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PE20080399A1 - Derivados de alquilpiridazina - Google Patents

Derivados de alquilpiridazina

Info

Publication number
PE20080399A1
PE20080399A1 PE2007000856A PE2007000856A PE20080399A1 PE 20080399 A1 PE20080399 A1 PE 20080399A1 PE 2007000856 A PE2007000856 A PE 2007000856A PE 2007000856 A PE2007000856 A PE 2007000856A PE 20080399 A1 PE20080399 A1 PE 20080399A1
Authority
PE
Peru
Prior art keywords
propyl
dimethyl
undeca
triene
tricycle
Prior art date
Application number
PE2007000856A
Other languages
English (en)
Inventor
Kurt Amrein
Daniel Huziker
Bernd Kuhn
Alexander V Mayweg
Werner Neidhart
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PE20080399A1 publication Critical patent/PE20080399A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/08—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA I DONDE R1 Y R2 SON CADA UNO CICLOALQUILO, ARILALQUILO, ARILOXIALQUILO, ENTRE OTROS; R3 ES H, ALQUILO, CICLOALQUILO, TRIFLUORMETILO; R4 ES 2,2-DIMETIL-PROPILO, 3-METILBUTILO, ISO-PROPILO, CILCLOPROPILMETILO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 3-(2,2-DIMETIL-PROPIL)-5,6,7,8,9,10-HEXAHIDRO-CICLOOCTA[C]PIRIDAZINA; (1SR,8RS)-5-(2,2-DIMETIL-PROPIL)-3,4-DIAZA-TRICICLO-[6.2.1.02,7]UNDECA-2,4,6-TRIENO; (1S,8R)-1,11,11-TRIMETIL-5-(3-METIL-BUTIL)-3,4-DIAZA-TRICICLO-[6.2.1.02,7]UNDECA-2,4-6-TRIENO; ENTRE OTROS. DICHOS COMPUESTOS SON UTILES EN LA PROFILAXIS Y TERAPIA DE ENFERMEDADES CAUSADAS POR TRASTORNOS ASOCIADOS CON LA ENZIMA 11BETA-HIDROXI-ESTEROIDE-DESHIDROGENASA I TALES COMO DIBETES TIPO II, DISLIPIDEMIA E HIPERTENSION
PE2007000856A 2006-07-05 2007-07-04 Derivados de alquilpiridazina PE20080399A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP06116596 2006-07-05

Publications (1)

Publication Number Publication Date
PE20080399A1 true PE20080399A1 (es) 2008-04-28

Family

ID=38566130

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2007000856A PE20080399A1 (es) 2006-07-05 2007-07-04 Derivados de alquilpiridazina

Country Status (19)

Country Link
US (1) US7547697B2 (es)
EP (1) EP2044034B1 (es)
JP (1) JP4959794B2 (es)
KR (1) KR101089012B1 (es)
CN (1) CN101484428B (es)
AR (1) AR061806A1 (es)
AU (1) AU2007271273B2 (es)
BR (1) BRPI0714200A2 (es)
CA (1) CA2655692C (es)
CL (1) CL2007001945A1 (es)
ES (1) ES2391583T3 (es)
IL (1) IL196120A (es)
MX (1) MX2008016426A (es)
NO (1) NO20090009L (es)
PE (1) PE20080399A1 (es)
RU (1) RU2417989C2 (es)
TW (1) TWI329104B (es)
WO (1) WO2008003611A1 (es)
ZA (1) ZA200810862B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CL2008001839A1 (es) 2007-06-21 2009-01-16 Incyte Holdings Corp Compuestos derivados de 2,7-diazaespirociclos, inhibidores de 11-beta hidroxil esteroide deshidrogenasa tipo 1; composicion farmaceutica que comprende a dichos compuestos; utiles para tratar la obesidad, diabetes, intolerancia a la glucosa, diabetes tipo ii, entre otras enfermedades.
EP2025674A1 (de) 2007-08-15 2009-02-18 sanofi-aventis Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
US8501940B2 (en) 2008-07-15 2013-08-06 Hoffmann-La Roche Inc. Tetrahydrocinnoline derivatives
WO2011107494A1 (de) 2010-03-03 2011-09-09 Sanofi Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
US8933024B2 (en) 2010-06-18 2015-01-13 Sanofi Azolopyridin-3-one derivatives as inhibitors of lipases and phospholipases
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
TW201215387A (en) 2010-07-05 2012-04-16 Sanofi Aventis Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013045413A1 (en) 2011-09-27 2013-04-04 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
ES2563157T3 (es) * 2011-11-14 2016-03-11 F. Hoffmann-La Roche Ag 1-Piridazinil-hidroxiimino-3-fenil-propanos como agonistas de GPBAR1
EP3235813A1 (en) 2016-04-19 2017-10-25 Cidqo 2012, S.L. Aza-tetra-cyclo derivatives

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050272036A1 (en) * 2002-07-27 2005-12-08 Barton Peter J Ketones
TW200503994A (en) * 2003-01-24 2005-02-01 Novartis Ag Organic compounds

Also Published As

Publication number Publication date
TW200811115A (en) 2008-03-01
ES2391583T3 (es) 2012-11-28
EP2044034A1 (en) 2009-04-08
CL2007001945A1 (es) 2008-02-08
MX2008016426A (es) 2009-01-19
ZA200810862B (en) 2009-12-30
IL196120A (en) 2013-02-28
CN101484428B (zh) 2011-11-16
US20080009499A1 (en) 2008-01-10
AU2007271273A1 (en) 2008-01-10
BRPI0714200A2 (pt) 2012-12-25
JP4959794B2 (ja) 2012-06-27
KR101089012B1 (ko) 2011-12-01
RU2417989C2 (ru) 2011-05-10
US7547697B2 (en) 2009-06-16
IL196120A0 (en) 2009-09-01
TWI329104B (en) 2010-08-21
NO20090009L (no) 2009-01-08
KR20090026214A (ko) 2009-03-11
EP2044034B1 (en) 2012-08-22
CA2655692A1 (en) 2008-01-10
CN101484428A (zh) 2009-07-15
WO2008003611A1 (en) 2008-01-10
CA2655692C (en) 2012-01-03
AU2007271273B2 (en) 2011-09-01
AR061806A1 (es) 2008-09-24
RU2009103650A (ru) 2010-08-10
JP2009541434A (ja) 2009-11-26

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