[go: up one dir, main page]

NO954441L - Tricyklopolyazamakrocyklofosfonsyrer, komplekser og derivater derav for anvendelse som kontrastmidler - Google Patents

Tricyklopolyazamakrocyklofosfonsyrer, komplekser og derivater derav for anvendelse som kontrastmidler

Info

Publication number
NO954441L
NO954441L NO954441A NO954441A NO954441L NO 954441 L NO954441 L NO 954441L NO 954441 A NO954441 A NO 954441A NO 954441 A NO954441 A NO 954441A NO 954441 L NO954441 L NO 954441L
Authority
NO
Norway
Prior art keywords
complexes
derivatives
contrast agents
tricyclopolyazamacrocyclophosphonic
acids
Prior art date
Application number
NO954441A
Other languages
English (en)
Other versions
NO954441D0 (no
Inventor
Garry E Kiefer
Original Assignee
Dow Chemical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dow Chemical Co filed Critical Dow Chemical Co
Publication of NO954441D0 publication Critical patent/NO954441D0/no
Publication of NO954441L publication Critical patent/NO954441L/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18Bridged systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/22Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01RMEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00Arrangements or instruments for measuring magnetic variables
    • G01R33/20Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/28Details of apparatus provided for in groups G01R33/44 - G01R33/64
    • G01R33/281Means for the use of in vitro contrast agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • General Physics & Mathematics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Luminescent Compositions (AREA)

Abstract

Tri- og tetracyklopolyazamakrocyklofosfonsyreforbindelser og deres derivater er beskrevet som kan danne inerte komplek-ser med Gd-, Mn- eller Fe-ioner. Den totale ladning av kom-plekset kan varieres for å forandre in vivo biolokaliseringen. Kompleksene er anvendelige som kontrastmidler for diagnostiske formål.
NO954441A 1993-05-06 1995-11-06 Tricyklopolyazamakrocyklofosfonsyrer, komplekser og derivater derav for anvendelse som kontrastmidler NO954441L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/058,622 US5385893A (en) 1993-05-06 1993-05-06 Tricyclopolyazamacrocyclophosphonic acids, complexes and derivatives thereof, for use as contrast agents
PCT/US1994/005071 WO1994026276A1 (en) 1993-05-06 1994-05-06 Tricyclopolyazamacrocyclophosphonic acids, complexes and derivatives thereof, for use as contrast agents

Publications (2)

Publication Number Publication Date
NO954441D0 NO954441D0 (no) 1995-11-06
NO954441L true NO954441L (no) 1996-01-05

Family

ID=22017946

Family Applications (1)

Application Number Title Priority Date Filing Date
NO954441A NO954441L (no) 1993-05-06 1995-11-06 Tricyklopolyazamakrocyklofosfonsyrer, komplekser og derivater derav for anvendelse som kontrastmidler

Country Status (17)

Country Link
US (1) US5385893A (no)
EP (1) EP0697872B1 (no)
JP (1) JP3553940B2 (no)
KR (1) KR960702462A (no)
CN (1) CN1125906A (no)
AT (1) ATE316377T1 (no)
AU (1) AU687400B2 (no)
BG (1) BG100194A (no)
CA (1) CA2162172A1 (no)
DE (1) DE69434618T2 (no)
FI (1) FI955336A (no)
HU (1) HUT72649A (no)
LV (1) LV11429B (no)
NO (1) NO954441L (no)
PL (1) PL311649A1 (no)
SG (1) SG46496A1 (no)
WO (1) WO1994026276A1 (no)

Families Citing this family (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5645818A (en) * 1989-03-24 1997-07-08 Guerbet S.A. Diagnostic compositions comprising a complex formed by a nitrogenous macrocyclic ligand with metal ions
US5739294A (en) * 1991-12-10 1998-04-14 The Dow Chemical Company Bicyclopol yazamacrocyclophosphonic acid complexes for use as contrast agents
US5714604A (en) * 1993-05-06 1998-02-03 The Dow Chemical Company Process for the preparation of azamacrocyclic or acyclic aminophosphonate ester derivatives
US5672335A (en) * 1994-11-30 1997-09-30 Schering Aktiengesellschaft Use of metal complexes as liver and gallbladder X-ray diagnostic agents
US6207826B1 (en) * 1995-03-27 2001-03-27 Isis Pharmaceuticals, Inc. Macrocyclic compounds having nitrogen-containing linkages
US6107482A (en) * 1995-03-27 2000-08-22 Isis Pharmaceuticals, Inc. Nitrogenous macrocyclic compounds
DE19546234C1 (de) * 1995-12-04 1997-08-28 Schering Ag Neue makrobicyclische Verbindungen, Verfahren zu ihrer Herstellung und diese makrobicyclischen Verbindungen enthaltende pharmazeutische Mittel
US5834456A (en) * 1996-02-23 1998-11-10 The Dow Chemical Company Polyazamacrocyclofluoromonoalkylphosphonic acids, and their complexes, for use as contrast agents
ATE254129T1 (de) * 1996-04-19 2003-11-15 Dow Global Technologies Inc Fluoreszierende chelate als gewebespezifische bildgebende mittel
WO1999065905A1 (en) * 1998-06-15 1999-12-23 Unilever Plc Bleach catalysts and formulations containing them
US6794371B1 (en) * 1999-10-18 2004-09-21 The Dow Chemical Company Aminoalkylenephosphonates for treatment of bone disorders
AU1092601A (en) * 1999-10-18 2001-04-30 Dow Global Technologies Inc. Aminoalkylenephosphonates for treatment of bone disorders
WO2006020779A2 (en) * 2004-08-10 2006-02-23 Dow Global Technologies Inc. Targeting chelants and chelates
US20100111856A1 (en) 2004-09-23 2010-05-06 Herman Gill Zirconium-radiolabeled, cysteine engineered antibody conjugates
ES2669510T3 (es) 2004-09-23 2018-05-28 Genentech, Inc. Anticuerpos y conjugados modificados por ingeniería genética con cisteína
CN103030696B (zh) 2006-05-30 2016-09-28 健泰科生物技术公司 抗体和免疫偶联物及其用途
US8436147B2 (en) 2006-10-27 2013-05-07 Genentech, Inc. Antibodies and immunoconjugates and uses therefor
EP2125896A2 (en) 2007-02-09 2009-12-02 Genetech, Inc. Anti-robo4 antibodies and uses therefor
CN101802013B (zh) 2007-07-16 2014-07-02 健泰科生物技术公司 人源化抗cd79b抗体和免疫偶联物及使用方法
SI2474557T1 (sl) 2007-07-16 2014-12-31 Genentech, Inc. Protiteles proti CD79b in imunokonjugati in postopki za uporabo
EP2247620B1 (en) 2008-01-31 2016-05-18 Genentech, Inc. Anti-cd79b antibodies and immunoconjugates and methods of use
MA33256B1 (fr) 2009-04-01 2012-05-02 Genentech Inc Anticorps et immunoconjugués anti-fcrh5 et procédés d'utilisation
EP3248619A3 (en) 2009-06-04 2018-03-07 Novartis AG Methods for identification of sites for igg conjugation
EP2477740B1 (de) * 2009-09-18 2015-01-21 Clariant Finance (BVI) Limited Verfahren zur Herstellung von verbrückten Mangan-Komplexen des Triazacyclononans
CN107337734A (zh) 2009-12-04 2017-11-10 弗·哈夫曼-拉罗切有限公司 多特异性抗体、抗体类似物、组合物和方法
SG185430A1 (en) 2010-06-03 2012-12-28 Genentech Inc Immuno-pet imaging of antibodies and immunoconjugates and uses therefor
AU2011265054B2 (en) 2010-06-08 2016-09-15 Genentech, Inc. Cysteine engineered antibodies and conjugates
CN104428006B (zh) 2012-07-04 2017-09-08 弗·哈夫曼-拉罗切有限公司 共价连接的抗原‑抗体缀合物
KR20150030755A (ko) 2012-07-04 2015-03-20 에프. 호프만-라 로슈 아게 항-바이오틴 항체 및 사용 방법
ES2600154T3 (es) 2012-07-04 2017-02-07 F. Hoffmann-La Roche Ag Anticuerpos antiteofilina y métodos de uso
CN105873615B (zh) 2014-01-03 2020-12-25 豪夫迈·罗氏有限公司 共价连接的helicar-抗helicar抗体缀合物及其用途
MX2016008191A (es) 2014-01-03 2017-11-16 Hoffmann La Roche Conjugados de toxina polipeptidica-anticuerpo unidos covalentemente.
US10561737B2 (en) 2014-01-03 2020-02-18 Hoffmann-La Roche Inc. Bispecific anti-hapten/anti-blood brain barrier receptor antibodies, complexes thereof and their use as blood brain barrier shuttles
SG11201701128YA (en) 2014-09-12 2017-03-30 Genentech Inc Cysteine engineered antibodies and conjugates
EP3233905B1 (en) 2014-12-17 2020-01-29 F.Hoffmann-La Roche Ag Novel methods for enzyme mediated polypeptide conjugation using sortase
JP6895953B2 (ja) 2015-09-25 2021-06-30 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft ソルターゼaを利用してチオエステルを作製するための方法
JP6998862B2 (ja) 2015-09-25 2022-02-04 エフ.ホフマン-ラ ロシュ アーゲー 可溶性ソルターゼa
BR112018003594A2 (pt) 2015-09-25 2018-09-25 Hoffmann La Roche cadeia pesada de imunoglobulina recombinante, anticorpos, método de produção de conjugado e conjugados
JP6998863B2 (ja) 2015-09-25 2022-02-04 エフ.ホフマン-ラ ロシュ アーゲー 深共融溶媒におけるソルターゼaを利用したアミド基転移
WO2017089848A1 (en) * 2015-11-26 2017-06-01 Debreceni Egyetem New 2, 1 l -diaza-[3.3](2,6)pyridinophane compounds and their application as ligands of essential metal ion based mri contrast agents and 52mn based pet contrast agents
US10494379B2 (en) 2015-11-26 2019-12-03 Debreceni Egyetem 6-oxa-3,9,15-triaza-bicyclo[9.3.1]pentadeca-1(14),11(15),12-triene derivatives based compounds and their application as ligands of essential metal ion based MRI and 52MN based PET contrast agents
WO2017089847A1 (en) 2015-11-26 2017-06-01 Debreceni Egyetem New 3,6,9, 15-tetraaza-bicyclo [9.3.1 ]pentadeca- 1(14), 11(15), 12-triene based compounds and their application as ligands of essential metal ion based mri and 52mn based pet contrast agents
FR3045053B1 (fr) 2015-12-09 2018-01-05 Cisbio Bioassays Agents complexants hydrosolubles a base de triazapyridinophane et complexes de lanthanide fluorescents correspondants
WO2017167712A1 (en) 2016-03-30 2017-10-05 F. Hoffmann-La Roche Ag Improved sortase
BR112019018051A2 (pt) 2017-04-12 2020-04-07 Hoffmann La Roche método para produzir um composto, composto e substância
WO2019012019A1 (en) 2017-07-13 2019-01-17 F. Hoffmann-La Roche Ag NEW BINDING AGENT AND DOSAGE FOR PIVKA
WO2019077113A1 (en) 2017-10-20 2019-04-25 F. Hoffmann-La Roche Ag COPY PROTECTION FOR ANTIBODIES
CA3082442A1 (en) 2017-11-30 2019-06-06 Genentech, Inc. Anti-pd-l1 antibodies and methods of using the same for detection of pd-l1
CN111801351A (zh) 2018-03-14 2020-10-20 豪夫迈·罗氏有限公司 抗体亲和力成熟的方法
WO2019175127A1 (en) 2018-03-14 2019-09-19 F. Hoffmann-La Roche Ag Novel anti-troponint antibodies
CN111936522B (zh) 2018-04-18 2024-07-02 豪夫迈·罗氏有限公司 新型抗胸苷激酶抗体
WO2020043868A1 (en) 2018-08-31 2020-03-05 F. Hoffmann-La Roche Ag Thymidine kinase (tk-1) in prognostic indices for dlbcl
US20220001043A1 (en) 2018-09-28 2022-01-06 Imaginab, Inc. Cd8 imaging constructs and methods of use thereof
CN114144675A (zh) 2019-07-22 2022-03-04 豪夫迈·罗氏有限公司 S100a9作为血液生物标志物用于子宫内膜异位症的非侵入性诊断
KR20220024699A (ko) 2019-07-22 2022-03-03 에프. 호프만-라 로슈 아게 자궁내막증의 비침습적 진단을 위한 혈액 바이오마커로서의 s100a12
BR112022000945A2 (pt) 2019-07-22 2022-03-08 Hoffmann La Roche Métodos para avaliar se uma paciente tem endometriose ou está em risco de desenvolver endometriose, para selecionar uma paciente para terapia e para monitorar uma paciente que sofre de endometriose ou que está sendo tratada para endometriose
CN114144676A (zh) 2019-07-22 2022-03-04 豪夫迈·罗氏有限公司 S100a6作为血液生物标志物用于子宫内膜异位症的非侵入性诊断
WO2021013781A1 (en) 2019-07-22 2021-01-28 F. Hoffmann-La Roche Ag Substance p as blood biomarker for the non-invasive diagnosis of endometriosis
CN114728984A (zh) 2019-11-15 2022-07-08 豪夫迈·罗氏有限公司 用于患者样品中质谱测量的β-内酰胺类抗生素的衍生化
JP2023550278A (ja) 2020-10-30 2023-12-01 エフ. ホフマン-ラ ロシュ アーゲー 胆管癌のマーカーとしてのtimp1
EP4237441A1 (en) 2020-11-02 2023-09-06 F. Hoffmann-La Roche AG Sars-cov-2 nucleocapsid antibodies
WO2022207628A1 (en) 2021-03-30 2022-10-06 F. Hoffmann-La Roche Ag Scf as blood biomarker for the non-invasive diagnosis of endometriosis
JP2024511867A (ja) 2021-04-01 2024-03-15 エフ. ホフマン-ラ ロシュ アーゲー 子宮内膜症の非侵襲的診断のための血液バイオマーカーとしてのpsp94
JP2024518180A (ja) 2021-05-17 2024-04-25 エフ. ホフマン-ラ ロシュ アーゲー 腺筋症の非侵襲的診断のための血液バイオマーカーとしてのsFRP4
JP2024541945A (ja) 2021-10-26 2024-11-13 エフ. ホフマン-ラ ロシュ アーゲー SARS-CoV-2受容体結合ドメイン抗体
EP4448564A1 (en) 2021-12-17 2024-10-23 F. Hoffmann-La Roche AG A novel antibody for detection of amyloid beta 42 (a-beta42)
WO2023131594A1 (en) 2022-01-05 2023-07-13 F. Hoffmann-La Roche Ag Derivatization of compounds in patient samples for therapeutic drug monitoring (tdm)
WO2023247752A1 (en) 2022-06-23 2023-12-28 F. Hoffmann-La Roche Ag Method for diagnosing endometriosis and for classifying the stage of endometriosis
WO2024017983A1 (en) 2022-07-22 2024-01-25 F. Hoffmann-La Roche Ag Meteorin-like protein (metrnl) as (blood) biomarker for the diagnosis of polycystic ovarian syndrome
WO2024017985A1 (en) 2022-07-22 2024-01-25 F. Hoffmann-La Roche Ag Fibroblast growth factor binding protein 1 (fgfbp1) as (blood) biomarker for the diagnosis of polycystic ovarian syndrome
WO2024017982A1 (en) 2022-07-22 2024-01-25 F. Hoffmann-La Roche Ag Leukotriene a4 hydrolase (lta4h) as (blood) biomarker for the diagnosis of polycystic ovarian syndrome
WO2025026908A1 (en) 2023-07-28 2025-02-06 Roche Diagnostics Gmbh Serum epha1 as biomarker for endometriosis

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2609390A (en) * 1950-06-01 1952-09-02 Frederick C Bersworth Phosphonic alkylene polyamino acids and method of producing same
US3336221A (en) * 1964-11-05 1967-08-15 Calgon Corp Method of inhibiting precipitation and scale formation
US3331773A (en) * 1966-07-22 1967-07-18 Grace W R & Co Process for inhibiting precipitation in water
US3434969A (en) * 1967-08-11 1969-03-25 Calgon Corp Scale inhibiting
GB1441081A (en) * 1974-01-09 1976-06-30 Ici Ltd Tetra-aza-macrocycles and their metal complexes
US4980148A (en) * 1985-02-06 1990-12-25 Mallinckrodt, Inc. Methods for enhancing magnetic resonance imaging
US4899755A (en) * 1985-05-08 1990-02-13 The General Hospital Corporation Hepatobiliary NMR contrast agents
US4880008A (en) * 1985-05-08 1989-11-14 The General Hospital Corporation Vivo enhancement of NMR relaxivity
DE3825040A1 (de) * 1988-07-20 1990-01-25 Schering Ag, 13353 Berlin 5- oder 6-ring- enthaltende makrocyclische polyaza-verbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
US5247077A (en) * 1989-06-23 1993-09-21 Celltech Limited Tri-aza macrocycles and processes for their preparation
ATE192047T1 (de) * 1991-12-10 2000-05-15 Dow Chemical Co Bicylclische, polyazamakrocyclocarbonsäure- komplexe, konjugate, herstellung und verwendung als kontraststoffe
US5428139A (en) * 1991-12-10 1995-06-27 The Dow Chemical Company Bicyclopolyazamacrocyclophosphonic acid complexes for use as radiopharmaceuticals
CA2103553A1 (en) * 1991-12-10 1993-06-11 Garry E. Kiefer Bicyclopolyazamacrocyclocarboxylic acid complexes their conjugates, processes for their preparation, and use as radiopharmaceuticals
ES2110593T3 (es) * 1991-12-10 1998-02-16 Dow Chemical Co Acido bicicloazamacrociclofosfonico, conjugados, agentes de contraste y preparacion.

Also Published As

Publication number Publication date
EP0697872A4 (en) 2003-04-02
AU687400B2 (en) 1998-02-26
JP3553940B2 (ja) 2004-08-11
LV11429B (en) 1997-04-20
HUT72649A (en) 1996-05-28
BG100194A (en) 1996-12-31
CA2162172A1 (en) 1994-11-24
LV11429A (lv) 1996-08-20
PL311649A1 (en) 1996-03-04
FI955336A0 (fi) 1995-11-06
CN1125906A (zh) 1996-07-03
DE69434618D1 (de) 2006-04-13
NO954441D0 (no) 1995-11-06
JPH08511003A (ja) 1996-11-19
US5385893A (en) 1995-01-31
WO1994026276A1 (en) 1994-11-24
HU9502023D0 (en) 1995-09-28
ATE316377T1 (de) 2006-02-15
FI955336A (fi) 1995-12-22
SG46496A1 (en) 1998-02-20
EP0697872B1 (en) 2006-01-25
DE69434618T2 (de) 2006-08-10
EP0697872A1 (en) 1996-02-28
KR960702462A (ko) 1996-04-27
AU6784994A (en) 1994-12-12

Similar Documents

Publication Publication Date Title
NO954441L (no) Tricyklopolyazamakrocyklofosfonsyrer, komplekser og derivater derav for anvendelse som kontrastmidler
NO954440L (no) 2 pyridylmetylenpolyazamakrocyklo-fosfonsyrer, komplekser og derivater derav, for anvendelse som kontrastmidler
AU2054097A (en) Polyazamacrocyclofluoromonoalkylphosphonic acids, and their complexes, for use as contrast agents
DK0874645T3 (da) Perflouralkylholdige metalkomplekser og deres anvendelse i NMR-diagnostik
CA2123048A1 (en) Tetrazole derivatives of bile acids, processes for their preparation and the use of these compounds as medicaments
GR3026658T3 (en) Hydrazino-type radionuclide chelators having an n 3?s configuration
IL96946A0 (en) Boronic acid derivatives and diagnostic methods and kits incorporating the same
CA2123052A1 (en) Monomeric bile acid derivatives, processes for their preparation and the use of these compounds as medicaments
AU4299496A (en) Novel multiple-substituent dtpa derivatives and metal complexes thereof, pharmaceutical compositions containing such complexes, their use in diagnosis and therapy, methods ofpreparing the complexing agents and complexes and methods of preparing the pharmaceutical compositions
AU1378395A (en) Metal chelators
CA2001765A1 (en) Chelants possessing ortho ligating functionality and complexes thereof
DK0570575T3 (da) Bicykloazamakrocyklophosphonsyre, komplekser, konjugater, kontrastmidler og fremstilling heraf
EP1038524A4 (en) L-THREONATE IRON, PHARMACEUTICAL COMPOSITION AND USE FOR IMPROVEMENT AND TREATMENT OF ANEMIA IN PEOPLE
WO1991015466A3 (en) Aminopolycarboxylic acid chelating agents
NO954442L (no) Bicyklopolyazamakrocyklofosfonsyrer, deres komplekser og konjugater, for anvendelse som kontrastmidler, og fremgangsmåter for deres fremstilling
FI961339A0 (fi) Triaryylieteenijohdannaiset käytettäväksi hoidossa
MY141501A (en) Bicyclopolyazamacrocyclophosphonic acids, their complexes and conjugates, for use as contrast agents and processes for their preparation