[go: up one dir, main page]

ZA200604869B - Modified macromolecules and methods of making and using thereof - Google Patents

Modified macromolecules and methods of making and using thereof Download PDF

Info

Publication number
ZA200604869B
ZA200604869B ZA200604869A ZA200604869A ZA200604869B ZA 200604869 B ZA200604869 B ZA 200604869B ZA 200604869 A ZA200604869 A ZA 200604869A ZA 200604869 A ZA200604869 A ZA 200604869A ZA 200604869 B ZA200604869 B ZA 200604869B
Authority
ZA
South Africa
Prior art keywords
group
compound
modified
glycosaminoglycan
aminooxy
Prior art date
Application number
ZA200604869A
Other languages
English (en)
Inventor
Glenn D Prestwich
Shu Xiao Zheng
Liu Yanchun
Original Assignee
Univ Utah Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Utah Res Found filed Critical Univ Utah Res Found
Publication of ZA200604869B publication Critical patent/ZA200604869B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/20—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0069—Chondroitin-4-sulfate, i.e. chondroitin sulfate A; Dermatan sulfate, i.e. chondroitin sulfate B or beta-heparin; Chondroitin-6-sulfate, i.e. chondroitin sulfate C; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08H—DERIVATIVES OF NATURAL MACROMOLECULAR COMPOUNDS
    • C08H1/00—Macromolecular products derived from proteins
    • C08H1/06—Macromolecular products derived from proteins derived from horn, hoofs, hair, skin or leather
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/02—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques
    • C08J3/03—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques in aqueous media
    • C08J3/075—Macromolecular gels
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C08L5/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0068—General culture methods using substrates
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2305/00—Characterised by the use of polysaccharides or of their derivatives not provided for in groups C08J2301/00 or C08J2303/00
    • C08J2305/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins
    • C12N2533/54—Collagen; Gelatin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/70—Polysaccharides
    • C12N2533/80—Hyaluronan

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Dispersion Chemistry (AREA)
  • Transplantation (AREA)
  • General Engineering & Computer Science (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Surgery (AREA)
  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Oncology (AREA)
ZA200604869A 2003-12-04 2004-12-06 Modified macromolecules and methods of making and using thereof ZA200604869B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US52679703P 2003-12-04 2003-12-04

Publications (1)

Publication Number Publication Date
ZA200604869B true ZA200604869B (en) 2007-11-28

Family

ID=34676658

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200604869A ZA200604869B (en) 2003-12-04 2004-12-06 Modified macromolecules and methods of making and using thereof

Country Status (8)

Country Link
US (2) US7981871B2 (fr)
EP (1) EP1694712A1 (fr)
JP (1) JP4993465B2 (fr)
AU (1) AU2004297231B2 (fr)
CA (1) CA2549295C (fr)
IL (1) IL176089A0 (fr)
WO (1) WO2005056608A1 (fr)
ZA (1) ZA200604869B (fr)

Families Citing this family (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003299509A1 (en) * 2002-06-21 2004-05-13 University Of Utah Research Foundation Crosslinked compounds and methods of making and using thereof
WO2005072778A2 (fr) * 2004-01-29 2005-08-11 Biosynexus, Inc. Utilisation de groupes fonctionnels amino-oxy dans la preparation de vaccins
ITRM20040318A1 (it) * 2004-06-28 2004-09-28 Univ Palermo Idrogeli di acido ialuronico e alfa, beta-poliaspartilidrazide e loro applicazioni in campo biomedico e farmaceutico.
US8821583B2 (en) 2004-10-05 2014-09-02 The Board Of Trustees Of The Leland Stanford Junior University Interpenetrating polymer network hydrogel
WO2007059890A1 (fr) * 2005-11-22 2007-05-31 Centre National De Recherche Scientifique Nouveaux derives d’acide hyaluronique, leur procede de preparation et leurs utilisations
US20070128246A1 (en) * 2005-12-06 2007-06-07 Hossainy Syed F A Solventless method for forming a coating
US20090082254A1 (en) * 2006-02-14 2009-03-26 Novo Nordisk A/S Coupling of Polypeptides at the C-Terminus
WO2007102149A2 (fr) * 2006-03-07 2007-09-13 Prochon Biotech Ltd. Dérivés hydrazido de l'acide hyaluronique
CN100348620C (zh) * 2006-04-07 2007-11-14 华南理工大学 酶解小麦面筋蛋白与多糖接枝聚合的方法
WO2008008857A2 (fr) * 2006-07-11 2008-01-17 University Of Utah Research Foundation Macromolécules thiolées et procédés de fabrication et d'utilisation de celles-ci
US7902332B2 (en) 2006-11-30 2011-03-08 General Electric Company Fluorine-labeled compounds
CN101200504B (zh) * 2006-12-11 2010-05-12 上海百瑞吉生物医药有限公司 高分子巯基化改性衍生物及其交联材料
CN101220090B (zh) * 2007-01-09 2010-10-13 上海百瑞吉生物医药有限公司 明胶多重改性衍生物及其交联材料
BRPI0806892A2 (pt) * 2007-01-22 2014-04-29 Akzo Nobel Nv Processo para preparar éter de celulose
CA2677498C (fr) 2007-02-05 2016-05-17 Carbylan Biosurgery, Inc. Formulations polymeres utilisables pour la delivrance d'agents bioactifs
DK2497505T3 (en) * 2007-04-16 2016-12-05 Regentis Biomaterials Ltd Compositions and methods of the cage-forming
US9011894B2 (en) 2007-06-29 2015-04-21 Carbylan Therapeutics, Inc. Sterile hyaluronic acid polymer compositions and related methods
CN101338036B (zh) * 2007-07-06 2010-11-03 常州百瑞吉生物医药有限公司 生物相容快速凝胶化水凝胶及其喷雾剂的制备方法
US20090171455A1 (en) * 2007-12-31 2009-07-02 Boston Scientific Scimed, Inc. Biodegradable polymers
US8343942B2 (en) 2008-04-04 2013-01-01 University Of Utah Research Foundation Methods for treating interstitial cystitis
WO2009124266A2 (fr) 2008-04-04 2009-10-08 University Of Utah Research Foundation Ethers de glycoaminoglycosan semi-synthétiques alkylés et leurs procédés de fabrication et d’utilisation
US8865412B2 (en) * 2008-05-28 2014-10-21 Baxter International Inc. Methods and assays for oversulfated glycosaminoglycans
CN101721349B (zh) 2008-10-16 2011-07-20 常州百瑞吉生物医药有限公司 可注射原位交联水凝胶及其制备方法和用途
CN102573920B (zh) * 2009-07-27 2015-01-14 利普森技术有限公司 非凝血蛋白的糖基多唾液酸化
CN104530182A (zh) * 2009-07-27 2015-04-22 利普森技术有限公司 非凝血蛋白的糖基多唾液酸化
WO2011017101A2 (fr) 2009-07-27 2011-02-10 Fina Biosolutions, Llc Procédé de production de vaccins à protéine-carbohydrate à niveau réduit de carbohydrate libre
JP5683587B2 (ja) 2009-07-30 2015-03-11 カービラン バイオサージェリー， インコーポレイテッド 修飾ヒアルロン酸ポリマー組成物および関連する方法
SI2480075T1 (sl) * 2009-09-23 2020-11-30 Glenpharma Ab Sestavki in postopki za induciranje ali povečanje reparacije vezivnega tkiva
CN102892753B (zh) 2009-12-17 2016-01-20 法纳生物解决办法有限责任公司 在制备缀合疫苗中用于活化多糖的化学试剂
US20130035307A1 (en) * 2010-01-26 2013-02-07 University Of Utah Research Foundation Methods for treating or preventing the spread of cancer using semi-synthetic glycosaminoglycosan ethers
WO2011097342A1 (fr) * 2010-02-04 2011-08-11 University Of Utah Research Foundation Hyaluronanne à modification hydrophobe et procédés de fabrication et d'utilisation de celui-ci
EP2560738B8 (fr) 2010-04-23 2019-09-25 Serum Institute of India Private Limited Méthode simple d'élimination simultanée de nombreuses impuretés à partir de surnageants de culture jusqu'à des niveaux ultra-faibles
CN102399295B (zh) 2010-09-09 2013-11-06 常州百瑞吉生物医药有限公司 低巯基化改性度生物相容高分子巯基化衍生物及其交联材料和用途
EP2630232A4 (fr) 2010-10-22 2014-04-02 Biotime Inc Méthodes de modification des réseaux de régulation transcriptionnelle dans des cellules souches
CA2818728C (fr) * 2010-11-23 2020-09-22 Elastagen Pty Ltd Preparations et/ou formulations a base de proteines reticulees avec des polysaccharides
ITTO20110135A1 (it) * 2011-02-17 2012-08-18 Metlac S P A Composizione di rivestimento per substrati metallici e relativi substrati metallici rivestiti.
EP2801377B1 (fr) 2011-03-04 2019-08-07 The Regents of The University of California Hydrogen contenant des cellules pour la libération locale des facteurs de croissance pour favoriser la récupération motrice après un accident vasculaire cérébral
EP2688402B1 (fr) 2011-03-23 2018-10-24 University of Utah Research Foundation Composés pour traiter ou prévenir une inflammation des voies urinaires
US10865383B2 (en) 2011-07-12 2020-12-15 Lineage Cell Therapeutics, Inc. Methods and formulations for orthopedic cell therapy
US10154881B2 (en) * 2012-08-10 2018-12-18 Arizona Board Of Regents For And On Behalf Of Arizona State University Methods and compositions for tissue adhesives
EP2716751A1 (fr) 2012-10-08 2014-04-09 BioTime, Inc. Descendance différenciée des lignées de cellules progénitrices clonales
CN102898545B (zh) * 2012-11-15 2015-06-10 山东众山生物科技有限公司 一种降低透明质酸粘度的方法
CZ304267B6 (cs) * 2012-11-27 2014-02-05 Contipro Biotech S.R.O. Fotoreaktivní derivát kyseliny hyaluronové, způsob jeho přípravy, 3D síťovaný derivát kyseliny hyaluronové, způsob jeho přípravy a použití
US20150352142A1 (en) 2013-01-11 2015-12-10 Carbylan Therapeutics, Inc. Stabilized compositions comprising hyaluronic acid
KR101628677B1 (ko) * 2013-04-02 2016-06-09 주식회사 나이벡 세포외기질 단백질-골미네랄 복합체를 함유하는 조직 구조 모사체 및 그 제조방법
US10137199B2 (en) 2013-05-14 2018-11-27 Biotime, Inc. Thiolated hyaluronan-based hydrogels cross-linked using oxidized glutathione
AU2014275130B2 (en) 2013-06-05 2019-09-12 Reverse Bioengineering, Inc. Compositions and methods for induced tissue regeneration in mammalian species
WO2015053280A1 (fr) * 2013-10-08 2015-04-16 キユーピー株式会社 Acide hyaluronique modifié contenant un groupe carboxyméthyle et/ou un sel de ce dernier et/ou procédé de production d'acide hyaluronique modifié contenant un groupe carboxyméthyle et/ou de sel de ce dernier
JP5734536B1 (ja) * 2013-10-08 2015-06-17 キユーピー株式会社 カルボキシメチル基含有修飾ヒアルロン酸および／またはその塩の架橋物およびその製造方法
JPWO2015053282A1 (ja) * 2013-10-08 2017-03-09 キユーピー株式会社 カルボキシメチル基含有修飾ヒアルロン酸および／またはその塩の架橋物およびその製造方法
US9334432B2 (en) * 2013-11-20 2016-05-10 Ppg Industries Ohio, Inc. Curable compositions that include hydrazide functional materials
US11078462B2 (en) 2014-02-18 2021-08-03 ReCyte Therapeutics, Inc. Perivascular stromal cells from primate pluripotent stem cells
US10240127B2 (en) 2014-07-03 2019-03-26 ReCyte Therapeutics, Inc. Exosomes from clonal progenitor cells
JP6046869B1 (ja) * 2015-04-14 2016-12-21 キユーピー株式会社 カルボキシメチル基含有修飾ヒアルロン酸および／またはその塩の架橋物およびその製造方法。
WO2017066349A1 (fr) 2015-10-13 2017-04-20 Symic Ip, Llc Bioconjugué se liant à la ve-cadhérine
WO2017100313A1 (fr) 2015-12-07 2017-06-15 Biotime, Inc. Procédés de ré-dérivation de diverses cellules de tissu adipeux brun dérivées de cellules souches pluripotentes
AU2017246580A1 (en) 2016-04-04 2018-10-11 Biotime, Inc. Pluripotent stem cell-derived 3D retinal tissue and uses thereof
WO2018053111A1 (fr) 2016-09-15 2018-03-22 University Of Utah Research Foundation Compositions de gélification in situ pour le traitement ou la prévention d'une inflammation et d'une lésion tissulaire
JPWO2018079812A1 (ja) * 2016-10-31 2019-09-19 キユーピー株式会社 ゲル組成物及びその製造方法
EP3638266A1 (fr) 2017-06-12 2020-04-22 BioTime, Inc. Implants, procédés de fabrication d'implants et méthodes de traitement de défauts de lipoatrophie avec ceux-ci
JP2020530839A (ja) 2017-07-31 2020-10-29 バイオタイム インコーポレイテッド 疾患または外傷性損傷を原因とする視覚喪失を回復させるまたは予防するための組成物および方法
CN118126415A (zh) * 2017-09-19 2024-06-04 香港科技大学 生物可相容材料以及用于制备和使用所述生物可相容材料的方法
KR102038434B1 (ko) * 2018-01-16 2019-10-30 한국원자력연구원 동물의 연골 유래 세포외기질 막의 분해도 조절 방법 및 이를 이용하여 분해도가 조절된 동물의 연골 유래 세포외기질 막
AR115549A1 (es) 2018-06-15 2021-02-03 Croma Pharma Gmbh Composición de hidrogel que comprende un polímero reticulado
CA3101410A1 (fr) 2018-06-15 2019-12-19 Croma-Pharma Gmbh Acide hyaluronique stabilise
CN111228653A (zh) 2018-11-13 2020-06-05 格莱科米拉治疗公司 用电离辐射加强癌症治疗的方法
CN113366025A (zh) 2019-01-30 2021-09-07 鲍希与洛姆伯股份有限公司 交联的聚合物网络及其用途
WO2020222914A1 (fr) * 2019-04-29 2020-11-05 Bausch & Lomb Incorporated Réseau polymère glycophospholipide et son utilisation
PH12019000192A1 (en) * 2019-05-22 2020-11-23 Department Of Science And Tech Philippine Nuclear Research Institute A carboxymethyl hyaluronic hydrogels prepared by gamma-irradiation
CN110279610B (zh) 2019-06-26 2021-06-11 常州百瑞吉生物医药有限公司 一种透明质酸皮肤保护组合物及其制备方法和应用
US11795320B2 (en) * 2019-09-20 2023-10-24 Bausch + Lomb Ireland Limited Grafted polymer and use thereof
CN110787325A (zh) * 2019-09-21 2020-02-14 常州百瑞吉生物医药有限公司 用于预防腹（盆）腔术后组织粘连的二硫键交联透明质酸凝胶及其制备方法
US11771876B2 (en) * 2019-09-24 2023-10-03 The Charles Stark Draper Laboratory, Inc. System for inner ear drug delivery via trans-round window membrane injection
ES2985960T3 (es) 2019-12-19 2024-11-07 Croma Pharma Gmbh Hialuronano modificado con tiol e hidrogel que comprende el hialuronano reticulado
DE102021212812A1 (de) 2021-11-15 2023-05-17 Bauerfeind Ag Entzündungshemmendes viskosupplementierendes Mittel enthaltend Hyaluronsäure

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO812612L (no) 1980-08-06 1982-02-08 Ferring Pharma Ltd Enzym-inhibitorer.
US5135919A (en) * 1988-01-19 1992-08-04 Children's Medical Center Corporation Method and a pharmaceutical composition for the inhibition of angiogenesis
DE68927904T2 (de) * 1988-09-01 1997-09-04 Takeda Chemical Industries Ltd Fumagillol-Derivate
US6017954A (en) * 1989-08-10 2000-01-25 Children's Medical Center Corp. Method of treating tumors using O-substituted fumagillol derivatives
US5290807A (en) * 1989-08-10 1994-03-01 Children's Medical Center Corporation Method for regressing angiogenesis using o-substituted fumagillol derivatives
DK0544000T3 (da) 1990-08-17 1997-11-03 Drug Delivery System Inst Ltd N-acetylcarboxymethylchitosanderivater og fremgangsmåde til fremstilling deraf.
JPH06157344A (ja) * 1992-02-07 1994-06-03 Childrens Medical Center Corp:The 血管新生阻害のための医薬製剤及び血管新生阻害方法
US5504074A (en) * 1993-08-06 1996-04-02 Children's Medical Center Corporation Estrogenic compounds as anti-angiogenic agents
US5616568A (en) * 1993-11-30 1997-04-01 The Research Foundation Of State University Of New York Functionalized derivatives of hyaluronic acid
BR9507479A (pt) * 1994-04-26 1997-09-16 Childrens Medical Center Angipstantina e processo de uso para inibição de angiogenese
US5837682A (en) * 1996-03-08 1998-11-17 The Children's Medical Center Corporation Angiostatin fragments and method of use
US5945403A (en) * 1997-05-30 1999-08-31 The Children's Medical Center Corporation Angiostatin fragments and method of use
US5639725A (en) * 1994-04-26 1997-06-17 Children's Hospital Medical Center Corp. Angiostatin protein
US6551610B2 (en) * 1995-04-13 2003-04-22 Poly-Med, Inc. Multifaceted compositions for post-surgical adhesion prevention
US5861372A (en) * 1996-02-22 1999-01-19 The Children's Medical Center Corporation Aggregate angiostatin and method of use
WO1996040662A2 (fr) * 1995-06-07 1996-12-19 Cellpro, Incorporated Composes de liaison contenant un groupe aminooxy et leur utilisation pour la formation de conjugues
US5854205A (en) * 1995-10-23 1998-12-29 The Children's Medical Center Corporation Therapeutic antiangiogenic compositions and methods
US5854221A (en) * 1996-12-12 1998-12-29 The Children's Medical Center Corporation Endothelial cell proliferation inhibitor and method of use
PT1704878E (pt) * 1995-12-18 2013-07-17 Angiodevice Internat Gmbh Composições de polímeros reticulados e métodos para a sua utilização
US6251959B1 (en) 1996-05-09 2001-06-26 Nippon Suisan Kaisha, Ltd. Chitin derivatives having carboxylated lower alkyl groups as hydrophilic substituents and hydrophobic substituents, and micellar aqueous composition thereof
US6060534A (en) * 1996-07-11 2000-05-09 Scimed Life Systems, Inc. Medical devices comprising ionically and non-ionically crosslinked polymer hydrogels having improved mechanical properties
US6174861B1 (en) * 1996-10-22 2001-01-16 The Children's Medical Center Corporation Methods of inhibiting angiogenesis via increasing in vivo concentrations of endostatin protein
EP1021204B1 (fr) * 1997-09-26 2005-12-28 Noven Pharmaceuticals, Inc. Compositions bioadhesives et methodes d'administration locale d'agents actifs
US6630457B1 (en) * 1998-09-18 2003-10-07 Orthogene Llc Functionalized derivatives of hyaluronic acid, formation of hydrogels in situ using same, and methods for making and using same
US6329170B1 (en) * 1999-04-23 2001-12-11 Northwest Hospital Nucleic acids and proteins of a rat ganglioside GM1-specific α1→2fucosyltransferase and uses thereof
WO2001023565A1 (fr) * 1999-09-28 2001-04-05 Gentest Corporation P-glycoproteines provenant de macaca fascicularis et utilisations correspondantes
US6521223B1 (en) * 2000-02-14 2003-02-18 Genzyme Corporation Single phase gels for the prevention of adhesions
US6749865B2 (en) * 2000-02-15 2004-06-15 Genzyme Corporation Modification of biopolymers for improved drug delivery
JP2004513071A (ja) * 2000-05-23 2004-04-30 ザ・トラスティーズ・オブ・コロンビア・ユニバーシティ・イン・ザ・シティ・オブ・ニューヨーク 肺の弾性繊維損傷に関連した呼吸器疾患の治療方法
JP4410913B2 (ja) * 2000-06-12 2010-02-10 壽製薬株式会社 新規糖脂質誘導体の製造方法
WO2002006373A1 (fr) * 2000-07-17 2002-01-24 University Of Utah Research Foundation Films d'hydrogel et procedes de fabrication et d'utilisation de ces films
AU2001265400A1 (en) * 2000-07-28 2002-02-13 Anika Therapeutics, Inc. Bioabsorbable composites of derivatized hyaluronic acid
DE10114244A1 (de) * 2001-03-22 2002-10-02 Heraeus Kulzer Gmbh & Co Kg Antibiotikum-/Antibiotika-Zubereitung mit retardierender Wirkstofffreisetzung
DE10114245A1 (de) 2001-03-22 2002-10-02 Heraeus Kulzer Gmbh & Co Kg Herstellung und Verwendung einer Antibiotikum-/Antibiotika-Zubereitung
WO2002090390A1 (fr) 2001-05-04 2002-11-14 University Of Utah Research Foundation Acide hyaluronique contenant des bioconjugues: administration ciblee de medicaments anticancereux dans des cellules cancereuses
US20030113478A1 (en) * 2001-12-12 2003-06-19 Dang Mai Huong Surface coating method and coated device
AU2003299509A1 (en) * 2002-06-21 2004-05-13 University Of Utah Research Foundation Crosslinked compounds and methods of making and using thereof
JP4030368B2 (ja) * 2002-07-05 2008-01-09 富士フイルム株式会社 細胞培養担体
US7267982B2 (en) 2002-07-05 2007-09-11 Fujifilm Corporation Carrier for cell culture
JP4017958B2 (ja) * 2002-10-24 2007-12-05 富士フイルム株式会社 細胞培養担体
US7022523B2 (en) 2002-10-24 2006-04-04 Fuji Photo Film Co., Ltd. Carrier for cell culture

Also Published As

Publication number Publication date
CA2549295A1 (fr) 2005-06-23
US20080025950A1 (en) 2008-01-31
CA2549295C (fr) 2016-05-03
AU2004297231A1 (en) 2005-06-23
AU2004297231B2 (en) 2012-02-02
EP1694712A1 (fr) 2006-08-30
JP4993465B2 (ja) 2012-08-08
JP2007520589A (ja) 2007-07-26
IL176089A0 (en) 2006-10-05
US8691793B2 (en) 2014-04-08
WO2005056608A1 (fr) 2005-06-23
US20120142907A1 (en) 2012-06-07
US7981871B2 (en) 2011-07-19

Similar Documents

Publication Publication Date Title
US7981871B2 (en) Modified macromolescules and associated methods of synthesis and use
EP2399940A2 (fr) Macromolécules modifiées et leurs procédés de fabrication et d'utilisation
US8324184B2 (en) Anti-adhesion composites and methods of use thereof
US10064889B2 (en) Mercapto-modified biocompatible macromolecule derivatives with low degree of mercapto-modification and the cross-linked materials and uses thereof
US7651702B2 (en) Crosslinking hyaluronan and chitosanic polymers
EP1539799B1 (fr) Composés reticulés et leurs procédés de préparation et d'utilisation
US20080032920A1 (en) Macromolecules modified with electrophilic groups and methods of making and using thereof
WO2008008857A2 (fr) Macromolécules thiolées et procédés de fabrication et d'utilisation de celles-ci
EP1773399B1 (fr) Hydrogels d'acide hyaluronique et de polyaspartyl-hydrazide alpha, beta et leurs utilisations pharmaceutiques et biomedicales
CN1837265A (zh) 一种透明质酸－羧甲基纤维素复合改性的方法
Brekke et al. Hyaluronan as a biomaterial
JP6648142B2 (ja) グリコサミノグリカンおよびタンパク質を含む組成物
Ivanov Hyaluronic Acid-Based Biomaterials
Ruini Chitosan based biomaterials: soft tissue engineering applications
Ciardelli et al. Chitosan based biomaterials: soft tissue engineering applications