|
GB9718972D0
(en)
*
|
1996-09-25 |
1997-11-12 |
Zeneca Ltd |
Chemical compounds
|
|
IL149034A0
(en)
|
1999-11-05 |
2002-11-10 |
Astrazeneca Ab |
Quinazoline derivatives as vegf inhibitors
|
|
GB0008269D0
(en)
*
|
2000-04-05 |
2000-05-24 |
Astrazeneca Ab |
Combination chemotherapy
|
|
AU779695B2
(en)
|
2000-04-07 |
2005-02-10 |
Astrazeneca Ab |
Quinazoline compounds
|
|
GB0126879D0
(en)
*
|
2001-11-08 |
2002-01-02 |
Astrazeneca Ab |
Combination therapy
|
|
ATE347908T1
(en)
*
|
2002-01-29 |
2007-01-15 |
Vlaams Interuniv Inst Biotech |
PREVENTION OF TISSUE ADHESION
|
|
KR101093345B1
(en)
*
|
2002-02-01 |
2011-12-14 |
아스트라제네카 아베 |
Quinazoline compounds
|
|
US6924285B2
(en)
|
2002-03-30 |
2005-08-02 |
Boehringer Ingelheim Pharma Gmbh & Co. |
Bicyclic heterocyclic compounds, pharmaceutical compositions containing these compounds, their use and process for preparing them
|
|
EP1521747B1
(en)
|
2002-07-15 |
2018-09-05 |
Symphony Evolution, Inc. |
Receptor-type kinase modulators and methods of use
|
|
BR0313116A
(en)
*
|
2002-08-09 |
2005-07-05 |
Astrazeneca Ab |
Method for producing a vascular and / or antiangiogenic permeability reducing effect on a warm-blooded animal such as a human, method for treating cancer in a warm-blooded animal such as a human, and use of zd6474 or a pharmaceutically acceptable salt thereof.
|
|
DE10237423A1
(en)
|
2002-08-16 |
2004-02-19 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
Treating immunological (or related) diseases, e.g. inflammatory bowel disease, rheumatoid arthritis or psoriasis, comprises administration of 3-methylene-2-indolinone derivative or quinazoline compound
|
|
GB0223380D0
(en)
*
|
2002-10-09 |
2002-11-13 |
Astrazeneca Ab |
Combination therapy
|
|
AU2003278383B2
(en)
|
2002-11-04 |
2007-06-14 |
Astrazeneca Ab |
Quinazoline derivatives as Src tyrosine kinase inhibitors
|
|
JP2006517575A
(en)
*
|
2003-02-13 |
2006-07-27 |
アストラゼネカ アクチボラグ |
Combination therapy
|
|
GB0303289D0
(en)
*
|
2003-02-13 |
2003-03-19 |
Astrazeneca Ab |
Combination therapy
|
|
US20050043233A1
(en)
*
|
2003-04-29 |
2005-02-24 |
Boehringer Ingelheim International Gmbh |
Combinations for the treatment of diseases involving cell proliferation, migration or apoptosis of myeloma cells or angiogenesis
|
|
BRPI0412426A
(en)
*
|
2003-07-10 |
2006-09-05 |
Astrazeneca Ab |
use of zd6474 or a pharmaceutically acceptable salt thereof and a platinum antitumor agent, pharmaceutical composition, kit, and method for producing an antiangiogenic and / or vascular permeability reducing effect in a warm-blooded animal
|
|
GB0316176D0
(en)
*
|
2003-07-10 |
2003-08-13 |
Astrazeneca Ab |
Combination therapy
|
|
BRPI0412885A
(en)
|
2003-07-18 |
2006-10-03 |
Amgen Inc |
polypeptides, specific binding agents, nucleic acid molecules and isolated cell lines, host cells, compositions and antigen binding domain or antibody and methods of treating cancer and solid tumor in a patient, detecting growth factor level hepatocyte (hgf) in a sample, obtaining antibody and inhibiting hgf binding to met and decreasing or preventing the binding of any of the hepatocyte growth factor (hgf) -specific binding agents
|
|
GB0317665D0
(en)
|
2003-07-29 |
2003-09-03 |
Astrazeneca Ab |
Qinazoline derivatives
|
|
GB0318423D0
(en)
*
|
2003-08-06 |
2003-09-10 |
Astrazeneca Ab |
Chemical compounds
|
|
HRP20080329T3
(en)
*
|
2003-09-16 |
2008-08-31 |
Astrazeneca Ab |
Quinazoline derivatives as tyrosine kinase inhibitors
|
|
US20070043010A1
(en)
*
|
2003-09-25 |
2007-02-22 |
Astrazeneca Uk Limited |
Quinazoline derivatives
|
|
GB0330002D0
(en)
*
|
2003-12-24 |
2004-01-28 |
Astrazeneca Ab |
Quinazoline derivatives
|
|
US7632840B2
(en)
|
2004-02-03 |
2009-12-15 |
Astrazeneca Ab |
Quinazoline compounds for the treatment of hyperproliferative disorders
|
|
GB0421438D0
(en)
*
|
2004-09-27 |
2004-10-27 |
Astrazeneca Ab |
Combination therapy
|
|
GB0411378D0
(en)
*
|
2004-05-21 |
2004-06-23 |
Astrazeneca Ab |
Pharmaceutical compositions
|
|
EP2277595A3
(en)
|
2004-06-24 |
2011-09-28 |
Novartis Vaccines and Diagnostics, Inc. |
Compounds for immunopotentiation
|
|
CA2578956A1
(en)
*
|
2004-09-27 |
2006-04-06 |
Astrazeneca Ab |
Combination comprising zd6474 and an imatinib
|
|
GB0424339D0
(en)
*
|
2004-11-03 |
2004-12-08 |
Astrazeneca Ab |
Combination therapy
|
|
MX2007006230A
(en)
|
2004-11-30 |
2007-07-25 |
Amgen Inc |
Quinolines and quinazoline analogs and their use as medicaments for treating cancer.
|
|
NZ556029A
(en)
|
2004-12-21 |
2010-04-30 |
Astrazeneca Ab |
Antibodies directed to angiopoietin-2 and uses thereof
|
|
CN1854130B
(en)
*
|
2005-04-15 |
2011-04-20 |
中国医学科学院药物研究所 |
Chinazoline derivative, its production, medicinal composition and use
|
|
AU2006299902B2
(en)
|
2005-05-18 |
2012-11-01 |
Array Biopharma Inc. |
Heterocyclic inhibitors of MEK and methods of use thereof
|
|
AU2011203358B2
(en)
*
|
2005-09-30 |
2013-05-30 |
Genzyme Corporation |
Chemical process
|
|
GB0519879D0
(en)
|
2005-09-30 |
2005-11-09 |
Astrazeneca Ab |
Chemical process
|
|
GB0519878D0
(en)
*
|
2005-09-30 |
2005-11-09 |
Astrazeneca Ab |
Chemical compound
|
|
US20080108664A1
(en)
|
2005-12-23 |
2008-05-08 |
Liu Belle B |
Solid-state form of AMG 706 and pharmaceutical compositions thereof
|
|
JO2660B1
(en)
|
2006-01-20 |
2012-06-17 |
نوفارتيس ايه جي |
PI-3 Kinase inhibitors and methods of their use
|
|
AR059066A1
(en)
|
2006-01-27 |
2008-03-12 |
Amgen Inc |
COMBINATIONS OF THE ANGIOPOYETINE INHIBITOR -2 (ANG2) AND THE VASCULAR ENDOTELIAL GROWTH FACTOR INHIBITOR (VEGF)
|
|
JP2009526050A
(en)
|
2006-02-10 |
2009-07-16 |
アムジエン・インコーポレーテツド |
AMG 706 hydrate form
|
|
TW200808739A
(en)
|
2006-04-06 |
2008-02-16 |
Novartis Vaccines & Diagnostic |
Quinazolines for PDK1 inhibition
|
|
TW200813091A
(en)
|
2006-04-10 |
2008-03-16 |
Amgen Fremont Inc |
Targeted binding agents directed to uPAR and uses thereof
|
|
CN101472915A
(en)
|
2006-04-19 |
2009-07-01 |
诺瓦提斯公司 |
Indazole compounds and methods for inhibition of CDC7
|
|
US8217177B2
(en)
|
2006-07-14 |
2012-07-10 |
Amgen Inc. |
Fused heterocyclic derivatives and methods of use
|
|
PE20121506A1
(en)
|
2006-07-14 |
2012-11-26 |
Amgen Inc |
TRIAZOLOPYRIDINE COMPOUNDS AS C-MET INHIBITORS
|
|
CL2007002225A1
(en)
|
2006-08-03 |
2008-04-18 |
Astrazeneca Ab |
SPECIFIC UNION AGENT FOR A RECEIVER OF THE GROWTH FACTOR DERIVED FROM PLATES (PDGFR-ALFA); NUCLEIC ACID MOLECULA THAT CODIFIES IT; VECTOR AND CELL GUESTS THAT UNDERSTAND IT; CONJUGADO UNDERSTANDING THE AGENT; AND USE OF THE AGENT OF A
|
|
US8044049B2
(en)
|
2006-08-04 |
2011-10-25 |
Takeda Pharmaceutical Company Limited |
Fused heterocyclic derivative and use thereof
|
|
WO2008023161A1
(en)
|
2006-08-23 |
2008-02-28 |
Kudos Pharmaceuticals Limited |
2-methylmorpholine pyrido-, pyrazo- and pyrimido-pyrimidine derivatives as mtor inhibitors
|
|
WO2008037996A1
(en)
|
2006-09-29 |
2008-04-03 |
Astrazeneca Ab |
Combination of zd6474 and bevacizumab for cancer therapy
|
|
EP2073803B1
(en)
|
2006-10-12 |
2018-09-19 |
Astex Therapeutics Limited |
Pharmaceutical combinations
|
|
EP2073807A1
(en)
|
2006-10-12 |
2009-07-01 |
Astex Therapeutics Limited |
Pharmaceutical combinations
|
|
WO2008046242A1
(en)
*
|
2006-10-16 |
2008-04-24 |
Institute Of Mataria Medica, Chinese Academy Of Medical Sciences |
The novel quinazoline derivatives,preparation methods and uses thereof
|
|
EP1921070A1
(en)
|
2006-11-10 |
2008-05-14 |
Boehringer Ingelheim Pharma GmbH & Co. KG |
Bicyclic heterocycles, medicaments comprising them, their use and process for their preparation
|
|
WO2008079291A2
(en)
|
2006-12-20 |
2008-07-03 |
Amgen Inc. |
Substituted heterocycles and methods of use
|
|
EP2118069B1
(en)
|
2007-01-09 |
2014-01-01 |
Amgen Inc. |
Bis-aryl amide derivatives useful for the treatment of cancer
|
|
US7998949B2
(en)
|
2007-02-06 |
2011-08-16 |
Boehringer Ingelheim International Gmbh |
Bicyclic heterocycles, drugs containing said compounds, use thereof, and method for production thereof
|
|
US20080190689A1
(en)
*
|
2007-02-12 |
2008-08-14 |
Ballard Ebbin C |
Inserts for engine exhaust systems
|
|
US8314087B2
(en)
|
2007-02-16 |
2012-11-20 |
Amgen Inc. |
Nitrogen-containing heterocyclyl ketones and methods of use
|
|
PE20081887A1
(en)
|
2007-03-20 |
2009-01-16 |
Dainippon Sumitomo Pharma Co |
NEW ADENINE COMPOUND
|
|
US8044056B2
(en)
|
2007-03-20 |
2011-10-25 |
Dainippon Sumitomo Pharma Co., Ltd. |
Adenine compound
|
|
US8914063B2
(en)
|
2007-05-15 |
2014-12-16 |
Lg Electronics Inc. |
Mobile terminal equipped with mode setting key and method of controlling the mobile terminal
|
|
CL2008001626A1
(en)
|
2007-06-05 |
2009-06-05 |
Takeda Pharmaceuticals Co |
Compounds derived from fused heterocycles, a pharmaceutical agent that comprises them and their use in the prophylaxis and treatment of cancer.
|
|
EA023555B1
(en)
|
2007-08-21 |
2016-06-30 |
Амген Инк. |
HUMAN c-fms ANTIGEN BINDING PROTEINS
|
|
US8324395B2
(en)
|
2007-08-23 |
2012-12-04 |
Takeda Pharmaceutical Company Limited |
Heterocyclic compound and use thereof
|
|
TWI453021B
(en)
|
2007-10-11 |
2014-09-21 |
Astrazeneca Ab |
Novel protein kinase B inhibitor
|
|
JP5421925B2
(en)
|
2007-12-19 |
2014-02-19 |
ジェネンテック, インコーポレイテッド |
5-Anilinoimidazopyridine and method of use
|
|
EP2240475B1
(en)
|
2007-12-20 |
2013-09-25 |
Novartis AG |
Thiazole derivatives used as pi 3 kinase inhibitors
|
|
ES2387707T3
(en)
|
2007-12-21 |
2012-09-28 |
Genentech, Inc. |
Azaindolizines and use procedures
|
|
WO2009094210A1
(en)
*
|
2008-01-22 |
2009-07-30 |
Concert Pharmaceuticals Inc. |
Vandetanib derivatives
|
|
CA2711582A1
(en)
|
2008-02-07 |
2009-08-13 |
Boehringer Ingelheim International Gmbh |
Spirocyclic heterocycles, formulations containing said compounds, use thereof and processes for the preparation thereof
|
|
AU2009215375A1
(en)
*
|
2008-02-21 |
2009-08-27 |
Astrazeneca Ab |
Combination therapy 238
|
|
CA2723989C
(en)
|
2008-05-13 |
2017-04-25 |
Astrazeneca Ab |
Fumarate salt of 4-(3-chloro-2-fluoroanilino)-7-methoxy-6-{[1-(n-methylcarbamoylmethyl)piperidin-4-yl]oxy}quinazoline
|
|
EP2294184A4
(en)
|
2008-06-30 |
2013-03-06 |
Mesoblast Inc |
Treatment of eye diseases and excessive neovascularization using a combined therapy
|
|
US8648191B2
(en)
|
2008-08-08 |
2014-02-11 |
Boehringer Ingelheim International Gmbh |
Cyclohexyloxy substituted heterocycles, pharmaceutical compositions containing these compounds and processes for preparing them
|
|
JP5778577B2
(en)
|
2008-09-19 |
2015-09-16 |
メディミューン,エルエルシー |
Antibodies against DLL4 and uses thereof
|
|
EP2399921B1
(en)
|
2008-12-01 |
2015-08-12 |
Takeda Pharmaceutical Company Limited |
Heterocyclic compound and use thereof
|
|
JO3101B1
(en)
|
2008-12-02 |
2017-09-20 |
Takeda Pharmaceuticals Co |
Benzothiazole derivatives as anticancer agents
|
|
TW201028410A
(en)
|
2008-12-22 |
2010-08-01 |
Astrazeneca Ab |
Chemical compounds 610
|
|
CA2748158A1
(en)
|
2008-12-23 |
2010-07-01 |
Astrazeneca Ab |
Targeted binding agents directed to .alpha.5.beta.1 and uses thereof
|
|
CA2750519C
(en)
|
2009-02-05 |
2018-09-25 |
Immunogen, Inc. |
Benzodiazepine derivatives
|
|
CA2755061A1
(en)
|
2009-03-13 |
2010-09-16 |
Cellzome Limited |
Pyrimidine derivatives as mtor inhibitors
|
|
WO2010108503A1
(en)
|
2009-03-24 |
2010-09-30 |
Life & Brain Gmbh |
Promotion of neuronal integration in neural stem cell grafts
|
|
US20120040955A1
(en)
|
2009-04-14 |
2012-02-16 |
Richard John Harrison |
Fluoro substituted pyrimidine compounds as jak3 inhibitors
|
|
US8293753B2
(en)
|
2009-07-02 |
2012-10-23 |
Novartis Ag |
Substituted 2-carboxamide cycloamino ureas
|
|
WO2011029807A1
(en)
|
2009-09-11 |
2011-03-17 |
Cellzome Limited |
Ortho substituted pyrimidine compounds as jak inhibitors
|
|
CN102666545B
(en)
|
2009-10-20 |
2016-04-06 |
塞尔卓姆有限公司 |
As the heterocycle Pyrazolopyrimidine analogs of JAK inhibitor
|
|
CN102070608A
(en)
*
|
2009-11-19 |
2011-05-25 |
天津药物研究院 |
4-substituted phenylamino-7-substituted alkoxy-quinazoline derivant and preparation method and application thereof
|
|
RS60033B1
(en)
|
2009-11-24 |
2020-04-30 |
Medimmune Ltd |
Targeted binding agents against b7-h1
|
|
EP2507237A1
(en)
|
2009-12-03 |
2012-10-10 |
Dainippon Sumitomo Pharma Co., Ltd. |
Imidazoquinolines which act via toll - like receptors (tlr)
|
|
MX341687B
(en)
|
2010-02-10 |
2016-08-30 |
Immunogen Inc |
Cd20 antibodies and uses thereof.
|
|
ES2535116T3
(en)
|
2010-03-04 |
2015-05-05 |
Cellzome Limited |
Urea derivatives with morpholino as mtor inhibitors
|
|
KR20130094693A
(en)
|
2010-04-30 |
2013-08-26 |
셀좀 리미티드 |
Pyrazole compounds as jak inhibitors
|
|
SA111320519B1
(en)
|
2010-06-11 |
2014-07-02 |
Astrazeneca Ab |
Pyrimidinyl compounds for use as ATR inhibitors
|
|
WO2011161217A2
(en)
|
2010-06-23 |
2011-12-29 |
Palacký University in Olomouc |
Targeting of vegfr2
|
|
WO2012000970A1
(en)
|
2010-07-01 |
2012-01-05 |
Cellzome Limited |
Triazolopyridines as tyk2 inhibitors
|
|
AR082418A1
(en)
|
2010-08-02 |
2012-12-05 |
Novartis Ag |
CRYSTAL FORMS OF 1- (4-METHYL-5- [2- (2,2,2-TRIFLUORO-1,1-DIMETHYL-Ethyl) -PIRIDIN-4-IL] -TIAZOL-2-IL) -AMIDE OF 2 -AMIDA OF THE ACID (S) -PIRROLIDIN-1,2-DICARBOXILICO
|
|
US9040545B2
(en)
|
2010-08-20 |
2015-05-26 |
Cellzome Limited |
Heterocyclyl pyrazolopyrimidine analogues as selective JAK inhibitors
|
|
RU2013114360A
(en)
|
2010-08-31 |
2014-10-10 |
Дженентек, Инк. |
BIOMARKERS AND TREATMENT METHODS
|
|
AU2011328237A1
(en)
|
2010-11-09 |
2013-05-23 |
Cellzome Limited |
Pyridine compounds and aza analogues thereof as TYK2 inhibitors
|
|
CN102532103B
(en)
*
|
2010-12-20 |
2014-07-09 |
天津药物研究院 |
Quinazolinyl aryl urea derivatives and preparation method and application thereof
|
|
WO2012104776A1
(en)
|
2011-01-31 |
2012-08-09 |
Novartis Ag |
Novel heterocyclic derivatives
|
|
SG191965A1
(en)
|
2011-02-15 |
2013-08-30 |
Immunogen Inc |
Methods of preparation of conjugates
|
|
US20130324532A1
(en)
|
2011-02-17 |
2013-12-05 |
Cancer Therapeutics Crc Pty Limited |
Fak inhibitors
|
|
ES2724525T3
(en)
|
2011-02-17 |
2019-09-11 |
Cancer Therapeutics Crc Pty Ltd |
FAK selective inhibitors
|
|
ES2620521T3
(en)
|
2011-03-23 |
2017-06-28 |
Amgen Inc. |
Dual condensed tricyclic inhibitors of CDK 4/6 and FLT3
|
|
JP2014510122A
(en)
|
2011-04-04 |
2014-04-24 |
セルゾーム リミテッド |
Dihydropyrrolopyrimidine derivatives as mTOR inhibitors
|
|
WO2012143320A1
(en)
|
2011-04-18 |
2012-10-26 |
Cellzome Limited |
(7h-pyrrolo[2,3-d]pyrimidin-2-yl)amine compounds as jak3 inhibitors
|
|
AU2012288892B2
(en)
|
2011-07-28 |
2016-04-21 |
Cellzome Limited |
Heterocyclyl pyrimidine analogues as JAK inhibitors
|
|
WO2013017479A1
(en)
|
2011-07-29 |
2013-02-07 |
Cellzome Limited |
Pyrazolo[4,3-c]pyridine derivatives as jak inhibitors
|
|
WO2013017480A1
(en)
|
2011-07-29 |
2013-02-07 |
Cellzome Limited |
Pyrazolo[4,3-c]pyridine derivatives as jak inhibitors
|
|
US9745288B2
(en)
|
2011-08-16 |
2017-08-29 |
Indiana University Research And Technology Corporation |
Compounds and methods for treating cancer by inhibiting the urokinase receptor
|
|
RU2014115476A
(en)
|
2011-09-20 |
2015-10-27 |
Целльзом Лимитед |
PYRAZOLO [4, 3-C] PTRIDINE DERIVATIVES AS KINASE INHIBITORS
|
|
CA2849189A1
(en)
|
2011-09-21 |
2013-03-28 |
Cellzome Limited |
Morpholino substituted urea or carbamate derivatives as mtor inhibitors
|
|
BR112014008241A2
(en)
|
2011-10-07 |
2017-04-18 |
Cellzome Ltd |
compound, pharmaceutical composition, methods for treating, controlling, retarding or preventing disease and disorder, and for preparing a compound, and use of a compound
|
|
KR20140090218A
(en)
|
2011-10-28 |
2014-07-16 |
노파르티스 아게 |
Novel purine derivatives and their use in the treatment of disease
|
|
CA2860095A1
(en)
|
2011-12-23 |
2013-06-27 |
Cellzome Limited |
Pyrimidine-2,4-diamine derivatives as kinase inhibitors
|
|
AR090263A1
(en)
|
2012-03-08 |
2014-10-29 |
Hoffmann La Roche |
COMBINED ANTIBODY THERAPY AGAINST HUMAN CSF-1R AND USES OF THE SAME
|
|
CN104349779A
(en)
|
2012-05-16 |
2015-02-11 |
诺华股份有限公司 |
Dosage regimen for a pi-3 kinase inhibitor
|
|
US9738724B2
(en)
|
2012-06-08 |
2017-08-22 |
Sutro Biopharma, Inc. |
Antibodies comprising site-specific non-natural amino acid residues, methods of their preparation and methods of their use
|
|
ES2611788T3
(en)
|
2012-06-26 |
2017-05-10 |
Sutro Biopharma, Inc. |
Modified Fc proteins comprising site-specific non-natural amino acid residues, conjugates thereof, methods for their preparation and methods for use
|
|
WO2014026243A1
(en)
|
2012-08-17 |
2014-02-20 |
Cancer Therapeutics Crc Pty Limited |
Vegfr3 inhibitors
|
|
WO2014031566A1
(en)
|
2012-08-22 |
2014-02-27 |
Immunogen, Inc. |
Cytotoxic benzodiazepine derivatives
|
|
EP2890696A1
(en)
|
2012-08-29 |
2015-07-08 |
Amgen, Inc. |
Quinazolinone compounds and derivatives thereof
|
|
HRP20190878T1
(en)
|
2012-08-31 |
2019-07-26 |
Sutro Biopharma, Inc. |
Modified amino acids comprising an azido group
|
|
WO2014041349A1
(en)
|
2012-09-12 |
2014-03-20 |
Cancer Therapeutics Crc Pty Ltd |
Tetrahydropyran-4-ylethylamino- or tetrahydropyranyl-4-ethyloxy-pyrimidines or -pyridazines as isoprenylcysteincarboxymethyl transferase inhibitors
|
|
WO2014045101A1
(en)
|
2012-09-21 |
2014-03-27 |
Cellzome Gmbh |
Tetrazolo quinoxaline derivatives as tankyrase inhibitors
|
|
US20150259649A1
(en)
*
|
2012-11-08 |
2015-09-17 |
Emory University |
Cellular compositions used to restore stem cell or progenitor cell function and methods related thereto
|
|
JP2016509045A
(en)
|
2013-02-22 |
2016-03-24 |
エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト |
How to treat cancer and prevent drug resistance
|
|
EP2961434A2
(en)
|
2013-02-28 |
2016-01-06 |
ImmunoGen, Inc. |
Conjugates comprising cell-binding agents and cytotoxic agents
|
|
EP2961435B1
(en)
|
2013-02-28 |
2019-05-01 |
ImmunoGen, Inc. |
Conjugates comprising cell-binding agents and cytotoxic agents
|
|
JP2016510751A
(en)
|
2013-03-06 |
2016-04-11 |
ジェネンテック, インコーポレイテッド |
Methods of treating and preventing anticancer drug resistance
|
|
EP2968565A2
(en)
|
2013-03-14 |
2016-01-20 |
Genentech, Inc. |
Methods of treating cancer and preventing cancer drug resistance
|
|
CN105339001A
(en)
|
2013-03-15 |
2016-02-17 |
基因泰克公司 |
Ways to treat cancer and prevent cancer resistance
|
|
AR095443A1
(en)
|
2013-03-15 |
2015-10-14 |
Fundación Centro Nac De Investig Oncológicas Carlos Iii |
HEREROCICLES CONDENSED WITH ACTION ON ATR
|
|
WO2014194030A2
(en)
|
2013-05-31 |
2014-12-04 |
Immunogen, Inc. |
Conjugates comprising cell-binding agents and cytotoxic agents
|
|
ES2658039T3
(en)
|
2013-07-10 |
2018-03-08 |
Sutro Biopharma, Inc. |
Antibodies comprising multiple site-specific non-natural amino acid residues, methods for their preparation and methods of use
|
|
PT3039424T
(en)
|
2013-08-28 |
2020-09-03 |
Crown Bioscience Inc Taicang |
Gene expression signatures predictive of subject response to a multi-kinase inhibitor and methods of using the same
|
|
CN103483276B
(en)
*
|
2013-09-22 |
2018-04-17 |
南京恒道医药科技有限公司 |
Preparation method of vandetanib impurity
|
|
WO2015054658A1
(en)
|
2013-10-11 |
2015-04-16 |
Sutro Biopharma, Inc. |
Modified amino acids comprising tetrazine functional groups, methods of preparation, and methods of their use
|
|
MX378409B
(en)
|
2013-12-06 |
2025-03-10 |
Novartis Ag |
DOSAGE REGIMEN FOR AN ALPHA-ISOMORPHIC SELECTIVE PHOSPHATIDYLINOSITOL 3-KINASE INHIBITOR.
|
|
CA2943329A1
(en)
|
2014-03-24 |
2015-10-01 |
Genentech, Inc. |
Cancer treatment with c-met antagonists and correlation of the latter with hgf expression
|
|
HK1247955A1
(en)
|
2015-01-08 |
2018-10-05 |
小利兰.斯坦福大学托管委员会 |
Factors and cells that provide for induction of bone, bone marrow, and cartilage
|
|
GB201510019D0
(en)
|
2015-06-09 |
2015-07-22 |
Cancer Therapeutics Crc Pty Ltd |
Compounds
|
|
CN106317022A
(en)
*
|
2015-06-25 |
2017-01-11 |
中美华世通生物医药科技(武汉)有限公司 |
Preparation method and use of compound
|
|
CA3002954A1
(en)
|
2015-11-02 |
2017-05-11 |
Novartis Ag |
Dosage regimen for a phosphatidylinositol 3-kinase inhibitor
|
|
CN105254614B
(en)
*
|
2015-11-16 |
2017-08-15 |
山东罗欣药业集团股份有限公司 |
A kind of synthetic method of ZD6474 compound
|
|
BR112018015238A2
(en)
|
2016-01-27 |
2018-12-18 |
Sutro Biopharma Inc |
antibody conjugate, antibody, kit, pharmaceutical composition, and methods for treating or preventing a disease or condition and for diagnosing a disease or condition
|
|
CA3012718A1
(en)
|
2016-02-08 |
2017-08-17 |
Vitrisa Therapeutics, Inc. |
Compositions with improved intravitreal half-life and uses thereof
|
|
CN106349230A
(en)
*
|
2016-08-09 |
2017-01-25 |
浙江医药高等专科学校 |
Benzo-quinazoline tyrosine kinase inhibitor with nitrothiophene sulfamide structure and application
|
|
CN106317039A
(en)
*
|
2016-08-09 |
2017-01-11 |
浙江医药高等专科学校 |
Ethoxy benzo quinazoline type tyrosine kinase inhibitor containing thiophenesulfonyl structure, preparation method and application
|
|
CN106349231A
(en)
*
|
2016-08-09 |
2017-01-25 |
浙江医药高等专科学校 |
Benzoquinazoline tyrosine kinase inhibitor containing halothiophene sulfonamide structure
|
|
CN106317040A
(en)
*
|
2016-08-09 |
2017-01-11 |
浙江医药高等专科学校 |
Benzo quinazoline tyrosine kinase inhibitor containing thiophene-sulfonamide structure, preparation method and application
|
|
CN106279135A
(en)
*
|
2016-08-09 |
2017-01-04 |
浙江医药高等专科学校 |
A kind of Benzoquinazole class tyrosine kinase inhibitor of thiophenesulfonyl amine structure
|
|
CN106478598B
(en)
*
|
2016-08-30 |
2018-11-13 |
山东罗欣药业集团股份有限公司 |
A kind of Vande Thani hydrate crystal and preparation method thereof
|
|
CN106397401B
(en)
*
|
2016-08-30 |
2018-11-13 |
山东罗欣药业集团股份有限公司 |
A kind of crystalline compounds of anticancer drug and preparation method thereof
|
|
WO2018045379A1
(en)
|
2016-09-02 |
2018-03-08 |
Dana-Farber Cancer Institute, Inc. |
Composition and methods of treating b cell disorders
|
|
WO2018060833A1
(en)
|
2016-09-27 |
2018-04-05 |
Novartis Ag |
Dosage regimen for alpha-isoform selective phosphatidylinositol 3-kinase inhibitor alpelisib
|
|
CN110177780B
(en)
|
2016-12-05 |
2022-11-01 |
阿普罗斯治疗公司 |
Pyrimidine compounds containing acidic groups
|
|
US10786502B2
(en)
|
2016-12-05 |
2020-09-29 |
Apros Therapeutics, Inc. |
Substituted pyrimidines containing acidic groups as TLR7 modulators
|
|
SG11201906223TA
(en)
|
2016-12-22 |
2019-08-27 |
Amgen Inc |
Benzisothiazole, isothiazolo[3,4-b]pyridine, quinazoline, phthalazine, pyrido[2,3-d]pyridazine and pyrido[2,3-d]pyrimidine derivatives as kras g12c inhibitors for treating lung, pancreatic or colorectal cancer
|
|
JOP20190272A1
(en)
|
2017-05-22 |
2019-11-21 |
Amgen Inc |
Kras g12c inhibitors and methods of using the same
|
|
US20200207859A1
(en)
|
2017-07-26 |
2020-07-02 |
Sutro Biopharma, Inc. |
Methods of using anti-cd74 antibodies and antibody conjugates in treatment of t-cell lymphoma
|
|
UY37870A
(en)
|
2017-09-08 |
2019-03-29 |
Amgen Inc |
KRAS G12C INHIBITORS AND METHODS TO USE THEM FIELD OF THE INVENTION
|
|
SG11202002310UA
(en)
|
2017-09-18 |
2020-04-29 |
Sutro Biopharma Inc |
Anti- folate receptor alpha antibody conjugates and their uses
|
|
NL2019801B1
(en)
|
2017-10-25 |
2019-05-02 |
Univ Leiden |
Delivery vectors
|
|
MA52501A
(en)
|
2018-05-04 |
2021-03-10 |
Amgen Inc |
KRAS G12C INHIBITORS AND THEIR PROCEDURES FOR USE
|
|
CA3099118A1
(en)
|
2018-05-04 |
2019-11-07 |
Amgen Inc. |
Kras g12c inhibitors and methods of using the same
|
|
MX2020011907A
(en)
|
2018-05-10 |
2021-01-29 |
Amgen Inc |
Kras g12c inhibitors for the treatment of cancer.
|
|
AU2019278998B2
(en)
|
2018-06-01 |
2023-11-09 |
Amgen Inc. |
KRAS G12C inhibitors and methods of using the same
|
|
JP7351859B2
(en)
|
2018-06-04 |
2023-09-27 |
アプロス セラピューティクス, インコーポレイテッド |
Pyrimidine compounds containing acidic groups useful for treating diseases related to TLR7 regulation
|
|
JP7357644B2
(en)
|
2018-06-11 |
2023-10-06 |
アムジエン・インコーポレーテツド |
KRAS G12C inhibitors for treating cancer
|
|
AU2019336588B2
(en)
|
2018-06-12 |
2022-07-28 |
Amgen Inc. |
KRAS G12C inhibitors encompassing a piperazine ring and use thereof in the treatment of cancer
|
|
GB201810092D0
(en)
|
2018-06-20 |
2018-08-08 |
Ctxt Pty Ltd |
Compounds
|
|
GB201810581D0
(en)
|
2018-06-28 |
2018-08-15 |
Ctxt Pty Ltd |
Compounds
|
|
EP3852811A1
(en)
|
2018-09-17 |
2021-07-28 |
Sutro Biopharma, Inc. |
Combination therapies with anti-folate receptor antibody conjugates
|
|
JP7516029B2
(en)
|
2018-11-16 |
2024-07-16 |
アムジエン・インコーポレーテツド |
Improved synthesis of key intermediates for KRAS G12C inhibitor compounds
|
|
JP7377679B2
(en)
|
2018-11-19 |
2023-11-10 |
アムジエン・インコーポレーテツド |
Combination therapy comprising a KRASG12C inhibitor and one or more additional pharmaceutically active agents for the treatment of cancer
|
|
WO2020106640A1
(en)
|
2018-11-19 |
2020-05-28 |
Amgen Inc. |
Kras g12c inhibitors and methods of using the same
|
|
US12441736B2
(en)
|
2018-12-20 |
2025-10-14 |
Amgen Inc. |
KIF18A inhibitors
|
|
ES2996960T3
(en)
|
2018-12-20 |
2025-02-13 |
Amgen Inc |
Heteroaryl amides useful as kif18a inhibitors
|
|
JOP20210154B1
(en)
|
2018-12-20 |
2023-09-17 |
Amgen Inc |
KIF18A inhibitors
|
|
EP3897855B1
(en)
|
2018-12-20 |
2023-06-07 |
Amgen Inc. |
Kif18a inhibitors
|
|
SG11202106635WA
(en)
|
2018-12-21 |
2021-07-29 |
Daiichi Sankyo Co Ltd |
Combination of antibody-drug conjugate and kinase inhibitor
|
|
US20230148450A9
(en)
|
2019-03-01 |
2023-05-11 |
Revolution Medicines, Inc. |
Bicyclic heteroaryl compounds and uses thereof
|
|
WO2020180770A1
(en)
|
2019-03-01 |
2020-09-10 |
Revolution Medicines, Inc. |
Bicyclic heterocyclyl compounds and uses thereof
|
|
JP7523465B2
(en)
|
2019-03-28 |
2024-07-26 |
アンプリア セラピューティクス リミテッド |
Salts and Crystalline Forms of FAK Inhibitors
|
|
EP3962951A1
(en)
|
2019-05-03 |
2022-03-09 |
Sutro Biopharma, Inc. |
Anti-bcma antibody conjugates
|
|
EP3738593A1
(en)
|
2019-05-14 |
2020-11-18 |
Amgen, Inc |
Dosing of kras inhibitor for treatment of cancers
|
|
CR20210665A
(en)
|
2019-05-21 |
2022-01-25 |
Amgen Inc |
Solid state forms
|
|
CN114302880B
(en)
|
2019-08-02 |
2025-07-15 |
美国安进公司 |
KIF18A inhibitors
|
|
WO2021026099A1
(en)
|
2019-08-02 |
2021-02-11 |
Amgen Inc. |
Kif18a inhibitors
|
|
CN114391012B
(en)
|
2019-08-02 |
2025-10-31 |
美国安进公司 |
Pyridine derivatives as KIF18A inhibitors
|
|
US20220281843A1
(en)
|
2019-08-02 |
2022-09-08 |
Amgen Inc. |
Kif18a inhibitors
|
|
US20220298143A1
(en)
|
2019-08-31 |
2022-09-22 |
Etern Biopharma (Shanghai) Co., Ltd. |
Pyrazole Derivatives for FGFR Inhibitor and Preparation Method Thereof
|
|
EP4684786A2
(en)
|
2019-10-24 |
2026-01-28 |
Amgen Inc. |
Pyridopyrimidine derivatives useful as kras g12c and kras g12d inhibitors in the treatment of cancer
|
|
US11739074B2
(en)
|
2019-11-04 |
2023-08-29 |
Revolution Medicines, Inc. |
Ras inhibitors
|
|
CN120988055A
(en)
|
2019-11-04 |
2025-11-21 |
锐新医药公司 |
RAS inhibitors
|
|
CA3160142A1
(en)
|
2019-11-04 |
2021-05-14 |
Revolution Medicines, Inc. |
Ras inhibitors
|
|
JP7812056B2
(en)
|
2019-11-08 |
2026-02-09 |
レヴォリューション・メディスンズ,インコーポレイテッド |
Bicyclic heteroaryl compounds and uses thereof
|
|
AU2020383535A1
(en)
|
2019-11-14 |
2022-05-05 |
Amgen Inc. |
Improved synthesis of KRAS G12C inhibitor compound
|
|
TWI882037B
(en)
|
2019-11-14 |
2025-05-01 |
美商安進公司 |
Improved synthesis of kras g12c inhibitor compound
|
|
CN114980976A
(en)
|
2019-11-27 |
2022-08-30 |
锐新医药公司 |
Covalent RAS inhibitors and uses thereof
|
|
BR112022010086A2
(en)
|
2020-01-07 |
2022-09-06 |
Revolution Medicines Inc |
SHP2 INHIBITOR DOSAGE AND CANCER TREATMENT METHODS
|
|
WO2021178597A1
(en)
|
2020-03-03 |
2021-09-10 |
Sutro Biopharma, Inc. |
Antibodies comprising site-specific glutamine tags, methods of their preparation and methods of their use
|
|
TW202214253A
(en)
|
2020-06-18 |
2022-04-16 |
美商銳新醫藥公司 |
Methods for delaying, preventing, and treating acquired resistance to ras inhibitors
|
|
WO2022053130A1
(en)
|
2020-09-09 |
2022-03-17 |
Sid Alex Group, S.R.O. |
Antago-mir-155 for treatment of v-src, c-src-tyrosine kinase-induced cancers
|
|
MX2023003060A
(en)
|
2020-09-15 |
2023-04-05 |
Revolution Medicines Inc |
Indole derivatives as ras inhibitors in the treatment of cancer.
|
|
EP4267250A1
(en)
|
2020-12-22 |
2023-11-01 |
Qilu Regor Therapeutics Inc. |
Sos1 inhibitors and uses thereof
|
|
IL308193A
(en)
|
2021-05-05 |
2024-01-01 |
Revolution Medicines Inc |
Ras inhibitors
|
|
TW202309053A
(en)
|
2021-05-05 |
2023-03-01 |
美商銳新醫藥公司 |
Ras inhibitors
|
|
WO2022235866A1
(en)
|
2021-05-05 |
2022-11-10 |
Revolution Medicines, Inc. |
Covalent ras inhibitors and uses thereof
|
|
AR127308A1
(en)
|
2021-10-08 |
2024-01-10 |
Revolution Medicines Inc |
RAS INHIBITORS
|
|
US20250282782A1
(en)
|
2021-12-17 |
2025-09-11 |
Genzyme Corporation |
Pyrazolopyrazine compounds as shp2 inhibitors
|
|
EP4227307A1
(en)
|
2022-02-11 |
2023-08-16 |
Genzyme Corporation |
Pyrazolopyrazine compounds as shp2 inhibitors
|
|
EP4487865A1
(en)
|
2022-03-04 |
2025-01-08 |
Panolos Bioscience, Inc. |
Composition for combi-therapy comprising vegf-grab and pd-1 or pd-l1 antagonist
|
|
EP4490146B1
(en)
|
2022-03-07 |
2026-02-18 |
Amgen Inc. |
A process for preparing 4-methyl-2-propan-2-yl-pyridine-3-carbonitrile
|
|
CN119136806A
(en)
|
2022-03-08 |
2024-12-13 |
锐新医药公司 |
Methods for treating immune-refractory lung cancer
|
|
EP4531927A1
(en)
|
2022-05-24 |
2025-04-09 |
Daiichi Sankyo Company, Limited |
Dosage regimen of an anti-cdh6 antibody-drug conjugate
|
|
JP2025521232A
(en)
|
2022-06-10 |
2025-07-08 |
レボリューション メディシンズ インコーポレイテッド |
Macrocyclic RAS inhibitors
|
|
TW202408589A
(en)
|
2022-06-30 |
2024-03-01 |
美商舒卓生物製藥公司 |
Anti-ror1 antibodies and antibody conjugates, compositions comprising anti‑ror1 antibodies or antibody conjugates, and methods of making and using anti-ror1 antibodies and antibody conjugates
|
|
GEAP202516749A
(en)
|
2022-10-14 |
2025-07-25 |
Black Diamond Therapeutics Inc |
Methods of treating cancers using isoquinoline or 6-aza-quinoline derivatives
|
|
EP4687905A1
(en)
|
2023-03-30 |
2026-02-11 |
Revolution Medicines, Inc. |
Compositions for inducing ras gtp hydrolysis and uses thereof
|
|
EP4688790A1
(en)
|
2023-04-07 |
2026-02-11 |
Revolution Medicines, Inc. |
Macrocyclic ras inhibitors
|
|
WO2024211663A1
(en)
|
2023-04-07 |
2024-10-10 |
Revolution Medicines, Inc. |
Condensed macrocyclic compounds as ras inhibitors
|
|
KR20250169290A
(en)
|
2023-04-14 |
2025-12-02 |
레볼루션 메디슨즈, 인크. |
Crystalline form of RAS inhibitor, composition containing same and method of use thereof
|
|
KR20250172857A
(en)
|
2023-04-14 |
2025-12-09 |
레볼루션 메디슨즈, 인크. |
Crystalline form of RAS inhibitor
|
|
WO2024229406A1
(en)
|
2023-05-04 |
2024-11-07 |
Revolution Medicines, Inc. |
Combination therapy for a ras related disease or disorder
|
|
WO2025034702A1
(en)
|
2023-08-07 |
2025-02-13 |
Revolution Medicines, Inc. |
Rmc-6291 for use in the treatment of ras protein-related disease or disorder
|
|
US20250154171A1
(en)
|
2023-10-12 |
2025-05-15 |
Revolution Medicines, Inc. |
Ras inhibitors
|
|
WO2025081117A2
(en)
|
2023-10-13 |
2025-04-17 |
Sutro Biopharma, Inc. |
Anti-tissue factor antibodies and antibody conjugates, compositions comprising anti-tissue factor antibodies or antibody conjugates, and methods of making and using anti-tissue factor antibodies and antibody conjugates
|
|
WO2025137507A1
(en)
|
2023-12-22 |
2025-06-26 |
Regor Pharmaceuticals, Inc. |
Sos1 inhibitors and uses thereof
|
|
WO2025171296A1
(en)
|
2024-02-09 |
2025-08-14 |
Revolution Medicines, Inc. |
Ras inhibitors
|
|
WO2025240847A1
(en)
|
2024-05-17 |
2025-11-20 |
Revolution Medicines, Inc. |
Ras inhibitors
|
|
WO2025250825A1
(en)
|
2024-05-30 |
2025-12-04 |
Sutro Biopharma, Inc. |
Anti-trop2 antibodies, compositions comprising anti-trop2 antibodies and methods of making and using anti-trop2 antibodies
|
|
WO2025253311A1
(en)
|
2024-06-04 |
2025-12-11 |
Hetero Labs Limited |
1,2-dicarboxamide compounds as kinase inhibitors
|
|
WO2025255438A1
(en)
|
2024-06-07 |
2025-12-11 |
Revolution Medicines, Inc. |
Methods of treating a ras protein-related disease or disorder
|
|
WO2025265060A1
(en)
|
2024-06-21 |
2025-12-26 |
Revolution Medicines, Inc. |
Therapeutic compositions and methods for managing treatment-related effects
|
|
WO2026006747A1
(en)
|
2024-06-28 |
2026-01-02 |
Revolution Medicines, Inc. |
Ras inhibitors
|
|
WO2026015796A1
(en)
|
2024-07-12 |
2026-01-15 |
Revolution Medicines, Inc. |
Methods of treating a ras related disease or disorder
|
|
WO2026015801A1
(en)
|
2024-07-12 |
2026-01-15 |
Revolution Medicines, Inc. |
Methods of treating a ras related disease or disorder
|
|
WO2026015790A1
(en)
|
2024-07-12 |
2026-01-15 |
Revolution Medicines, Inc. |
Methods of treating a ras related disease or disorder
|
|
WO2026015825A1
(en)
|
2024-07-12 |
2026-01-15 |
Revolution Medicines, Inc. |
Use of ras inhibitor for treating pancreatic cancer
|