AR041595A1 - Tratamiento terapeutico - Google Patents
Tratamiento terapeuticoInfo
- Publication number
- AR041595A1 AR041595A1 ARP030103717A ARP030103717A AR041595A1 AR 041595 A1 AR041595 A1 AR 041595A1 AR P030103717 A ARP030103717 A AR P030103717A AR P030103717 A ARP030103717 A AR P030103717A AR 041595 A1 AR041595 A1 AR 041595A1
- Authority
- AR
- Argentina
- Prior art keywords
- acceptable
- salt
- therapeutic treatment
- pharmaceutical use
- combination
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Se describe una combinación que comprende un antagonista del receptor de endotelina, o una sal aceptable para uso farmacéutico del mismo, y un EGFR TKI, o una sal aceptable para uso farmacéutico del mismo. Reivindicación 4: Una combinación de acuerdo con cualquiera de las cláusulas 1-3 donde el antagonista del receptor de endotelina se selecciona entre ZD4054, o una sal del mismo aceptable para uso farmacéutico, y EGFR TKI se selecciona entre ZD1839, o una sal del mismo aceptable para uso farmacéutico. Reivindicación 9: Una combinación que comprende una combinación de acuerdo con las cláusulas 1-4, caracterizada porque para utilizar en el tratamiento del cáncer.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0223854.1A GB0223854D0 (en) | 2002-10-12 | 2002-10-12 | Therapeutic treatment |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR041595A1 true AR041595A1 (es) | 2005-05-26 |
Family
ID=9945876
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP030103717A AR041595A1 (es) | 2002-10-12 | 2003-10-10 | Tratamiento terapeutico |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US20060122180A1 (es) |
| EP (1) | EP1553950B1 (es) |
| JP (1) | JP2006510605A (es) |
| KR (1) | KR20050056238A (es) |
| CN (1) | CN100342853C (es) |
| AR (1) | AR041595A1 (es) |
| AT (1) | ATE369136T1 (es) |
| AU (1) | AU2003269259B2 (es) |
| BR (1) | BR0315140A (es) |
| CA (1) | CA2501959A1 (es) |
| CY (1) | CY1107605T1 (es) |
| DE (1) | DE60315490T2 (es) |
| DK (1) | DK1553950T3 (es) |
| ES (1) | ES2289316T3 (es) |
| GB (1) | GB0223854D0 (es) |
| HK (1) | HK1078784A1 (es) |
| IS (1) | IS2473B (es) |
| MX (1) | MXPA05003808A (es) |
| MY (1) | MY135441A (es) |
| NO (1) | NO20051658L (es) |
| NZ (1) | NZ539137A (es) |
| PL (1) | PL375584A1 (es) |
| PT (1) | PT1553950E (es) |
| RU (1) | RU2005114487A (es) |
| SA (1) | SA04240502B1 (es) |
| TW (1) | TW200412971A (es) |
| UA (1) | UA82492C2 (es) |
| UY (1) | UY28017A1 (es) |
| WO (1) | WO2004035057A1 (es) |
| ZA (1) | ZA200502874B (es) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0218526D0 (en) * | 2002-08-09 | 2002-09-18 | Astrazeneca Ab | Combination therapy |
| GB0219660D0 (en) | 2002-08-23 | 2002-10-02 | Astrazeneca Ab | Therapeutic use |
| WO2004100991A1 (en) * | 2003-05-15 | 2004-11-25 | Universite Catholique De Louvain | Use of endothelin-1 antagonists for improving cancer therapy |
| GB0320806D0 (en) * | 2003-09-05 | 2003-10-08 | Astrazeneca Ab | Therapeutic treatment |
| GB0403744D0 (en) | 2004-02-20 | 2004-03-24 | Astrazeneca Ab | Chemical process |
| GB0425854D0 (en) * | 2004-11-25 | 2004-12-29 | Astrazeneca Ab | Therapeutic treatment |
| CA2701385A1 (en) * | 2007-10-12 | 2009-04-16 | Astrazeneca Ab | Composition 064 |
| DK2464218T3 (en) | 2009-08-10 | 2015-07-20 | Univ Texas | Treatment of brain metastases with inhibitors of endothelin receptors in combination with a cytotoxic agent for chemotherapy |
| CN111886010A (zh) | 2018-01-12 | 2020-11-03 | Enb治疗公司 | 用于治疗与etbr激活相关的癌症的氘化化合物、组合物和方法 |
| CN114423425A (zh) * | 2019-07-17 | 2022-04-29 | Enb治疗公司 | 通过使用内皮素b受体拮抗剂治疗尿路上皮癌和肾癌 |
| CN117255791A (zh) | 2021-06-22 | 2023-12-19 | 亚克医药株式会社 | 化合物、内皮素a受体拮抗剂及医药组合物 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5514691A (en) * | 1993-05-20 | 1996-05-07 | Immunopharmaceutics, Inc. | N-(4-halo-isoxazolyl)-sulfonamides and derivatives thereof that modulate the activity of endothelin |
| US5464853A (en) * | 1993-05-20 | 1995-11-07 | Immunopharmaceutics, Inc. | N-(5-isoxazolyl)biphenylsulfonamides, N-(3-isoxazolyl)biphenylsulfonamides and derivatives thereof that modulate the activity of endothelin |
| AU661533B2 (en) * | 1992-01-20 | 1995-07-27 | Astrazeneca Ab | Quinazoline derivatives |
| US6063911A (en) * | 1993-12-01 | 2000-05-16 | Marine Polymer Technologies, Inc. | Methods and compositions for treatment of cell proliferative disorders |
| GB9508538D0 (en) * | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quinazoline derivatives |
| UA58494C2 (uk) * | 1995-06-07 | 2003-08-15 | Зенека Лімітед | Похідні n-гетероарилпіридинсульфонаміду, фармацевтична композиція, спосіб одержання та спосіб протидії впливам ендотеліну |
| US5780435A (en) * | 1995-12-15 | 1998-07-14 | Praecis Pharmaceuticals Incorporated | Methods for treating prostate cancer with LHRH-R antagonists |
| TR200003166T2 (tr) * | 1998-04-29 | 2001-02-21 | Osi Pharmaceuticals, Inc. | N-(3-etinilfenilamino)-6, 7-bis(2-metoksietoksi)-4-kuinozolamin mesilat anhidrat ve monohidrat. |
| US6355678B1 (en) * | 1998-06-29 | 2002-03-12 | Parker Hughes Institute | Inhibitors of the EGF-receptor tyrosine kinase and methods for their use |
| GB0008368D0 (en) * | 2000-04-06 | 2000-05-24 | Astrazeneca Ab | Combination product |
| US20020055457A1 (en) * | 2000-08-07 | 2002-05-09 | Janus Todd J. | Methods of treating cancer and the pain associated therewith using endothelin antagonists |
| US20030092757A1 (en) * | 2001-04-11 | 2003-05-15 | Amitabh Singh | Favorable modulation of health-related quality of life and health-related quality-adjusted time-to-progression of disease in patients with prostate cancer |
| DE10155076A1 (de) * | 2001-11-09 | 2003-05-22 | Merck Patent Gmbh | Verwendung von Endothelin-Rezeptor-Antagonisten zur Behandlung von Tumorerkrankungen |
-
2002
- 2002-10-12 GB GBGB0223854.1A patent/GB0223854D0/en not_active Ceased
-
2003
- 2003-07-10 UA UAA200504329A patent/UA82492C2/uk unknown
- 2003-10-07 EP EP03751038A patent/EP1553950B1/en not_active Expired - Lifetime
- 2003-10-07 DE DE60315490T patent/DE60315490T2/de not_active Expired - Lifetime
- 2003-10-07 RU RU2005114487/15A patent/RU2005114487A/ru unknown
- 2003-10-07 BR BR0315140-9A patent/BR0315140A/pt not_active IP Right Cessation
- 2003-10-07 MX MXPA05003808A patent/MXPA05003808A/es active IP Right Grant
- 2003-10-07 PT PT03751038T patent/PT1553950E/pt unknown
- 2003-10-07 CN CNB2003801013102A patent/CN100342853C/zh not_active Expired - Fee Related
- 2003-10-07 ES ES03751038T patent/ES2289316T3/es not_active Expired - Lifetime
- 2003-10-07 AU AU2003269259A patent/AU2003269259B2/en not_active Ceased
- 2003-10-07 WO PCT/GB2003/004347 patent/WO2004035057A1/en active IP Right Grant
- 2003-10-07 CA CA002501959A patent/CA2501959A1/en not_active Abandoned
- 2003-10-07 KR KR1020057006232A patent/KR20050056238A/ko not_active Application Discontinuation
- 2003-10-07 JP JP2004544431A patent/JP2006510605A/ja active Pending
- 2003-10-07 US US10/530,794 patent/US20060122180A1/en not_active Abandoned
- 2003-10-07 PL PL03375584A patent/PL375584A1/xx not_active Application Discontinuation
- 2003-10-07 AT AT03751038T patent/ATE369136T1/de active
- 2003-10-07 NZ NZ539137A patent/NZ539137A/en not_active IP Right Cessation
- 2003-10-07 DK DK03751038T patent/DK1553950T3/da active
- 2003-10-09 TW TW092128113A patent/TW200412971A/zh unknown
- 2003-10-10 AR ARP030103717A patent/AR041595A1/es unknown
- 2003-10-10 MY MYPI20033877A patent/MY135441A/en unknown
- 2003-10-13 UY UY28017A patent/UY28017A1/es not_active Application Discontinuation
-
2004
- 2004-02-18 SA SA04240502A patent/SA04240502B1/ar unknown
-
2005
- 2005-04-04 NO NO20051658A patent/NO20051658L/no not_active Application Discontinuation
- 2005-04-08 ZA ZA200502874A patent/ZA200502874B/en unknown
- 2005-04-26 IS IS7825A patent/IS2473B/is unknown
- 2005-11-28 HK HK05110831A patent/HK1078784A1/xx not_active IP Right Cessation
-
2007
- 2007-10-08 CY CY20071101275T patent/CY1107605T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MXPA05003808A (es) | 2005-06-08 |
| US20060122180A1 (en) | 2006-06-08 |
| AU2003269259A1 (en) | 2004-05-04 |
| SA04240502B1 (ar) | 2008-09-14 |
| CY1107605T1 (el) | 2013-03-13 |
| CN1703224A (zh) | 2005-11-30 |
| CA2501959A1 (en) | 2004-04-29 |
| EP1553950B1 (en) | 2007-08-08 |
| EP1553950A1 (en) | 2005-07-20 |
| PL375584A1 (en) | 2005-11-28 |
| UY28017A1 (es) | 2004-04-30 |
| DK1553950T3 (da) | 2007-10-15 |
| UA82492C2 (uk) | 2008-04-25 |
| KR20050056238A (ko) | 2005-06-14 |
| MY135441A (en) | 2008-04-30 |
| ES2289316T3 (es) | 2008-02-01 |
| DE60315490D1 (de) | 2007-09-20 |
| BR0315140A (pt) | 2005-08-16 |
| RU2005114487A (ru) | 2006-02-10 |
| CN100342853C (zh) | 2007-10-17 |
| PT1553950E (pt) | 2007-09-26 |
| IS2473B (is) | 2008-12-15 |
| JP2006510605A (ja) | 2006-03-30 |
| AU2003269259B2 (en) | 2007-03-15 |
| NZ539137A (en) | 2008-01-31 |
| TW200412971A (en) | 2004-08-01 |
| ATE369136T1 (de) | 2007-08-15 |
| WO2004035057A1 (en) | 2004-04-29 |
| NO20051658L (no) | 2005-05-06 |
| HK1078784A1 (en) | 2006-03-24 |
| DE60315490T2 (de) | 2008-05-08 |
| IS7825A (is) | 2005-04-26 |
| GB0223854D0 (en) | 2002-11-20 |
| ZA200502874B (en) | 2006-02-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |