ES2485316T3 - Usos inmunológicos de compuestos inmunomoduladores para vacunas y terapia anti-enfermedades infecciosas - Google Patents
Usos inmunológicos de compuestos inmunomoduladores para vacunas y terapia anti-enfermedades infecciosas Download PDFInfo
- Publication number
- ES2485316T3 ES2485316T3 ES11151126.7T ES11151126T ES2485316T3 ES 2485316 T3 ES2485316 T3 ES 2485316T3 ES 11151126 T ES11151126 T ES 11151126T ES 2485316 T3 ES2485316 T3 ES 2485316T3
- Authority
- ES
- Spain
- Prior art keywords
- vaccines
- infectious disease
- immunomodulatory compounds
- disease therapy
- methods
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 230000002519 immonomodulatory effect Effects 0.000 title abstract 2
- 208000035473 Communicable disease Diseases 0.000 title 1
- 230000002924 anti-infective effect Effects 0.000 title 1
- 230000001900 immune effect Effects 0.000 title 1
- 208000015181 infectious disease Diseases 0.000 title 1
- 238000002560 therapeutic procedure Methods 0.000 title 1
- 229960005486 vaccine Drugs 0.000 title 1
- 230000028993 immune response Effects 0.000 abstract 2
- 230000035945 sensitivity Effects 0.000 abstract 2
- 239000013566 allergen Substances 0.000 abstract 1
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 230000002163 immunogen Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/4035—Isoindoles, e.g. phthalimide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pulmonology (AREA)
- Hematology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Un compuesto, que es 3-(4-amino-1-oxo-1,3-dihidro-isoindol-2-il)-piperidin-2,6-diona, para el uso en un método para reducir la resistencia adquirida a rituximab en un paciente de cáncer, en el que el compuesto se administra antes de la administración de rituximab.
Description
Claims (1)
-
imagen1
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US71282305P | 2005-09-01 | 2005-09-01 | |
US712823P | 2005-09-01 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2485316T3 true ES2485316T3 (es) | 2014-08-13 |
Family
ID=37806889
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES11151126.7T Active ES2485316T3 (es) | 2005-09-01 | 2006-08-31 | Usos inmunológicos de compuestos inmunomoduladores para vacunas y terapia anti-enfermedades infecciosas |
ES06824878T Active ES2359162T3 (es) | 2005-09-01 | 2006-08-31 | Usos inmunologicos de compuestos inmunomoduladores para vacunas y terapia de enfermedades anti-infecciosas. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES06824878T Active ES2359162T3 (es) | 2005-09-01 | 2006-08-31 | Usos inmunologicos de compuestos inmunomoduladores para vacunas y terapia de enfermedades anti-infecciosas. |
Country Status (14)
Country | Link |
---|---|
US (2) | US8715677B2 (es) |
EP (2) | EP1928492B1 (es) |
JP (2) | JP2009507030A (es) |
AT (1) | ATE499112T1 (es) |
CA (1) | CA2621136C (es) |
CY (1) | CY1112325T1 (es) |
DE (1) | DE602006020300D1 (es) |
DK (1) | DK1928492T3 (es) |
ES (2) | ES2485316T3 (es) |
HR (1) | HRP20110348T1 (es) |
PL (1) | PL1928492T3 (es) |
RS (1) | RS51840B (es) |
SI (1) | SI1928492T1 (es) |
WO (1) | WO2007028047A2 (es) |
Families Citing this family (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20090068210A1 (en) * | 2007-07-09 | 2009-03-12 | Munshi Nikhil C | Immunotherapy for hematological malignancies |
US9200253B1 (en) * | 2007-08-06 | 2015-12-01 | Anthrogenesis Corporation | Method of producing erythrocytes |
BRPI0817525A2 (pt) | 2007-09-26 | 2014-11-18 | Celgene Corp | Composto, composição farmacêutica, e, metódo de tratamento, controle ou prevenção de uma doença ou distúrbio. |
WO2009131730A2 (en) | 2008-01-31 | 2009-10-29 | University Of Iowa Research Foundation | IMMUNOGENIC COMPOSITIONS FOR ACTIVATING γδ T CELLS |
US20090298882A1 (en) * | 2008-05-13 | 2009-12-03 | Muller George W | Thioxoisoindoline compounds and compositions comprising and methods of using the same |
PL2358697T3 (pl) | 2008-10-29 | 2016-04-29 | Celgene Corp | Związki izoindolinowe do zastosowania w leczeniu raka |
EP2396312A1 (en) | 2009-02-11 | 2011-12-21 | Celgene Corporation | Isotopologues of lenalidomide |
LT2391355T (lt) | 2009-05-19 | 2017-03-10 | Celgene Corporation | 4-amino-2-(2,6-dioksopiperidin-3-il)izoindolin-1,3-diono kompozicijos |
CN102770412A (zh) | 2009-12-22 | 2012-11-07 | 细胞基因公司 | (甲基磺酰基)乙基苯异吲哚啉衍生物及其治疗应用 |
CA2807552A1 (en) | 2010-08-06 | 2012-02-09 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
PT3590949T (pt) | 2010-10-01 | 2022-08-02 | Modernatx Inc | Ácidos ribonucleicos contendo n1-metilpseudouracilos e suas utilizações |
WO2012096884A1 (en) | 2011-01-10 | 2012-07-19 | Celgene Corporation | Phenethylsulfone isoindoline derivatives as inhibitors of pde 4 and/or cytokines |
WO2012135299A1 (en) | 2011-03-28 | 2012-10-04 | Deuteria Pharmaceuticals Inc | 2',6'-dioxo-3'-deutero-piperdin-3-yl-isoindoline compounds |
JP2014511687A (ja) | 2011-03-31 | 2014-05-19 | モデルナ セラピューティクス インコーポレイテッド | 工学操作された核酸の送達および製剤 |
US20140221427A1 (en) | 2011-06-22 | 2014-08-07 | Celgene Corporation | Isotopologues of pomalidomide |
US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
AU2012308663B2 (en) | 2011-09-14 | 2017-06-08 | Amgen (Europe) GmbH | Formulations of cyclopropanecarboxylic acid {2-[(1S)-1-(3-ethoxy-4-methoxy-phenyl)-2-methanesulfonyl-ethyl]-3-oxo-2,3-dihydro-1H-isoindol-4-yl}-amide |
KR20190099538A (ko) | 2011-10-03 | 2019-08-27 | 모더나 세라퓨틱스, 인코포레이티드 | 변형된 뉴클레오사이드, 뉴클레오타이드, 및 핵산, 및 이들의 용도 |
SG11201402666WA (en) | 2011-12-16 | 2014-10-30 | Moderna Therapeutics Inc | Modified nucleoside, nucleotide, and nucleic acid compositions |
MX373934B (es) | 2011-12-27 | 2025-03-05 | Celgene Corp | Formulaciones de (+) - 2 - [1 - (3 - etoxi - 4 - metoxi - fenil) - 2 - metansulfonil - etil] - 4 - acetil aminoisoindolin - 1, 3 - diona. |
US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
EP2847329A4 (en) | 2012-04-02 | 2016-08-10 | Moderna Therapeutics Inc | MODIFIED POLYNUCLEOTIDES FOR THE PREPARATION OF CYTOPLASMA AND CYTOSCELETTE PROTEINS |
US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
US9878056B2 (en) | 2012-04-02 | 2018-01-30 | Modernatx, Inc. | Modified polynucleotides for the production of cosmetic proteins and peptides |
EP2858665A1 (en) | 2012-06-06 | 2015-04-15 | Bionor Immuno AS | Vaccine |
TWI690322B (zh) * | 2012-10-02 | 2020-04-11 | 法商傳斯堅公司 | 含病毒的調配物及其使用 |
RS63237B1 (sr) | 2012-11-26 | 2022-06-30 | Modernatx Inc | Terminalno modifikovana rnk |
AU2014205043B2 (en) | 2013-01-14 | 2018-10-04 | Deuterx, Llc | 3-(5-substituted-4-oxoquinazolin-3(4h)-yl)-3-deutero-piperidine-2,6-dione derivatives |
EP2764866A1 (en) | 2013-02-07 | 2014-08-13 | IP Gesellschaft für Management mbH | Inhibitors of nedd8-activating enzyme |
KR20150125963A (ko) * | 2013-03-01 | 2015-11-10 | 아스텍스 파마수티컬스, 인크. | 약물 조합체 |
US8980864B2 (en) | 2013-03-15 | 2015-03-17 | Moderna Therapeutics, Inc. | Compositions and methods of altering cholesterol levels |
US9839632B2 (en) | 2013-04-02 | 2017-12-12 | Celgene Corporation | Methods and compositions using 4-amino-2-(2,6-dioxo-piperidine-3-yl)-isoindoline-1,3-dione for treatment and management of central nervous system cancers |
EP2801364A1 (en) * | 2013-05-07 | 2014-11-12 | Centre Hospitalier Universitaire Vaudois (CHUV) | Salmonella strain for use in the treatment and/or prevention of cancer |
EP2815749A1 (en) | 2013-06-20 | 2014-12-24 | IP Gesellschaft für Management mbH | Solid form of 4-amino-2-(2,6-dioxopiperidine-3-yl)isoindoline-1,3-dione having specified X-ray diffraction pattern |
WO2015007337A1 (en) | 2013-07-19 | 2015-01-22 | Bionor Immuno As | Method for the vaccination against hiv |
EP3052106A4 (en) | 2013-09-30 | 2017-07-19 | ModernaTX, Inc. | Polynucleotides encoding immune modulating polypeptides |
US10323076B2 (en) | 2013-10-03 | 2019-06-18 | Modernatx, Inc. | Polynucleotides encoding low density lipoprotein receptor |
US20170165321A1 (en) | 2014-07-11 | 2017-06-15 | Bionor Immuno As | Method for reducing and/or delaying pathological effects of human immunodeficiency virus i (hiv) or for reducing the risk of developing acquired immunodeficiency syndrome (aids) |
US20180140694A1 (en) | 2015-05-04 | 2018-05-24 | Bionor Immuno As | Dosage regimen for hiv vaccine |
TWI727211B (zh) * | 2018-09-27 | 2021-05-11 | 大江生醫股份有限公司 | 紅菽草萃取物用於提升玻尿酸合成酶之基因表現量的用途 |
WO2021261635A1 (ko) | 2020-06-26 | 2021-12-30 | 대한민국(농림축산식품부 농림축산검역본부장) | 신규 면역증강제 및 이를 포함하는 백신 조성물 |
Family Cites Families (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2444713A1 (fr) | 1978-12-18 | 1980-07-18 | Pasteur Institut | Procede de production d'un adn comprenant le genome du virus de l'hepatite b et vecteur le comportant |
EP0466813A4 (en) * | 1989-04-05 | 1992-07-15 | Peter Y. S Fung | Active specific immunotherapy of adenocarcinomas producing immunosuppressive mucins |
JPH07503239A (ja) | 1992-01-21 | 1995-04-06 | イミユロジク・フアーマシユーチカル・コーポレーシヨン | ヒスタミン誘導体を免疫調節剤として免疫療法で用いる方法 |
US5698579A (en) | 1993-07-02 | 1997-12-16 | Celgene Corporation | Cyclic amides |
US5728385A (en) * | 1993-08-12 | 1998-03-17 | Classen Immunotherapies, Inc. | Method and composition for an early vaccine to protect against both common infectious diseases and chronic immune mediated disorders or their sequelae |
HU228769B1 (en) | 1996-07-24 | 2013-05-28 | Celgene Corp | Substituted 2(2,6-dioxopiperidin-3-yl)phthalimides and -1-oxoisoindolines and their use for production of pharmaceutical compositions for mammals to reduce the level of tnf-alpha |
US5635517B1 (en) | 1996-07-24 | 1999-06-29 | Celgene Corp | Method of reducing TNFalpha levels with amino substituted 2-(2,6-dioxopiperidin-3-YL)-1-oxo-and 1,3-dioxoisoindolines |
ATE530542T1 (de) | 1996-07-24 | 2011-11-15 | Celgene Corp | Amino substituierte 2-(2,6-dioxopiperidin-3-yl)- phthalimide zur verringerung der tnf-alpha-stufen |
US5798368A (en) | 1996-08-22 | 1998-08-25 | Celgene Corporation | Tetrasubstituted 2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolines and method of reducing TNFα levels |
US6281230B1 (en) | 1996-07-24 | 2001-08-28 | Celgene Corporation | Isoindolines, method of use, and pharmaceutical compositions |
JP4214537B2 (ja) | 1996-08-12 | 2009-01-28 | セルジーン コーポレーション | 新規な免疫治療薬とこの薬物を使用してサイトカインレベルを抵減する方法 |
US5874448A (en) | 1997-11-18 | 1999-02-23 | Celgene Corporation | Substituted 2-(2,6 dioxo-3-fluoropiperidin-3-yl)-isoindolines and method of reducing TNFα levels |
US5955476A (en) | 1997-11-18 | 1999-09-21 | Celgene Corporation | Substituted 2-(2,6-dioxo-3-fluoropiperidin-3-yl)-isoindolines and method of reducing inflammatory cytokine levels |
TR200101504T2 (tr) | 1998-03-16 | 2002-06-21 | Celgene Corporation | 2-(2,6-dioksopiperidin-3-il)izoindolin türevleri, bunların hazırlanması ve enflamatuar sitokinlerin inhibitörleri olarak kullanımı. |
AU771015B2 (en) | 1999-03-18 | 2004-03-11 | Celgene Corporation | Substituted 1-oxo- and 1,3-dioxoisoindolines and their use in pharmaceutical compositions for reducing inflammatory cytokine levels |
WO2001045750A1 (en) | 1999-12-21 | 2001-06-28 | The Regents Of The University Of California | Method for preventing an anaphylactic reaction |
AUPR030800A0 (en) * | 2000-09-22 | 2000-10-12 | Pharmalink International Limited | Immunomodulatory preparation |
US6458810B1 (en) | 2000-11-14 | 2002-10-01 | George Muller | Pharmaceutically active isoindoline derivatives |
US7091353B2 (en) | 2000-12-27 | 2006-08-15 | Celgene Corporation | Isoindole-imide compounds, compositions, and uses thereof |
US20030045552A1 (en) * | 2000-12-27 | 2003-03-06 | Robarge Michael J. | Isoindole-imide compounds, compositions, and uses thereof |
US20030129161A1 (en) * | 2001-09-17 | 2003-07-10 | Hsien-Jue Chu | Interleukin-12 as a veterinary vaccine adjuvant |
EP1496934A4 (en) * | 2002-04-19 | 2006-08-02 | Endocyte Inc | IMPROVED IMMUNOTHERAPY BY ADJUVANT |
US7323479B2 (en) | 2002-05-17 | 2008-01-29 | Celgene Corporation | Methods for treatment and management of brain cancer using 1-oxo-2-(2,6-dioxopiperidin-3-yl)-4-methylisoindoline |
CN103494817A (zh) * | 2002-05-17 | 2014-01-08 | 细胞基因公司 | 用于治疗和控制多发性骨髓瘤的方法及组合物 |
JP2006503110A (ja) * | 2002-10-09 | 2006-01-26 | トーラーレックス, インク. | エフェクタt細胞または制御性t細胞に選択的に結合する分子およびその使用方法 |
EP1596871A4 (en) * | 2003-02-28 | 2006-08-23 | Drew M Pardoll | T-CELL REGULATION |
US20050048054A1 (en) | 2003-07-11 | 2005-03-03 | Shino Hanabuchi | Lymphocytes; methods |
US9713375B1 (en) | 2015-02-26 | 2017-07-25 | Brett Einar Rahm | Collapsible portable table |
-
2006
- 2006-08-31 ES ES11151126.7T patent/ES2485316T3/es active Active
- 2006-08-31 RS RS20110194A patent/RS51840B/en unknown
- 2006-08-31 ES ES06824878T patent/ES2359162T3/es active Active
- 2006-08-31 WO PCT/US2006/034271 patent/WO2007028047A2/en active Application Filing
- 2006-08-31 DK DK06824878.0T patent/DK1928492T3/da active
- 2006-08-31 EP EP06824878A patent/EP1928492B1/en active Active
- 2006-08-31 US US11/514,447 patent/US8715677B2/en not_active Expired - Fee Related
- 2006-08-31 EP EP11151126.7A patent/EP2301535B1/en active Active
- 2006-08-31 AT AT06824878T patent/ATE499112T1/de active
- 2006-08-31 PL PL06824878T patent/PL1928492T3/pl unknown
- 2006-08-31 DE DE602006020300T patent/DE602006020300D1/de active Active
- 2006-08-31 JP JP2008529318A patent/JP2009507030A/ja not_active Withdrawn
- 2006-08-31 SI SI200631013T patent/SI1928492T1/sl unknown
- 2006-08-31 CA CA2621136A patent/CA2621136C/en not_active Expired - Fee Related
-
2011
- 2011-04-13 CY CY20111100376T patent/CY1112325T1/el unknown
- 2011-05-10 HR HR20110348T patent/HRP20110348T1/hr unknown
-
2012
- 2012-04-02 US US13/437,739 patent/US20120190110A1/en not_active Abandoned
-
2013
- 2013-07-03 JP JP2013140191A patent/JP5796040B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP2301535B1 (en) | 2014-05-28 |
DK1928492T3 (da) | 2011-06-06 |
US20070048327A1 (en) | 2007-03-01 |
JP2013241424A (ja) | 2013-12-05 |
PL1928492T3 (pl) | 2011-09-30 |
CA2621136C (en) | 2014-10-14 |
EP1928492A2 (en) | 2008-06-11 |
CA2621136A1 (en) | 2007-03-08 |
ES2359162T3 (es) | 2011-05-19 |
RS51840B (en) | 2012-02-29 |
JP5796040B2 (ja) | 2015-10-21 |
US20120190110A1 (en) | 2012-07-26 |
US8715677B2 (en) | 2014-05-06 |
EP2301535A1 (en) | 2011-03-30 |
WO2007028047A2 (en) | 2007-03-08 |
JP2009507030A (ja) | 2009-02-19 |
HRP20110348T1 (hr) | 2011-07-31 |
DE602006020300D1 (de) | 2011-04-07 |
ATE499112T1 (de) | 2011-03-15 |
CY1112325T1 (el) | 2015-12-09 |
EP1928492B1 (en) | 2011-02-23 |
SI1928492T1 (sl) | 2011-09-30 |
WO2007028047A3 (en) | 2007-06-14 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2485316T3 (es) | Usos inmunológicos de compuestos inmunomoduladores para vacunas y terapia anti-enfermedades infecciosas | |
ES2528384T3 (es) | Métodos de utilización de inhibidores del receptor de adenosina para potenciar la respuesta inmunitaria y la inflamación | |
ES2562022T3 (es) | Estimulación del sistema inmunitario con polidextrosa | |
CY2017013I2 (el) | ΑΝΤΙΣΩΜΑ ΕΝΑΝΤΙΟΝ PDGFR-α ΓΙΑ ΧΡΗΣΗ ΣΤΗΝ ΘΕΡΑΠΕΥΤΙΚΗ ΑΓΩΓΗ ΟΓΚΩΝ | |
DE602005012107D1 (de) | Pharmazeutische formulierungen mit einem antibioti | |
EP1593159A4 (en) | RADIOLOGICAL IMAGE SENSOR DEVICE | |
WO2007079190A3 (en) | Device and method for enhancing immune response by electrical stimulation | |
EA200870129A1 (ru) | Человеческие антитела против il-23, композиции, способы и применение | |
EP1800693A4 (en) | ADJUVANT THERAPY USING ANTI-GLYPICAN-3 ANTIBODY | |
IL191788A0 (en) | Human monoclonal antibodies to protein tyrosine kinase 7 (ptk7) and methods for using anti-ptk7 antibodies | |
ATE410167T1 (de) | Flüssige pharmazeutische palonosetronformulierungen | |
NO20032586D0 (no) | Nukleinsyrevaksiner som anvender tumor antigen-kodende nukleinsyrer med cytokin adjuvant-kodende nukleinsyre | |
NL1028326A1 (nl) | Beeldgevend tomografieapparaat. | |
EA200701166A1 (ru) | Альфа-тимозиновые пептиды в качестве адъювантов противораковых вакцин | |
EP1646401A4 (en) | SPECIFIC HUMAN ANTIBODIES | |
BRPI0517782A (pt) | formulações de benzotiazol e uso das mesmas | |
ES2642487T3 (es) | Anticuerpos humanos contra IL13 y usos terapéuticos | |
EP1594899A4 (en) | IDIOTYPIC VACCINE | |
EP1478657A4 (en) | TETRAVALENT ANTI-ROTAVIRUS VACCINE SEQUENCE ANALYSIS | |
RU2004130267A (ru) | Способ вакцинации детей против краснухи на крайнем севере | |
TH98381A (th) | สารก่อภูมิคุ้มกันซึ่งประกอบด้วยตัวเสริมที่มีกรดพอลิอิโนซินิก-กรดพอลิไซติดิลิกเป็นส่วนประกอบหลัก | |
AU2003294192A8 (en) | Inclusion bodies as antigens for the oral vaccination of animals | |
ITPD20050185A1 (it) | Testa fotografica per treppiedi e simili | |
ITBA20020046A1 (it) | Dispositivo ad uso femminile per permettere la minzione in posizione eretta. | |
ATE441412T1 (de) | Substituierte beta-aminoalkohole als arzneimittel |