ATE316377T1 - Tricyclopolyazamacrocyclophosphonsäuren, ihre komplexe und derivate, für eine verwendung als kontrastmittel - Google Patents
Tricyclopolyazamacrocyclophosphonsäuren, ihre komplexe und derivate, für eine verwendung als kontrastmittelInfo
- Publication number
- ATE316377T1 ATE316377T1 AT94916043T AT94916043T ATE316377T1 AT E316377 T1 ATE316377 T1 AT E316377T1 AT 94916043 T AT94916043 T AT 94916043T AT 94916043 T AT94916043 T AT 94916043T AT E316377 T1 ATE316377 T1 AT E316377T1
- Authority
- AT
- Austria
- Prior art keywords
- complexes
- derivatives
- contrast agents
- tricyclopolyazamacrocyclophosphonic
- acids
- Prior art date
Links
- 239000002253 acid Substances 0.000 title abstract 2
- 239000002872 contrast media Substances 0.000 title abstract 2
- 150000007513 acids Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 150000002500 ions Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/18—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
- G01R33/281—Means for the use of in vitro contrast agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- General Physics & Mathematics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Luminescent Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/058,622 US5385893A (en) | 1993-05-06 | 1993-05-06 | Tricyclopolyazamacrocyclophosphonic acids, complexes and derivatives thereof, for use as contrast agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE316377T1 true ATE316377T1 (de) | 2006-02-15 |
Family
ID=22017946
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT94916043T ATE316377T1 (de) | 1993-05-06 | 1994-05-06 | Tricyclopolyazamacrocyclophosphonsäuren, ihre komplexe und derivate, für eine verwendung als kontrastmittel |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US5385893A (de) |
| EP (1) | EP0697872B1 (de) |
| JP (1) | JP3553940B2 (de) |
| KR (1) | KR960702462A (de) |
| CN (1) | CN1125906A (de) |
| AT (1) | ATE316377T1 (de) |
| AU (1) | AU687400B2 (de) |
| BG (1) | BG100194A (de) |
| CA (1) | CA2162172A1 (de) |
| DE (1) | DE69434618T2 (de) |
| FI (1) | FI955336A (de) |
| HU (1) | HUT72649A (de) |
| LV (1) | LV11429B (de) |
| NO (1) | NO954441L (de) |
| PL (1) | PL311649A1 (de) |
| SG (1) | SG46496A1 (de) |
| WO (1) | WO1994026276A1 (de) |
Families Citing this family (72)
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| US5645818A (en) * | 1989-03-24 | 1997-07-08 | Guerbet S.A. | Diagnostic compositions comprising a complex formed by a nitrogenous macrocyclic ligand with metal ions |
| US5739294A (en) * | 1991-12-10 | 1998-04-14 | The Dow Chemical Company | Bicyclopol yazamacrocyclophosphonic acid complexes for use as contrast agents |
| US5714604A (en) * | 1993-05-06 | 1998-02-03 | The Dow Chemical Company | Process for the preparation of azamacrocyclic or acyclic aminophosphonate ester derivatives |
| US5672335A (en) * | 1994-11-30 | 1997-09-30 | Schering Aktiengesellschaft | Use of metal complexes as liver and gallbladder X-ray diagnostic agents |
| US6207826B1 (en) * | 1995-03-27 | 2001-03-27 | Isis Pharmaceuticals, Inc. | Macrocyclic compounds having nitrogen-containing linkages |
| US6107482A (en) * | 1995-03-27 | 2000-08-22 | Isis Pharmaceuticals, Inc. | Nitrogenous macrocyclic compounds |
| DE19546234C1 (de) * | 1995-12-04 | 1997-08-28 | Schering Ag | Neue makrobicyclische Verbindungen, Verfahren zu ihrer Herstellung und diese makrobicyclischen Verbindungen enthaltende pharmazeutische Mittel |
| US5834456A (en) * | 1996-02-23 | 1998-11-10 | The Dow Chemical Company | Polyazamacrocyclofluoromonoalkylphosphonic acids, and their complexes, for use as contrast agents |
| ATE254129T1 (de) * | 1996-04-19 | 2003-11-15 | Dow Global Technologies Inc | Fluoreszierende chelate als gewebespezifische bildgebende mittel |
| WO1999065905A1 (en) * | 1998-06-15 | 1999-12-23 | Unilever Plc | Bleach catalysts and formulations containing them |
| US6794371B1 (en) * | 1999-10-18 | 2004-09-21 | The Dow Chemical Company | Aminoalkylenephosphonates for treatment of bone disorders |
| AU1092601A (en) * | 1999-10-18 | 2001-04-30 | Dow Global Technologies Inc. | Aminoalkylenephosphonates for treatment of bone disorders |
| WO2006020779A2 (en) * | 2004-08-10 | 2006-02-23 | Dow Global Technologies Inc. | Targeting chelants and chelates |
| US20100111856A1 (en) | 2004-09-23 | 2010-05-06 | Herman Gill | Zirconium-radiolabeled, cysteine engineered antibody conjugates |
| ES2669510T3 (es) | 2004-09-23 | 2018-05-28 | Genentech, Inc. | Anticuerpos y conjugados modificados por ingeniería genética con cisteína |
| CN103030696B (zh) | 2006-05-30 | 2016-09-28 | 健泰科生物技术公司 | 抗体和免疫偶联物及其用途 |
| US8436147B2 (en) | 2006-10-27 | 2013-05-07 | Genentech, Inc. | Antibodies and immunoconjugates and uses therefor |
| EP2125896A2 (de) | 2007-02-09 | 2009-12-02 | Genetech, Inc. | Antikörper gegen robo4 und anwendungen davon |
| CN101802013B (zh) | 2007-07-16 | 2014-07-02 | 健泰科生物技术公司 | 人源化抗cd79b抗体和免疫偶联物及使用方法 |
| SI2474557T1 (sl) | 2007-07-16 | 2014-12-31 | Genentech, Inc. | Protiteles proti CD79b in imunokonjugati in postopki za uporabo |
| EP2247620B1 (de) | 2008-01-31 | 2016-05-18 | Genentech, Inc. | Anti-cd79b-antikörper und immunkonjugate sowie verfahren zu ihrer verwendung |
| MA33256B1 (fr) | 2009-04-01 | 2012-05-02 | Genentech Inc | Anticorps et immunoconjugués anti-fcrh5 et procédés d'utilisation |
| EP3248619A3 (de) | 2009-06-04 | 2018-03-07 | Novartis AG | Verfahren zur identifizierung von stellen zur igg-konjugation |
| EP2477740B1 (de) * | 2009-09-18 | 2015-01-21 | Clariant Finance (BVI) Limited | Verfahren zur Herstellung von verbrückten Mangan-Komplexen des Triazacyclononans |
| CN107337734A (zh) | 2009-12-04 | 2017-11-10 | 弗·哈夫曼-拉罗切有限公司 | 多特异性抗体、抗体类似物、组合物和方法 |
| SG185430A1 (en) | 2010-06-03 | 2012-12-28 | Genentech Inc | Immuno-pet imaging of antibodies and immunoconjugates and uses therefor |
| AU2011265054B2 (en) | 2010-06-08 | 2016-09-15 | Genentech, Inc. | Cysteine engineered antibodies and conjugates |
| CN104428006B (zh) | 2012-07-04 | 2017-09-08 | 弗·哈夫曼-拉罗切有限公司 | 共价连接的抗原‑抗体缀合物 |
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| WO2017089848A1 (en) * | 2015-11-26 | 2017-06-01 | Debreceni Egyetem | New 2, 1 l -diaza-[3.3](2,6)pyridinophane compounds and their application as ligands of essential metal ion based mri contrast agents and 52mn based pet contrast agents |
| US10494379B2 (en) | 2015-11-26 | 2019-12-03 | Debreceni Egyetem | 6-oxa-3,9,15-triaza-bicyclo[9.3.1]pentadeca-1(14),11(15),12-triene derivatives based compounds and their application as ligands of essential metal ion based MRI and 52MN based PET contrast agents |
| WO2017089847A1 (en) | 2015-11-26 | 2017-06-01 | Debreceni Egyetem | New 3,6,9, 15-tetraaza-bicyclo [9.3.1 ]pentadeca- 1(14), 11(15), 12-triene based compounds and their application as ligands of essential metal ion based mri and 52mn based pet contrast agents |
| FR3045053B1 (fr) | 2015-12-09 | 2018-01-05 | Cisbio Bioassays | Agents complexants hydrosolubles a base de triazapyridinophane et complexes de lanthanide fluorescents correspondants |
| WO2017167712A1 (en) | 2016-03-30 | 2017-10-05 | F. Hoffmann-La Roche Ag | Improved sortase |
| BR112019018051A2 (pt) | 2017-04-12 | 2020-04-07 | Hoffmann La Roche | método para produzir um composto, composto e substância |
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| CA3082442A1 (en) | 2017-11-30 | 2019-06-06 | Genentech, Inc. | Anti-pd-l1 antibodies and methods of using the same for detection of pd-l1 |
| CN111801351A (zh) | 2018-03-14 | 2020-10-20 | 豪夫迈·罗氏有限公司 | 抗体亲和力成熟的方法 |
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| US20220001043A1 (en) | 2018-09-28 | 2022-01-06 | Imaginab, Inc. | Cd8 imaging constructs and methods of use thereof |
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| WO2024017985A1 (en) | 2022-07-22 | 2024-01-25 | F. Hoffmann-La Roche Ag | Fibroblast growth factor binding protein 1 (fgfbp1) as (blood) biomarker for the diagnosis of polycystic ovarian syndrome |
| WO2024017982A1 (en) | 2022-07-22 | 2024-01-25 | F. Hoffmann-La Roche Ag | Leukotriene a4 hydrolase (lta4h) as (blood) biomarker for the diagnosis of polycystic ovarian syndrome |
| WO2025026908A1 (en) | 2023-07-28 | 2025-02-06 | Roche Diagnostics Gmbh | Serum epha1 as biomarker for endometriosis |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2609390A (en) * | 1950-06-01 | 1952-09-02 | Frederick C Bersworth | Phosphonic alkylene polyamino acids and method of producing same |
| US3336221A (en) * | 1964-11-05 | 1967-08-15 | Calgon Corp | Method of inhibiting precipitation and scale formation |
| US3331773A (en) * | 1966-07-22 | 1967-07-18 | Grace W R & Co | Process for inhibiting precipitation in water |
| US3434969A (en) * | 1967-08-11 | 1969-03-25 | Calgon Corp | Scale inhibiting |
| GB1441081A (en) * | 1974-01-09 | 1976-06-30 | Ici Ltd | Tetra-aza-macrocycles and their metal complexes |
| US4980148A (en) * | 1985-02-06 | 1990-12-25 | Mallinckrodt, Inc. | Methods for enhancing magnetic resonance imaging |
| US4899755A (en) * | 1985-05-08 | 1990-02-13 | The General Hospital Corporation | Hepatobiliary NMR contrast agents |
| US4880008A (en) * | 1985-05-08 | 1989-11-14 | The General Hospital Corporation | Vivo enhancement of NMR relaxivity |
| DE3825040A1 (de) * | 1988-07-20 | 1990-01-25 | Schering Ag, 13353 Berlin | 5- oder 6-ring- enthaltende makrocyclische polyaza-verbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel |
| US5247077A (en) * | 1989-06-23 | 1993-09-21 | Celltech Limited | Tri-aza macrocycles and processes for their preparation |
| ATE192047T1 (de) * | 1991-12-10 | 2000-05-15 | Dow Chemical Co | Bicylclische, polyazamakrocyclocarbonsäure- komplexe, konjugate, herstellung und verwendung als kontraststoffe |
| US5428139A (en) * | 1991-12-10 | 1995-06-27 | The Dow Chemical Company | Bicyclopolyazamacrocyclophosphonic acid complexes for use as radiopharmaceuticals |
| CA2103553A1 (en) * | 1991-12-10 | 1993-06-11 | Garry E. Kiefer | Bicyclopolyazamacrocyclocarboxylic acid complexes their conjugates, processes for their preparation, and use as radiopharmaceuticals |
| ES2110593T3 (es) * | 1991-12-10 | 1998-02-16 | Dow Chemical Co | Acido bicicloazamacrociclofosfonico, conjugados, agentes de contraste y preparacion. |
-
1993
- 1993-05-06 US US08/058,622 patent/US5385893A/en not_active Expired - Lifetime
-
1994
- 1994-05-06 KR KR1019950704947A patent/KR960702462A/ko not_active Application Discontinuation
- 1994-05-06 AT AT94916043T patent/ATE316377T1/de not_active IP Right Cessation
- 1994-05-06 JP JP52558694A patent/JP3553940B2/ja not_active Expired - Fee Related
- 1994-05-06 PL PL94311649A patent/PL311649A1/xx unknown
- 1994-05-06 SG SG1996005135A patent/SG46496A1/en unknown
- 1994-05-06 EP EP94916043A patent/EP0697872B1/de not_active Expired - Lifetime
- 1994-05-06 CA CA002162172A patent/CA2162172A1/en not_active Abandoned
- 1994-05-06 WO PCT/US1994/005071 patent/WO1994026276A1/en active IP Right Grant
- 1994-05-06 CN CN94192528A patent/CN1125906A/zh active Pending
- 1994-05-06 AU AU67849/94A patent/AU687400B2/en not_active Ceased
- 1994-05-06 DE DE69434618T patent/DE69434618T2/de not_active Expired - Fee Related
- 1994-05-06 HU HU9502023A patent/HUT72649A/hu unknown
-
1995
- 1995-11-06 NO NO954441A patent/NO954441L/no unknown
- 1995-11-06 FI FI955336A patent/FI955336A/fi unknown
- 1995-12-05 BG BG100194A patent/BG100194A/xx unknown
- 1995-12-06 LV LVP-95-361A patent/LV11429B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0697872A4 (de) | 2003-04-02 |
| AU687400B2 (en) | 1998-02-26 |
| JP3553940B2 (ja) | 2004-08-11 |
| LV11429B (en) | 1997-04-20 |
| HUT72649A (en) | 1996-05-28 |
| BG100194A (en) | 1996-12-31 |
| CA2162172A1 (en) | 1994-11-24 |
| LV11429A (lv) | 1996-08-20 |
| PL311649A1 (en) | 1996-03-04 |
| FI955336A0 (fi) | 1995-11-06 |
| CN1125906A (zh) | 1996-07-03 |
| DE69434618D1 (de) | 2006-04-13 |
| NO954441D0 (no) | 1995-11-06 |
| JPH08511003A (ja) | 1996-11-19 |
| US5385893A (en) | 1995-01-31 |
| WO1994026276A1 (en) | 1994-11-24 |
| HU9502023D0 (en) | 1995-09-28 |
| FI955336A (fi) | 1995-12-22 |
| NO954441L (no) | 1996-01-05 |
| SG46496A1 (en) | 1998-02-20 |
| EP0697872B1 (de) | 2006-01-25 |
| DE69434618T2 (de) | 2006-08-10 |
| EP0697872A1 (de) | 1996-02-28 |
| KR960702462A (ko) | 1996-04-27 |
| AU6784994A (en) | 1994-12-12 |
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