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AR082418A1 - CRYSTAL FORMS OF 1- (4-METHYL-5- [2- (2,2,2-TRIFLUORO-1,1-DIMETHYL-Ethyl) -PIRIDIN-4-IL] -TIAZOL-2-IL) -AMIDE OF 2 -AMIDA OF THE ACID (S) -PIRROLIDIN-1,2-DICARBOXILICO - Google Patents

CRYSTAL FORMS OF 1- (4-METHYL-5- [2- (2,2,2-TRIFLUORO-1,1-DIMETHYL-Ethyl) -PIRIDIN-4-IL] -TIAZOL-2-IL) -AMIDE OF 2 -AMIDA OF THE ACID (S) -PIRROLIDIN-1,2-DICARBOXILICO

Info

Publication number
AR082418A1
AR082418A1 ARP110102747A ARP110102747A AR082418A1 AR 082418 A1 AR082418 A1 AR 082418A1 AR P110102747 A ARP110102747 A AR P110102747A AR P110102747 A ARP110102747 A AR P110102747A AR 082418 A1 AR082418 A1 AR 082418A1
Authority
AR
Argentina
Prior art keywords
trifluoro
amide
dimethyl
ethyl
methyl
Prior art date
Application number
ARP110102747A
Other languages
Spanish (es)
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of AR082418A1 publication Critical patent/AR082418A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente se refiere a formas sólidas específicas de 1-(4-metil-5-[2-(2,2,2-trifluoro-1,1-dimetil-etil)-piridin-4-il]-tiazol-2-il-amida de 2-amida del ácido (S)-pirrolidin-1,2-dicarboxílico, y sus hidratos y solvatos. La presente se refiere además a procesos para la preparación de estas formas sólidas, a composiciones farmacéuticas que comprenden tales formas sólidas, y a métodos para utilizar las formas sólidas mencionadas y composiciones farmacéuticas para tratar enfermedades.Reivindicación 1: Una forma cristalina del compuesto de la fórmula (1) o un hidrato o solvato de la forma cristalina del compuesto de la fórmula (1).This refers to specific solid forms of 1- (4-methyl-5- [2- (2,2,2-trifluoro-1,1-dimethyl-ethyl) -pyridin-4-yl] -thiazol-2- (S) -Pyrrolidin-1,2-dicarboxylic acid 2-amide, and its hydrates and solvates, also relates to processes for the preparation of these solid forms, to pharmaceutical compositions comprising such solid forms and to methods for using the solid forms mentioned and pharmaceutical compositions for treating diseases. Claim 1: A crystalline form of the compound of the formula (1) or a hydrate or solvate of the crystalline form of the compound of the formula (1).

ARP110102747A 2010-08-02 2011-07-29 CRYSTAL FORMS OF 1- (4-METHYL-5- [2- (2,2,2-TRIFLUORO-1,1-DIMETHYL-Ethyl) -PIRIDIN-4-IL] -TIAZOL-2-IL) -AMIDE OF 2 -AMIDA OF THE ACID (S) -PIRROLIDIN-1,2-DICARBOXILICO AR082418A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US36983710P 2010-08-02 2010-08-02

Publications (1)

Publication Number Publication Date
AR082418A1 true AR082418A1 (en) 2012-12-05

Family

ID=44503814

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP110102747A AR082418A1 (en) 2010-08-02 2011-07-29 CRYSTAL FORMS OF 1- (4-METHYL-5- [2- (2,2,2-TRIFLUORO-1,1-DIMETHYL-Ethyl) -PIRIDIN-4-IL] -TIAZOL-2-IL) -AMIDE OF 2 -AMIDA OF THE ACID (S) -PIRROLIDIN-1,2-DICARBOXILICO

Country Status (3)

Country Link
AR (1) AR082418A1 (en)
TW (1) TW201206922A (en)
WO (1) WO2012016970A1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2013014887A (en) * 2011-06-21 2014-02-17 Novartis Ag Polymorphs of (s)-pyrrolidine-1,2-dicarboxylic acid 2-amide 1-({4-methyl-5-[2-(2,2,2-trifluoro-1,1-dimethyl-ethyl)-pyridin- 4-yl]-thiazol-2-yl}-amide.
AU2013241752B2 (en) * 2012-03-29 2016-07-07 Novartis Ag Pharmaceutical diagnostic
US8980259B2 (en) * 2012-07-20 2015-03-17 Novartis Ag Combination therapy
EP3003377A1 (en) * 2013-05-31 2016-04-13 Novartis AG Combination therapy containing a pi3k-alpha inhibitor and fgfr kinase inhibitor for treating cancer
JP6723229B2 (en) * 2014-10-03 2020-07-15 ノバルティス アーゲー Pharmaceutical composition containing alpericib
CN118477076A (en) * 2016-02-19 2024-08-13 国家医疗保健研究所 Methods for treating PIK3CA-associated overgrowth syndrome
CN116925023B (en) * 2023-07-18 2025-11-21 江苏桐孚高新材料有限公司 Improved synthesis of 2-perfluoroalkyl-4H-pyran-4-one derivatives

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Also Published As

Publication number Publication date
WO2012016970A1 (en) 2012-02-09
TW201206922A (en) 2012-02-16

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