[go: up one dir, main page]

ATE270078T1 - Knochentransplantatmatrix - Google Patents

Knochentransplantatmatrix

Info

Publication number
ATE270078T1
ATE270078T1 AT96937686T AT96937686T ATE270078T1 AT E270078 T1 ATE270078 T1 AT E270078T1 AT 96937686 T AT96937686 T AT 96937686T AT 96937686 T AT96937686 T AT 96937686T AT E270078 T1 ATE270078 T1 AT E270078T1
Authority
AT
Austria
Prior art keywords
matrix
bone transplant
transplant matrix
bone
biodegradable
Prior art date
Application number
AT96937686T
Other languages
English (en)
Inventor
Michael K Kwan
Stephen D Pacetti
Ronald K Yamamoto
Original Assignee
Depuy Acromed Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Depuy Acromed Inc filed Critical Depuy Acromed Inc
Application granted granted Critical
Publication of ATE270078T1 publication Critical patent/ATE270078T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A61L24/0042—Materials resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A61L24/0036—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/0047—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L24/0073—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material with a macromolecular matrix
    • A61L24/0084—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material with a macromolecular matrix containing fillers of phosphorus-containing inorganic compounds, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/26—Mixtures of macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/46—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A61F2002/2817—Bone stimulation by chemical reactions or by osteogenic or biological products for enhancing ossification, e.g. by bone morphogenetic or morphogenic proteins [BMP] or by transforming growth factors [TGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A61F2002/2835—Bone graft implants for filling a bony defect or an endoprosthesis cavity, e.g. by synthetic material or biological material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
    • A61F2002/3006—Properties of materials and coating materials
    • A61F2002/30062—(bio)absorbable, biodegradable, bioerodable, (bio)resorbable, resorptive
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
    • A61F2002/3006—Properties of materials and coating materials
    • A61F2002/30092—Properties of materials and coating materials using shape memory or superelastic materials, e.g. nitinol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30108—Shapes
    • A61F2002/30199—Three-dimensional shapes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30667—Features concerning an interaction with the environment or a particular use of the prosthesis
    • A61F2002/30677—Means for introducing or releasing pharmaceutical products, e.g. antibiotics, into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2210/0004—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof bioabsorbable
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2210/0014—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof using shape memory or superelastic materials, e.g. nitinol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0063—Three-dimensional shapes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00179—Ceramics or ceramic-like structures
    • A61F2310/00293—Ceramics or ceramic-like structures containing a phosphorus-containing compound, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00365—Proteins; Polypeptides; Degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00365—Proteins; Polypeptides; Degradation products thereof
    • A61F2310/00383—Gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/30—Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A61L2300/406—Antibiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
    • A61L2300/414—Growth factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/602—Type of release, e.g. controlled, sustained, slow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/64—Animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Materials Engineering (AREA)
  • Dermatology (AREA)
  • Surgery (AREA)
  • Composite Materials (AREA)
  • Dispersion Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Inorganic Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Molecular Biology (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)
  • Prostheses (AREA)
  • Glass Compositions (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Diaphragms For Electromechanical Transducers (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT96937686T 1995-10-16 1996-10-15 Knochentransplantatmatrix ATE270078T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US552395P 1995-10-16 1995-10-16
US08/633,554 US5776193A (en) 1995-10-16 1996-04-17 Bone grafting matrix
PCT/US1996/016496 WO1997014376A1 (en) 1995-10-16 1996-10-15 Bone grafting matrix
US10/086,225 US6764517B2 (en) 1995-10-16 2002-02-22 Tissue repair matrix

Publications (1)

Publication Number Publication Date
ATE270078T1 true ATE270078T1 (de) 2004-07-15

Family

ID=28046145

Family Applications (2)

Application Number Title Priority Date Filing Date
AT96937686T ATE270078T1 (de) 1995-10-16 1996-10-15 Knochentransplantatmatrix
AT03709281T ATE490744T1 (de) 1995-10-16 2003-02-21 Gewebsreparaturmatrix

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT03709281T ATE490744T1 (de) 1995-10-16 2003-02-21 Gewebsreparaturmatrix

Country Status (13)

Country Link
US (4) US5776193A (de)
EP (2) EP0855884B1 (de)
JP (2) JP4275732B2 (de)
CN (2) CN1172724C (de)
AT (2) ATE270078T1 (de)
AU (2) AU705303B2 (de)
CA (2) CA2232986C (de)
DE (1) DE69632829T2 (de)
DK (1) DK0855884T3 (de)
ES (1) ES2224182T3 (de)
NZ (2) NZ321756A (de)
PT (1) PT855884E (de)
WO (2) WO1997014376A1 (de)

Families Citing this family (261)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6132674A (en) * 1995-10-12 2000-10-17 Bristol-Myers Squibb Company Method of making an orthopaedic implant having a porous surface
US5776193A (en) * 1995-10-16 1998-07-07 Orquest, Inc. Bone grafting matrix
IT1282207B1 (it) * 1995-11-20 1998-03-16 Fidia Advanced Biopolymers Srl Sistemi di coltura di cellule staminali di midollo osseo umano in matrici tridimensionali costituiti da esteri dell'acido ialuronico
US6221854B1 (en) * 1996-03-05 2001-04-24 Orquest, Inc. Method of promoting bone growth with hyaluronic acid and growth factors
US20110207666A1 (en) * 1996-03-05 2011-08-25 Depuy Spine, Inc. Method of promoting bone growth with hyaluronic acid and growth factors
US20020098222A1 (en) * 1997-03-13 2002-07-25 John F. Wironen Bone paste
EP1014897B1 (de) * 1997-05-30 2008-10-29 Osteobiologics, Inc. Faserverstärkte,poröse,biologisch abbaubare implantatvorrichtung
US7524335B2 (en) * 1997-05-30 2009-04-28 Smith & Nephew, Inc. Fiber-reinforced, porous, biodegradable implant device
DE19726412A1 (de) * 1997-06-21 1998-12-24 Merck Patent Gmbh Implantatmaterial mit einer Träger-Wirkstoff-Kombination
US6241771B1 (en) * 1997-08-13 2001-06-05 Cambridge Scientific, Inc. Resorbable interbody spinal fusion devices
US6296667B1 (en) * 1997-10-01 2001-10-02 Phillips-Origen Ceramic Technology, Llc Bone substitutes
US6977095B1 (en) * 1997-10-01 2005-12-20 Wright Medical Technology Inc. Process for producing rigid reticulated articles
US20040081704A1 (en) * 1998-02-13 2004-04-29 Centerpulse Biologics Inc. Implantable putty material
US20030147860A1 (en) * 2002-02-07 2003-08-07 Marchosky J. Alexander Compositions and methods for forming and strengthening bone
DE19855890A1 (de) * 1998-12-03 2000-06-08 Nerlich Michael Poröse Kompositmatrix, deren Herstellung und Verwendung
US6224629B1 (en) * 1998-12-09 2001-05-01 Purzer Pharmaceuticals Co. Ltd. Bone substitute composition and process of preparation thereof
IT1302534B1 (it) * 1998-12-21 2000-09-05 Fidia Advanced Biopolymers Srl Composizioni iniettabili, biocompatibili e biodegradabili comprendentialmeno un derivato dell'acido ialuronico, cellule condrogeniche, per
DE19962090B4 (de) * 1998-12-22 2014-07-17 Karl Weis Verfahren zur Herstellung von Formkörpern
US6383519B1 (en) * 1999-01-26 2002-05-07 Vita Special Purpose Corporation Inorganic shaped bodies and methods for their production and use
DE60006356T2 (de) * 1999-02-04 2004-09-09 SDGI Holding, Inc., Wilmington Hochmineralisierte osteogene schwammzusammensetzungen und ihre verwendung
AU770196B2 (en) * 1999-02-04 2004-02-12 Warsaw Orthopedic, Inc. Osteogenic paste compositions and uses thereof
US8226729B2 (en) * 2000-10-24 2012-07-24 Warsaw Orthopedic, Inc. Spinal fusion methods and devices
JP4472804B2 (ja) * 1999-05-18 2010-06-02 学校法人松本歯科大学 骨補填剤及びその製造方法
EP1203074A4 (de) 1999-06-29 2003-09-10 J Alexander Marchosky Zusammensetzungen und verfahren zur bildung und festigung von knochen
AU759643B2 (en) * 1999-07-20 2003-04-17 University Of Southern California Identification of pluripotent pre-mesenchymal, pre-hematopoietic progenitor cell
US6458162B1 (en) 1999-08-13 2002-10-01 Vita Special Purpose Corporation Composite shaped bodies and methods for their production and use
US6162258A (en) * 1999-08-25 2000-12-19 Osteotech, Inc. Lyophilized monolithic bone implant and method for treating bone
DE19956503A1 (de) 1999-11-24 2001-06-21 Universitaetsklinikum Freiburg Spritzbares Knochenersatzmaterial
KR100331608B1 (ko) * 1999-11-25 2002-04-09 김정근 동물 뼈를 이용한 골이식 대체재 및 그 제조 방법
WO2001082828A2 (en) * 2000-04-28 2001-11-08 Anthony Atala Tissue engineered testicular prosthesis and use thereof
CA2410637C (en) * 2000-05-31 2007-04-10 Mnemoscience Gmbh Shape memory polymers seeded with dissociated cells for tissue engineering
DE10028975B4 (de) * 2000-06-16 2005-06-30 Henkel Kgaa Zusammensetzungen zur Behandlung von Zahn- und/oder Knochengewebe
DE10029520A1 (de) * 2000-06-21 2002-01-17 Merck Patent Gmbh Beschichtung für metallische Implantatmaterialien
US7726319B1 (en) 2000-08-24 2010-06-01 Osteotech, Inc. Method for removal of water associated with bone while diminishing the dimensional changes associated with lyophilization
JP2004512145A (ja) * 2000-10-31 2004-04-22 デピュイ・アクロメッド・インコーポレイテッド 骨および軟骨の修復用の鉱物質化したコラーゲン−多糖類型基質
US20020114795A1 (en) * 2000-12-22 2002-08-22 Thorne Kevin J. Composition and process for bone growth and repair
WO2002059395A2 (en) * 2000-12-28 2002-08-01 The Board Of Regents Of The University Of Nebraska Electrolytic deposition of coatings for prosthetic metals and alloys
US6558709B2 (en) * 2001-01-05 2003-05-06 Howmedica Osteonics Corp. Calcium phosphate composition and method of preparing same
US9080146B2 (en) 2001-01-11 2015-07-14 Celonova Biosciences, Inc. Substrates containing polyphosphazene as matrices and substrates containing polyphosphazene with a micro-structured surface
US7700819B2 (en) * 2001-02-16 2010-04-20 Kci Licensing, Inc. Biocompatible wound dressing
US7763769B2 (en) * 2001-02-16 2010-07-27 Kci Licensing, Inc. Biocompatible wound dressing
US20020115742A1 (en) * 2001-02-22 2002-08-22 Trieu Hai H. Bioactive nanocomposites and methods for their use
JP4790917B2 (ja) * 2001-02-23 2011-10-12 独立行政法人科学技術振興機構 人工椎体
US6949251B2 (en) * 2001-03-02 2005-09-27 Stryker Corporation Porous β-tricalcium phosphate granules for regeneration of bone tissue
GB0115320D0 (en) * 2001-06-22 2001-08-15 Univ Nottingham Matrix
IL144446A0 (en) * 2001-07-19 2002-05-23 Prochon Biotech Ltd Plasma protein matrices and methods for their preparation
JP2003180820A (ja) * 2001-10-09 2003-07-02 Techno Network Shikoku Co Ltd 生体材料、医薬品、食品、医療用具、細胞培養器具および組織誘導材料の製造方法
JP4403268B2 (ja) * 2001-10-21 2010-01-27 独立行政法人産業技術総合研究所 リン酸カルシウム多孔質焼結体の製造方法及びそれを用いた人工骨の製造方法
JP2003169845A (ja) * 2001-12-07 2003-06-17 Japan Science & Technology Corp スポンジ状多孔質アパタイト・コラーゲン複合体、スポンジ状超多孔質アパタイト・コラーゲン複合体及びそれらの製造方法
JP4695334B2 (ja) * 2002-02-22 2011-06-08 デピュイ スパイン、インコーポレイテッド 組織修復マトリックス
TW200400062A (en) 2002-04-03 2004-01-01 Mathys Medizinaltechnik Ag Kneadable, pliable bone replacement material
US7247288B2 (en) * 2002-04-18 2007-07-24 Carnegie Mellon University Method of manufacturing hydroxyapatite and uses therefor in delivery of nucleic acids
US7776600B2 (en) 2002-04-18 2010-08-17 Carnegie Mellon University Method of manufacturing hydroxyapatite and uses therefor in delivery of nucleic acids
AU2003226788A1 (en) 2002-04-29 2003-11-17 Biomet Deutschland Gmbh Structured composites as a matrix (scaffold) for the tissue engineering of bones
US7163965B2 (en) * 2002-05-01 2007-01-16 Japan Science And Technology Agency Process for producing porous composite materials
US20030225347A1 (en) * 2002-06-03 2003-12-04 Argenta Louis C. Directed tissue growth employing reduced pressure
US7166133B2 (en) 2002-06-13 2007-01-23 Kensey Nash Corporation Devices and methods for treating defects in the tissue of a living being
US7846141B2 (en) 2002-09-03 2010-12-07 Bluesky Medical Group Incorporated Reduced pressure treatment system
GB0224986D0 (en) 2002-10-28 2002-12-04 Smith & Nephew Apparatus
WO2004041320A1 (ja) * 2002-11-06 2004-05-21 National Institute For Materials Science 自己組織化したアパタイト／コラーゲン複合体を含むアパタイト／コラーゲン架橋多孔体及びその製造方法
ITMI20030186A1 (it) * 2003-02-05 2004-08-06 Consiglio Nazionale Ricerche Procedimento di sintesi di tessuto osseo artificiale,
GB0307011D0 (en) * 2003-03-27 2003-04-30 Regentec Ltd Porous matrix
EP1642599B1 (de) * 2003-05-26 2010-12-01 HOYA Corporation Poröser verbundstoff mit calciumphosphat und herstellungsverfahren dafür
WO2005000483A1 (en) * 2003-06-06 2005-01-06 Tufts University Method for forming inorganic coatings
DE10328892A1 (de) * 2003-06-26 2005-05-12 Curasan Ag Knochenaufbaumittel und Herstellungsverfahren
US7955616B2 (en) * 2003-09-23 2011-06-07 Orthocon, Inc. Absorbable implants and methods for their use in hemostasis and in the treatment of osseous defects
JP4699902B2 (ja) * 2003-10-27 2011-06-15 Ｈｏｙａ株式会社 リン酸カルシウムセラミックス多孔体及びその製造方法
JP4671596B2 (ja) * 2003-11-26 2011-04-20 京セラ株式会社 多孔質骨修復材料およびその製造方法
US20070231788A1 (en) * 2003-12-31 2007-10-04 Keyvan Behnam Method for In Vitro Assay of Demineralized Bone Matrix
EP1701729B1 (de) * 2003-12-31 2018-05-02 Warsaw Orthopedic, Inc. Verbesserte knochenmatrixzusammensetzungen und verfahren
US8734525B2 (en) * 2003-12-31 2014-05-27 Warsaw Orthopedic, Inc. Osteoinductive demineralized cancellous bone
US7189263B2 (en) * 2004-02-03 2007-03-13 Vita Special Purpose Corporation Biocompatible bone graft material
JP4643166B2 (ja) * 2004-03-30 2011-03-02 独立行政法人物質・材料研究機構 アパタイト／コラーゲン複合体繊維を含む多孔体の平均気孔径制御方法
US20070190101A1 (en) * 2004-03-31 2007-08-16 Chunlin Yang Flowable bone grafts
US10058642B2 (en) 2004-04-05 2018-08-28 Bluesky Medical Group Incorporated Reduced pressure treatment system
US7909805B2 (en) 2004-04-05 2011-03-22 Bluesky Medical Group Incorporated Flexible reduced pressure treatment appliance
US8062272B2 (en) 2004-05-21 2011-11-22 Bluesky Medical Group Incorporated Flexible reduced pressure treatment appliance
GB0409446D0 (en) 2004-04-28 2004-06-02 Smith & Nephew Apparatus
US7815826B2 (en) 2004-05-12 2010-10-19 Massachusetts Institute Of Technology Manufacturing process, such as three-dimensional printing, including solvent vapor filming and the like
US9220595B2 (en) 2004-06-23 2015-12-29 Orthovita, Inc. Shapeable bone graft substitute and instruments for delivery thereof
CN101084025A (zh) * 2004-09-14 2007-12-05 新加坡科技研究局 多孔生物材料－填充物复合物及其制造方法
US7722895B1 (en) * 2004-09-20 2010-05-25 Warsaw Orthopedic, Inc. Osteogenic implants with combined implant materials, and materials and methods for same
US7473678B2 (en) 2004-10-14 2009-01-06 Biomimetic Therapeutics, Inc. Platelet-derived growth factor compositions and methods of use thereof
DE602005027229D1 (de) 2004-10-25 2011-05-12 Celonova Biosciences Germany Gmbh Beladbare polyphosphazenhaltige teilchen für therapeutische und/oder diagnostische anwendungen sowie herstellungs- und verwendungsverfahren dafür
US9107850B2 (en) 2004-10-25 2015-08-18 Celonova Biosciences, Inc. Color-coded and sized loadable polymeric particles for therapeutic and/or diagnostic applications and methods of preparing and using the same
US9114162B2 (en) 2004-10-25 2015-08-25 Celonova Biosciences, Inc. Loadable polymeric particles for enhanced imaging in clinical applications and methods of preparing and using the same
US20210299056A9 (en) 2004-10-25 2021-09-30 Varian Medical Systems, Inc. Color-Coded Polymeric Particles of Predetermined Size for Therapeutic and/or Diagnostic Applications and Related Methods
CN100591364C (zh) * 2004-10-28 2010-02-24 独立行政法人物质·材料研究机构 含有磷灰石/胶原复合体纤维的多孔体的制造方法
EP1819371A2 (de) * 2004-11-23 2007-08-22 Ossacur AG Bioresorbierbares und oberflächen-mineralisiertes material zur füllung von knochendefekten
DE102005016443A1 (de) * 2004-11-23 2006-05-24 Ossacur Ag Bioresorbierbares und mineralisiertes Material zur Füllung von Knochendefekten
US20070038303A1 (en) * 2006-08-15 2007-02-15 Ebi, L.P. Foot/ankle implant and associated method
EP1819375A2 (de) * 2004-12-08 2007-08-22 Interpore Spine Ltd. Komposit mit kontinuierlicher phase für die muskel-skelett-reparatur
US8535357B2 (en) * 2004-12-09 2013-09-17 Biomet Sports Medicine, Llc Continuous phase compositions for ACL repair
DE102005034420A1 (de) * 2004-12-23 2006-07-06 Ossacur Ag Gelartiges Material zur Füllung von Knochen- und/oder Knorpeldefekten
US7621963B2 (en) * 2005-04-13 2009-11-24 Ebi, Llc Composite bone graft material
US20060233849A1 (en) * 2005-04-13 2006-10-19 Simon Bruce J Composite bone graft material
US7740794B1 (en) 2005-04-18 2010-06-22 Biomet Sports Medicine, Llc Methods of making a polymer and ceramic composite
US8506646B2 (en) * 2005-04-29 2013-08-13 Warsaw Orthopedic, Inc. Multi-purpose medical implant devices
US7857853B2 (en) 2005-04-29 2010-12-28 Sdgi Holdings, Inc Synthetic loadbearing collagen-mineral composites useful for spinal implants, and methods of manufacture
US20060251628A1 (en) * 2005-05-06 2006-11-09 Mohamed Attawia Defatted, dewatered bone marrow
WO2006124946A2 (en) * 2005-05-16 2006-11-23 Purdue Research Foundation Engineered extracellular matrices
GB0517499D0 (en) 2005-08-26 2005-10-05 West Hertfordshire Hospitals N Surgical scaffold
AU2006286158A1 (en) * 2005-09-02 2007-03-08 Colbar Lifescience Ltd. Cross-linked polysaccharide and protein matrices and methods for their preparation
US8921109B2 (en) 2005-09-19 2014-12-30 Histogenics Corporation Cell-support matrix having narrowly defined uniformly vertically and non-randomly organized porosity and pore density and a method for preparation thereof
US9005646B2 (en) 2005-10-12 2015-04-14 Lifenet Health Compositions for repair of defects in tissues, and methods of making the same
US9132208B2 (en) * 2008-08-07 2015-09-15 Lifenet Health Composition for a tissue repair implant and methods of making the same
ES2393756T3 (es) 2005-11-01 2012-12-27 Warsaw Orthopedic, Inc. Métodos para producir composiciones de matriz ósea
EP1951331A4 (de) * 2005-11-14 2010-03-24 Seoul Nat Univ Ind Foundation Verfahren zur herstellung einer kollagen/ apatit-verbundmembran für die gelenkte knochenregeneration
US8287914B2 (en) * 2006-01-12 2012-10-16 Rutgers, The State University Of New Jersey Biomimetic hydroxyapatite synthesis
US20100040668A1 (en) * 2006-01-12 2010-02-18 Rutgers, The State University Of New Jersey Biomimetic Hydroxyapatite Composite Materials and Methods for the Preparation Thereof
CA2637616A1 (en) 2006-01-19 2007-07-26 Osteotech, Inc. Injectable and moldable bone substitute materials
US20070173949A1 (en) * 2006-01-25 2007-07-26 Sharps Lewis S Bonding system for orthopedic implants
US7939092B2 (en) * 2006-02-01 2011-05-10 Warsaw Orthopedic, Inc. Cohesive osteogenic putty and materials therefor
DE102006011211A1 (de) * 2006-03-02 2007-09-06 Ossacur Ag Material zur Behandlung von Knochen- und/oder Knorpeldefekten
US20100131064A1 (en) * 2006-04-05 2010-05-27 University Of Nebraska Bioresorbable polymer reconstituted bone and methods of formation thereof
US20070269476A1 (en) 2006-05-16 2007-11-22 Voytik-Harbin Sherry L Engineered extracellular matrices control stem cell behavior
EP2896411B1 (de) 2006-06-29 2023-08-30 Orthovita, Inc. Bioaktiver Knochentransplantatersatz
WO2008023708A1 (en) 2006-08-22 2008-02-28 Mitsubishi Electric Corporation Laser processing apparatus, method of bone junction, implant member, process for producing implant member, and implant member production apparatus
JP2008061897A (ja) * 2006-09-08 2008-03-21 Saga Univ 生体インプラント
US8084055B2 (en) * 2006-09-21 2011-12-27 Purdue Research Foundation Collagen preparation and method of isolation
DE102006048833A1 (de) * 2006-10-16 2008-04-17 Universität Rostock Behandlung von Osteoporose
CA2668189C (en) * 2006-11-03 2016-01-26 Biomimetic Therapeutics, Inc. Compositions and methods for arthrodetic procedures comprising a solution of platelet derived growth factor (pdgf) incorporated in a biocompatible matrix
US7931651B2 (en) 2006-11-17 2011-04-26 Wake Lake University Health Sciences External fixation assembly and method of use
US7544212B2 (en) * 2006-12-08 2009-06-09 Collagen Matrix, Inc. Bone implant composite
US7381224B1 (en) 2006-12-08 2008-06-03 Collagen Matrix, Inc. Bone implant composite
AU2007234612B2 (en) 2006-12-14 2013-06-27 Johnson & Johnson Regenerative Therapeutics, Llc Protein stabilization formulations
US8048857B2 (en) * 2006-12-19 2011-11-01 Warsaw Orthopedic, Inc. Flowable carrier compositions and methods of use
US7718616B2 (en) * 2006-12-21 2010-05-18 Zimmer Orthobiologics, Inc. Bone growth particles and osteoinductive composition thereof
US8377016B2 (en) 2007-01-10 2013-02-19 Wake Forest University Health Sciences Apparatus and method for wound treatment employing periodic sub-atmospheric pressure
EP1964583A1 (de) 2007-02-09 2008-09-03 Royal College of Surgeons in Ireland Verfahren zur Herstellung eines Kollagen/Hydroxyapatitverbundgerüsts
US8431148B2 (en) * 2007-03-08 2013-04-30 Warsaw Orthopedic, Inc. Bone void filler
CA2945295C (en) 2007-06-15 2020-01-14 Warsaw Orthopedic, Inc. Method of treating tissue
WO2008157495A2 (en) 2007-06-15 2008-12-24 Osteotech, Inc. Bone matrix compositions and methods
US9554920B2 (en) 2007-06-15 2017-01-31 Warsaw Orthopedic, Inc. Bone matrix compositions having nanoscale textured surfaces
ITMI20071298A1 (it) * 2007-06-29 2008-12-30 Univ Bologna Alma Mater Materiale composito poroso, relativo processo di preparazione e suo uso per la realizzazione di dispositivi per l'ingegneria tissutale
US7678764B2 (en) 2007-06-29 2010-03-16 Johnson & Johnson Regenerative Therapeutics, Llc Protein formulations for use at elevated temperatures
US9492278B2 (en) * 2007-07-10 2016-11-15 Warsaw Orthopedic, Inc. Delivery system
US8058237B2 (en) 2007-08-07 2011-11-15 Advanced Technologies & Regenerative Medicine, LLC Stable composition of GDF-5 and method of storage
US20110076316A1 (en) * 2007-10-08 2011-03-31 Sureshan Sivananthan Scalable matrix for the in vivo cultivation of bone and cartilage
US8834520B2 (en) 2007-10-10 2014-09-16 Wake Forest University Devices and methods for treating spinal cord tissue
WO2009052492A2 (en) * 2007-10-19 2009-04-23 Osteotech, Inc. Demineralized bone matrix compositions and methods
US7998499B2 (en) * 2007-10-25 2011-08-16 Collagen Matrix, Inc. Calcium-containing bone implants
JP2009132601A (ja) * 2007-11-01 2009-06-18 Hoya Corp アパタイト／コラーゲン複合体繊維を含む多孔体及びその製造方法
WO2009061887A2 (en) * 2007-11-06 2009-05-14 University Of Connecticut Ceramic/structural protein composites and method of preparation thereof
US9149563B2 (en) * 2007-11-06 2015-10-06 The University Of Connecticut Calcium phosphate/structural protein composites and method of preparation thereof
US20090131867A1 (en) 2007-11-16 2009-05-21 Liu Y King Steerable vertebroplasty system with cavity creation element
US20090131886A1 (en) 2007-11-16 2009-05-21 Liu Y King Steerable vertebroplasty system
US9510885B2 (en) 2007-11-16 2016-12-06 Osseon Llc Steerable and curvable cavity creation system
GB0722820D0 (en) 2007-11-21 2008-01-02 Smith & Nephew Vacuum assisted wound dressing
EP3360519B1 (de) 2007-11-21 2020-11-18 Smith & Nephew plc Wundauflage
ES2555204T3 (es) 2007-11-21 2015-12-29 T.J. Smith & Nephew Limited Dispositivo de succión y venda
US11253399B2 (en) 2007-12-06 2022-02-22 Smith & Nephew Plc Wound filling apparatuses and methods
US20130096518A1 (en) 2007-12-06 2013-04-18 Smith & Nephew Plc Wound filling apparatuses and methods
GB0723875D0 (en) 2007-12-06 2008-01-16 Smith & Nephew Wound management
AU2008335152B2 (en) 2007-12-10 2013-09-12 Indiana University Research And Technology Corporation Collagen-based matrices with stem cells
JP5925990B2 (ja) 2008-01-09 2016-05-25 ウェイク・フォレスト・ユニヴァーシティ・ヘルス・サイエンシズ 損傷した中枢神経系組織を処置するための装置
KR20100130178A (ko) * 2008-01-09 2010-12-10 이노베이티브 헬스 테크놀로지스, 엘엘씨 임플란트 펠렛 및 골 증강과 보존을 수행하는 방법
WO2009088519A1 (en) * 2008-01-11 2009-07-16 Rutgers, The State University Of New Jersey Biomimetic hydroxyapatite composite materials and methods for the preparation thereof
GB0803564D0 (en) 2008-02-27 2008-04-02 Smith & Nephew Fluid collection
US20140031944A1 (en) * 2008-03-18 2014-01-30 Yoh Sawatari Cylindrical graft and method for preparing a recipient site and implanting a cylindrical graft into alveolar jaw bone
WO2009122902A1 (ja) * 2008-04-02 2009-10-08 Hoya株式会社 アパタイト/コラーゲン複合体からなる膨張性多孔体、及びその製造方法
EP2276458A1 (de) * 2008-04-14 2011-01-26 Advanced Technologies and Regenerative Medicine, LLC Flüssige gepufferte gdf-5-formulierungen
US9616153B2 (en) 2008-04-17 2017-04-11 Warsaw Orthopedic, Inc. Rigid bone graft substitute
CN102056619A (zh) 2008-04-18 2011-05-11 科尔普兰特有限公司 产生和使用原胶原的方法
US20090263507A1 (en) * 2008-04-18 2009-10-22 Warsaw Orthopedic, Inc. Biological markers and response to treatment for pain, inflammation, neuronal or vascular injury and methods of use
US20090263458A1 (en) * 2008-04-21 2009-10-22 Lasse Daniel Efskind Material for surgical use in traumatology
CN105664197A (zh) * 2008-04-24 2016-06-15 麦德托尼克公司 冷电离辐射灭菌
JP2009268685A (ja) * 2008-05-07 2009-11-19 Hoya Corp アパタイト／コラーゲン複合体で被覆してなる人工骨、及びその製造方法
KR20100007180A (ko) * 2008-07-11 2010-01-22 세원셀론텍(주) 뼈 재생용 콜라겐 젤 조성물의 제조방법
WO2010009294A1 (en) 2008-07-18 2010-01-21 Wake Forest University Heath Sciences Apparatus and method for cardiac tissue modulation by topical application of vacuum to minimize cell death and damage
KR100932945B1 (ko) 2009-01-16 2009-12-21 원광대학교산학협력단 골 분말과 피브린 글루로 이루어진 고형의 스캐폴드
WO2010093959A2 (en) 2009-02-12 2010-08-19 Osteotech, Inc. Delivery systems, tools, and methods of use
US10806833B1 (en) 2009-05-11 2020-10-20 Integra Lifesciences Corporation Adherent resorbable matrix
US20100298832A1 (en) 2009-05-20 2010-11-25 Osseon Therapeutics, Inc. Steerable curvable vertebroplasty drill
AU2010275697B2 (en) * 2009-07-23 2014-01-30 Progentix Orthobiology B.V. Injectable and moldable osteoinductive ceramic materials
MX2012004917A (es) 2009-10-29 2012-08-15 Prosidyan Inc Material de injerto oseo, bioactivo, dinamico que tiene porosidad diseñada por ingenieria.
US8567162B2 (en) * 2009-10-29 2013-10-29 Prosidyan, Inc. Dynamic bioactive bone graft material and methods for handling
US8758791B2 (en) 2010-01-26 2014-06-24 Warsaw Orthopedic, Inc. Highly compression resistant matrix with porous skeleton
WO2015147923A1 (en) 2010-03-03 2015-10-01 Novabone Products, Llc Kit for delivering bone grafting materials
US9144629B2 (en) 2010-03-03 2015-09-29 Novabone Products, Llc Ionically crosslinked materials and methods for production
WO2011109581A1 (en) 2010-03-03 2011-09-09 Novabone Products, Llc Devices and methods for the regeneration of bony defects
CN101791438B (zh) * 2010-03-16 2013-02-27 浙江大学 骨修复用生物活性聚(乳酸-羟基乙酸)/胶原/羟基磷灰石复合纤维膜的制备方法
CA2796274A1 (en) 2010-04-16 2011-10-20 Apatech Limited Biomaterial
US9061095B2 (en) 2010-04-27 2015-06-23 Smith & Nephew Plc Wound dressing and method of use
WO2011137377A1 (en) 2010-04-29 2011-11-03 Dfine, Inc. System for use in treatment of vertebral fractures
US9295695B2 (en) 2010-04-30 2016-03-29 Skeletal Kinetics, Llc Temperature-insensitive calcium phosphate cements
WO2011143226A1 (en) 2010-05-11 2011-11-17 Howmedica Osteonics Corp. Organophosphorous, multivalent metal compounds, & polymer adhesive interpenetrating network compositions & methods
US8858577B2 (en) 2010-05-19 2014-10-14 University Of Utah Research Foundation Tissue stabilization system
GB201011173D0 (en) 2010-07-02 2010-08-18 Smith & Nephew Provision of wound filler
US8877220B2 (en) * 2010-08-05 2014-11-04 Collagen Matrix, Inc. Self-expandable biopolymer-mineral composite
WO2012051420A2 (en) 2010-10-13 2012-04-19 Cibor, Inc. Synthetic bone grafts constructed from carbon foam materials
US8926710B2 (en) 2010-10-25 2015-01-06 Warsaw Orthopedic, Inc. Osteoinductive bone graft injectable cement
CA2817584C (en) 2010-11-15 2018-01-02 Zimmer Orthobiologics, Inc. Bone void fillers
CN103403095B (zh) 2010-11-25 2016-12-14 史密夫及内修公开有限公司 组合物i – ii及其产品和用途
GB201020005D0 (en) 2010-11-25 2011-01-12 Smith & Nephew Composition 1-1
US8551525B2 (en) 2010-12-23 2013-10-08 Biostructures, Llc Bone graft materials and methods
WO2012099852A1 (en) 2011-01-17 2012-07-26 Cibor, Inc. Reinforced carbon fiber/carbon foam intervertebral spine fusion device
US8852214B2 (en) 2011-02-04 2014-10-07 University Of Utah Research Foundation System for tissue fixation to bone
KR101883144B1 (ko) * 2011-02-25 2018-07-31 신세스 게엠바하 골형성 촉진 임플란트 및 골 성장의 유도 방법
WO2012158527A2 (en) 2011-05-13 2012-11-22 Howmedica Osteonics Organophosphorous & multivalent metal compound compositions & methods
EP2529764A1 (de) 2011-05-31 2012-12-05 Curasan AG Biologisch degradierbares kompositmaterial
US20150159066A1 (en) 2011-11-25 2015-06-11 Smith & Nephew Plc Composition, apparatus, kit and method and uses thereof
WO2013142763A1 (en) 2012-03-22 2013-09-26 University Of Connecticut Biomimetic scaffold for bone regeneration
US10207027B2 (en) 2012-06-11 2019-02-19 Globus Medical, Inc. Bioactive bone graft substitutes
CN102805881B (zh) * 2012-06-18 2014-02-19 浙江星月生物科技股份有限公司 一种胶原基骨软骨三层复合物及其制备方法
US20130345826A1 (en) 2012-06-22 2013-12-26 Collagen Matrix, Inc. Implants for Bone and Cartilage Repair
US10219804B2 (en) 2012-07-30 2019-03-05 Conextions, Inc. Devices, systems, and methods for repairing soft tissue and attaching soft tissue to bone
US10390935B2 (en) 2012-07-30 2019-08-27 Conextions, Inc. Soft tissue to bone repair devices, systems, and methods
US9427309B2 (en) 2012-07-30 2016-08-30 Conextions, Inc. Soft tissue repair devices, systems, and methods
US10835241B2 (en) 2012-07-30 2020-11-17 Conextions, Inc. Devices, systems, and methods for repairing soft tissue and attaching soft tissue to bone
US11944531B2 (en) 2012-07-30 2024-04-02 Conextions, Inc. Devices, systems, and methods for repairing soft tissue and attaching soft tissue to bone
US11253252B2 (en) 2012-07-30 2022-02-22 Conextions, Inc. Devices, systems, and methods for repairing soft tissue and attaching soft tissue to bone
US11957334B2 (en) 2012-07-30 2024-04-16 Conextions, Inc. Devices, systems, and methods for repairing soft tissue and attaching soft tissue to bone
US9066853B2 (en) * 2013-01-15 2015-06-30 Warsaw Orthopedic, Inc. Clonidine compounds in a biodegradable fiber
US9381274B2 (en) 2013-03-14 2016-07-05 Prosidyan, Inc. Bone graft implants containing allograft
US8883195B2 (en) 2013-03-14 2014-11-11 Prosidyan, Inc. Bioactive porous bone graft implants
US8889178B2 (en) 2013-03-14 2014-11-18 Prosidyan, Inc Bioactive porous bone graft compositions in synthetic containment
US20160120706A1 (en) 2013-03-15 2016-05-05 Smith & Nephew Plc Wound dressing sealant and use thereof
RU2563621C2 (ru) * 2013-09-16 2015-09-20 Федеральное государственное бюджетное учреждение науки Институт физики полупроводников им. А.В. Ржанова Сибирского отделения Российской академии наук (ИФП СО РАН) Биорезорбируемая полимерная клеточная матрица
CN103536965B (zh) * 2013-09-24 2014-11-05 北京大学口腔医学院 具严格等级结构的三维矿化胶原支架的制备方法、及其产品和应用
US9878071B2 (en) 2013-10-16 2018-01-30 Purdue Research Foundation Collagen compositions and methods of use
US9539286B2 (en) 2013-10-18 2017-01-10 Globus Medical, Inc. Bone grafts including osteogenic stem cells, and methods relating to the same
US9486483B2 (en) 2013-10-18 2016-11-08 Globus Medical, Inc. Bone grafts including osteogenic stem cells, and methods relating to the same
US9579421B2 (en) 2014-02-07 2017-02-28 Globus Medical Inc. Bone grafts and methods of making and using bone grafts
US9463264B2 (en) 2014-02-11 2016-10-11 Globus Medical, Inc. Bone grafts and methods of making and using bone grafts
US11583384B2 (en) 2014-03-12 2023-02-21 Conextions, Inc. Devices, systems, and methods for repairing soft tissue and attaching soft tissue to bone
WO2015138760A1 (en) 2014-03-12 2015-09-17 Conextions, Inc. Soft tissue repair devices, systems, and methods
US9895354B2 (en) 2014-04-04 2018-02-20 University Of Kentucky Research Foundation Bilayered calcium sulfate/calcium phosphate space-making composites with multiple drug delivery capabilities
US9539363B2 (en) * 2014-04-24 2017-01-10 Warsaw Orthopedic, Inc. Collagen matrix
CN104147641B (zh) * 2014-07-11 2016-08-31 深圳职业技术学院 一种用于个性化的骨修复材料和其制备方法
US10077420B2 (en) 2014-12-02 2018-09-18 Histogenics Corporation Cell and tissue culture container
US10238507B2 (en) 2015-01-12 2019-03-26 Surgentec, Llc Bone graft delivery system and method for using same
US11919941B2 (en) 2015-04-21 2024-03-05 Purdue Research Foundation Cell-collagen-silica composites and methods of making and using the same
US10016529B2 (en) 2015-06-10 2018-07-10 Globus Medical, Inc. Biomaterial compositions, implants, and methods of making the same
US11426489B2 (en) 2015-06-10 2022-08-30 Globus Medical, Inc. Biomaterial compositions, implants, and methods of making the same
US11052175B2 (en) 2015-08-19 2021-07-06 Musculoskeletal Transplant Foundation Cartilage-derived implants and methods of making and using same
US9580543B1 (en) * 2016-02-05 2017-02-28 Xerox Corporation Method of making branched polyester resin with a target glass transition temperature
FI127762B (en) 2016-09-19 2019-02-15 Tty Saeaetioe Process for making porous composite material
US11696822B2 (en) 2016-09-28 2023-07-11 Conextions, Inc. Devices, systems, and methods for repairing soft tissue and attaching soft tissue to bone
CN109862834B (zh) 2016-10-27 2022-05-24 Dfine有限公司 具有接合剂递送通道的可弯曲的骨凿
CN106512104A (zh) * 2016-10-31 2017-03-22 北京奥精医药科技有限公司 矿化胶原基牙槽骨修复材料及其制备方法
JP7256119B2 (ja) 2016-11-28 2023-04-11 ディファイン インコーポレイテッド 腫瘍切除装置及び関連する方法
WO2018107036A1 (en) 2016-12-09 2018-06-14 Dfine, Inc. Medical devices for treating hard tissues and related methods
EP3565486B1 (de) 2017-01-06 2021-11-10 Dfine, Inc. Osteotom mit distalem abschnitt zum gleichzeitigen vorschieben und artikulieren
CN106798949B (zh) * 2017-02-22 2019-09-20 福建吉特瑞生物科技有限公司 一种多孔羟基磷灰石骨修复材料及其制备方法
US11739291B2 (en) 2017-04-25 2023-08-29 Purdue Research Foundation 3-dimensional (3D) tissue-engineered muscle for tissue restoration
US12102317B2 (en) 2017-12-20 2024-10-01 Conextions, Inc. Devices, systems, and methods for repairing soft tissue and attaching soft tissue to bone
US11547397B2 (en) 2017-12-20 2023-01-10 Conextions, Inc. Devices, systems, and methods for repairing soft tissue and attaching soft tissue to bone
CN118303936A (zh) 2018-02-20 2024-07-09 科内克思申斯股份有限公司 用于将软组织固定到骨的医疗装置系统
US11116647B2 (en) 2018-04-13 2021-09-14 Surgentec, Llc Bone graft delivery system and method for using same
US10687828B2 (en) 2018-04-13 2020-06-23 Surgentec, Llc Bone graft delivery system and method for using same
KR101938263B1 (ko) * 2018-07-31 2019-01-14 강호창 치과용 이중구조 멤브레인의 제조방법
WO2020097339A1 (en) 2018-11-08 2020-05-14 Dfine, Inc. Tumor ablation device and related systems and methods
EP4031040A4 (de) 2019-09-18 2023-11-15 Merit Medical Systems, Inc. Osteotom mit aufblasbarem teil und mehrdrahtgelenk
WO2021076837A1 (en) 2019-10-17 2021-04-22 The Texas A&M University System Drug eluting shape memory foam
KR20220110203A (ko) * 2019-12-04 2022-08-05 데이텀 덴탈 엘티디. 비수술적 치주질환 치료를 위한 콜라겐-하이드록시아파타이트 장치
US11896736B2 (en) 2020-07-13 2024-02-13 Globus Medical, Inc Biomaterial implants and methods of making the same
CN112494463B (zh) * 2020-11-23 2022-10-18 潍坊医学院 一种小檗碱/矿化胶原复合膜及其制备方法和应用
CN114425104B (zh) * 2021-12-21 2023-03-03 中国人民解放军空军军医大学 一种载药骨引导/诱导复合结构及其制备方法和应用
IL314660A (en) * 2022-02-07 2024-09-01 Martin J Moskovitz Cryosurgical device and materials and methods for its use
WO2024197316A1 (en) 2023-03-23 2024-09-26 Celularity Inc. Bone growth composition

Family Cites Families (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1271763A (en) * 1969-05-12 1972-04-26 Fmc Corp New or improved structures for example, prstuetic structures, and a method of preparing them
US4455256A (en) * 1981-05-05 1984-06-19 The Regents Of The University Of California Bone morphogenetic protein
US4294753A (en) * 1980-08-04 1981-10-13 The Regents Of The University Of California Bone morphogenetic protein process
US4440750A (en) * 1982-02-12 1984-04-03 Collagen Corporation Osteogenic composition and method
US4434094A (en) * 1983-04-12 1984-02-28 Collagen Corporation Partially purified osteogenic factor and process for preparing same from demineralized bone
US4789663A (en) * 1984-07-06 1988-12-06 Collagen Corporation Methods of bone repair using collagen
US4627982A (en) * 1984-07-16 1986-12-09 Collagen Corporation Partially purified bone-inducing factor
US4563350A (en) * 1984-10-24 1986-01-07 Collagen Corporation Inductive collagen based bone repair preparations
US4888366A (en) * 1984-10-24 1989-12-19 Collagen Corporation Inductive collagen-based bone repair preparations
CA1260391A (en) * 1985-03-28 1989-09-26 Karl A. Piez Xenogeneic collagen/mineral preparations in bone repair
US5246457A (en) * 1985-03-28 1993-09-21 Collagen Corporation Xenogeneic collagen/mineral preparations in bone repair
US4698326A (en) * 1985-12-20 1987-10-06 Regents Of The University Of Minnesota Composition and method for osseous repair
US4780450A (en) * 1985-12-20 1988-10-25 The University Of Maryland At Baltimore Physically stable composition and method of use thereof for osseous repair
US5133755A (en) 1986-01-28 1992-07-28 Thm Biomedical, Inc. Method and apparatus for diodegradable, osteogenic, bone graft substitute device
US4962091A (en) * 1986-05-23 1990-10-09 Syntex (U.S.A.) Inc. Controlled release of macromolecular polypeptides
US5306311A (en) * 1987-07-20 1994-04-26 Regen Corporation Prosthetic articular cartilage
WO1989004646A1 (en) * 1987-11-13 1989-06-01 Jefferies Steven R Bone repair material and delayed drug delivery
US4863732A (en) * 1987-12-16 1989-09-05 Collagen Corporation Injectable composition for inductive bone repair
GB2215209B (en) 1988-03-14 1992-08-26 Osmed Inc Method and apparatus for biodegradable, osteogenic, bone graft substitute device
US4975526A (en) * 1989-02-23 1990-12-04 Creative Biomolecules, Inc. Bone collagen matrix for zenogenic implants
GB8819755D0 (en) * 1988-08-19 1988-09-21 Geistlich Soehne Ag Chemical compound
US5264214A (en) * 1988-11-21 1993-11-23 Collagen Corporation Composition for bone repair
US5162430A (en) * 1988-11-21 1992-11-10 Collagen Corporation Collagen-polymer conjugates
US5092883A (en) * 1988-12-28 1992-03-03 Eppley Barry L Method for promoting soft connective tissue growth and repair in mammals
DE3907663A1 (de) * 1989-03-09 1990-09-13 Espe Stiftung Knochenersatzteil aus glasionomerzement
WO1991001720A1 (en) * 1989-08-07 1991-02-21 Herman Wade Schlameus Composition and method of promoting hard tissue healing
US5236456A (en) * 1989-11-09 1993-08-17 Osteotech, Inc. Osteogenic composition and implant containing same
US5071655A (en) * 1990-01-12 1991-12-10 Baylink David J Pharmaceutical combination for treatment of bone-wasting diseases
US5645591A (en) 1990-05-29 1997-07-08 Stryker Corporation Synthetic bone matrix
US5219998A (en) * 1990-06-04 1993-06-15 Levin Robert H Yeast-derived epidermal growth factor
EP0475077B1 (de) * 1990-09-10 1996-06-12 Synthes AG, Chur Membran für Knochenregenerierung
US5231169A (en) * 1990-10-17 1993-07-27 Norian Corporation Mineralized collagen
EP0513334A4 (en) * 1990-11-30 1993-08-04 Celtrix Laboratories, Inc. Use of a bone morphogenetic protein in synergistic combination with tgf--g(b) for bone repair
US5208219A (en) * 1991-02-14 1993-05-04 Celtrix Pharmaceuticals Inc. Method for inducing bone growth
US5149691A (en) * 1991-03-12 1992-09-22 Creative Biomolecules, Inc. Issue repair and regeneration through the use of platelet derived growth factor (pdgf) in combination with dexamethasone
JP3064470B2 (ja) 1991-04-19 2000-07-12 杉郎 大谷 人工補填補綴材料
CA2102808A1 (en) * 1991-05-10 1992-11-11 Hanne Bentz Targeted delivery of bone growth factors
DE4120325A1 (de) * 1991-06-20 1992-12-24 Merck Patent Gmbh Implantatwerkstoff
DE4121043A1 (de) * 1991-06-26 1993-01-07 Merck Patent Gmbh Knochenersatzmaterial mit fgf
US5356629A (en) 1991-07-12 1994-10-18 United States Surgical Corporation Composition for effecting bone repair
US5270300A (en) * 1991-09-06 1993-12-14 Robert Francis Shaw Methods and compositions for the treatment and repair of defects or lesions in cartilage or bone
US5306303A (en) * 1991-11-19 1994-04-26 The Medical College Of Wisconsin, Inc. Bone induction method
US5876452A (en) 1992-02-14 1999-03-02 Board Of Regents, University Of Texas System Biodegradable implant
US6013853A (en) 1992-02-14 2000-01-11 The University Of Texas System Continuous release polymeric implant carrier
DE69307299T2 (de) * 1992-02-14 1997-04-30 Board of Regents, the University of Texas System, Austin, Tex. Mehrphasiges, biologisch abbaubares implantat/träger und verfahren zu seiner herstellung
JPH07503896A (ja) * 1992-02-21 1995-04-27 インペリアル・ケミカル・インダストリーズ・ピーエルシー 酸化触媒
US5532217A (en) * 1992-04-24 1996-07-02 Silver; Frederick H. Process for the mineralization of collagen fibers, product produced thereby and use thereof to repair bone
IL106159A0 (en) * 1992-06-30 1993-10-20 Dow Chemical Co Targeted delivery of growth factors for bone regeneration
JPH08502082A (ja) 1992-07-02 1996-03-05 コラーゲン コーポレイション 生体適合性ポリマー結合体
AU671721B2 (en) * 1993-01-12 1996-09-05 Genentech Inc. Tgf-beta formulation for inducing bone growth
US5531794A (en) 1993-09-13 1996-07-02 Asahi Kogaku Kogyo Kabushiki Kaisha Ceramic device providing an environment for the promotion and formation of new bone
JP3061732B2 (ja) * 1993-09-13 2000-07-10 旭光学工業株式会社 骨誘導と骨形成の場を提供するセラミックス機能材料及びその製造方法
WO1995008304A1 (en) * 1993-09-21 1995-03-30 The Penn State Research Foundation Bone substitute composition comprising hydroxyapatite and a method of production therefor
JP3410195B2 (ja) * 1994-02-28 2003-05-26 テルモ株式会社 生体吸収性プラスチックとコラーゲンの複合材料
US5577792A (en) * 1995-02-21 1996-11-26 Prince Corporation Multiple visor system with aligned pivot axes
US6902584B2 (en) 1995-10-16 2005-06-07 Depuy Spine, Inc. Bone grafting matrix
US5776193A (en) 1995-10-16 1998-07-07 Orquest, Inc. Bone grafting matrix

Also Published As

Publication number Publication date
NZ321756A (en) 1999-11-29
EP0855884A4 (de) 2001-08-08
EP1482872B1 (de) 2010-12-08
WO1997014376A1 (en) 1997-04-24
US20040220680A1 (en) 2004-11-04
AU705303B2 (en) 1999-05-20
DE69632829D1 (de) 2004-08-05
CA2476929C (en) 2011-06-21
JP4526525B2 (ja) 2010-08-18
US5776193A (en) 1998-07-07
US7842097B2 (en) 2010-11-30
EP1482872A4 (de) 2006-02-15
DK0855884T3 (da) 2004-08-16
AU2003213235B2 (en) 2008-09-11
CN1646070A (zh) 2005-07-27
CN1172724C (zh) 2004-10-27
PT855884E (pt) 2004-09-30
EP0855884B1 (de) 2004-06-30
CN1646070B (zh) 2012-06-13
CN1204245A (zh) 1999-01-06
ATE490744T1 (de) 2010-12-15
US6187047B1 (en) 2001-02-13
DE69632829T2 (de) 2005-04-14
EP0855884A1 (de) 1998-08-05
CA2232986A1 (en) 1997-04-24
EP1482872A1 (de) 2004-12-08
AU2003213235A1 (en) 2003-09-09
CA2476929A1 (en) 2003-09-04
JP4275732B2 (ja) 2009-06-10
ES2224182T3 (es) 2005-03-01
WO2003071991A1 (en) 2003-09-04
US6764517B2 (en) 2004-07-20
JPH11513590A (ja) 1999-11-24
CA2232986C (en) 2008-11-25
NZ535466A (en) 2005-08-26
JP2007007452A (ja) 2007-01-18
US20020183855A1 (en) 2002-12-05
AU7516796A (en) 1997-05-07

Similar Documents

Publication Publication Date Title
ATE270078T1 (de) Knochentransplantatmatrix
AU4283800A (en) Calcium phosphate bone substitute
IL147974A0 (en) Composite shaped bodies and methods for their production and use
ATE257716T1 (de) Resorbierbares knochenersatz- und knochenaufbaumaterial
DE69606194D1 (de) Chirurgisches transplantat/stent-system
DE69622548D1 (de) Gewebetransplantat zur blasenrekonstruktion
EP1465556A4 (de) Bearbeitbare vorgeformte implantate aus einem kalziumphosphat-knochenersatzmaterial
DK1163018T3 (da) Mineralisering og cellulær mønstring på biomaterialeoverflader
GR3024277T3 (en) Tgf-beta formulation for inducing bone growth.
DE69840069D1 (de) Kalziumphosphat-mikroträger und -mikrokugeln
AU3210895A (en) Storage stable calcium phosphate cements
EP0520690A3 (en) Calcium phosphate type hardening material for repairing living hard tissue
DE69840171D1 (de) Faserverstärkte,poröse,biologisch abbaubare implantatvorrichtung
IL121155A0 (en) System for producing an artificial sound environment
EP0929297A4 (de) Mineralium-ähnlichekalziumphosphatpartikel innerhalb von knochenhohlräumen
PL334249A1 (en) Method of producing a suspension of non-soluble calcium salts in a proteinous composition
ID21760A (id) Proses pembuatan kalsium karbonat
AU2725299A (en) Calcium salts of lipopeptide antibiotics, method for producing same and their use
ID21632A (id) Proses pembuatan kalsium karbonat
ES2174828T3 (es) Colageno mineralizado.
DE69931541D1 (de) Calciumphosphatzement
HUP0003957A2 (en) Method for producing calcium borate
EP1277482A3 (de) Mineralisierung und zelluläre Strukturierung von Biomaterialoberflächen
KR970006169A (ko) 탄산칼슘의 제조방법
DE69531627D1 (de) Humane hypertrophe chrondrozyten zelllinien

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 0855884

Country of ref document: EP