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AR074001A1 - Compuestos de isoindolina y composiciones farmaceuticas y uso para tratamiento de cancer - Google Patents

Compuestos de isoindolina y composiciones farmaceuticas y uso para tratamiento de cancer

Info

Publication number
AR074001A1
AR074001A1 ARP090104177A AR074001A1 AR 074001 A1 AR074001 A1 AR 074001A1 AR P090104177 A ARP090104177 A AR P090104177A AR 074001 A1 AR074001 A1 AR 074001A1
Authority
AR
Argentina
Prior art keywords
alkyl
heterocyclyl
optionally substituted
heteroaryl
membered
Prior art date
Application number
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English (en)
Original Assignee
Celgene Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celgene Corp filed Critical Celgene Corp
Publication of AR074001A1 publication Critical patent/AR074001A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P37/00—Drugs for immunological or allergic disorders
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    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Anesthesiology (AREA)
  • Dermatology (AREA)
  • Transplantation (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Oncology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Ophthalmology & Optometry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Reivindicacion 1: Un compuesto caracterizado porque tiene la formula 1, o una sal, solvato, prodroga o estereoisomero farmacéuticamente aceptable del mismo, en donde: X es C(=O) o CH2; Y es O, cianamida (N-:::N) o amida (NH); m es un numero entero de 0, 1, 2 o 3; R1 es hidrogeno o alquilo C1-6; R2 es hidrogeno, -NO2, alquilo C1-10, alquil C0-6-(heteroarilo de 5 a 10 miembros), alquil C0-6-(heterociclilo de 5 a 6 miembros), alquil C0-6-OH, alquil C0-4-NH2, -NHCO-alquilo C1-6 , -OR21 o -(CH2-Z)0-2-(heteroarilo de 5 a 10 miembros), donde cada heteroarilo y heterociclilo está sustituido opcionalmente con uno o más alquilo C1-6; R3 es hidrogeno, halogeno, -NO2, alquil C0-6-(heteroarilo de 5 a 10 miembros), alquil C0-6-(heterociclilo de 5 a 6 miembros), alquil C0-6-OH, alquil C0-4-NH2, -NHCO-alquilo C1-6, -OR21 o -(CH2-Z)0-2-(heteroarilo de 6 a 10 miembros), donde cada heteroarilo y heterociclilo está sustituido opcionalmente con uno o más alquilo C1-6; R21 es arilo C6-10, heteroarilo de 5 a 10 miembros, heterociclilo de 5 a 10 miembros o -CO(CH2)0-2R22, en donde el arilo, heteroarilo y heterociclilo están, cada uno, sustituido opcionalmente con uno o más alquilo C1-6; R22 es -NH2 o heterociclilo de 5 a 10 miembros; y Z es CH2, NH u O; siempre que cuando R1 es hidrogeno, entonces R2 no es hidrogeno o alquilo C1-10, siempre que cuando Y es O, entonces R3 no es halogeno; y siempre que cuando Y es O y R3 es halogeno, entonces R2 es alquil C0-6-(heterociclilo de 5-6 miembros). Reivindicacion 6: Un compuesto caracterizado porque tiene la formula (2), o una sal, solvato, prodroga o estereoisomero farmacéuticamente aceptable del mismo, en donde: X es C(=O) o CH2; m es un numero entero de 0, 1, 2 o 3;R4 es cicloalquilo C3-10, heterociclilo de 5 a 10 miembros, heteroarilo de 5 a 10 miembros o alquil C0-4-NR41R42; en donde cada cicloalquilo, heterociclilo y heteroarilo está sustituido opcionalmente con uno o más entre halogeno, alquilo C1-6, -CO-NR43R44, -COOR45 o alquil C0-4-arilo C6-10, en donde el propio arilo puede estar sustituido opcionalmente con uno o más halogenos; y R41, R42, R43, R44 y R45 son cada uno, de manera independiente, hidrogeno o alquilo C1-6. Reivindicacion 9: Un compuesto caracterizado porque tiene la formula (3) o una sal. solvato, prodroga o estereoisomero farmacéuticamente aceptable del mismo, en donde: X es C(=O) o CH2; m es un numero entero de 0, 1, 2 o 3; R5 y R6 son cada uno, de manera independiente: hidrogeno, halo, alquilo C1-6, oxo, -NO2, alcoxi C1-6, -Z-alquilo C1-6, alquil C0-6-(heteroarilo de 5 a 10 miembros), alquil C0-6-(heterociclilo de 5 a 6 miembros), alquil C0-6-OH, alquil C0-4-NH2, -NHCO-alquilo C1-6 , -OR21 o -(CH2-Y)0-2-(heteroarilo de 5 a 10 miembros), en donde Z es S o SO2; en donde R21 es como se definio previamente; en donde cada heteroarilo y heterociclilo anterior está sustituido opcionalmente con uno o más alquilo C1-6; y en donde el alquilo o alcoxi anterior puede estar sustituido opcionalmente con uno o más entre: halogeno; ciano; nitro; amino; alquilidendioxi C1-6, alcoxi C1-6, el mismo sustituido opcionalmente con uno o más halogenos; o alquiltio C1-6, el mismo sustituido opcionalmente con uno o más halogenos, R7 es -COR71 o -PO(OR72)(OR73); R71 es alquilo C1-10, arilo C6-10, o heterociclilo de 5 a 10 miembros: en donde el alquilo, arilo, heterociclilo puede estar sustituido opcionalmente con uno o más amino, alquilamino C1-6, di(alquil C1-6)amino, o -COOR74; y R72, R73 y R74 son, cada uno de forma independiente, hidrogeno o alquilo C1-10.
ARP090104177 2008-10-29 2009-10-29 Compuestos de isoindolina y composiciones farmaceuticas y uso para tratamiento de cancer AR074001A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10947508P 2008-10-29 2008-10-29

Publications (1)

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AR074001A1 true AR074001A1 (es) 2010-12-15

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Family Applications (6)

Application Number Title Priority Date Filing Date
ARP090104177 AR074001A1 (es) 2008-10-29 2009-10-29 Compuestos de isoindolina y composiciones farmaceuticas y uso para tratamiento de cancer
ARP160103712A AR106942A2 (es) 2008-10-29 2016-12-02 Compuestos de isoindolina y composiciones farmacéuticas de los mismos
ARP160103716A AR106945A2 (es) 2008-10-29 2016-12-02 Compuestos de isoindolina y composiciones farmacéuticas de los mismos
ARP160103713A AR106943A2 (es) 2008-10-29 2016-12-02 Compuestos de isoindolina y composiciones farmacéuticas de los mismos
ARP160103715A AR106944A2 (es) 2008-10-29 2016-12-02 Compuestos de isoindolina y composiciones farmacéuticas de los mismos
ARP160103802A AR106963A2 (es) 2008-10-29 2016-12-12 Compuestos de isoindolina y composiciones farmacéuticas de los mismos

Family Applications After (5)

Application Number Title Priority Date Filing Date
ARP160103712A AR106942A2 (es) 2008-10-29 2016-12-02 Compuestos de isoindolina y composiciones farmacéuticas de los mismos
ARP160103716A AR106945A2 (es) 2008-10-29 2016-12-02 Compuestos de isoindolina y composiciones farmacéuticas de los mismos
ARP160103713A AR106943A2 (es) 2008-10-29 2016-12-02 Compuestos de isoindolina y composiciones farmacéuticas de los mismos
ARP160103715A AR106944A2 (es) 2008-10-29 2016-12-02 Compuestos de isoindolina y composiciones farmacéuticas de los mismos
ARP160103802A AR106963A2 (es) 2008-10-29 2016-12-12 Compuestos de isoindolina y composiciones farmacéuticas de los mismos

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US (6) US8129375B2 (es)
EP (3) EP2985281B1 (es)
JP (3) JP5603876B2 (es)
KR (3) KR101696938B1 (es)
CN (2) CN102264720B (es)
AR (6) AR074001A1 (es)
AU (1) AU2009311477B2 (es)
BR (1) BRPI0919942B1 (es)
CA (2) CA2957226C (es)
CL (1) CL2011000957A1 (es)
CO (1) CO6361916A2 (es)
DK (1) DK2358697T3 (es)
ES (2) ES2559388T3 (es)
HK (1) HK1154859A1 (es)
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PL (1) PL2358697T3 (es)
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