ATE211772T1 - Nanbv-diagnostika: polynukleotide, geeignet für reihenuntersuchungen auf hepatitis c-virus - Google Patents
Nanbv-diagnostika: polynukleotide, geeignet für reihenuntersuchungen auf hepatitis c-virusInfo
- Publication number
- ATE211772T1 ATE211772T1 AT90305421T AT90305421T ATE211772T1 AT E211772 T1 ATE211772 T1 AT E211772T1 AT 90305421 T AT90305421 T AT 90305421T AT 90305421 T AT90305421 T AT 90305421T AT E211772 T1 ATE211772 T1 AT E211772T1
- Authority
- AT
- Austria
- Prior art keywords
- virus
- hepatitis
- polynucleotides suitable
- hcv
- serial examinations
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6853—Nucleic acid amplification reactions using modified primers or templates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6858—Allele-specific amplification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
- C12Q1/701—Specific hybridization probes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
- C12Q1/701—Specific hybridization probes
- C12Q1/706—Specific hybridization probes for hepatitis
- C12Q1/707—Specific hybridization probes for hepatitis non-A, non-B Hepatitis, excluding hepatitis D
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
- C12N2770/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicinal Chemistry (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US35596189A | 1989-05-18 | 1989-05-18 | |
US45663789A | 1989-12-21 | 1989-12-21 | |
US50543590A | 1990-04-04 | 1990-04-04 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE211772T1 true ATE211772T1 (de) | 2002-01-15 |
Family
ID=27408242
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT90305421T ATE211772T1 (de) | 1989-05-18 | 1990-05-18 | Nanbv-diagnostika: polynukleotide, geeignet für reihenuntersuchungen auf hepatitis c-virus |
Country Status (17)
Country | Link |
---|---|
EP (1) | EP0398748B1 (de) |
JP (3) | JP2656996B2 (de) |
AT (1) | ATE211772T1 (de) |
AU (1) | AU638719B2 (de) |
BG (1) | BG60348B2 (de) |
CA (1) | CA2017157C (de) |
DE (1) | DE69033891T2 (de) |
DK (1) | DK0398748T3 (de) |
ES (1) | ES2166749T3 (de) |
FI (1) | FI105279B (de) |
GE (1) | GEP20002164B (de) |
HU (1) | HUT59964A (de) |
LV (1) | LV10729B (de) |
MC (1) | MC2188A1 (de) |
NO (1) | NO303503B1 (de) |
RO (1) | RO113059B1 (de) |
WO (1) | WO1990014436A1 (de) |
Families Citing this family (66)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6489246A (en) * | 1987-09-30 | 1989-04-03 | Sony Corp | Fixing method for color sorting mechanism of color cathode-ray tube |
US6861212B1 (en) | 1987-11-18 | 2005-03-01 | Chiron Corporation | NANBV diagnostics and vaccines |
US5712088A (en) * | 1987-11-18 | 1998-01-27 | Chiron Corporation | Methods for detecting Hepatitis C virus using polynucleotides specific for same |
US5698390A (en) * | 1987-11-18 | 1997-12-16 | Chiron Corporation | Hepatitis C immunoassays |
US5714596A (en) * | 1987-11-18 | 1998-02-03 | Chiron Corporation | NANBV diagnostics: polynucleotides useful for screening for hepatitis C virus |
US6171782B1 (en) | 1987-11-18 | 2001-01-09 | Chiron Corporation | Antibody compositions to HCV and uses thereof |
US6027729A (en) * | 1989-04-20 | 2000-02-22 | Chiron Corporation | NANBV Diagnostics and vaccines |
US7166287B1 (en) | 1989-12-18 | 2007-01-23 | Glaxo Wellcome Inc. | Viral agent |
BR9006422A (pt) | 1989-12-18 | 1991-09-24 | Wellcome Found | Processo para preparar um polipeptidio viral pt-nanbh e processo para detectar o mesmo |
CA2044296A1 (en) * | 1990-06-12 | 1991-12-13 | Hiroaki Okamoto | Oligonucleotide primers, and their application for high-fidelity detection of non-a, non-b hepatitis virus |
US5747339A (en) | 1990-06-25 | 1998-05-05 | Research Foundation For Microbial Diseases Of Osaka | Non-A, non-B hepatitis virus genomic CDNA and antigen polypeptide |
AU7967191A (en) * | 1990-06-30 | 1992-01-23 | Akzo N.V. | Non-a non-b sequences |
DK0469348T3 (da) * | 1990-07-11 | 1997-04-01 | Shionogi & Co | cDNA-sekvens og detektering af hepatitis C-virus |
WO1992001714A1 (en) * | 1990-07-24 | 1992-02-06 | Yamanouchi Pharmaceutical Co., Ltd. | Non-a non-b hepatitis virus antigen |
JP2714255B2 (ja) * | 1990-08-10 | 1998-02-16 | カイロン コーポレイション | Nanbv診断法:c型肝炎ウイルスのスクリーニングに有用なポリヌクレオチド |
WO1992009634A1 (en) * | 1990-11-29 | 1992-06-11 | Toray Industries, Incorporated | Non-a non-b hepatitis virus antigen protein |
AU1459792A (en) * | 1991-01-14 | 1992-08-27 | James N. Gamble Institute Of Medical Research | Basic structural immunogenic polypeptides having epitopes for hcv, antibodies, polynucleotide sequences, vaccines and methods |
ES2066547T3 (es) * | 1991-03-01 | 1995-03-01 | Akzo Nobel Nv | Peptidos, inmunoquimicamente reactivos con anticuerpos dirigidos contra virus de hepatitis no-a, no-b. |
US5574132A (en) * | 1991-04-05 | 1996-11-12 | Biochem Immunosystems Inc. | Peptides and mixtures thereof for detecting antibodies to hepatitis C virus (HCV) |
EP0510952A1 (de) * | 1991-04-26 | 1992-10-28 | Immuno Japan Inc. | Oligonukleotid-Primer und ihre Anwendung zum Nachweis von Non-A, Non-B-Hepatitis mit höchster Genauigkeit |
FR2677372B1 (fr) * | 1991-06-06 | 1994-11-10 | Pasteur Institut | Sequences nucleotidiques et peptidiques d'un isolat de virus de l'hepatite c, applications diagnostiques et therapeutiques. |
IT1249684B (it) * | 1991-07-19 | 1995-03-09 | Sorin Biomedica Spa | Epitopi della proteina env del virus dell'epatite c. |
DE69223562T2 (de) * | 1991-08-27 | 1998-06-04 | Hoffmann La Roche | Verfahren und Reagenzien zum Nachweis von Hepatitis C |
JPH06502770A (ja) * | 1991-09-12 | 1994-03-31 | シーダーズ−サイナイ・メディカル・センター | C型肝炎ウイルスrnaの直接検出法 |
PL171972B1 (pl) * | 1991-09-13 | 1997-07-31 | Chiron Corp | Sposób wytwarzania polipeptydu HCV PL |
WO1993009253A1 (en) * | 1991-11-07 | 1993-05-13 | Baxter Diagnostics Inc. | Epitope mapping ot the c33c region of hcv |
AU671967B2 (en) | 1991-11-21 | 1996-09-19 | Common Services Agency | Hepatitis-C virus testing |
GB9204274D0 (en) * | 1992-02-28 | 1992-04-08 | Wellcome Found | Novel peptides |
US5866139A (en) * | 1992-06-04 | 1999-02-02 | Institut Pasteur | Nucleotide and peptide sequences of a hepatitis C virus isolate, diagnostic and therapeutic applications |
US5922857A (en) * | 1992-09-28 | 1999-07-13 | Chiron Corporation | Methods and compositions for controlling translation of HCV proteins |
JPH06153961A (ja) * | 1992-11-27 | 1994-06-03 | Imuno Japan:Kk | C型肝炎ウイルス部分遺伝子、ならびにc型肝炎ウイルス遺 伝子の高感度検出法 |
DE69433160T2 (de) | 1993-05-12 | 2004-07-08 | Chiron Corp. (N.D.Ges.D. Staates Delaware), Emeryville | Konserviertes Motiv der Hepatitis C Virus E2/NS1 Region |
AU3241095A (en) * | 1994-07-29 | 1996-03-04 | Chiron Corporation | Novel hepatitis c e1 and e2 truncated polypeptides and methods of obtaining the same |
JP3793571B2 (ja) | 1994-07-29 | 2006-07-05 | カイロン コーポレイション | 新規c型肝炎e1およびe2短縮型ポリペプチドならびにこれらを得る方法 |
US5837442A (en) | 1995-11-29 | 1998-11-17 | Roche Molecular Systems, Inc. | Oligonucleotide primers for amplifying HCV nucleic acid |
ES2328536T3 (es) | 1997-05-06 | 2009-11-13 | Novartis Vaccines And Diagnostics, Inc. | Produccion intracelular de polipeptido e2 truncado de la hepatitis c. |
DE19832050C2 (de) * | 1998-07-16 | 2002-10-10 | Biotest Pharma Gmbh | Verfahren zum Nachweis von Hepatitis B- bzw. Hepatitis C-Virusgenomen in Plasmaproben und spezifische Primer |
EP1154793B1 (de) | 1999-02-26 | 2010-09-15 | Novartis Vaccines and Diagnostics, Inc. | Verwendung von bioadhaesiven und adjuvantien für die mukosale anwendung von antigenen |
AU2875700A (en) | 1999-02-26 | 2000-09-14 | Chiron Corporation | Microemulsions with adsorbed macromoelecules and microparticles |
US7196066B1 (en) | 1999-11-03 | 2007-03-27 | Powderject Vaccines, Inc. | DNA-vaccines based on constructs derived from the genomes of human and animal pathogens |
BRPI0111682B8 (pt) * | 2000-06-15 | 2021-07-27 | Chiron Corp | suporte sólido de imunoensaio, kit de teste de imunodiagnóstico, métodos de produção de um suporte sólido de imunoensaio, e de detecção de infecção pelo vírus da hepatite c (hcv) em uma amostra biológica, e, uso de um suporte sólido de imunoensaio |
US7022830B2 (en) | 2000-08-17 | 2006-04-04 | Tripep Ab | Hepatitis C virus codon optimized non-structural NS3/4A fusion gene |
RU2286172C2 (ru) | 2000-08-17 | 2006-10-27 | Трипеп Аб | Вакцины, содержащие рибавирин, и способы их использования |
DE60130998T2 (de) | 2000-08-17 | 2008-07-17 | Tripep Ab | Ribavirin-enthaltende vakzine |
US6680059B2 (en) | 2000-08-29 | 2004-01-20 | Tripep Ab | Vaccines containing ribavirin and methods of use thereof |
US6586584B2 (en) | 2001-01-29 | 2003-07-01 | Becton, Dickinson And Company | Sequences and methods for detection of Hepatitis C virus |
WO2002099035A2 (en) | 2001-05-31 | 2002-12-12 | Chiron Corporation | Chimeric alphavirus replicon particles |
AR045702A1 (es) | 2001-10-03 | 2005-11-09 | Chiron Corp | Composiciones de adyuvantes. |
AU2003215316A1 (en) | 2002-02-20 | 2003-09-09 | Chiron Corporation | Microparticles with adsorbed polypeptide-containing molecules |
US7598421B2 (en) | 2002-05-08 | 2009-10-06 | Ucl Biomedica Plc | Materials for the delivery of biologically-active material to cells |
CA2511512C (en) | 2002-12-27 | 2013-10-29 | Chiron Corporation | Immunogenic compositions containing phospholipid |
KR101173871B1 (ko) | 2003-02-06 | 2012-08-16 | 앤저 테라퓨틱스 인코퍼레이티드 | 변형된 독립생존 미생물, 백신 조성물 및 그것의 사용방법 |
US7695725B2 (en) | 2003-02-06 | 2010-04-13 | Aduro Biotech | Modified free-living microbes, vaccine compositions and methods of use thereof |
ES2382332T3 (es) | 2003-02-06 | 2012-06-07 | Aduro Biotech | Listeria atenuada para entrar en células no fagocíticas, vacunas que comprenden esta listeria y métodos de uso de las mismas |
US7731967B2 (en) | 2003-04-30 | 2010-06-08 | Novartis Vaccines And Diagnostics, Inc. | Compositions for inducing immune responses |
US7842289B2 (en) | 2003-12-24 | 2010-11-30 | Aduro Biotech | Recombinant nucleic acid molecules, expression cassettes, and bacteria, and methods of use thereof |
US20060165716A1 (en) | 2004-07-29 | 2006-07-27 | Telford John L | Immunogenic compositions for gram positive bacteria such as streptococcus agalactiae |
US7871625B2 (en) | 2004-08-27 | 2011-01-18 | Novartis Vaccines And Diagnostics, Inc. | HCV multiple epitope fusion antigens with modified proteolytic cleavage sites and uses thereof |
WO2007031867A2 (en) | 2005-05-25 | 2007-03-22 | Tripep Ab | A hepatitis c virus non-stru tural ns3/4a fusion gene |
US20110136678A1 (en) * | 2006-10-20 | 2011-06-09 | Erwin Sablon | Methodology for analysis of sequence variations within the hcv ns3/4a genomic region |
WO2009022236A2 (en) | 2007-08-16 | 2009-02-19 | Tripep Ab | Immunogen platform |
EP2244695A1 (de) | 2007-12-07 | 2010-11-03 | Novartis AG | Zusammensetzungen zur induktion von immunantworten |
WO2009130588A2 (en) | 2008-04-22 | 2009-10-29 | Tripep Ab | Immunogen platform |
EP2283112B1 (de) | 2008-05-19 | 2016-10-12 | Aduro Biotech | Zusammensetzungen mit prfa-mutanten von listerien und anwendungsverfahren dafür |
KR20120022760A (ko) | 2009-03-09 | 2012-03-12 | 윌리엄 헨리 | 담체로서 시그널 펩티드를 가지는 박테리아 독소를 포함하는 햅텐-담체 접합체와 면역원성 조성물에 있어서 이의 용도 |
FI122954B (fi) | 2011-01-31 | 2012-09-14 | Teknoware Oy | LED-putkilamppu ja valaisinjärjestely |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4683195A (en) * | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
US4683202A (en) * | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
DE318216T1 (de) * | 1987-11-18 | 1990-06-13 | Chiron Corp., Emeryville, Calif. | Nanbv-diagnostika und vakzine. |
US5191064A (en) * | 1988-09-30 | 1993-03-02 | The Research Foundation For Microbial Diseases (Osaka University) | Non-a, non-b hepatitis virus antigen peptide |
UA50829C2 (uk) * | 1989-03-17 | 2002-11-15 | Чірон Корпорейшн | Очищений поліпептид, що містить антиген вірусу гепатиту с, полінуклеотид, вектор, клітини, система експресії, моноклональне антитіло, препарат поліклональних антитіл, нуклеотидна проба, аналітичні набори, спосіб виявлення нуклеїнових кислот, способи імуноаналізу, вакцина, спосіб одержання антитіл |
CA2032907C (en) * | 1989-12-22 | 2002-05-14 | Richard R. Lesniewski | Hepatitis c assay |
CA2079677A1 (en) * | 1990-04-03 | 1991-10-04 | Kenneth H. Burk | Purified hcv and hcv proteins and peptides |
-
1990
- 1990-05-18 JP JP2508534A patent/JP2656996B2/ja not_active Expired - Lifetime
- 1990-05-18 AU AU58123/90A patent/AU638719B2/en not_active Expired
- 1990-05-18 GE GE1876A patent/GEP20002164B/en unknown
- 1990-05-18 DE DE69033891T patent/DE69033891T2/de not_active Expired - Lifetime
- 1990-05-18 MC MC@@@@@@@@@@@@D patent/MC2188A1/xx unknown
- 1990-05-18 WO PCT/US1990/002853 patent/WO1990014436A1/en active IP Right Grant
- 1990-05-18 ES ES90305421T patent/ES2166749T3/es not_active Expired - Lifetime
- 1990-05-18 EP EP90305421A patent/EP0398748B1/de not_active Expired - Lifetime
- 1990-05-18 DK DK90305421T patent/DK0398748T3/da active
- 1990-05-18 RO RO149205A patent/RO113059B1/ro unknown
- 1990-05-18 HU HU904754A patent/HUT59964A/hu unknown
- 1990-05-18 AT AT90305421T patent/ATE211772T1/de not_active IP Right Cessation
- 1990-05-18 CA CA002017157A patent/CA2017157C/en not_active Expired - Lifetime
-
1991
- 1991-11-18 FI FI915443A patent/FI105279B/fi active
- 1991-11-18 BG BG095495A patent/BG60348B2/bg unknown
- 1991-11-18 NO NO914517A patent/NO303503B1/no not_active IP Right Cessation
-
1993
- 1993-06-01 LV LVP-93-456A patent/LV10729B/en unknown
-
1996
- 1996-10-30 JP JP30570796A patent/JP3701754B2/ja not_active Expired - Lifetime
-
1997
- 1997-05-19 JP JP14598597A patent/JP3698520B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
DK0398748T3 (da) | 2002-03-18 |
DE69033891T2 (de) | 2002-08-29 |
EP0398748A2 (de) | 1990-11-22 |
LV10729A (lv) | 1995-06-20 |
CA2017157C (en) | 2003-07-29 |
AU5812390A (en) | 1990-12-18 |
RO113059B1 (ro) | 1998-03-30 |
JP3701754B2 (ja) | 2005-10-05 |
LV10729B (en) | 1995-12-20 |
HUT59964A (en) | 1992-07-28 |
AU638719B2 (en) | 1993-07-08 |
JPH05500155A (ja) | 1993-01-21 |
JPH1089A (ja) | 1998-01-06 |
DE69033891D1 (de) | 2002-02-21 |
GEP20002164B (en) | 2000-07-10 |
WO1990014436A1 (en) | 1990-11-29 |
EP0398748A3 (de) | 1991-10-23 |
CA2017157A1 (en) | 1990-11-18 |
MC2188A1 (fr) | 1992-09-16 |
NO914517L (no) | 1992-01-16 |
NO914517D0 (no) | 1991-11-18 |
BG60348B2 (bg) | 1994-09-30 |
NO303503B1 (no) | 1998-07-20 |
FI105279B (fi) | 2000-07-14 |
HU904754D0 (en) | 1992-01-28 |
FI915443A0 (fi) | 1991-11-18 |
ES2166749T3 (es) | 2002-05-01 |
JPH10113176A (ja) | 1998-05-06 |
EP0398748B1 (de) | 2002-01-09 |
JP2656996B2 (ja) | 1997-09-24 |
JP3698520B2 (ja) | 2005-09-21 |
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