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ES2528384T3 - Métodos de utilización de inhibidores del receptor de adenosina para potenciar la respuesta inmunitaria y la inflamación - Google Patents

Métodos de utilización de inhibidores del receptor de adenosina para potenciar la respuesta inmunitaria y la inflamación Download PDF

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Publication number
ES2528384T3
ES2528384T3 ES02804693.6T ES02804693T ES2528384T3 ES 2528384 T3 ES2528384 T3 ES 2528384T3 ES 02804693 T ES02804693 T ES 02804693T ES 2528384 T3 ES2528384 T3 ES 2528384T3
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Spain
Prior art keywords
immune response
inflammation
enhance
methods
adenosine receptor
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Expired - Lifetime
Application number
ES02804693.6T
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English (en)
Inventor
Michail V. Sitkovsky
Akio Ohta
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GOVERNMENT OF United States, HEALT, Secretary of, Department of
Belmark Inc
Original Assignee
GOVERNMENT OF United States, HEALT, Secretary of, Department of
Belmark Inc
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Application filed by GOVERNMENT OF United States, HEALT, Secretary of, Department of, Belmark Inc filed Critical GOVERNMENT OF United States, HEALT, Secretary of, Department of
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    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/52—Purines, e.g. adenine
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    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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Abstract

Un antagonista del receptor de adenosina A2a para el uso en el tratamiento de un tumor en un sujeto, tratamiento que comprende la administración al sujeto de una dosis terapéuticamente efectiva de dicho antagonista y un antígeno específico del tumor y una célula asesina T, mejorando así la respuesta inmunitaria y el tratamiento del tumor.

Description

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Claims (1)

  1. imagen1
ES02804693.6T 2001-12-12 2002-11-14 Métodos de utilización de inhibidores del receptor de adenosina para potenciar la respuesta inmunitaria y la inflamación Expired - Lifetime ES2528384T3 (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US34077201P 2001-12-12 2001-12-12
US340772P 2001-12-12
US34258501P 2001-12-19 2001-12-19
US342585P 2001-12-19
PCT/US2002/036829 WO2003050241A2 (en) 2001-12-12 2002-11-14 Methods for using extracellular adenosine inhibitors and adenosine receptor inhibitors to enhance immune response and inflammation

Publications (1)

Publication Number Publication Date
ES2528384T3 true ES2528384T3 (es) 2015-02-09

Family

ID=26992233

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Application Number Title Priority Date Filing Date
ES02804693.6T Expired - Lifetime ES2528384T3 (es) 2001-12-12 2002-11-14 Métodos de utilización de inhibidores del receptor de adenosina para potenciar la respuesta inmunitaria y la inflamación

Country Status (8)

Country Link
US (5) US8080554B2 (es)
EP (1) EP1465634B1 (es)
JP (1) JP2005516917A (es)
AU (1) AU2002356962C1 (es)
CA (1) CA2470104C (es)
DK (1) DK1465634T3 (es)
ES (1) ES2528384T3 (es)
WO (1) WO2003050241A2 (es)

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US8080554B2 (en) 2011-12-20
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US20140056922A1 (en) 2014-02-27
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US20120093856A1 (en) 2012-04-19
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