ATE277058T1 - Polyazomacrocyclofluoromonoalkylphosphensäure, ihre komplexe zur verwendung als kontrastmittel - Google Patents
Polyazomacrocyclofluoromonoalkylphosphensäure, ihre komplexe zur verwendung als kontrastmittelInfo
- Publication number
- ATE277058T1 ATE277058T1 AT97908699T AT97908699T ATE277058T1 AT E277058 T1 ATE277058 T1 AT E277058T1 AT 97908699 T AT97908699 T AT 97908699T AT 97908699 T AT97908699 T AT 97908699T AT E277058 T1 ATE277058 T1 AT E277058T1
- Authority
- AT
- Austria
- Prior art keywords
- complexes
- contrast agents
- acid
- polyazomacrocyclofluoromonoalkylphosphenic
- polyazamacrocyclofluoromonoalkylphosphonic
- Prior art date
Links
- 239000002253 acid Substances 0.000 title abstract 2
- 239000002872 contrast media Substances 0.000 title abstract 2
- 229910052688 Gadolinium Inorganic materials 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000002500 ions Chemical class 0.000 abstract 1
- 229910052742 iron Inorganic materials 0.000 abstract 1
- 229910052746 lanthanum Inorganic materials 0.000 abstract 1
- 229910052748 manganese Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having three nitrogen atoms as the only ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6524—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having four or more nitrogen atoms as the only ring hetero atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/606,162 US5834456A (en) | 1996-02-23 | 1996-02-23 | Polyazamacrocyclofluoromonoalkylphosphonic acids, and their complexes, for use as contrast agents |
| PCT/US1997/002799 WO1997031005A1 (en) | 1996-02-23 | 1997-02-21 | Polyazamacrocyclofluoromonoalkylphosphonic acids, and their complexes, for use as contrast agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE277058T1 true ATE277058T1 (de) | 2004-10-15 |
Family
ID=24426818
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97908699T ATE277058T1 (de) | 1996-02-23 | 1997-02-21 | Polyazomacrocyclofluoromonoalkylphosphensäure, ihre komplexe zur verwendung als kontrastmittel |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US5834456A (de) |
| EP (1) | EP0882055B1 (de) |
| AT (1) | ATE277058T1 (de) |
| AU (1) | AU2054097A (de) |
| DE (1) | DE69730820T2 (de) |
| WO (1) | WO1997031005A1 (de) |
Families Citing this family (51)
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| US6019959A (en) * | 1997-07-31 | 2000-02-01 | Schering Aktiengesellschaft | Oligomeric compounds that contain perfluoroalkyl, process for their production, and their use in NMR diagnosis |
| US6565828B2 (en) | 2000-04-07 | 2003-05-20 | Bristol-Myers Squibb Company | Macrocyclic chelants for metallopharmaceuticals |
| US6776977B2 (en) | 2001-01-09 | 2004-08-17 | Bristol-Myers Squibb Pharma Company | Polypodal chelants for metallopharmaceuticals |
| US7048907B2 (en) * | 2001-02-05 | 2006-05-23 | Biophysics Assay Laboratory, Inc. | Synthesis, compositions and methods for the measurement of the concentration of stable-isotope labeled compounds in life forms and life form excretory products |
| US6670456B2 (en) * | 2001-02-28 | 2003-12-30 | Dow Global Technologies Inc. | Actinium-225 complexes and conjugates for targeted radiotherapy |
| US6911017B2 (en) * | 2001-09-19 | 2005-06-28 | Advanced Cardiovascular Systems, Inc. | MRI visible catheter balloon |
| US20040115822A1 (en) * | 2002-09-12 | 2004-06-17 | Schapaugh Randal Lee | Methods of measuring the dissolution rate of an analyte in a non-aqueous liquid composition |
| EP1778699A4 (de) * | 2004-08-10 | 2009-02-25 | Dow Global Technologies Inc | Targeting von chelanten und chelaten |
| US20100111856A1 (en) | 2004-09-23 | 2010-05-06 | Herman Gill | Zirconium-radiolabeled, cysteine engineered antibody conjugates |
| KR101270829B1 (ko) | 2004-09-23 | 2013-06-07 | 제넨테크, 인크. | 시스테인 유전자조작 항체 및 접합체 |
| MX2008015132A (es) | 2006-05-30 | 2008-12-10 | Genentech Inc | Anticuerpos e inmunoconjugados y sus usos. |
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| PL2474557T3 (pl) | 2007-07-16 | 2015-02-27 | Genentech Inc | Przeciwciała anty- CD79b i immunokoniugaty i sposoby stosowania |
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| AU2010256410B2 (en) | 2009-06-04 | 2016-10-20 | Massachusetts Institute Of Technology | Methods for identification of sites for IgG conjugation |
| RU2580038C2 (ru) | 2009-12-04 | 2016-04-10 | Дженентек, Инк. | Мультиспецифические антитела, аналоги антител, композиции и способы |
| US8722020B2 (en) | 2010-03-31 | 2014-05-13 | General Electric Company | Hydroxylated contrast enhancement agents |
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| US8362281B2 (en) | 2010-03-31 | 2013-01-29 | General Electric Company | Intermediates for hydroxylated contrast enhancement agents |
| MX336109B (es) | 2010-06-03 | 2016-01-08 | Genentech Inc | Formacion de imagenes inmuno-tep de anticuerpos e inmunoconjugados y usos de lo mismo. |
| RU2755066C2 (ru) | 2010-06-08 | 2021-09-13 | Дженентек, Инк. | Полученные с помощью генной инженерии антитела с цистеиновыми заменами и их конъюгаты |
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| WO2014006123A1 (en) | 2012-07-04 | 2014-01-09 | F. Hoffmann-La Roche Ag | Anti-biotin antibodies and methods of use |
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| WO2015101586A1 (en) | 2014-01-03 | 2015-07-09 | F. Hoffmann-La Roche Ag | Bispecific anti-hapten/anti-blood brain barrier receptor antibodies, complexes thereof and their use as blood brain barrier shuttles |
| RU2694981C2 (ru) | 2014-01-03 | 2019-07-18 | Ф. Хоффманн-Ля Рош Аг | Ковалентно связанные конъюгаты хеликар-антитело против хеликара и их применения |
| RU2682754C2 (ru) | 2014-01-03 | 2019-03-21 | Ф. Хоффманн-Ля Рош Аг | Конъюгаты полипептидного токсина и антитела, соединенных ковалентной связью |
| EP3191521A2 (de) | 2014-09-12 | 2017-07-19 | F. Hoffmann-La Roche AG | Cystein-manipulierte antikörper und konjugate |
| WO2016096741A1 (en) | 2014-12-17 | 2016-06-23 | F. Hoffmann-La Roche Ag | Novel methods for enzyme mediated polypeptide conjugation using sortase |
| CN104945312A (zh) * | 2015-06-24 | 2015-09-30 | 黄荣辉 | 一种2,6-二氯甲基吡啶盐酸盐的制备方法 |
| EP3353310B1 (de) | 2015-09-25 | 2020-04-29 | H. Hoffnabb-La Roche Ag | Verfahren zur herstellung von thioestern unter verwendung einer sortase a |
| CN108138158B (zh) | 2015-09-25 | 2021-11-09 | 豪夫迈·罗氏有限公司 | 可溶性分选酶a |
| KR102692686B1 (ko) | 2015-09-25 | 2024-08-06 | 에프. 호프만-라 로슈 아게 | 소르타아제 접합 루프를 포함하는 재조합 면역글로불린 중쇄 및 이의 접합체 |
| JP6998863B2 (ja) | 2015-09-25 | 2022-02-04 | エフ．ホフマン－ラ ロシュ アーゲー | 深共融溶媒におけるソルターゼａを利用したアミド基転移 |
| WO2017167712A1 (en) | 2016-03-30 | 2017-10-05 | F. Hoffmann-La Roche Ag | Improved sortase |
| KR102495650B1 (ko) | 2017-04-12 | 2023-02-02 | 에프. 호프만-라 로슈 아게 | 알데히드 함유 표적 분자의 라벨링 방법 |
| EP3652214A1 (de) | 2017-07-13 | 2020-05-20 | H. Hoffnabb-La Roche Ag | Neues bindemittel und assay für pivka |
| CN111212850B (zh) | 2017-10-20 | 2024-04-16 | 豪夫迈·罗氏有限公司 | 关于抗体的复制保护 |
| JP7402158B2 (ja) | 2017-11-30 | 2023-12-20 | ジェネンテック， インコーポレイテッド | 抗ｐｄ－ｌ１抗体及びｐｄ－ｌ１を検出するためにそれを使用する方法 |
| WO2019175131A1 (en) | 2018-03-14 | 2019-09-19 | F. Hoffmann-La Roche Ag | Method for affinity maturation of antibodies |
| JP2021515567A (ja) | 2018-03-14 | 2021-06-24 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 新規抗トロポニンｔ抗体 |
| JP2021522192A (ja) | 2018-04-18 | 2021-08-30 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 新規抗チミジンキナーゼ抗体 |
| JP7577647B2 (ja) | 2018-08-31 | 2024-11-05 | エフ． ホフマン－ラ ロシュ アーゲー | Ｄｌｂｃｌについての予後指標におけるチミジンキナーゼ（ｔｋ－１） |
| WO2020069433A1 (en) | 2018-09-28 | 2020-04-02 | Imaginab, Inc. | Cd8 imaging constructs and methods of use thereof |
| CN116457660A (zh) | 2020-10-30 | 2023-07-18 | 豪夫迈·罗氏有限公司 | Timp1作为胆管癌的标志物 |
| EP4448564A1 (de) | 2021-12-17 | 2024-10-23 | F. Hoffmann-La Roche AG | Neuer antikörper zum nachweis von amyloid beta 42 (a-beta42) |
| CN118638117B (zh) * | 2024-05-29 | 2024-12-13 | 江苏宝东医药科技有限公司 | 一种绿色制备1,4,7,10-四氮杂-2,6-吡啶环蕃方法 |
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| US5064633A (en) * | 1984-06-04 | 1991-11-12 | The Dow Chemical Company | Macrocyclic aminophosphonic acid complexes, their formulations and use |
| US5059412A (en) * | 1984-06-04 | 1991-10-22 | The Dow Chemical Company | Macrocyclic aminophosphonic acid complexes for the treatment of calcific tumors |
| US5316757A (en) * | 1984-10-18 | 1994-05-31 | Board Of Regents, The University Of Texas System | Synthesis of polyazamacrocycles with more than one type of side-chain chelating groups |
| US5342606A (en) * | 1984-10-18 | 1994-08-30 | Board Of Regents, The University Of Texas System | Polyazamacrocyclic compounds for complexation of metal ions |
| US5362476A (en) * | 1984-10-18 | 1994-11-08 | Board Of Regents, The University Of Texas System | Alkyl phosphonate polyazamacrocyclic cheates for MRI |
| US5188816A (en) * | 1984-10-18 | 1993-02-23 | Board Of Regents, The University Of Texas System | Using polyazamacrocyclic compounds for intracellular measurement of metal ions using MRS |
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| GB8719041D0 (en) * | 1987-08-12 | 1987-09-16 | Parker D | Conjugate compounds |
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| GB8723438D0 (en) * | 1987-10-06 | 1987-11-11 | Amersham Int Plc | Cationic complexes of technetium-99m |
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| DE4317588C2 (de) * | 1993-05-24 | 1998-04-16 | Schering Ag | Fluorhaltige makrocyclische Metallkomplexe, Verfahren zu ihrer Herstellung, sowie ihre Verwendung |
| WO1994027644A1 (en) * | 1993-06-02 | 1994-12-08 | Bracco S.P.A. | Iodinated paramagnetic chelates, and their use as contrast agents |
| JPH0797340A (ja) * | 1993-06-03 | 1995-04-11 | Terumo Corp | Ｍｒｉ造影剤組成物 |
| ES2191044T3 (es) * | 1993-11-26 | 2003-09-01 | Dow Global Technologies Inc | Procedimiento para preparar poliazamacrociclos. |
| IT1265440B1 (it) * | 1993-12-24 | 1996-11-22 | Bracco Spa | Formulazioni diagnostiche paramagnetiche e metodo d'uso delle stesse |
-
1996
- 1996-02-23 US US08/606,162 patent/US5834456A/en not_active Expired - Fee Related
-
1997
- 1997-02-21 AT AT97908699T patent/ATE277058T1/de not_active IP Right Cessation
- 1997-02-21 DE DE69730820T patent/DE69730820T2/de not_active Expired - Fee Related
- 1997-02-21 EP EP97908699A patent/EP0882055B1/de not_active Expired - Lifetime
- 1997-02-21 AU AU20540/97A patent/AU2054097A/en not_active Abandoned
- 1997-02-21 WO PCT/US1997/002799 patent/WO1997031005A1/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| DE69730820T2 (de) | 2005-09-29 |
| WO1997031005A1 (en) | 1997-08-28 |
| EP0882055A1 (de) | 1998-12-09 |
| DE69730820D1 (de) | 2004-10-28 |
| US5834456A (en) | 1998-11-10 |
| AU2054097A (en) | 1997-09-10 |
| EP0882055B1 (de) | 2004-09-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |