[go: up one dir, main page]

ATE437672T1 - Vorrichtung zur okularen iontophorese zur verabreichung mehrerer wirkstoffe - Google Patents

Vorrichtung zur okularen iontophorese zur verabreichung mehrerer wirkstoffe

Info

Publication number
ATE437672T1
ATE437672T1 AT04011635T AT04011635T ATE437672T1 AT E437672 T1 ATE437672 T1 AT E437672T1 AT 04011635 T AT04011635 T AT 04011635T AT 04011635 T AT04011635 T AT 04011635T AT E437672 T1 ATE437672 T1 AT E437672T1
Authority
AT
Austria
Prior art keywords
occular
administration
active ingredients
reservoir
iontophoresis device
Prior art date
Application number
AT04011635T
Other languages
English (en)
Inventor
Jean-Marie Parel
Francine Behar
Original Assignee
Eyegate Pharma Sas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eyegate Pharma Sas filed Critical Eyegate Pharma Sas
Application granted granted Critical
Publication of ATE437672T1 publication Critical patent/ATE437672T1/de

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/172Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/02Details
    • A61N1/04Electrodes
    • A61N1/0404Electrodes for external use
    • A61N1/0408Use-related aspects
    • A61N1/0428Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
    • A61N1/0432Anode and cathode
    • A61N1/044Shape of the electrode
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008Introducing ophthalmic products into the ocular cavity or retaining products therein
    • A61F9/0017Introducing ophthalmic products into the ocular cavity or retaining products therein implantable in, or in contact with, the eye, e.g. ocular inserts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/02Details
    • A61N1/04Electrodes
    • A61N1/0404Electrodes for external use
    • A61N1/0408Use-related aspects
    • A61N1/0428Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
    • A61N1/0448Drug reservoir

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Electrotherapy Devices (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
AT04011635T 1998-01-05 1998-12-17 Vorrichtung zur okularen iontophorese zur verabreichung mehrerer wirkstoffe ATE437672T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9800009A FR2773320B1 (fr) 1998-01-05 1998-01-05 Dispositif pour le transfert intraoculaire de produits actifs par iontophorese

Publications (1)

Publication Number Publication Date
ATE437672T1 true ATE437672T1 (de) 2009-08-15

Family

ID=9521510

Family Applications (2)

Application Number Title Priority Date Filing Date
AT04011635T ATE437672T1 (de) 1998-01-05 1998-12-17 Vorrichtung zur okularen iontophorese zur verabreichung mehrerer wirkstoffe
AT98403189T ATE292493T1 (de) 1998-01-05 1998-12-17 Vorrichtung zur intraokularen übertragung von aktiven wirkstoffen durch iontophorese

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT98403189T ATE292493T1 (de) 1998-01-05 1998-12-17 Vorrichtung zur intraokularen übertragung von aktiven wirkstoffen durch iontophorese

Country Status (13)

Country Link
US (1) US6154671A (de)
EP (2) EP1452203B1 (de)
JP (1) JP4308353B2 (de)
KR (1) KR100551706B1 (de)
AT (2) ATE437672T1 (de)
BR (1) BR9900009A (de)
CA (1) CA2257749C (de)
DE (2) DE69829637T2 (de)
DK (1) DK0927560T3 (de)
ES (2) ES2327636T3 (de)
FR (1) FR2773320B1 (de)
IL (1) IL127711A (de)
PT (1) PT927560E (de)

Families Citing this family (83)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7346389B1 (en) * 1998-09-24 2008-03-18 Newsome David A Dilation enhancer with pre-medicated contact lenses
US6101411A (en) * 1998-09-24 2000-08-08 Newsome; David A. Dilation enhancer
US6319240B1 (en) * 1999-05-25 2001-11-20 Iomed, Inc. Methods and apparatus for ocular iontophoresis
US6728573B1 (en) * 2000-02-23 2004-04-27 Iomed, Inc. Ocular iontophoretic apparatus handle
US7252655B2 (en) * 1999-05-25 2007-08-07 Iomed, Inc. Ocular iontophoretic apparatus handle
US6539251B2 (en) 1999-05-25 2003-03-25 Iomed, Inc. Ocular iontophoretic apparatus
US6546283B1 (en) 2000-10-18 2003-04-08 Iomed, Inc. High current density iontophoretic device and method of use thereof
US20030045830A1 (en) * 2001-04-17 2003-03-06 De Bizemont Therese Gene therapy with chimeric oligonucleotides delivered by a method comprising a step of iontophoresis
US20050004625A1 (en) * 2001-06-29 2005-01-06 Chow Alan Y. Treatment of degenerative retinal disease via electrical stimulation of surface structures
US20050033202A1 (en) * 2001-06-29 2005-02-10 Chow Alan Y. Mechanically activated objects for treatment of degenerative retinal disease
US7031776B2 (en) * 2001-06-29 2006-04-18 Optobionics Methods for improving damaged retinal cell function
US20040106965A1 (en) * 2001-06-29 2004-06-03 Chow Alan Y. Methods and apparatus for treatment of degenerative retinal disease via indirect electrical stimulation
JP2004535462A (ja) * 2001-07-20 2004-11-25 イオメド インコーポレイテッド 眼、眼球結膜、眼瞼結膜、瞼、眼窩周囲の軟組織及び皮膚の細胞増殖阻害剤として、イオン導入によって送達する5−フルオロウラシルの使用方法。
DE60219189T2 (de) * 2001-07-20 2008-01-03 Iomed, Inc., Salt Lake City Iontophoretische okularvorrichtung zur abgabe von medikamenten auf methotrexat-basis und deren verwendung zur behandlung von neoplastischen, angiogenen, fibroplastischen und/oder immunsuppressiven augenunregelmässigkeiten
FR2830766B1 (fr) * 2001-10-12 2004-03-12 Optis France Sa Dispositif de delivrance de medicaments par iontophorese transpalpebrale
FR2830767B1 (fr) * 2001-10-12 2004-03-12 Optis France Sa Dispositif de delivrance de medicaments par iontophorese ou electroporation introculaire
FR2836832B1 (fr) 2002-03-08 2005-02-04 Optis France Sa Ensemble de connexion a usage medical pour le transfert de fluides
ZA200408449B (en) 2002-05-17 2007-09-26 Othera Pharmaceuticals Inc Amelioration of the development of cataracts and other opthalmic diseases
FR2851912B1 (fr) 2003-03-03 2005-05-13 Optis France Sa Connecteur d'alimentation uniforme pour des dispositifs de delivrance de principes actifs
US7589107B2 (en) 2003-05-19 2009-09-15 Othera Holding, Inc. Amelioration of vitrectomy-induced cataracts
US7825134B2 (en) * 2003-05-19 2010-11-02 Othera Holding, Inc. Amelioration of cataracts, macular degeneration and other ophthalmic diseases
FR2855761B1 (fr) * 2003-06-03 2006-02-24 Optis France Sa Dispositif oculaire de delivrance variable de principes actifs par iontophorese
CN100558360C (zh) * 2003-11-20 2009-11-11 奥特拉控股公司 羟胺组合物在制备缓解黄斑变性和其他眼科疾病的药物中的用途
AU2005212306B2 (en) * 2004-02-06 2010-07-01 Biovisics Medical, Inc. Treatment of vision disorders using electrical, light, and/or sound energy
BRPI0509334A (pt) 2004-04-30 2007-10-16 Eyegate Pharma S A dispositivo de iontoforese ocular, que diminui as irritações
FR2869531B1 (fr) * 2004-04-30 2006-07-14 Optis France Sa Sa Dispositif de iontophorese oculaire diminuant les irritations
CN1964711A (zh) * 2004-05-25 2007-05-16 奥特拉药物公司 眼睛选择性药物及前体药物
US20060089590A1 (en) * 2004-10-27 2006-04-27 John Higuchi Methods and devices for sustained in-vivo release of an active agent
US7229468B2 (en) * 2004-11-23 2007-06-12 Wong Jr Edward K Medical device and method for temperature control and treatment of the eye and surrounding tissues
US8262715B2 (en) * 2004-11-23 2012-09-11 Eye Delivery System, Llc Medical device and method for temperature control and treatment of the eye and surrounding tissues via magnetic drug therapy
US20070282282A1 (en) * 2004-11-23 2007-12-06 Wong Edward K Jr Medical device and method for temperature control and treatment of the eye and surrounding tissues
WO2006072887A1 (en) * 2005-01-05 2006-07-13 Eyegate Pharma Sa Ocular iontophoresis device for delivering sirna and aptamers
WO2006123248A2 (en) * 2005-04-18 2006-11-23 INSERM (Institut National de la Santé et de la Recherche Médicale) Improved methods and devices for delivering a therapeutic product to the ocular sphere of a subject
WO2006127592A2 (en) * 2005-05-26 2006-11-30 Othera Pharmaceuticals, Inc. Use of hydroxylamine derivates for inhibiting vitrectomy-induced cataracts
US20070260171A1 (en) * 2005-09-27 2007-11-08 Higuchi John W Intraocular iontophoretic device and associated methods
US8755880B2 (en) * 2005-10-24 2014-06-17 Aciont, Inc. Intraocular iontophoretic device and associated methods
US8634907B2 (en) 2005-10-24 2014-01-21 Aciont, Inc. Intraocular iontophoretic device and associated methods
EP1940507A4 (de) * 2005-10-24 2011-04-20 Aciont Inc Intraokulare iontophoretische vorrichtung und relevante verfahren
US8099162B2 (en) * 2005-11-29 2012-01-17 Eyegate Pharma, S.A.S. Ocular iontophoresis device
FR2893852B1 (fr) * 2005-11-29 2010-09-03 Eyegate Pharma Sa Dispositif d'iontophorese oculaire
US20070203190A1 (en) * 2006-02-22 2007-08-30 Ghanshyam Patil Hydroxylamines and derivatives for the inhibition of complement activation
US20070202186A1 (en) 2006-02-22 2007-08-30 Iscience Interventional Corporation Apparatus and formulations for suprachoroidal drug delivery
JPWO2007123142A1 (ja) * 2006-04-20 2009-09-03 Tti・エルビュー株式会社 イオントフォレーシス装置
US20070299386A1 (en) * 2006-06-23 2007-12-27 Minu, L.L.C. Delivery of an ocular agent using iontophoresis
WO2008013913A2 (en) * 2006-07-26 2008-01-31 Aciont, Inc. Method and device for minimally invasive site specific ocular drug delivery
US8923961B2 (en) 2006-10-18 2014-12-30 The Cleveland Clinic Foundation Electrode assembly for delivering a therapeutic agent into ocular tissue
CN105998028A (zh) 2007-02-22 2016-10-12 科尔比制药公司 羟胺化合物及其用法
US9125807B2 (en) 2007-07-09 2015-09-08 Incept Llc Adhesive hydrogels for ophthalmic drug delivery
US8480638B2 (en) * 2007-10-04 2013-07-09 Aciont, Inc. Intraocular iontophoretic device and associated methods
JP2011505917A (ja) * 2007-12-05 2011-03-03 アイゲート ファーマ エスエーエス イオントフォレシスによってsiRNAを送達する方法
CN101970042A (zh) * 2008-02-25 2011-02-09 眼门药品公司 经由离子电渗法增强递送治疗药物至眼部组织
FR2928536B1 (fr) 2008-03-14 2012-04-27 Inst Nat Sante Rech Med Dispositif d'injection dans l'oeil
EP2370155B1 (de) * 2008-12-31 2018-07-04 Eyegate Pharmaceuticals, Inc. System für augeniontophorese mit pufferung
CA2750242C (en) 2009-02-12 2018-05-22 Incept, Llc Drug delivery through hydrogel plugs
AU2011233663B2 (en) 2010-04-03 2016-04-14 Praful Doshi Medical devices including medicaments and methods of making and using same
US10413506B2 (en) 2010-04-03 2019-09-17 Praful Doshi Medical devices including medicaments and methods of making and using same including enhancing comfort, enhancing drug penetration, and treatment of myopia
AU2011270754B2 (en) 2010-06-25 2015-04-23 The U.S.A., As Represented By The Secretary, Department Of Health And Human Services Methods of treatment using sterculic acid
US8961501B2 (en) 2010-09-17 2015-02-24 Incept, Llc Method for applying flowable hydrogels to a cornea
WO2012051575A2 (en) 2010-10-15 2012-04-19 Iscience Interventional Corporation Device for ocular access
ES2539717T3 (es) * 2011-01-12 2015-07-03 Sooft Italia S.P.A. Dispositivo para la administración corneal de rivoflavina mediante iontoforesis para el tratamiento de queratocono
WO2012162459A1 (en) * 2011-05-26 2012-11-29 Pepose Jay Device and method for administering eye medications
US10226417B2 (en) 2011-09-16 2019-03-12 Peter Jarrett Drug delivery systems and applications
WO2013086015A1 (en) 2011-12-05 2013-06-13 Incept, Llc Medical organogel processes and compositions
US10981961B2 (en) 2013-03-11 2021-04-20 University Of Florida Research Foundation, Incorporated Delivery of card protein as therapy for occular inflammation
AU2014259694B2 (en) 2013-05-03 2018-11-08 Clearside Biomedical, Inc. Apparatus and methods for ocular injection
ITVE20130043A1 (it) * 2013-07-31 2015-02-01 I A C E R S R L Dispositivo perfezionato oftalmologico per il trattamento di malattie corneali quali il cheratocono.
ES2672327T3 (es) * 2014-01-27 2018-06-13 Opia Technologies Dispositivo de iontoforesis ocular
JP5828535B1 (ja) * 2014-10-10 2015-12-09 石根 三井 矯正角膜クロスリンキング用コンタクトレンズ
CN104353183B (zh) * 2014-10-31 2016-12-07 厦门微科格瑞生物科技有限公司 电解液位置固定的可佩戴智能药物导入结构
BR112017009054A2 (pt) 2015-01-22 2018-01-30 Eyegate Pharmaceuticals Inc lente de contato para terapia ocular.
US10206814B2 (en) * 2016-01-06 2019-02-19 David R. Hardten System and method for the delivery of medications or fluids to the eye
EP3452165A1 (de) * 2016-05-02 2019-03-13 Clearside Biomedical, Inc. Systeme und verfahren zur verabreichung eines augenmedikaments
IL305537B2 (en) 2016-08-12 2025-02-01 Clearside Biomedical Inc Devices and methods for adjusting the insertion depth of a needle for administering a drug
JP2020513983A (ja) 2017-03-23 2020-05-21 ドヘニー アイ インスティテュート 光干渉断層撮影の多重en−face血管造影平均化システム、方法および装置
WO2020072468A1 (en) 2018-10-01 2020-04-09 Biovisics Medical, Llc System and methods for controlled electrical modulation for vision therapy
EP3886974A2 (de) 2018-11-30 2021-10-06 Biovisics Medical, Inc. Kopfgetragene vorrichtungen für die sichttherapie
US11399976B2 (en) 2019-01-09 2022-08-02 Twenty Twenty Therapeutics Llc Eye mounted device for therapeutic agent release
BR112021013451A2 (pt) 2019-01-09 2021-10-19 Twenty Twenty Therapeutics Llc Método, sistema, e, meio de armazenamento legível por máquina não transitório
WO2020210471A1 (en) 2019-04-10 2020-10-15 Biovisics Medical, Inc. Systems and interfaces for ocular therapy
ES2992491T3 (es) 2019-06-14 2024-12-13 I Lumen Scient Inc Dispositivo médico portátil
WO2021011255A1 (en) 2019-07-12 2021-01-21 Biovisics Medical, Inc. Ocular therapy modes and systems
CN110547907A (zh) * 2019-08-15 2019-12-10 中南大学湘雅二医院 一种用于眼内手术的双环虹膜扩张器
EP4529903A1 (de) 2022-07-08 2025-04-02 Terumo Kabushiki Kaisha Vorrichtung zur verabreichung eines intraokularen arzneimittels, wirkstoffreservoir und verfahren zum betrieb einer vorrichtung zur verabreichung eines intraokularen arzneimittels

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US551880A (en) * 1895-12-24 Theodore b
US2525381A (en) * 1947-09-25 1950-10-10 Tower Paul Contact-type electrode holder
US3122137A (en) * 1961-10-30 1964-02-25 Erlanger Gustav Device for facilitating iontophoresis treatment of eyes
SU995783A1 (ru) 1980-07-21 1983-02-15 Омский Государственный Ордена Трудового Красного Знамени Медицинский Институт Им.М.И.Калинина Устройство дл электрофореза лекарственных веществ в ткани глаза
US4678466A (en) * 1981-06-25 1987-07-07 Rosenwald Peter L Internal medication delivery method and vehicle
US4564016A (en) 1982-05-24 1986-01-14 The Board Of Trustees Of The Leland Stanford Junior University Apparatus for introducing ionized drugs into the posterior segment of the eye and method
US5053000A (en) * 1985-11-13 1991-10-01 Imperial Chemical Industries Plc Ocular treatment
IL86076A (en) * 1988-04-14 1992-12-01 Inventor S Funding Corp Ltd Transdermal drug delivery device
US4955378A (en) * 1988-05-02 1990-09-11 University Of South Florida Apparatus and methods for performing electrofusion at specific anatomical sites
EP0464138A1 (de) * 1989-03-17 1992-01-08 Candela Laser Corporation Lasertherapiestrahlgerät für glaukombehandlung
US5174304A (en) * 1990-02-16 1992-12-29 Latina Mark A Electrocycloablation apparatus and method
US5472436A (en) * 1994-07-26 1995-12-05 Fremstad; Daria A. Ocular appliance for delivering medication
US5522864A (en) * 1994-10-25 1996-06-04 Wallace; Larry B. Apparatus and method for ocular treatment
AUPM982694A0 (en) * 1994-12-02 1995-01-05 University Of Queensland, The Iontophoresis method and apparatus
US5676648A (en) * 1996-05-08 1997-10-14 The Aps Organization, Llp Iontophoretic drug delivery apparatus and method for use

Also Published As

Publication number Publication date
CA2257749A1 (en) 1999-07-05
US6154671A (en) 2000-11-28
CA2257749C (en) 2009-03-24
ES2327636T3 (es) 2009-11-02
IL127711A0 (en) 1999-10-28
DE69829637T2 (de) 2006-03-09
EP0927560B1 (de) 2005-04-06
EP1452203A2 (de) 2004-09-01
DE69841028D1 (de) 2009-09-10
JP4308353B2 (ja) 2009-08-05
FR2773320B1 (fr) 2000-03-03
KR19990066875A (ko) 1999-08-16
ATE292493T1 (de) 2005-04-15
DK0927560T3 (da) 2005-08-15
DE69829637D1 (de) 2005-05-12
FR2773320A1 (fr) 1999-07-09
KR100551706B1 (ko) 2006-07-06
PT927560E (pt) 2005-07-29
JPH11244323A (ja) 1999-09-14
EP1452203B1 (de) 2009-07-29
ES2236880T3 (es) 2005-07-16
IL127711A (en) 2004-06-20
EP0927560A1 (de) 1999-07-07
EP1452203A3 (de) 2004-09-08
BR9900009A (pt) 2001-03-20

Similar Documents

Publication Publication Date Title
ATE437672T1 (de) Vorrichtung zur okularen iontophorese zur verabreichung mehrerer wirkstoffe
US20250032782A1 (en) Nasal stimulation devices and methods
US6101411A (en) Dilation enhancer
Kane et al. A history of local electrical analgesia
Szeto et al. Sensory feedback using electrical stimulation of the tactile sense
US3991755A (en) Iontophoresis apparatus for applying local anesthetics
US7346389B1 (en) Dilation enhancer with pre-medicated contact lenses
Koshino et al. Enhancement of rolandic mu-rhythm by pattern vision
DE60022544D1 (de) Behandlung von augenerkrankungen
EP2158937A3 (de) Künstliche Netzhautvorrichtung
US6083250A (en) Apparatus and method for inhibiting lesion formation by selectively treating the prodromal stage of the lesion with a pulsatile electrical stimulation
WO2003039622A3 (en) Novel iontophoretic drug delivery systems
Alberts A simple view of parkinsonian tremor. Electrical stimulation of cortex adjacent to the rolandic fissure in awake man
DE69724168D1 (de) Vorrichtung zur Behandlung des menschlichen Körpers durch endermatische Elektrotherapie
Dillman et al. Levator myectomy in synkinetic ptosis
Reynolds Lectures on the clinical uses of electricity
Bierman Diagnosis and treatment of Bell's palsy
Landau A physiological-anatomical analysis of nerve function: the peripheral pathway for pain
SU942744A1 (ru) Устройство дл электрофореза лекарственных веществ в ткани глаза
CN2282899Y (zh) 离子导入仪的接口电路及电极
AU2017204782B2 (en) Nasal stimulation devices and methods
Sukhomlinova et al. Normal Physiology. Module 1
Mądroszkiewicz New Method of Operation for Detachment of the Retina with tearing of the Macula lutea
Novello et al. An ethnological approach to self-injurious behavior
Colborn et al. The variable anatomy of the nerve to the extensor carpi radialis brevis

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties