Molecular Basis of Inheritance

MOLECULAR BASIS OF INHERITANCE
1. In a nucleotide, the nitrogen base is joined to the sugar

molecule by
a) Phosphodiester bond b) Glycosidic bond
c) Hydrogen bond d) (a) &(b)
2. If a double stranded DNA has 20% Thymine, the
percentage of Guanine in the DNA
a) 30% b) 10%
c) 90% d) 40%
3. If a DNA contains 1000 base pairs, what would be its
length?
a) 3400 Å b) 34000 Å
c) 6800 d) 1000 Å
4. What is not True for DNA in prokaryotes
a) present in the form of a compact structure called
nucleoid
b) the coils are maintained by non-histone basic proteins
c) found in cytoplasm in a supercoiled condition
d) packaged as nucleosomes along with histones
5. Pick the right difference between a DNA and RNA
a) Sugar and phosphate b) sugar and purines
c) purines and phosphate d) sugar and pyrimidines
6. In the following questions, a statement of Assertion
(A) is followed by a statement of Reason (R).
(1) If both Assertion and Reason are true and the reason
is the correct explanation of the assertion, then mark (a)
(2) If both Assertion and Reason are true but the reason
is not the correct explanation of the assertion, then mark
(b)
(3) If Assertion is true but Reason are false, then mark (c)
(4) If both Asser
7. Hershey and Chase experiment proving DNA as the
genetic material was based on the principle
a) Transduction b) transformation
c) transcription d) translation
8. A bacterial colony containing DNA made up of 100%
N15 nitrogen bases is allowed to replicate in a medium
containing N14 bases. After one round of replication the
result would be
a) All individuals will be identical to parents
b) All individuals will be hybrids
c) Only 50% individuals would be hybrids

d) All individuals would have DNA made up of 100% N14
9. Teminism is
a) a central dogma reverse
b) a central dogma of molecular biology
c) a circular flow of hereditary material
d) an effect of cytoplasm on functioning of DNA
10. Cistron is
a) The coding sequence of DNA
b) The functional unit of DNA molecule that codes for a
particular gene product
c) Intervening non coding sequence of DNA
d) The sequences which are removed during RNA
splicing.
11. Read the statements given below and identify the
incorrect statement.
a) The human genome contains 3164.7 million nucleotide
bases.
b) The average gene consists of 30,000 bp
c) The total number of genes is estimated at 30,000.
d) Chromosome Y has 231 genes e) Less than 2% of the
genome codes for proteins.
12. The coding sequences found in split genes are called
a) Operons b) introns
c) exons d) cistrons
13. The removal of which enzyme affects the synthesis of
hnRNA in eukaryotes
a) RNA polymerase II b) RNA primase
c) RNA polymerase III d) RNA polymerase I
14. Sickle cell anemia is caused
a) When valine is replaced by glutamic acid in beta
polypeptide chain
b) When glutamic acid is replaced by valine in beta
polypeptide chain
c) When glutamic acid is replaced by valine in alpha
polypeptide chain
d) When valine is replaced by glutamic acid in alpha
polypeptide chain
15. Wobble position means
a) Base paring b) altered base on code
c) third altered base on codon d) none of the above
16. Peptidyl transferase
a) Is a 23s rRNA b) forms peptide bonds
c) component of ribosome d) all the three
17. Which mRNA will be translated to a polypeptide
chain containing 8 amino acids?
a) AUGUUAAUAGACGAGUAGCGACGAUGU
b) AUGAGACGGACUGCAUUCCCAACCUGA
c) AUGCCCAACCGUUAUUCAUGCUAG
d) AUGUCGACAGUCUAAAACAGCGGG
18. Arrange the following events in the order of synthesis
of a protein
i) A peptide bond forms
ii) A tRNA matches its anticodon to the codon in the A-
site
iii) The movement of second tRNA complex from A-site
to P-site
iv) The large subunit attaches to the small subunit and
the initiator tRNA fits in the P-site

v) A small subunit binds to the mRNA
vi) The activated amino acid tRNA complex attaches the
initiation codon on mRNA
a) iv, v, iii, ii, i, vi b) iv, vi, v, ii, I, iii
c) v, iv, iii, ii, vi, I d) v, vi, iv, ii, i, iii
19. Select the incorrect statement out of the five given
below about lac operon when Lactose is present in the
medium.
a) Gene – A gets transcribed into mRNA which produces
β-galactoside permease
b) Inducer-Repressor complex is formed
c) Lactose inactivates repressor protein
d) RNA polymerase transcribe Z-gene, Y-gene and A-gene
e) Allolactose is the inducer of lac operon
20. The percentage of human genome which encodes
proteins is approximately
a) Less than 2% b) 5%
c) 25% d) 99%
21. Enzyme which can break and seal the DNA strand
a) Topoisomease II (b) Helicase
(c) Primase (d) Restriction endonuclease
22. Which of the statements give below is correct with
respect to frameshift mutation
a) a single nucleotide base change, insertion, or deletion
of the genetic material
b) Glutamine is replaced by valine
c) Sickle cell anemia is an example
d) insertions or deletions of a number of nucleotides in a
DNA sequence that is not divisible by three.
23. The transcription initiation factor associated with the
RNA polymerase holoenzyme in prokaryotes is
(a) β (b) ω (c) σ (d) αI
24. The stretch of codons between AUG and a stop
codon is called
a) open reading frame b) TATA box
c) colinearity d) degenerate
25. The structural genes of lac operon transcribe mRNA
which is
a) polycistronic b) replicative
c) monokaryotic d) monocistronic
26. If the sequence of bases in DNA is TACCGACCA, then
the sequence of codons on the transcript will be
a) ATGGCTGGT b) ATCCGAACU
c) AUGGCUGGU d) AUGGACUAA
27. Genes which are active all the time synthesizing
substances needed by the cell are called
a) Cellular luxury genes b) metabolic genes
c) house keeping genes d) control genes

Molecular Basis of Inheritance

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What is the difference between DNA and RNA?

What is the process of transcription?

MOLECULAR BASIS OF INHERITANCE

1. In a nucleotide, the nitrogen base is joined to the sugar

c) Only 50% individuals would be hybrids

the initiator tRNA fits in the P-site

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