ZA83328B - 5,6,7-trinor-4,8-itner-m-phenylene prostaglandin i2 derivative - Google Patents
5,6,7-trinor-4,8-itner-m-phenylene prostaglandin i2 derivativeInfo
- Publication number
- ZA83328B ZA83328B ZA83328A ZA83328A ZA83328B ZA 83328 B ZA83328 B ZA 83328B ZA 83328 A ZA83328 A ZA 83328A ZA 83328 A ZA83328 A ZA 83328A ZA 83328 B ZA83328 B ZA 83328B
- Authority
- ZA
- South Africa
- Prior art keywords
- carbon atoms
- hydrogen
- itner
- trinor
- derivative
- Prior art date
Links
- 125000004432 carbon atom Chemical group C* 0.000 abstract 6
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 150000002431 hydrogen Chemical group 0.000 abstract 3
- 125000002252 acyl group Chemical group 0.000 abstract 2
- 125000003435 aroyl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 208000001953 Hypotension Diseases 0.000 abstract 1
- 230000002959 anti-hypotensive effect Effects 0.000 abstract 1
- 230000000767 anti-ulcer Effects 0.000 abstract 1
- 150000001768 cations Chemical class 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 208000021822 hypotensive Diseases 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/09—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by hydrolysis
- C07C29/12—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by hydrolysis of esters of mineral acids
- C07C29/124—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by hydrolysis of esters of mineral acids of halides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/56—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by isomerisation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4015—Esters of acyclic unsaturated acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Furan Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP57006150A JPS58124778A (ja) | 1982-01-20 | 1982-01-20 | 5,6,7−トリノル−4,8−インタ−m−フエニレンPGI↓2誘導体 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA83328B true ZA83328B (en) | 1983-10-26 |
Family
ID=11630492
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA83328A ZA83328B (en) | 1982-01-20 | 1983-01-18 | 5,6,7-trinor-4,8-itner-m-phenylene prostaglandin i2 derivative |
Country Status (8)
Country | Link |
---|---|
US (1) | US4474802A (de) |
EP (1) | EP0084856B2 (de) |
JP (1) | JPS58124778A (de) |
AT (1) | ATE23716T1 (de) |
AU (1) | AU556348B2 (de) |
CA (1) | CA1226280A (de) |
DE (1) | DE3367774D1 (de) |
ZA (1) | ZA83328B (de) |
Families Citing this family (61)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3765646D1 (de) * | 1986-01-24 | 1990-11-29 | Toray Industries | 2,5,6,7-tetranor-4,8-inter-m-phenylen-pgi2-derivate. |
US4880939A (en) * | 1986-12-11 | 1989-11-14 | Toray Industries | 2,5,6,7-tetranor-18,18,19,19-tetradehydro-4,8-inter-m-phenylene PGI2 derivatives |
DK0463162T3 (da) * | 1989-02-27 | 1994-06-20 | Toray Industries | Fremgangsmåde til fremstilling af 5,6,7-trinor-4,8-inter-m-phenylen-PGI2-derivater |
EP0389162B1 (de) * | 1989-03-14 | 1993-12-08 | Toray Industries, Inc. | 2,5,6,7-Tetranor-4,8-inter-m-phenylen-PGI2-Derivate |
JP2608135B2 (ja) * | 1989-03-31 | 1997-05-07 | 科研製薬株式会社 | 糖尿病性神経障害治療剤 |
DE4104607A1 (de) * | 1991-02-12 | 1992-08-13 | Schering Ag | Prostacyclin- und carbacyclinderivate als mittel zur behandlung von fiebrigen erkrankungen |
JP3230246B2 (ja) * | 1991-04-11 | 2001-11-19 | 東レ株式会社 | 悪性腫瘍転移抑制剤 |
US5496850A (en) * | 1991-04-11 | 1996-03-05 | Toray Industries, Inc. | Antimetastasis agent of malignant tumors |
US5233059A (en) * | 1991-07-25 | 1993-08-03 | Iowa State University Research Foundation, Inc. | Synthesis of benzoprostacyclins using palladium catalysis |
US5169959A (en) * | 1991-09-23 | 1992-12-08 | Iowa State University Research Foundation, Inc. | Free radical-catalyzed synthesis of benzoprostacyclins |
JP3173008B2 (ja) * | 1991-10-25 | 2001-06-04 | 東レ株式会社 | 肝疾患治療剤 |
JP3102141B2 (ja) * | 1992-05-29 | 2000-10-23 | 東レ株式会社 | 養毛育毛剤 |
DE59305822D1 (de) * | 1992-08-07 | 1997-04-17 | Schering Ag | Verwendung von prostanderivaten zur herstellung eines arzneimittels zur behandlung der chronischen polyarthritis |
DE69322496T2 (de) * | 1992-09-18 | 1999-05-06 | Toray Industries, Inc., Tokio/Tokyo | Sulfonsäure derivat und deren pharmazeutische verwendung |
JPH07126161A (ja) * | 1993-10-29 | 1995-05-16 | Toray Ind Inc | 心不全治療剤 |
JP3541417B2 (ja) * | 1994-02-24 | 2004-07-14 | 日産化学工業株式会社 | フェニル置換ヒドロキシシクロペンテノン類、ペンタノン類及びフェニル置換プロスタグランジンi2類中間体並びにその製造法及び光学分割法 |
EP0742011B1 (de) * | 1994-11-17 | 2002-07-24 | Toray Industries, Inc. | Transdermal absorbierbare zubereitung |
CA2188931C (en) * | 1995-02-27 | 2007-09-11 | Reiji Kasukawa | Agent for treating cor pulmonale |
CZ168896A3 (en) * | 1995-06-27 | 1997-01-15 | Egyt Gyogyszervegyeszeti Gyar | Oxaindene derivatives and process for preparing thereof |
DE19530884C2 (de) * | 1995-08-11 | 1997-07-31 | Schering Ag | Verwendung von Prostan-Derivaten sowie deren Kombination mit Antibiotika zur Behandlung von bakteriellen Meningitis |
US6232343B1 (en) | 1996-05-07 | 2001-05-15 | Toray Industries, Inc. | Ophthalmic preparations |
US6201015B1 (en) * | 1996-09-17 | 2001-03-13 | Toray Industries, Inc. | Therapeutic method for thrombocytopathy treatment |
WO1998037895A1 (fr) * | 1997-02-27 | 1998-09-03 | Toray Industries, Inc. | Medicaments permettant d'ameliorer la circulation pulmonaire |
EP0925788A4 (de) * | 1997-03-13 | 1999-12-01 | Toray Industries | Arzneimittel zur behandlung von diabetischen vaskulären verletzungen |
AU6310898A (en) * | 1997-03-14 | 1998-10-12 | Toray Industries, Inc. | Sustained-release prostaglandin i derivative preparation |
US6653345B2 (en) | 1997-09-16 | 2003-11-25 | Toray Industries, Inc. | C-C chemokine synthesis inhibitor |
CA2316539C (en) | 1997-12-26 | 2008-11-18 | Yamanouchi Pharmaceutical Co., Ltd. | Sustained-release pharmaceutical composition |
JP4019481B2 (ja) | 1998-01-23 | 2007-12-12 | ソニー株式会社 | 情報処理装置および方法、情報処理システム、並びに提供媒体 |
EP1022030A1 (de) * | 1998-08-12 | 2000-07-26 | Toray Industries, Inc. | Mittel zur regulation der produktion des plasminogen-aktivator-inhibitors 1 |
WO2000009135A1 (fr) * | 1998-08-14 | 2000-02-24 | Toray Industries, Inc. | Agents de protection des cellules péridermiques |
US20030092760A1 (en) * | 2001-03-12 | 2003-05-15 | Toray Industries, Inc. | Therapeutic agent for renal failure |
HU227157B1 (en) | 2001-07-30 | 2010-09-28 | Chinoin Gyogyszer Es Vegyeszet | Production of beraprost ester by selective oxidation |
JP3340732B1 (ja) * | 2001-10-05 | 2002-11-05 | 日本医薬品工業株式会社 | シクロペンタベンゾフラン誘導体の製造方法及びその製造原料となる新規化合物 |
GB0215757D0 (en) * | 2002-07-08 | 2002-08-14 | Cascade Biochem Ltd | Benzoprostacyclin intermediates methods for their preparation and products derived therefrom |
WO2004098611A1 (ja) | 2003-05-09 | 2004-11-18 | Toray Industries Inc. | 増強剤 |
AU2003243972A1 (en) * | 2003-06-25 | 2005-01-13 | Cardiovascular Institute, Ltd. | External preparation for improving coital function |
KR101300003B1 (ko) | 2005-07-08 | 2013-08-26 | 도레이 카부시키가이샤 | 요독증 개선을 위한 치료제 및 처치방법 |
JP5424291B2 (ja) * | 2006-03-03 | 2014-02-26 | 独立行政法人国立循環器病研究センター | 骨髄細胞の動員剤および動員方法 |
EP2094273B1 (de) | 2006-11-16 | 2013-03-06 | Gemmus Pharma Inc. | EP2- und EP4-Agonisten als Mittel zur Behandlung von viraler Influenza A Infektion |
LT2315587T (lt) | 2008-08-13 | 2018-01-10 | Actelion Pharmaceuticals Ltd. | Terapinės kompozicijos, turinčios macitentano |
KR20120093955A (ko) | 2009-10-14 | 2012-08-23 | 젬머스 파마 인코포레이티드 | 바이러스 감염에 대한 병용 요법 치료 |
CN102655866B (zh) | 2009-11-13 | 2013-11-13 | 东丽株式会社 | 糖尿病的治疗或预防药 |
CN103717585B (zh) | 2011-06-16 | 2015-11-25 | 琅歌生物技术股份有限公司 | 贝前列素的生产方法 |
CN103509044A (zh) * | 2012-06-21 | 2014-01-15 | 上海天伟生物制药有限公司 | 贝前列素钠中间体及其制备方法 |
EP2875022B1 (de) | 2012-07-19 | 2016-10-12 | Cayman Chemical Company, Incorporated | Difluorlactamverbindungen als ep4-rezeptorselektive agonisten zur verwendung bei der behandlung von ep4-vermittelten erkrankungen und zuständen |
CN103242274B (zh) * | 2013-05-22 | 2014-11-05 | 孙威 | 一种贝前列素钠化合物及其制备方法 |
EP3884935B1 (de) | 2013-08-09 | 2023-06-14 | Ardelyx, Inc. | Verbindungen und verfahren zur hemmung eines phosphattransports |
KR101986966B1 (ko) | 2015-08-12 | 2019-06-07 | 유나이티드 쎄러퓨틱스 코포레이션 | 베라프로스트의 제조 방법 |
KR101777632B1 (ko) | 2016-04-11 | 2017-09-12 | 연성정밀화학(주) | 베라프로스트 나트륨 결정형 및 이의 제조방법 |
CN106632372B (zh) * | 2016-09-26 | 2019-04-02 | 上海北卡医药技术有限公司 | 一种中间体及其制备方法和用途 |
AU2017378409A1 (en) | 2016-12-14 | 2019-07-04 | Respira Therapeutics, Inc. | Methods and compositions for treatment of pulmonary hypertension and other lung disorders |
CN107325122B (zh) * | 2017-01-06 | 2020-05-01 | 常州博海威医药科技股份有限公司 | 制备贝前列腺素的新中间体及其制备方法 |
MX2020000999A (es) | 2017-07-27 | 2020-07-22 | Allergan Inc | Agonistas del receptor de prostacyclin para reducir la grasa corporal. |
CN109305986B (zh) * | 2018-11-13 | 2021-02-19 | 济南康和医药科技有限公司 | 一种贝前列素钠中间体的合成方法 |
US10577340B1 (en) * | 2018-11-26 | 2020-03-03 | Chirogate International Inc. | Beraprost-314d crystals and methods for preparation thereof |
JP2022533251A (ja) | 2019-05-21 | 2022-07-21 | アルデリックス, インコーポレイテッド | 患者において血清リン酸塩を低下させるための組み合わせ |
CN110746450A (zh) * | 2019-09-17 | 2020-02-04 | 济南康和医药科技有限公司 | 一种贝前列素钠关键中间体的合成方法 |
CN112569181B (zh) * | 2019-09-27 | 2023-03-21 | 中国科学院上海高等研究院 | 一种快速增溶肾上腺素的方法 |
WO2021163400A1 (en) | 2020-02-12 | 2021-08-19 | Cytoagents, Inc. | Compositions and methods for treating coronavirus infections |
TW202317089A (zh) | 2021-06-16 | 2023-05-01 | 日商東麗股份有限公司 | 罹患慢性腎臟病的貓的治療方法 |
JPWO2023276983A1 (de) * | 2021-06-28 | 2023-01-05 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2734791A1 (de) * | 1977-07-29 | 1979-02-15 | Schering Ag | Neue prostaglandin-i tief 2 -derivate und verfahren zu ihrer herstellung |
JPS5931510B2 (ja) * | 1979-09-03 | 1984-08-02 | 東レ株式会社 | 5,6,7−トリノル−4,8−インタ−m−フエニレンPGI↓2誘導体 |
JPS57144276A (en) * | 1981-03-03 | 1982-09-06 | Toray Ind Inc | 5,6,7-trinor-4,8-inter-m-phenylene pgi2 derivative |
-
1982
- 1982-01-20 JP JP57006150A patent/JPS58124778A/ja active Granted
-
1983
- 1983-01-18 ZA ZA83328A patent/ZA83328B/xx unknown
- 1983-01-19 AU AU10609/83A patent/AU556348B2/en not_active Expired
- 1983-01-19 US US06/459,226 patent/US4474802A/en not_active Expired - Lifetime
- 1983-01-19 AT AT83100449T patent/ATE23716T1/de not_active IP Right Cessation
- 1983-01-19 DE DE8383100449T patent/DE3367774D1/de not_active Expired
- 1983-01-19 EP EP83100449A patent/EP0084856B2/de not_active Expired - Lifetime
- 1983-01-20 CA CA000419895A patent/CA1226280A/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
EP0084856B2 (de) | 1994-05-04 |
AU556348B2 (en) | 1986-10-30 |
AU1060983A (en) | 1983-07-28 |
EP0084856A1 (de) | 1983-08-03 |
JPH0153672B2 (de) | 1989-11-15 |
ATE23716T1 (de) | 1986-12-15 |
CA1226280A (en) | 1987-09-01 |
EP0084856B1 (de) | 1986-11-20 |
JPS58124778A (ja) | 1983-07-25 |
DE3367774D1 (de) | 1987-01-08 |
US4474802A (en) | 1984-10-02 |
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