ATE453648T1 - Verfahren zur herstellung von hexahydrofuroc2,3- büfuran-3-ol - Google Patents

Verfahren zur herstellung von hexahydrofuroc2,3- büfuran-3-ol

Info

Publication number: ATE453648T1
Authority: AT; Austria
Prior art keywords: bufuran; producing
Prior art date: 2001-09-10

Application number

AT02797968T

Other languages

English (en)

Inventor

Bart Kesteleyn

Dominique Surleraux

Peter J L M Quaedflieg

Original Assignee

Tibotec Pharm Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-09-10

Filing date

2002-09-06

Publication date

2010-01-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8180908&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE453648(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2002-09-06 Application filed by Tibotec Pharm Ltd filed Critical Tibotec Pharm Ltd

2010-01-15 Application granted granted Critical

2010-01-15 Publication of ATE453648T1 publication Critical patent/ATE453648T1/de

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/20—Oxygen atoms
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Virology (AREA)
Tropical Medicine & Parasitology (AREA)
Molecular Biology (AREA)
AIDS & HIV (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Furan Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT02797968T 2001-09-10 2002-09-06 Verfahren zur herstellung von hexahydrofuroc2,3- büfuran-3-ol ATE453648T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP01203416		2001-09-10
PCT/EP2002/010062 WO2003022853A1 (en)	2001-09-10	2002-09-06	Method for the preparation of hexahydro-furo[2,3-b]furan-3-ol

Publications (1)

Publication Number	Publication Date
ATE453648T1 true ATE453648T1 (de)	2010-01-15

Family

ID=8180908

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT02797968T ATE453648T1 (de)	2001-09-10	2002-09-06	Verfahren zur herstellung von hexahydrofuroc2,3- büfuran-3-ol

Country Status (28)

Country	Link
US (1)	US7126015B2 (de)
EP (1)	EP1448567B1 (de)
JP (1)	JP4521185B2 (de)
KR (1)	KR100894673B1 (de)
CN (2)	CN100519561C (de)
AP (1)	AP1758A (de)
AR (1)	AR036501A1 (de)
AT (1)	ATE453648T1 (de)
AU (1)	AU2002333809C1 (de)
BR (1)	BRPI0212341B8 (de)
CA (1)	CA2459168C (de)
CY (1)	CY1109974T1 (de)
DE (1)	DE60234952D1 (de)
DK (1)	DK1448567T3 (de)
EA (1)	EA010883B1 (de)
ES (1)	ES2338538T3 (de)
HK (1)	HK1068887A1 (de)
HR (1)	HRP20040320B1 (de)
HU (1)	HU229505B1 (de)
IL (2)	IL160166A0 (de)
MX (1)	MXPA04002247A (de)
NO (1)	NO328934B1 (de)
NZ (1)	NZ531641A (de)
PL (1)	PL224030B1 (de)
PT (1)	PT1448567E (de)
SI (1)	SI21463B (de)
WO (1)	WO2003022853A1 (de)
ZA (1)	ZA200401501B (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2005533821A (ja) *	2002-06-27	2005-11-10	スミスクラインビーチャムコーポレーション	（３α，３α／β，６α／β）ヘキサヒドロフロ［２，３−ｂ］フラン−３−オールの立体異性体の調製
AU2003275675A1 (en) *	2002-12-27	2004-07-29	Sumitomo Chemical Company, Limited	Process for producing hexahydrofurofuranol derivative, intermediate thereof and process for producing the same
RS51073B (sr)	2003-12-23	2010-10-31	Tibotec Pharmaceuticals Ltd.	Proces za pripremanje (3r,3as,6ar)-heksahidrofuro│2,3-b│ furan-3-il (1s,2r)-3-││(4-aminofenil) sulfonil│(izobutil) amino │-1-benzil-2-hidroksipropilkarbamata
TWI383975B (zh) *	2004-03-31	2013-02-01	Tibotec Pharm Ltd	製備（３Ｒ，３ａＳ，６ａＲ）六氫-呋喃并〔２，３-ｂ〕呋喃-３-醇之方法
JP5549898B2 (ja) *	2006-03-31	2014-07-16	独立行政法人産業技術総合研究所	５−ヒドロキシメチル−２−フルフラールの製造法
ES2359949T3 (es) *	2006-11-09	2011-05-30	Tibotec Pharmaceuticals	Métodos para preparar hexhidrofuro(2,3-b)furan-3-ol.
CN101024646B (zh) *	2007-02-06	2010-07-14	启东东岳药业有限公司	4-甲氧基呋喃并呋喃-2-酮的纯化方法
DE602008005012D1 (de)	2007-04-27	2011-03-31	Little Island Co Cork	Herstellungsverfahren für n-isobutyl-n-(2-hydroxy-rivate
US8592487B2 (en)	2007-10-26	2013-11-26	Concert Pharmaceuticals, Inc.	Deuterated darunavir
AR073248A1 (es)	2008-09-01	2010-10-20	Tibotec Pharm Ltd	Proceso para la preparacion de (1s, 2r)-3- ((4-aminofenil) sulfonil) ( isobutil) amino)-1- bencil-2- hidroxipropilcarbamato de (3r, 3as,6ar)- hexahidrofuro-(2,3-b) furan-3- ilo (darunavir) y compuestos intermediarios utiles en dicho proceso.
EP2358198A4 (de) *	2008-10-24	2012-11-14	Concert Pharmaceuticals Inc	Hydroxyethylamino sulfonamid derivate
US8921415B2 (en)	2009-01-29	2014-12-30	Mapi Pharma Ltd.	Polymorphs of darunavir
BR112012009956A2 (pt)	2009-10-30	2015-09-29	Lupin Ltd	um novo processo para a preparação de darunavir e etanolato darunavir de tamanho de partícula.
BR112012018862A2 (pt)	2010-01-28	2015-10-13	Mapi Pharma Ltd	processo para a preparação de darunavir e intermediários de darunavir
WO2012070057A1 (en)	2010-11-23	2012-05-31	Matrix Laboratories Ltd	Process for the preparation of (3r, 3as, 6ar)-hexahydrofuro [2, 3- b] furan-3-ol
US8802724B2 (en)	2010-11-30	2014-08-12	Purdue Research Foundation	Processes and intermediates for preparing substituted hexahydrofuro [2,3-b] furans
US9475821B2 (en)	2012-07-24	2016-10-25	Laurus Labs Private Limited	Process for preparation of Darunavir
ES2657227T3 (es) *	2012-08-09	2018-03-02	Sumitomo Chemical Company, Limited	Método para producir un derivado de hexahidrofurofuranol
CN103864813B (zh) *	2012-12-18	2017-02-22	上海迪赛诺化学制药有限公司	一种合成六氢呋喃并[2,3‑b]呋喃‑3‑醇及其对映体的方法
US10633390B2 (en) *	2015-06-25	2020-04-28	Msn Laboratories Private Limited	Process for the preparation of [(1S,2R)-3-[[(4-aminophenyl)sulfonyl] (2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]-carbamic acid (3R,3AS,6AR)hexahydro furo [2,3-B]furan-3-YL ester and its amorphous form
WO2017041228A1 (zh) *	2015-09-08	2017-03-16	浙江九洲药业股份有限公司	六氢呋喃并呋喃醇衍生物的制备方法、其中间体及其制备方法
CN107043385B (zh) *	2016-02-05	2019-07-09	成都博腾药业有限公司	一种制备地瑞那韦中间体的方法
ES2881949T3 (es)	2016-10-27	2021-11-30	Gilead Sciences Inc	Forma cristalina de base libre de darunavir
CN106928248B (zh) *	2017-02-04	2019-01-04	青岛科技大学	一种制备(3R,3aS,6aR)六氢呋喃并[2,3-b]呋喃-3-醇的方法
CN110272398B (zh)	2018-03-16	2022-11-29	江苏瑞科医药科技有限公司	六氢呋喃并呋喃醇衍生物的制备方法、其中间体及其制备方法
CN114853774A (zh) *	2022-06-24	2022-08-05	盐城迪赛诺制药有限公司	一种达卢那韦关键中间体的制备方法
CN115557964A (zh) *	2022-10-18	2023-01-03	启东东岳药业有限公司	一种药物化合物的制备方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4325970A (en) *	1980-10-09	1982-04-20	Hoffmann-La Roche Inc.	15-Acetyl-prostaglandins
NZ224497A (en) *	1987-05-18	1990-04-26	Janssen Pharmaceutica Nv	Pharmaceutical composition comprising flunarizine
US5281420A (en) *	1992-05-19	1994-01-25	The Procter & Gamble Company	Solid dispersion compositions of tebufelone
WO1995006030A1 (en)	1993-08-24	1995-03-02	G.D. Searle & Co.	Hydroxyethylamino sulphonamides useful as retroviral protease inhibitors
WO1994026749A1 (en) *	1993-05-14	1994-11-24	Merck & Co., Inc.	Hiv protease inhibitors
RU2089545C1 (ru) *	1994-09-28	1997-09-10	Ярославский государственный технический университет	Способ получения 2-метил-2-этил-1,3-диоксолан-4-ил-метилметакрилата
DE19510566A1 (de) *	1995-03-23	1996-09-26	Kali Chemie Pharma Gmbh	Benzazepin-, Benzoxazepin- und Benzothiazepin-N-essigsäurederivate sowie Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
DE19638020A1 (de) *	1996-09-18	1998-03-19	Solvay Pharm Gmbh	Die gastrointestinale Durchblutung fördernde Arzneimittel
KR20050084502A (ko) *	1997-01-30	2005-08-26	노파르티스 아게	오일을 함유하지 않은 사이클로스포린 ａ 함유 제약 조성물
JP4776775B2 (ja)	1998-06-23	2011-09-21	アメリカ合衆国	Ｈｉｖ感染哺乳動物を治療するための医薬組成物
AU4828199A (en) *	1998-06-23	2000-01-10	Board Of Trustees Of The University Of Illinois, The	Multi-drug resistant retroviral protease inhibitors and associated methods
KR100336090B1 (ko) *	1998-06-27	2002-05-27	윤승원	오일, 지방산 또는 이들의 혼합물을 함유한 난용성 약물의 고형분산제제
DE19906310A1 (de) *	1999-02-16	2000-08-17	Solvay Pharm Gmbh	Arzneimittel zur Behandlung von Bluthochdruck
DE19932555A1 (de) *	1999-07-13	2001-01-18	Solvay Pharm Gmbh	Arzneimittel mit protektiver Wirkung gegen oxidativ-toxische und insbesondere gegen kardiotoxische Substanzen
KR100792391B1 (ko) *	1999-10-06	2008-01-08	티보텍 파마슈티칼즈 리미티드	레트로바이러스 프로테아제 저해제로서의헥사하이드로푸로[2,3-ｂ]푸란-3-일-Ｎ-[3-[(1,3-벤조디옥솔-5-일설포닐)(이소부틸)아미노]-1-벤질-2-하이드록시프로필]카바메이트

2002
- 2002-09-06 DE DE60234952T patent/DE60234952D1/de not_active Expired - Lifetime
- 2002-09-06 KR KR1020047002113A patent/KR100894673B1/ko active IP Right Grant
- 2002-09-06 CN CNB028176391A patent/CN100519561C/zh not_active Expired - Lifetime
- 2002-09-06 EP EP02797968A patent/EP1448567B1/de not_active Expired - Lifetime
- 2002-09-06 DK DK02797968.1T patent/DK1448567T3/da active
- 2002-09-06 BR BRPI0212341A patent/BRPI0212341B8/pt not_active IP Right Cessation
- 2002-09-06 PT PT02797968T patent/PT1448567E/pt unknown
- 2002-09-06 JP JP2003526927A patent/JP4521185B2/ja not_active Expired - Lifetime
- 2002-09-06 IL IL16016602A patent/IL160166A0/xx unknown
- 2002-09-06 SI SI200220026A patent/SI21463B/sl active Search and Examination
- 2002-09-06 AP APAP/P/2004/002981A patent/AP1758A/en active
- 2002-09-06 CA CA2459168A patent/CA2459168C/en not_active Expired - Lifetime
- 2002-09-06 AU AU2002333809A patent/AU2002333809C1/en not_active Expired
- 2002-09-06 MX MXPA04002247A patent/MXPA04002247A/es active IP Right Grant
- 2002-09-06 WO PCT/EP2002/010062 patent/WO2003022853A1/en active IP Right Grant
- 2002-09-06 PL PL367817A patent/PL224030B1/pl unknown
- 2002-09-06 US US10/489,059 patent/US7126015B2/en not_active Expired - Lifetime
- 2002-09-06 NZ NZ531641A patent/NZ531641A/en not_active IP Right Cessation
- 2002-09-06 HU HU0402140A patent/HU229505B1/hu unknown
- 2002-09-06 EA EA200400430A patent/EA010883B1/ru not_active IP Right Cessation
- 2002-09-06 AT AT02797968T patent/ATE453648T1/de active
- 2002-09-06 ES ES02797968T patent/ES2338538T3/es not_active Expired - Lifetime
- 2002-09-06 CN CN200710186668XA patent/CN101172980B/zh not_active Expired - Lifetime
- 2002-09-09 AR ARP020103403A patent/AR036501A1/es active IP Right Grant
2004
- 2004-02-02 IL IL160166A patent/IL160166A/en active IP Right Grant
- 2004-02-24 ZA ZA2004/01501A patent/ZA200401501B/en unknown
- 2004-04-05 HR HRP20040320AA patent/HRP20040320B1/hr not_active IP Right Cessation
- 2004-04-06 NO NO20041434A patent/NO328934B1/no not_active IP Right Cessation
2005
- 2005-02-23 HK HK05101515.9A patent/HK1068887A1/xx not_active IP Right Cessation
2010
- 2010-03-30 CY CY20101100296T patent/CY1109974T1/el unknown

Also Published As

Publication number	Publication date
DE60234952D1 (de)	2010-02-11
CA2459168A1 (en)	2003-03-20
EA200400430A1 (ru)	2004-08-26
EP1448567A1 (de)	2004-08-25
AP1758A (en)	2007-07-30
AU2002333809B9 (en)	2008-06-26
WO2003022853A1 (en)	2003-03-20
KR20040029425A (ko)	2004-04-06
EA010883B1 (ru)	2008-12-30
HUP0402140A2 (hu)	2005-02-28
BR0212341A (pt)	2004-07-27
SI21463B (sl)	2011-08-31
HU229505B1 (hu)	2014-01-28
PL224030B1 (pl)	2016-11-30
CA2459168C (en)	2014-01-28
BRPI0212341B1 (pt)	2019-04-02
NO20041434L (no)	2004-06-10
KR100894673B1 (ko)	2009-04-24
CN100519561C (zh)	2009-07-29
PT1448567E (pt)	2010-03-12
AR036501A1 (es)	2004-09-15
HUP0402140A3 (en)	2007-05-29
ZA200401501B (en)	2005-07-27
HK1068887A1 (en)	2005-05-06
US20040249175A1 (en)	2004-12-09
SI21463A (sl)	2004-10-31
EP1448567B1 (de)	2009-12-30
IL160166A0 (en)	2004-07-25
BRPI0212341B8 (pt)	2021-05-25
CN101172980B (zh)	2011-11-16
HRP20040320B1 (hr)	2012-11-30
MXPA04002247A (es)	2005-09-07
DK1448567T3 (da)	2010-04-26
US7126015B2 (en)	2006-10-24
ES2338538T3 (es)	2010-05-10
PL367817A1 (en)	2005-03-07
HRP20040320A2 (en)	2005-04-30
CN101172980A (zh)	2008-05-07
CN1553915A (zh)	2004-12-08
CY1109974T1 (el)	2014-09-10
IL160166A (en)	2012-05-31
NO328934B1 (no)	2010-06-21
AU2002333809B2 (en)	2008-02-28
NZ531641A (en)	2005-08-26
AP2004002981A0 (en)	2004-03-31
JP4521185B2 (ja)	2010-08-11
AU2002333809C1 (en)	2009-02-05
AU2002333809B8 (en)	2008-07-03
JP2005502707A (ja)	2005-01-27

Publication	Publication Date	Title
DE60221399D1 (de)	2007-09-06	Verfahren zur herstellung von mitteldistillaten
ATE403641T1 (de)	2008-08-15	Verfahren zur herstellung von o- desmethylvenlafaxin
ATE453648T1 (de)	2010-01-15	Verfahren zur herstellung von hexahydrofuroc2,3- büfuran-3-ol
ATE468309T1 (de)	2010-06-15	Verfahren zur herstellung von olefinen
ATE364497T1 (de)	2007-07-15	Verfahren zur herstellung von verbindungsprofilen
DE60230908D1 (de)	2009-03-05	Verfahren zur herstellung von polyarylenethern
AT7110U9 (de)	2004-11-25	Verfahren zur herstellung von amlodipinmaleat
ATE286011T1 (de)	2005-01-15	Verfahren zur herstellung von 1-octen
ATE374463T1 (de)	2007-10-15	Verfahren zur herstellung von oxazolidinonen
ATE506351T1 (de)	2011-05-15	Verfahren zur herstellung von 10,11-dihydro-10- oxo-5h-dibenzoäb,füazepin-5-carboxamid
ATE296287T1 (de)	2005-06-15	Verfahren zur herstellung von repaglinide
DE50102444D1 (de)	2004-07-01	Verfahren zur herstellung von isocyanatoorganosilanen
ATE316518T1 (de)	2006-02-15	Verfahren zur herstellung von (r)-2-alkyl-3- phenyl-1-propanolen
DE60236754D1 (de)	2010-07-29	Verfahren zur herstellung von polyoxyalkylenpolyetherprodukten
ATE358172T1 (de)	2007-04-15	Verfahren zur herstellung von olefinen.
DE60210911D1 (de)	2006-06-01	Verfahren zur Herstellung von dehnungserfassenden Vorrichtungen
ATE441662T1 (de)	2009-09-15	Verfahren zur herstellung von echinocandinderivaten
ATE360610T1 (de)	2007-05-15	Verfahren zur herstellung von cilastatin
DE60103173D1 (de)	2004-06-09	Verfahren zur herstellung von 3-amino-2-chlor-4-methylpyridin
DE50111560D1 (de)	2007-01-11	Verfahren zur herstellung von guerbetalkoholen
ATE553103T1 (de)	2012-04-15	Verfahren zur herstellung von (s)-pantoprazol
DE50303611D1 (de)	2006-07-06	Verfahren zur herstellung von polyisobuten
ATE273315T1 (de)	2004-08-15	Verfahren zur herstellung von n- phosphonomethyliminodiessigsäure
DE50200870D1 (de)	2004-09-23	Verfahren zur herstellung von hydroxyalkylpolysiloxanen
ATE323677T1 (de)	2006-05-15	Verfahren zur herstellung von 4-amino-2,5- bisheterocyclylchinazolinen

Legal Events

Date	Code	Title	Description
2010-07-15	UEP	Publication of translation of european patent specification	Ref document number: 1448567 Country of ref document: EP

Date

Code

Title

Description

2010-07-15

UEP

Publication of translation of european patent specification

Ref document number: 1448567

Country of ref document: EP