DK99966956T patent/DK1140115T3/da active
- 1999-12-13 RU RU2001116085/15A patent/RU2248798C2/ru not_active IP Right Cessation
- 1999-12-13 CN CNB998144460A patent/CN1146429C/zh not_active Expired - Fee Related
- 1999-12-13 AU AU22830/00A patent/AU763907B2/en not_active Ceased
- 1999-12-13 AT AT99966956T patent/ATE238803T1/de active
- 1999-12-13 WO PCT/EP1999/009854 patent/WO2000037062A2/en active IP Right Grant
- 1999-12-13 HK HK02103200.8A patent/HK1042430B/zh not_active IP Right Cessation
- 1999-12-13 US US09/857,804 patent/US6429202B1/en not_active Expired - Lifetime
- 1999-12-13 EP EP99966956A patent/EP1140115B1/en not_active Expired - Lifetime
- 1999-12-13 ES ES99966956T patent/ES2197708T3/es not_active Expired - Lifetime
- 1999-12-13 PT PT99966956T patent/PT1140115E/pt unknown
- 1999-12-13 SK SK860-2001A patent/SK284884B6/sk not_active IP Right Cessation
- 1999-12-13 PL PL349534A patent/PL197153B1/pl unknown
- 1999-12-13 JP JP2000589173A patent/JP4842436B2/ja not_active Expired - Fee Related
- 1999-12-13 HU HU0104665A patent/HU228928B1/hu not_active IP Right Cessation
- 1999-12-13 IL IL14375199A patent/IL143751A0/xx active IP Right Grant
-
2001
- 2001-06-13 IL IL143751A patent/IL143751A/en not_active IP Right Cessation
- 2001-06-14 NO NO20012944A patent/NO328733B1/no not_active IP Right Cessation
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