ZA200810862B - Alkyl-pyridazine derivatives as inhibitors of 11 beta hydroxysteroid dehydrogenase type 1(11B-HSD 1) - Google Patents

Alkyl-pyridazine derivatives as inhibitors of 11 beta hydroxysteroid dehydrogenase type 1(11B-HSD 1)

Info

Publication number: ZA200810862B
Authority: ZA; South Africa
Prior art keywords: hsd; inhibitors; alkyl; hydroxysteroid dehydrogenase; dehydrogenase type
Prior art date: 2006-07-05

Application number

ZA200810862A

Other languages

English (en)

Inventor

Kurt Amrein

Daniel Hunziker

Bernd Kuhn

Alexander V Mayweg

Werner Neidhart

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-07-05

Filing date

2008-12-23

Publication date

2009-12-30

2008-12-23 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2009-12-30 Publication of ZA200810862B publication Critical patent/ZA200810862B/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/08—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Obesity (AREA)
Hematology (AREA)
Endocrinology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Child & Adolescent Psychology (AREA)
Emergency Medicine (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

ZA200810862A 2006-07-05 2008-12-23 Alkyl-pyridazine derivatives as inhibitors of 11 beta hydroxysteroid dehydrogenase type 1(11B-HSD 1) ZA200810862B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP06116596		2006-07-05

Publications (1)

Publication Number	Publication Date
ZA200810862B true ZA200810862B (en)	2009-12-30

Family

ID=38566130

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA200810862A ZA200810862B (en)	2006-07-05	2008-12-23	Alkyl-pyridazine derivatives as inhibitors of 11 beta hydroxysteroid dehydrogenase type 1(11B-HSD 1)

Country Status (19)

Country	Link
US (1)	US7547697B2 (xx)
EP (1)	EP2044034B1 (xx)
JP (1)	JP4959794B2 (xx)
KR (1)	KR101089012B1 (xx)
CN (1)	CN101484428B (xx)
AR (1)	AR061806A1 (xx)
AU (1)	AU2007271273B2 (xx)
BR (1)	BRPI0714200A2 (xx)
CA (1)	CA2655692C (xx)
CL (1)	CL2007001945A1 (xx)
ES (1)	ES2391583T3 (xx)
IL (1)	IL196120A (xx)
MX (1)	MX2008016426A (xx)
NO (1)	NO20090009L (xx)
PE (1)	PE20080399A1 (xx)
RU (1)	RU2417989C2 (xx)
TW (1)	TWI329104B (xx)
WO (1)	WO2008003611A1 (xx)
ZA (1)	ZA200810862B (xx)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CL2008001839A1 (es)	2007-06-21	2009-01-16	Incyte Holdings Corp	Compuestos derivados de 2,7-diazaespirociclos, inhibidores de 11-beta hidroxil esteroide deshidrogenasa tipo 1; composicion farmaceutica que comprende a dichos compuestos; utiles para tratar la obesidad, diabetes, intolerancia a la glucosa, diabetes tipo ii, entre otras enfermedades.
EP2025674A1 (de)	2007-08-15	2009-02-18	sanofi-aventis	Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
US8501940B2 (en)	2008-07-15	2013-08-06	Hoffmann-La Roche Inc.	Tetrahydrocinnoline derivatives
WO2011107494A1 (de)	2010-03-03	2011-09-09	Sanofi	Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
US8933024B2 (en)	2010-06-18	2015-01-13	Sanofi	Azolopyridin-3-one derivatives as inhibitors of lipases and phospholipases
US8530413B2 (en)	2010-06-21	2013-09-10	Sanofi	Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201221505A (en)	2010-07-05	2012-06-01	Sanofi Sa	Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
TW201215388A (en)	2010-07-05	2012-04-16	Sanofi Sa	(2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
TW201215387A (en)	2010-07-05	2012-04-16	Sanofi Aventis	Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
WO2013037390A1 (en)	2011-09-12	2013-03-21	Sanofi	6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013045413A1 (en)	2011-09-27	2013-04-04	Sanofi	6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
ES2563157T3 (es) *	2011-11-14	2016-03-11	F. Hoffmann-La Roche Ag	1-Piridazinil-hidroxiimino-3-fenil-propanos como agonistas de GPBAR1
EP3235813A1 (en)	2016-04-19	2017-10-25	Cidqo 2012, S.L.	Aza-tetra-cyclo derivatives

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20050272036A1 (en) *	2002-07-27	2005-12-08	Barton Peter J	Ketones
TW200503994A (en) *	2003-01-24	2005-02-01	Novartis Ag	Organic compounds

2007
- 2007-06-26 MX MX2008016426A patent/MX2008016426A/es active IP Right Grant
- 2007-06-26 RU RU2009103650/04A patent/RU2417989C2/ru not_active IP Right Cessation
- 2007-06-26 CA CA2655692A patent/CA2655692C/en not_active Expired - Fee Related
- 2007-06-26 WO PCT/EP2007/056347 patent/WO2008003611A1/en active Application Filing
- 2007-06-26 KR KR1020097002289A patent/KR101089012B1/ko not_active Expired - Fee Related
- 2007-06-26 CN CN2007800253323A patent/CN101484428B/zh not_active Expired - Fee Related
- 2007-06-26 BR BRPI0714200-5A patent/BRPI0714200A2/pt not_active IP Right Cessation
- 2007-06-26 JP JP2009517163A patent/JP4959794B2/ja not_active Expired - Fee Related
- 2007-06-26 EP EP07765621A patent/EP2044034B1/en not_active Not-in-force
- 2007-06-26 ES ES07765621T patent/ES2391583T3/es active Active
- 2007-06-26 AU AU2007271273A patent/AU2007271273B2/en not_active Ceased
- 2007-07-02 US US11/824,971 patent/US7547697B2/en not_active Expired - Fee Related
- 2007-07-03 AR ARP070102974A patent/AR061806A1/es not_active Application Discontinuation
- 2007-07-04 CL CL200701945A patent/CL2007001945A1/es unknown
- 2007-07-04 PE PE2007000856A patent/PE20080399A1/es not_active Application Discontinuation
- 2007-07-04 TW TW096124339A patent/TWI329104B/zh not_active IP Right Cessation
2008
- 2008-12-22 IL IL196120A patent/IL196120A/en not_active IP Right Cessation
- 2008-12-23 ZA ZA200810862A patent/ZA200810862B/xx unknown
2009
- 2009-01-02 NO NO20090009A patent/NO20090009L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
TW200811115A (en)	2008-03-01
ES2391583T3 (es)	2012-11-28
EP2044034A1 (en)	2009-04-08
CL2007001945A1 (es)	2008-02-08
MX2008016426A (es)	2009-01-19
IL196120A (en)	2013-02-28
CN101484428B (zh)	2011-11-16
US20080009499A1 (en)	2008-01-10
AU2007271273A1 (en)	2008-01-10
BRPI0714200A2 (pt)	2012-12-25
JP4959794B2 (ja)	2012-06-27
KR101089012B1 (ko)	2011-12-01
RU2417989C2 (ru)	2011-05-10
US7547697B2 (en)	2009-06-16
IL196120A0 (en)	2009-09-01
TWI329104B (en)	2010-08-21
NO20090009L (no)	2009-01-08
KR20090026214A (ko)	2009-03-11
PE20080399A1 (es)	2008-04-28
EP2044034B1 (en)	2012-08-22
CA2655692A1 (en)	2008-01-10
CN101484428A (zh)	2009-07-15
WO2008003611A1 (en)	2008-01-10
CA2655692C (en)	2012-01-03
AU2007271273B2 (en)	2011-09-01
AR061806A1 (es)	2008-09-24
RU2009103650A (ru)	2010-08-10
JP2009541434A (ja)	2009-11-26

Publication	Publication Date	Title
ZA200810862B (en)	2009-12-30	Alkyl-pyridazine derivatives as inhibitors of 11 beta hydroxysteroid dehydrogenase type 1(11B-HSD 1)
TWI347321B (en)	2011-08-21	Cyclohexylpyrazole-lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
HRP20150197T1 (xx)	2015-03-27	Spirocikli kao inhibitori 11-beta hidroksil steroid dehidrogenaze tipa 1
TWI365067B (en)	2012-06-01	N-2 adamantanyl-2-phenoxy-acetamide derivatives as 11-beta hydroxysteroid dehydrogenase inhibitors
PL1888582T3 (pl)	2011-05-31	Imidazo- oraz triazolopirydyny jako inhibitory dehydrogenazy 11-beta-hydroksysteroidowej typu I
TWI365871B (en)	2012-06-11	Tricyclic adamantylamide derivatives as 11-beta hydroxysteroid dehydrogenase inhibitors
IL192580A0 (en)	2009-02-11	Benzazole derivatives, compositions, and methods of use as aurora kinase inhibitors
IL196989A0 (en)	2009-11-18	Cyclic ii-?? hydroxysteroid dehydrogenase type 1 inhibitors
TWI372623B (en)	2012-09-21	Inhibitors of 11β-hydroxysteroid dehydrogenase
IL222698A0 (en)	2012-12-31	Benzazole derivatives, compositions, and methods of use as b- secretase inhibitors
PL2173173T3 (pl)	2014-07-31	Podstawione pochodne 6-anilinopuryny jako inhibitory oksydazy/dehydrogenazy cytokinin i preparaty zawierające te pochodne
IL208896A0 (en)	2011-01-31	Synthesis of inhibitors of 11beta-hydroxysteroid dehydrogenase type 1
ZA200903286B (en)	2010-10-27	Hydantoin derivatives used as MMP Inhibitors
PL2094263T3 (pl)	2014-03-31	Pochodne 2-adamantylo-butyroamidowe jako selektywne inhibitory 11beta-HSD1
IL192634A0 (en)	2009-08-03	Thiazoles as 11 beta-hsd1 inhibitors
IL197869A0 (en)	2009-12-24	Compositions of chk1 inhibitors
AU2008203254A1 (en)	2010-03-04	Compositions of phosphodiesterase type IV inhibitors
PL2091530T3 (pl)	2018-01-31	Kompozycja hamująca aktywność oksydazy nadph
IL196000A0 (en)	2009-09-01	2-arylindole derivatives as npges-i inhibitors
PL2035379T3 (pl)	2010-11-30	Inhibitory dehydrogenazy 11-beta-hydroksysteroidowej typu 1
ZA200710220B (en)	2009-03-25	Imidazo- and traizolopyridines as inhibitors as 11-beta hydroxysteroid dehydrogenase type I
HK1126185A (en)	2009-08-28	Cyclic 11-beta hydroxysteroid dehydrogenase type i inhibitors
HK1145838A (en)	2011-05-06	Triazolopyridine 11-beta hydroxysteroid dehydrogenase type i inhibitors
ZA200901286B (en)	2010-05-26	Cyclic 11-beta hydroxysteroid dehydrogenase type I inhibitors