DK1448567T3 - Fremgangsmåde til fremstilling af hexahydrofuro 2,3-B furan-3-ol - Google Patents

Fremgangsmåde til fremstilling af hexahydrofuro 2,3-B furan-3-ol

Info

Publication number: DK1448567T3
Authority: DK; Denmark
Prior art keywords: hexahydrofuro; furan; preparing; preparing hexahydrofuro
Prior art date: 2001-09-10

Application number

DK02797968.1T

Other languages

English (en)

Inventor

Bart Rudolf Romanie Kesteleyn

Dominique Louis Nestor Ghislain Surleraux

Peter J L M Quaedflieg

Original Assignee

Tibotec Pharm Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-09-10

Filing date

2002-09-06

Publication date

2010-04-26

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8180908&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1448567(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2002-09-06 Application filed by Tibotec Pharm Ltd filed Critical Tibotec Pharm Ltd

2010-04-26 Application granted granted Critical

2010-04-26 Publication of DK1448567T3 publication Critical patent/DK1448567T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/20—Oxygen atoms
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Virology (AREA)
Tropical Medicine & Parasitology (AREA)
Molecular Biology (AREA)
AIDS & HIV (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Furan Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DK02797968.1T 2001-09-10 2002-09-06 Fremgangsmåde til fremstilling af hexahydrofuro 2,3-B furan-3-ol DK1448567T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP01203416		2001-09-10
PCT/EP2002/010062 WO2003022853A1 (en)	2001-09-10	2002-09-06	Method for the preparation of hexahydro-furo[2,3-b]furan-3-ol

Publications (1)

Publication Number	Publication Date
DK1448567T3 true DK1448567T3 (da)	2010-04-26

Family

ID=8180908

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK02797968.1T DK1448567T3 (da)	2001-09-10	2002-09-06	Fremgangsmåde til fremstilling af hexahydrofuro 2,3-B furan-3-ol

Country Status (28)

Country	Link
US (1)	US7126015B2 (da)
EP (1)	EP1448567B1 (da)
JP (1)	JP4521185B2 (da)
KR (1)	KR100894673B1 (da)
CN (2)	CN100519561C (da)
AP (1)	AP1758A (da)
AR (1)	AR036501A1 (da)
AT (1)	ATE453648T1 (da)
AU (1)	AU2002333809C1 (da)
BR (1)	BRPI0212341B8 (da)
CA (1)	CA2459168C (da)
CY (1)	CY1109974T1 (da)
DE (1)	DE60234952D1 (da)
DK (1)	DK1448567T3 (da)
EA (1)	EA010883B1 (da)
ES (1)	ES2338538T3 (da)
HK (1)	HK1068887A1 (da)
HR (1)	HRP20040320B1 (da)
HU (1)	HU229505B1 (da)
IL (2)	IL160166A0 (da)
MX (1)	MXPA04002247A (da)
NO (1)	NO328934B1 (da)
NZ (1)	NZ531641A (da)
PL (1)	PL224030B1 (da)
PT (1)	PT1448567E (da)
SI (1)	SI21463B (da)
WO (1)	WO2003022853A1 (da)
ZA (1)	ZA200401501B (da)

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JP2005533821A (ja) *	2002-06-27	2005-11-10	スミスクラインビーチャムコーポレーション	（３α，３α／β，６α／β）ヘキサヒドロフロ［２，３−ｂ］フラン−３−オールの立体異性体の調製
AU2003275675A1 (en) *	2002-12-27	2004-07-29	Sumitomo Chemical Company, Limited	Process for producing hexahydrofurofuranol derivative, intermediate thereof and process for producing the same
RS51073B (sr)	2003-12-23	2010-10-31	Tibotec Pharmaceuticals Ltd.	Proces za pripremanje (3r,3as,6ar)-heksahidrofuro│2,3-b│ furan-3-il (1s,2r)-3-││(4-aminofenil) sulfonil│(izobutil) amino │-1-benzil-2-hidroksipropilkarbamata
TWI383975B (zh) *	2004-03-31	2013-02-01	Tibotec Pharm Ltd	製備（３Ｒ，３ａＳ，６ａＲ）六氫-呋喃并〔２，３-ｂ〕呋喃-３-醇之方法
JP5549898B2 (ja) *	2006-03-31	2014-07-16	独立行政法人産業技術総合研究所	５−ヒドロキシメチル−２−フルフラールの製造法
ES2359949T3 (es) *	2006-11-09	2011-05-30	Tibotec Pharmaceuticals	Métodos para preparar hexhidrofuro(2,3-b)furan-3-ol.
CN101024646B (zh) *	2007-02-06	2010-07-14	启东东岳药业有限公司	4-甲氧基呋喃并呋喃-2-酮的纯化方法
DE602008005012D1 (de)	2007-04-27	2011-03-31	Little Island Co Cork	Herstellungsverfahren für n-isobutyl-n-(2-hydroxy-rivate
US8592487B2 (en)	2007-10-26	2013-11-26	Concert Pharmaceuticals, Inc.	Deuterated darunavir
AR073248A1 (es)	2008-09-01	2010-10-20	Tibotec Pharm Ltd	Proceso para la preparacion de (1s, 2r)-3- ((4-aminofenil) sulfonil) ( isobutil) amino)-1- bencil-2- hidroxipropilcarbamato de (3r, 3as,6ar)- hexahidrofuro-(2,3-b) furan-3- ilo (darunavir) y compuestos intermediarios utiles en dicho proceso.
EP2358198A4 (en) *	2008-10-24	2012-11-14	Concert Pharmaceuticals Inc	HYDROXYETHYLAMINO SULFONAMIDE DERIVATIVES
US8921415B2 (en)	2009-01-29	2014-12-30	Mapi Pharma Ltd.	Polymorphs of darunavir
BR112012009956A2 (pt)	2009-10-30	2015-09-29	Lupin Ltd	um novo processo para a preparação de darunavir e etanolato darunavir de tamanho de partícula.
BR112012018862A2 (pt)	2010-01-28	2015-10-13	Mapi Pharma Ltd	processo para a preparação de darunavir e intermediários de darunavir
WO2012070057A1 (en)	2010-11-23	2012-05-31	Matrix Laboratories Ltd	Process for the preparation of (3r, 3as, 6ar)-hexahydrofuro [2, 3- b] furan-3-ol
US8802724B2 (en)	2010-11-30	2014-08-12	Purdue Research Foundation	Processes and intermediates for preparing substituted hexahydrofuro [2,3-b] furans
US9475821B2 (en)	2012-07-24	2016-10-25	Laurus Labs Private Limited	Process for preparation of Darunavir
ES2657227T3 (es) *	2012-08-09	2018-03-02	Sumitomo Chemical Company, Limited	Método para producir un derivado de hexahidrofurofuranol
CN103864813B (zh) *	2012-12-18	2017-02-22	上海迪赛诺化学制药有限公司	一种合成六氢呋喃并[2,3‑b]呋喃‑3‑醇及其对映体的方法
US10633390B2 (en) *	2015-06-25	2020-04-28	Msn Laboratories Private Limited	Process for the preparation of [(1S,2R)-3-[[(4-aminophenyl)sulfonyl] (2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]-carbamic acid (3R,3AS,6AR)hexahydro furo [2,3-B]furan-3-YL ester and its amorphous form
WO2017041228A1 (zh) *	2015-09-08	2017-03-16	浙江九洲药业股份有限公司	六氢呋喃并呋喃醇衍生物的制备方法、其中间体及其制备方法
CN107043385B (zh) *	2016-02-05	2019-07-09	成都博腾药业有限公司	一种制备地瑞那韦中间体的方法
ES2881949T3 (es)	2016-10-27	2021-11-30	Gilead Sciences Inc	Forma cristalina de base libre de darunavir
CN106928248B (zh) *	2017-02-04	2019-01-04	青岛科技大学	一种制备(3R,3aS,6aR)六氢呋喃并[2,3-b]呋喃-3-醇的方法
CN110272398B (zh)	2018-03-16	2022-11-29	江苏瑞科医药科技有限公司	六氢呋喃并呋喃醇衍生物的制备方法、其中间体及其制备方法
CN114853774A (zh) *	2022-06-24	2022-08-05	盐城迪赛诺制药有限公司	一种达卢那韦关键中间体的制备方法
CN115557964A (zh) *	2022-10-18	2023-01-03	启东东岳药业有限公司	一种药物化合物的制备方法

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2002
- 2002-09-06 DE DE60234952T patent/DE60234952D1/de not_active Expired - Lifetime
- 2002-09-06 KR KR1020047002113A patent/KR100894673B1/ko active IP Right Grant
- 2002-09-06 CN CNB028176391A patent/CN100519561C/zh not_active Expired - Lifetime
- 2002-09-06 EP EP02797968A patent/EP1448567B1/en not_active Expired - Lifetime
- 2002-09-06 DK DK02797968.1T patent/DK1448567T3/da active
- 2002-09-06 BR BRPI0212341A patent/BRPI0212341B8/pt not_active IP Right Cessation
- 2002-09-06 PT PT02797968T patent/PT1448567E/pt unknown
- 2002-09-06 JP JP2003526927A patent/JP4521185B2/ja not_active Expired - Lifetime
- 2002-09-06 IL IL16016602A patent/IL160166A0/xx unknown
- 2002-09-06 SI SI200220026A patent/SI21463B/sl active Search and Examination
- 2002-09-06 AP APAP/P/2004/002981A patent/AP1758A/en active
- 2002-09-06 CA CA2459168A patent/CA2459168C/en not_active Expired - Lifetime
- 2002-09-06 AU AU2002333809A patent/AU2002333809C1/en not_active Expired
- 2002-09-06 MX MXPA04002247A patent/MXPA04002247A/es active IP Right Grant
- 2002-09-06 WO PCT/EP2002/010062 patent/WO2003022853A1/en active IP Right Grant
- 2002-09-06 PL PL367817A patent/PL224030B1/pl unknown
- 2002-09-06 US US10/489,059 patent/US7126015B2/en not_active Expired - Lifetime
- 2002-09-06 NZ NZ531641A patent/NZ531641A/en not_active IP Right Cessation
- 2002-09-06 HU HU0402140A patent/HU229505B1/hu unknown
- 2002-09-06 EA EA200400430A patent/EA010883B1/ru not_active IP Right Cessation
- 2002-09-06 AT AT02797968T patent/ATE453648T1/de active
- 2002-09-06 ES ES02797968T patent/ES2338538T3/es not_active Expired - Lifetime
- 2002-09-06 CN CN200710186668XA patent/CN101172980B/zh not_active Expired - Lifetime
- 2002-09-09 AR ARP020103403A patent/AR036501A1/es active IP Right Grant
2004
- 2004-02-02 IL IL160166A patent/IL160166A/en active IP Right Grant
- 2004-02-24 ZA ZA2004/01501A patent/ZA200401501B/en unknown
- 2004-04-05 HR HRP20040320AA patent/HRP20040320B1/hr not_active IP Right Cessation
- 2004-04-06 NO NO20041434A patent/NO328934B1/no not_active IP Right Cessation
2005
- 2005-02-23 HK HK05101515.9A patent/HK1068887A1/xx not_active IP Right Cessation
2010
- 2010-03-30 CY CY20101100296T patent/CY1109974T1/el unknown

Also Published As

Publication number	Publication date
DE60234952D1 (de)	2010-02-11
CA2459168A1 (en)	2003-03-20
EA200400430A1 (ru)	2004-08-26
EP1448567A1 (en)	2004-08-25
AP1758A (en)	2007-07-30
AU2002333809B9 (en)	2008-06-26
WO2003022853A1 (en)	2003-03-20
KR20040029425A (ko)	2004-04-06
EA010883B1 (ru)	2008-12-30
HUP0402140A2 (hu)	2005-02-28
BR0212341A (pt)	2004-07-27
SI21463B (sl)	2011-08-31
HU229505B1 (hu)	2014-01-28
PL224030B1 (pl)	2016-11-30
CA2459168C (en)	2014-01-28
BRPI0212341B1 (pt)	2019-04-02
NO20041434L (no)	2004-06-10
KR100894673B1 (ko)	2009-04-24
CN100519561C (zh)	2009-07-29
PT1448567E (pt)	2010-03-12
AR036501A1 (es)	2004-09-15
HUP0402140A3 (en)	2007-05-29
ZA200401501B (en)	2005-07-27
HK1068887A1 (en)	2005-05-06
US20040249175A1 (en)	2004-12-09
SI21463A (sl)	2004-10-31
EP1448567B1 (en)	2009-12-30
IL160166A0 (en)	2004-07-25
BRPI0212341B8 (pt)	2021-05-25
CN101172980B (zh)	2011-11-16
ATE453648T1 (de)	2010-01-15
HRP20040320B1 (hr)	2012-11-30
MXPA04002247A (es)	2005-09-07
US7126015B2 (en)	2006-10-24
ES2338538T3 (es)	2010-05-10
PL367817A1 (en)	2005-03-07
HRP20040320A2 (en)	2005-04-30
CN101172980A (zh)	2008-05-07
CN1553915A (zh)	2004-12-08
CY1109974T1 (el)	2014-09-10
IL160166A (en)	2012-05-31
NO328934B1 (no)	2010-06-21
AU2002333809B2 (en)	2008-02-28
NZ531641A (en)	2005-08-26
AP2004002981A0 (en)	2004-03-31
JP4521185B2 (ja)	2010-08-11
AU2002333809C1 (en)	2009-02-05
AU2002333809B8 (en)	2008-07-03
JP2005502707A (ja)	2005-01-27

Publication	Publication Date	Title
DK1448567T3 (da)	2010-04-26	Fremgangsmåde til fremstilling af hexahydrofuro 2,3-B furan-3-ol
DK1277722T3 (da)	2005-04-25	Fremgangsmåde til fremstilling af methanol
EP1401840A4 (en)	2007-05-16	NEW 4-AMINO-5,6-SUBSTITUTED THIOPHENO 2,3 D \| PYRIMIDINE
DE60135854D1 (de)	2008-10-30	2-(4-Pyridyl)amino-6-dialkoxyphenyl-pyrido(2,3-d)pyrimidin-7-one
ATE314370T1 (de)	2006-01-15	2-(pyridin-2-ylamino)-pyrido(2,3-d)pyrimidin-7- one
DE60207241D1 (de)	2005-12-15	5-amino-5-phenyl-7-cyclobutyl-pyrrolo(2,3-d)pyrimidin-derivate
NO20034969D0 (no)	2003-11-07	Fremgangsmåte for fremstilling av olefiner
SI1416935T1 (sl)	2008-08-31	4-amino-6-fenil-pirolo(2,3-d)pirimidinski derivati
DE60205413D1 (de)	2005-09-15	Herstellungsverfahren
DK2135957T3 (da)	2019-05-13	Fremgangsmåde til fremstilling af glucaner
IS6487A (is)	2002-07-29	Aðferð til framleiðslu á Sítalóprami
IS7755A (is)	2005-03-17	Aðferð við framleiðslu á (S,S)-cis-2-benshýdríl-3-bensýlamínókínuklídín
DK1608653T3 (da)	2009-10-05	Substituerede 8-perfluoroalkyl-6,7,8,9- tetrahydropyrimido (1,2-a) pyrimidin-4-on derivater
DK1608654T3 (da)	2010-04-26	8-substituerede-6, 7, 8, 9-tetrahydropyrimido (1,2- a) pyrimidin-4-on-derivater
DK1373268T3 (da)	2008-10-13	Fremgangsmåde til fremstilling af anagrelid
NO20041200L (no)	2004-03-23	Fremgangsmate for fremstilling av citalopram.
AP2006003748A0 (en)	2006-10-31	Methods for the preparation of (3R,3aS,6aR) hexahydro-furo !2,3-b!furan-3-ol
DK1958938T3 (da)	2011-07-25	Fremgangsmåde til fremstilling af 10,11-dihydro-10-oxo-5H-dibenz[b,f]azepin-5-carboxamid
DE60205256D1 (de)	2005-09-01	Längliche, verfestigte thermoplastische hohlkörper
DK1322651T3 (da)	2008-06-02	Bicykliske, heteroaromatiske forbindelser
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