[go: up one dir, main page]

ATE254502T1 - Isolierung von immunglobulinen - Google Patents

Isolierung von immunglobulinen

Info

Publication number
ATE254502T1
ATE254502T1 AT97938801T AT97938801T ATE254502T1 AT E254502 T1 ATE254502 T1 AT E254502T1 AT 97938801 T AT97938801 T AT 97938801T AT 97938801 T AT97938801 T AT 97938801T AT E254502 T1 ATE254502 T1 AT E254502T1
Authority
AT
Austria
Prior art keywords
immunoglobulins
solid phase
phase matrix
matrix
designates
Prior art date
Application number
AT97938801T
Other languages
English (en)
Inventor
Allan Otto Fog Lihme
Marie Bendix Hansen
Original Assignee
Upfront Chromatography As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upfront Chromatography As filed Critical Upfront Chromatography As
Application granted granted Critical
Publication of ATE254502T1 publication Critical patent/ATE254502T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
    • B01D15/3804—Affinity chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3214—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the method for obtaining this coating or impregnating
    • B01J20/3217—Resulting in a chemical bond between the coating or impregnating layer and the carrier, support or substrate, e.g. a covalent bond
    • B01J20/3219—Resulting in a chemical bond between the coating or impregnating layer and the carrier, support or substrate, e.g. a covalent bond involving a particular spacer or linking group, e.g. for attaching an active group
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3244—Non-macromolecular compounds
    • B01J20/3246—Non-macromolecular compounds having a well defined chemical structure
    • B01J20/3248—Non-macromolecular compounds having a well defined chemical structure the functional group or the linking, spacer or anchoring group as a whole comprising at least one type of heteroatom selected from a nitrogen, oxygen or sulfur, these atoms not being part of the carrier as such
    • B01J20/3253—Non-macromolecular compounds having a well defined chemical structure the functional group or the linking, spacer or anchoring group as a whole comprising at least one type of heteroatom selected from a nitrogen, oxygen or sulfur, these atoms not being part of the carrier as such comprising a cyclic structure not containing any of the heteroatoms nitrogen, oxygen or sulfur, e.g. aromatic structures
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3244—Non-macromolecular compounds
    • B01J20/3246—Non-macromolecular compounds having a well defined chemical structure
    • B01J20/3248—Non-macromolecular compounds having a well defined chemical structure the functional group or the linking, spacer or anchoring group as a whole comprising at least one type of heteroatom selected from a nitrogen, oxygen or sulfur, these atoms not being part of the carrier as such
    • B01J20/3255—Non-macromolecular compounds having a well defined chemical structure the functional group or the linking, spacer or anchoring group as a whole comprising at least one type of heteroatom selected from a nitrogen, oxygen or sulfur, these atoms not being part of the carrier as such comprising a cyclic structure containing at least one of the heteroatoms nitrogen, oxygen or sulfur, e.g. heterocyclic or heteroaromatic structures
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
    • B01D15/1807—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns using counter-currents, e.g. fluidised beds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
AT97938801T 1996-08-30 1997-09-01 Isolierung von immunglobulinen ATE254502T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK93296 1996-08-30
PCT/DK1997/000359 WO1998008603A1 (en) 1996-08-30 1997-09-01 Isolation of immunoglobulins

Publications (1)

Publication Number Publication Date
ATE254502T1 true ATE254502T1 (de) 2003-12-15

Family

ID=8099153

Family Applications (2)

Application Number Title Priority Date Filing Date
AT03078126T ATE441476T1 (de) 1996-08-30 1997-09-01 Isolierung von immunoglobulinen
AT97938801T ATE254502T1 (de) 1996-08-30 1997-09-01 Isolierung von immunglobulinen

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT03078126T ATE441476T1 (de) 1996-08-30 1997-09-01 Isolierung von immunoglobulinen

Country Status (10)

Country Link
US (4) US6498236B1 (de)
EP (3) EP1386660B1 (de)
JP (1) JP4425994B2 (de)
AT (2) ATE441476T1 (de)
AU (1) AU729039C (de)
CA (2) CA2264177C (de)
DE (2) DE69739567D1 (de)
DK (1) DK1386660T3 (de)
ES (1) ES2332893T3 (de)
WO (1) WO1998008603A1 (de)

Families Citing this family (106)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2332893T3 (es) * 1996-08-30 2010-02-15 Upfront Chromatography A/S Aislamiento de inmunoglobulinas.
US6096872A (en) * 1997-10-14 2000-08-01 Ortho Diagnostic Systems, Inc. Viral clearance process
SE9804465D0 (sv) * 1998-12-22 1998-12-22 Amersham Pharm Biotech Ab A method for the removal/purification of serum albumins and means for use in the method
SE0002688D0 (sv) * 2000-07-17 2000-07-17 Amersham Pharm Biotech Ab Adsorption method and ligands
ES2545526T3 (es) 2001-02-01 2015-09-11 Sigma-Aldrich Co. Llc Matrices de afinidad mejorada con visibilidad mejorada para aplicaciones de arrastre molecular e inmunoprecipitación
EP1584242B1 (de) 2001-06-01 2010-01-20 Upfront Chromatography A/S Fraktionierung von proteinhaltigen Mischungen
US6957672B2 (en) * 2001-07-25 2005-10-25 Imperial Chemical Industries Plc Method for ensuring that coating compositions have correct color
DE10155984A1 (de) * 2001-11-15 2003-05-28 Boehringer Ingelheim Pharma Verfahren zur Reduktion des Liganden-leakage von Affinitätschromatographie-Matrices
ATE555666T1 (de) 2002-05-23 2012-05-15 Ortho Clinical Diagnostics Inc Einfang, konzentration und quantifizierung eines abnormalen prionproteins aus biologischen flüssigkeiten mittels tiefenfiltration
US6984806B2 (en) * 2002-07-23 2006-01-10 Illinois Tool Works Inc. Method and apparatus for retracting and advancing a welding wire
GB0220894D0 (en) * 2002-09-09 2002-10-16 Millipore Uk Ltd Method of separation
US7072616B2 (en) 2002-09-09 2006-07-04 Conexant Systems, Inc. Multi-protocol interchip interface
CA2500903A1 (en) * 2002-09-13 2004-03-25 Pall Corporation Preparation and use of mixed mode solid substrates for chromatography adsorbents and biochip arrays
US20070092960A1 (en) * 2003-03-21 2007-04-26 Upfront Chromatography A/S Method for high throughput volumes in the fractionation of bio-molecules by chromatographic systems
US7700743B2 (en) * 2003-07-22 2010-04-20 Millipore Corporation Immobilised affinity medium and its use in separation
US20040106131A1 (en) * 2003-08-18 2004-06-03 Swapan Roy Compositions and methods for proteomic investigations
SE0303532D0 (sv) * 2003-12-23 2003-12-23 Amersham Biosciences Ab Purification of immunoglobulins
WO2005077528A1 (en) * 2004-02-05 2005-08-25 Millipore Corporation Porous adsorptive or chromatographic media
SE0400490D0 (sv) 2004-02-26 2004-02-26 Amersham Biosciences Ab Plasmid purification
SE0400501D0 (sv) * 2004-02-27 2004-02-27 Amersham Biosciences Ab Antibody purification
EP1718386A1 (de) * 2004-02-27 2006-11-08 GE Healthcare Bio-Sciences AB Verfahren zur reinigung von antikörpern
DK1765866T3 (en) 2004-06-07 2014-03-24 Therapure Biopharma Inc ISOLATION OF plasma or serum protein
EP1765849A4 (de) * 2004-06-07 2007-09-05 Avt Plasma Ltd Verfahren zur proteinisolierung
SE0401665D0 (sv) 2004-06-24 2004-06-24 Amersham Biosciences Ab Purification of immunoglobulins
WO2006024303A1 (en) * 2004-09-01 2006-03-09 Cobento A/S Methods for purifying corrin-containing molecules
PL1827691T3 (pl) * 2004-10-21 2017-07-31 Ge Healthcare Bioprocess R&D Ab Matryca chromatograficzna
AU2005229674B2 (en) 2004-11-18 2010-11-04 Kedrion Melville Inc. Low concentration solvent/detergent process of immuneglobulin with pre-treatment
US20060202922A1 (en) * 2005-03-10 2006-09-14 Hanna Christopher P Method for optimizing a purification procedure
US20080220968A1 (en) 2005-07-05 2008-09-11 Ge Healthcare Bio-Sciences Ab [1, 2, 4] Triazolo [1, 5-A] Pyrimidine Derivatives as Chromatographic Adsorbent for the Selective Adsorption of Igg
WO2007064281A1 (en) * 2005-12-02 2007-06-07 Ge Healthcare Bio-Sciences Ab Hydrophobic interaction chromatography
US8481298B2 (en) * 2006-09-29 2013-07-09 Ge Healthcare Bio-Sciences Ab Separation matrix for viral purification
JP5448825B2 (ja) * 2006-10-19 2014-03-19 ヤンセン バイオテツク，インコーポレーテツド 非凝集抗体Ｆｃドメインの製造方法
US7691980B2 (en) 2007-01-09 2010-04-06 Bio-Rad Laboratories, Inc. Enhanced capacity and purification of antibodies by mixed mode chromatography in the presence of aqueous-soluble nonionic organic polymers
US7999085B2 (en) * 2007-01-09 2011-08-16 Bio-Rad Laboratories, Inc. Enhanced capacity and purification of protein by mixed mode chromatography in the presence of aqueous-soluble nonionic organic polymers
US8080272B2 (en) * 2007-01-09 2011-12-20 Biova, L.L.C. Method of separating components of technical eggs, edible eggs, yolk and whites and products therefrom
SG144809A1 (en) * 2007-01-11 2008-08-28 Millipore U K Ltd Benzimidazole compounds and their use as chromatographic ligands
CN102895797B (zh) * 2007-01-15 2016-01-20 厄普弗朗特色谱公司 从原料生产生物燃料和蛋白质
DK2139573T3 (da) 2007-03-28 2017-02-20 Patheon Holdings I B V Kolonne med ekpanderet leje og engangskromatografi
US20100113746A1 (en) * 2007-04-23 2010-05-06 Arvind Mallinath Lali Process for purification of immunoglobulins using a pseudobioaffinity adsorbent
AR069501A1 (es) 2007-11-30 2010-01-27 Genentech Inc Anticuerpos anti- vegf (factor de crecimiento endotelial vascular)
US8188242B2 (en) * 2008-04-08 2012-05-29 Bio-Rad Laboratories, Inc. Chromatography purification of antibodies
EP2355664B8 (de) 2008-09-30 2014-09-10 Upfront Chromatography A/S Verfahren zur Bereitstellung eines beta-Lactoglobulinprodukts und eines alpha-angereicherten Molkenproteinisolats
DE102009057993A1 (de) 2009-06-13 2011-01-20 Sartorius Stedim Biotech Gmbh Polysaccharidmatrix mit aufgepfropftem Polymer, Verfahren zu ihrer Herstellung und Verwendung
TW201106972A (en) 2009-07-27 2011-03-01 Genentech Inc Combination treatments
JP6195443B2 (ja) * 2009-07-28 2017-09-13 インストラクション・ゲーエムベーハー タンパク質及びペプチドと結合する特定の充填剤、並びに、それを用いた分離方法
CA2772715C (en) 2009-09-02 2019-03-26 Genentech, Inc. Mutant smoothened and methods of using the same
WO2011071577A1 (en) 2009-12-11 2011-06-16 Genentech, Inc. Anti-vegf-c antibodies and methods using same
AU2010333324A1 (en) 2009-12-17 2012-06-14 Instraction Gmbh Specific sorbent for binding proteins and peptides, and separation method using the same
KR101989628B1 (ko) 2009-12-21 2019-06-14 제넨테크, 인크. 항체 제제
AU2011312205B2 (en) 2010-10-05 2015-08-13 Curis, Inc. Mutant smoothened and methods of using the same
EP2570184A1 (de) * 2011-09-15 2013-03-20 InstrAction GmbH Sorptionsmittel, welches auf dessen Oberfläche ein aromatischen Ringsystem mit einer anionischen oder entprotonisierbaren Gruppe enthält, zur Reinigung organischer Moleküle
US8802448B2 (en) * 2011-07-27 2014-08-12 Pall Corporation Mixed mode ligands
US9309282B2 (en) * 2011-10-19 2016-04-12 Bio-Rad Laboratories, Inc. Solid phase for mixed-mode chromatographic purification of proteins
EP2771358A4 (de) * 2011-10-26 2015-08-26 Bio Rad Laboratories Entfernung von virustötenden substanzen in einer mischmoduschromatographie
US9492512B2 (en) * 2011-12-30 2016-11-15 Innomed S.A. Combination of growth factors, cytokines, antibacterial/antiviral factors, stem cell stimulating factors, complement proteins C3A/C4A, and chemotactic factors
DK2797609T3 (en) 2011-12-30 2017-01-09 Innomed S A COMBINING growth factors, cytokines, anti-bacterial / ANTIVIRALS FACTORS STEM CELL-STIMULATING FACTORS, complement C3A / C4A, immunoglobulins, and chemotactic factors
GB201202762D0 (en) 2012-02-17 2012-04-04 Autology Health Ltd High efficiency cell capture
MX358683B (es) 2012-07-11 2018-08-31 Cooperatie Avebe U A Aislados de proteina de papa.
BR112015005937A2 (pt) 2012-09-17 2017-07-04 Grace W R & Co meios e dispositivos cromatográficos
BR112015008661A2 (pt) 2012-10-23 2017-07-04 Upfront Chromatography As processos de separação para proteína de soja
IN2015DN03308A (de) * 2012-11-13 2015-10-09 Ge Healthcare Bio Sciences Ab
CN103030713A (zh) * 2012-12-21 2013-04-10 江南大学 一种具有降血脂活性的低分子量葡聚糖-烟酸聚合物的制备方法
AR095399A1 (es) 2013-03-13 2015-10-14 Genentech Inc Formulaciones con oxidación reducida, método
CA3113172A1 (en) 2013-03-13 2014-10-02 Genentech, Inc. Screen for compound that prevents protein oxidation based on comparison with l-tryptophan
AR095398A1 (es) 2013-03-13 2015-10-14 Genentech Inc Formulaciones con oxidación reducida
RS60534B1 (sr) 2013-03-13 2020-08-31 Hoffmann La Roche Formulacije sa smanjenom oksidacijom
US10023608B1 (en) 2013-03-13 2018-07-17 Amgen Inc. Protein purification methods to remove impurities
CN105209069B (zh) 2013-03-13 2019-08-23 豪夫迈·罗氏有限公司 抗体配制剂
JP2016513478A (ja) 2013-03-15 2016-05-16 ジェネンテック， インコーポレイテッド 細胞培養培地及び抗体を産生する方法
GB2513405A (en) 2013-04-26 2014-10-29 Adc Biotechnology Ltd Method of synthesising ADCs using affinity resins
US9661868B2 (en) 2013-07-16 2017-05-30 Mead Johnson Nutrition Company Expanded bed adsorption methods for isolation of basic milk proteins including lactoferrin
MX375378B (es) 2013-09-27 2025-03-06 Genentech Inc Formulaciones de anticuerpos anti-pdl1.
CN112353943A (zh) 2013-12-17 2021-02-12 豪夫迈·罗氏有限公司 用pd-1轴结合拮抗剂和紫杉烷治疗癌症的方法
JP2017501167A (ja) 2013-12-17 2017-01-12 ジェネンテック， インコーポレイテッド Ｏｘ４０結合アゴニスト及びｐｄ−１軸結合アンタゴニストを含む併用療法
WO2015095410A1 (en) 2013-12-17 2015-06-25 Genentech, Inc. Methods of treating cancer using pd-1 axis binding antagonists and an anti-cd20 antibody
PL3094390T3 (pl) 2014-01-16 2021-12-06 W.R. Grace & Co. - Conn. Nośniki do chromatografii powinowactwa i urządzenia do chromatografii
EP3102197B1 (de) 2014-02-04 2018-08-29 Genentech, Inc. Smoothened-mutant und verfahren zur verwendung davon
US20160347789A1 (en) * 2014-02-04 2016-12-01 Basf Se Method for purification of antibodies, antibody fragments or engineered variants thereof using specific anthraquinone dye-ligand structures
WO2015138928A2 (en) * 2014-03-14 2015-09-17 Bio-Rad Laboratories, Inc. Mixed mode ligands
CA2943834A1 (en) 2014-03-31 2015-10-08 Genentech, Inc. Combination therapy comprising anti-angiogenesis agents and ox40 binding agonists
CN107847907A (zh) 2014-05-02 2018-03-27 格雷斯公司 官能化载体材料以及制备和使用官能化载体材料的方法
WO2016044334A1 (en) 2014-09-15 2016-03-24 Genentech, Inc. Antibody formulations
GB201419184D0 (en) 2014-10-28 2014-12-10 Adc Biotechnology Ltd Method of synthesising biomolecule-effector/reporter-conjugates using affinity resins
GB201419185D0 (en) 2014-10-28 2014-12-10 Adc Biotechnology Ltd Method of synthesising ADCs using affinity resin
KR20170096112A (ko) 2014-11-17 2017-08-23 제넨테크, 인크. Ox40 결합 효능제 및 pd-1 축 결합 길항제를 포함하는 조합 요법
HK1244512A1 (zh) 2015-02-04 2018-08-10 健泰科生物技术公司 突变型smoothened及其使用方法
BR112017026193B1 (pt) 2015-06-05 2021-09-14 W.R. Grace & Co-Conn Adsorventes, método de produção dos adsorventes e uso dos adsorventes
HK1251493A1 (zh) 2015-06-17 2019-02-01 豪夫迈‧罗氏有限公司 使用pd-1轴结合拮抗剂和紫杉烷治疗局部晚期或转移性乳腺癌的方法
KR20180093078A (ko) 2015-12-30 2018-08-20 제넨테크, 인크. 단백질 제제를 위한 트립토판 유도체의 용도
ES3038408T3 (en) 2015-12-30 2025-10-13 Hoffmann La Roche Formulations with reduced degradation of polysorbate
EP3400246B1 (de) 2016-01-08 2020-10-21 H. Hoffnabb-La Roche Ag Verfahren zur behandlung von cea-positiven karzinomen mit pd-1-achsen-bindungsantagonisten und bispezifischen anti-cea/anti-cd3-antikörpern
JP2019509721A (ja) 2016-02-04 2019-04-11 キュリス，インコーポレイテッド 突然変異体スムースンド及びその使用方法
EP4112641A1 (de) 2016-03-15 2023-01-04 Chugai Seiyaku Kabushiki Kaisha Verfahren zur krebsbehandlung mit pd-1-achsenbindenden antagonisten und anti-gpc3-antikörpern
WO2018029124A1 (en) 2016-08-08 2018-02-15 F. Hoffmann-La Roche Ag Therapeutic and diagnostic methods for cancer
EP3592759A1 (de) 2017-03-07 2020-01-15 JMVA Biotech AB Modifizierte adsorptive oberflächen
CN111683976B (zh) 2018-02-05 2022-11-18 生物辐射实验室股份有限公司 具有阴离子交换-疏水混合模式配体的色谱树脂
CN115318256A (zh) 2018-03-08 2022-11-11 生物辐射实验室股份有限公司 阴离子交换-疏水混合模式色谱树脂
PL3781280T3 (pl) 2018-04-20 2022-08-16 Propharma Group Europe B.V. Sposób oddzielania z symulowanym ruchomym złożem
MY205645A (en) 2018-06-23 2024-11-02 Genentech Inc Methods of treating lung cancer with a pd-1 axis binding antagonist, a platinum agent, and a topoisomerase ii inhibitor
AU2019305637A1 (en) 2018-07-18 2021-03-11 Genentech, Inc. Methods of treating lung cancer with a PD-1 axis binding antagonist, an antimetabolite, and a platinum agent
BR112021002130A2 (pt) 2018-08-08 2021-05-04 Genentech, Inc. formulação líquida, artigo de fabricação ou kit e método para reduzir a oxidação de um polipeptídeo
CA3107770C (en) 2018-08-16 2023-09-05 Emd Millipore Corporation Closed bioprocessing device
JP7475336B2 (ja) 2018-09-21 2024-04-26 ジェネンテック， インコーポレイテッド トリプルネガティブ乳癌のための診断方法
JP6927247B2 (ja) * 2019-04-08 2021-08-25 昭和電工マテリアルズ株式会社 抗体の精製方法
JP7717627B2 (ja) 2019-09-05 2025-08-04 バイオ－ラッド・ラボラトリーズ・インコーポレーテッド アニオン交換－疎水性混合モードクロマトグラフィー樹脂
MX2022015877A (es) 2020-06-16 2023-01-24 Genentech Inc Metodos y composiciones para tratar cancer de mama triple negativo.

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH594696A5 (de) * 1975-03-18 1978-01-31 Battelle Memorial Institute
IL49752A (en) * 1975-07-09 1979-07-25 Kabi Ab Compositions having affinity for hepatitis virus and method for hepatitis virus removal or concentration
US4043997A (en) * 1976-05-28 1977-08-23 Cutter Laboratories, Inc. Method for isolating albumin using insoluble supports coupled to a dye
SE470261B (sv) 1984-05-17 1993-12-20 Jerker Porath Adsorbent för separation och immobilisering av proteiner, sätt att framställa ett adsorbent, samt dess användning för biopolymer fraktionering
SE470099B (sv) 1984-05-17 1993-11-08 Jerker Porath Sulfonaktiverade tioeteradsorbenter för separation av t ex protein
EP0197521B1 (de) * 1985-04-09 1989-08-02 TERUMO KABUSHIKI KAISHA trading as TERUMO CORPORATION Immunoglobulinadsorbent und Adsorptionsvorrichtung
DK158224C (da) * 1985-08-23 1990-09-24 Danske Sukkerfab Fremgangsmaade til fremstilling af indolderivater
SE500574C2 (sv) * 1986-02-13 1994-07-18 Gel Innovation Handelsbolag Nitrilofor adsorbent för separation och immobilisering av proteiner, sätt att framställa adsorbentet, samt dess användning för fraktionering och immobilisering av biopolymerer
FR2596177B1 (fr) 1986-03-19 1992-01-17 Infoscript Procede et dispositif de sauvegarde qualitative de donnees numerisees
EP0242222A3 (de) 1986-04-16 1988-05-11 Bata Industries Limited Verfahren zum Herstellen eines Schuhwerkleistens
FR2619568B1 (fr) * 1987-08-21 1989-07-07 Centre Nat Rech Scient Polymeres derives du polystyrene, leurs procedes de preparation et leurs applications pour l'analyse et la purification de molecules d'origine biologique
SE462165B (sv) * 1988-02-26 1990-05-14 Porath Jerker Saett att paa en baerare adsorbera sammansatta proteinkomplex, saerskilt vid biospecifika bestaemningsmetoder
US4981961A (en) 1988-09-12 1991-01-01 Bioprobe International, Inc. Synthetic affinity ligand compositions and methods for purification and recovery of organic molecules
DK165090D0 (da) 1990-07-09 1990-07-09 Kem En Tec As Konglomererede partikler
DK52791D0 (da) * 1991-03-22 1991-03-22 Kem En Tec As Adsorptionsmatricer
US5502022A (en) 1994-05-16 1996-03-26 Biosepra, Inc. Chromatography adsorbents utilizing mercapto heterocyclic ligands
SE9401960L (sv) * 1994-06-07 1995-12-08 Sven Oscarsson Alkalibeständigt proteinadsorbent
US20040214157A1 (en) 1994-06-29 2004-10-28 Simon C. Burton Chromatographic resins and methods for using same
US5652348A (en) 1994-09-23 1997-07-29 Massey University Chromatographic resins and methods for using same
GB9519197D0 (en) * 1995-09-20 1995-11-22 Affinity Chromatography Ltd Novel affinity ligands and their use
ES2332893T3 (es) * 1996-08-30 2010-02-15 Upfront Chromatography A/S Aislamiento de inmunoglobulinas.
US20050053939A1 (en) * 2001-11-09 2005-03-10 Ahmed Chenna Methods and compositions for enhancing detection in determinations employing cleavable electrophoretic tag reagents
US7514579B2 (en) * 2002-06-13 2009-04-07 Johns Hopkins University Boronic chalcone derivatives and uses thereof
WO2005024416A1 (en) * 2003-09-05 2005-03-17 Binghe Wang Water soluble boronic acid fluorescent reporter compounds and methods of use thereof

Also Published As

Publication number Publication date
US6919436B2 (en) 2005-07-19
JP2001501595A (ja) 2001-02-06
US7442779B2 (en) 2008-10-28
CA2876986C (en) 2017-08-29
EP0921855B1 (de) 2003-11-19
ATE441476T1 (de) 2009-09-15
CA2264177C (en) 2015-03-17
CA2264177A1 (en) 1998-03-05
CA2876986A1 (en) 1998-03-05
JP4425994B2 (ja) 2010-03-03
EP1386660B1 (de) 2009-09-02
ES2332893T3 (es) 2010-02-15
DE69726285D1 (de) 2003-12-24
US7745582B2 (en) 2010-06-29
DE69739567D1 (de) 2009-10-15
WO1998008603A1 (en) 1998-03-05
EP1386660A1 (de) 2004-02-04
AU729039B2 (en) 2001-01-25
DE69726285T2 (de) 2004-09-09
US6498236B1 (en) 2002-12-24
EP0921855A1 (de) 1999-06-16
DK1386660T3 (da) 2009-12-21
US20030187227A1 (en) 2003-10-02
AU729039C (en) 2001-08-02
EP2095873A1 (de) 2009-09-02
US20050176122A1 (en) 2005-08-11
AU4112397A (en) 1998-03-19
US20080132683A1 (en) 2008-06-05

Similar Documents

Publication Publication Date Title
ATE254502T1 (de) Isolierung von immunglobulinen
DE69128732D1 (de) Affinitätstrennung mit mikroporösen aktivierten Polyamidmembranen
GB9613683D0 (en) Oxidized oligosaccharides
DK0640135T3 (da) Immunoglobulinbindende proteiner, der er afledt af protein L, og anvendelser af disse
ATE299145T1 (de) Neues multimerisierendes reagenz
SE8901687D0 (sv) Fibronectin binding protein as well as its preparation
CA2085134A1 (en) Gdf-1
ATE252830T1 (de) Neue psoralene zur inaktivierung von pathogenen
DK0507407T3 (da) Multifunktionelle, i vand dispergerbare tværbindingsmidler
ATE211171T1 (de) Weitgehend reine rezeptorartige, tgf-beta-1- bindende moleküle und deren verwendungen
ATE268385T1 (de) Mykrobakterielle proteine, mikroorganismen welche diese produzieren und ihre verwendung als impfstoff und zum nachweis von zuberkulose
ATE267841T1 (de) Hochmolekulare und niedermolekulare fraktionen des von willebrand-faktors
DE69218471D1 (de) Verfahren zur Herstellung von biologisch aktiven Reagentien aus Succinimid enthaltenden Polymeren, analytisches Element und Verwendungsmethoden
EP0335654A3 (de) Riechstoff bindendes Protein aus Ratten
GB2267502B (en) Polymeric reaction products for use in immobilized buffered gels and membranes
ATE355319T1 (de) Composit-ionenaustauschmembranen
DK0665853T3 (da) Multimere polyvalente antitrombotiske midler
AU8040898A (en) Type-1 ribosome-inactivating protein
ATE256183T1 (de) Neue proteine von parasitischen würmern
DE69026637D1 (de) Markierung von Proteinen
ATE236659T1 (de) Entfernen von viren durch ultrafiltration aus proteinlösungen
ATE85058T1 (de) Jodhaltige polymere mit skeletten von dextran, verfahren zu ihrer herstellung und ihre verwendungen als kontrastmittel.
ATE223491T1 (de) Verfahren zur reinigung von biomolekül- oder proteinkomplexen
SE8800676D0 (sv) Bestemning av reaktanter och kombinationer av reaktanter involverade i biospecifika reaktioner
CA2112701A1 (en) Proteins s polypeptides and uses thereof

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties