ZA200403406B - [[2-(Amino-3,4-dioxo-icyclobuten-1-yl)amino]alkyl]-acid derivatives for the treatment of pain - Google Patents

[[2-(Amino-3,4-dioxo-icyclobuten-1-yl)amino]alkyl]-acid derivatives for the treatment of pain Download PDF

Info

Publication number: ZA200403406B
Authority: ZA; South Africa
Prior art keywords: pain; dioxo; amino; acid; day
Prior art date: 2001-10-10

Application number

ZA200403406A

Other languages

English (en)

Inventor

Brandt Michael Richard

Moyer John Allen

Zaleska Margaret Maria

Original Assignee

Wyeth Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-10-10

Filing date

2004-05-05

Publication date

2007-04-25

2004-05-05 Application filed by Wyeth Corp filed Critical Wyeth Corp

2007-04-25 Publication of ZA200403406B publication Critical patent/ZA200403406B/en

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Biomedical Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Plural Heterocyclic Compounds (AREA)

ZA200403406A 2001-10-10 2004-05-05 [[2-(Amino-3,4-dioxo-icyclobuten-1-yl)amino]alkyl]-acid derivatives for the treatment of pain ZA200403406B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US32824501P	2001-10-10	2001-10-10

Publications (1)

Publication Number	Publication Date
ZA200403406B true ZA200403406B (en)	2007-04-25

Family

ID=23280159

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA200403406A ZA200403406B (en)	2001-10-10	2004-05-05	[[2-(Amino-3,4-dioxo-icyclobuten-1-yl)amino]alkyl]-acid derivatives for the treatment of pain

Country Status (27)

Country	Link
US (2)	US7098200B2 (el)
EP (1)	EP1434588B1 (el)
JP (1)	JP4350512B2 (el)
KR (1)	KR100922703B1 (el)
CN (1)	CN100448449C (el)
AR (1)	AR036764A1 (el)
AT (1)	ATE515266T1 (el)
AU (1)	AU2009201746A1 (el)
BR (1)	BR0213237A (el)
CA (1)	CA2461348C (el)
CY (1)	CY1111909T1 (el)
DK (1)	DK1434588T3 (el)
EA (1)	EA009993B1 (el)
ES (1)	ES2367356T3 (el)
HK (1)	HK1064609A1 (el)
HU (1)	HUP0401773A3 (el)
IL (2)	IL161275A0 (el)
MX (1)	MXPA04003354A (el)
NO (1)	NO20041378L (el)
NZ (1)	NZ532159A (el)
PL (1)	PL368863A1 (el)
PT (1)	PT1434588E (el)
SI (1)	SI1434588T1 (el)
TW (1)	TWI321472B (el)
UA (1)	UA78529C2 (el)
WO (1)	WO2003031416A2 (el)
ZA (1)	ZA200403406B (el)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PT1839654E (pt) *	2002-11-22	2010-07-06	Gruenenthal Chemie	Utilizaão de (1r,2r)-3-(3-dimetilamino-1-etil-2-metilpropil) fenol para o tratamento de dor inflamatëria
MXPA05010763A (es) *	2003-04-09	2005-12-12	Wyeth Corp	Composiciones farmaceuticas para administracion intranasal de acido [2-(8, 9-dioxo-2, 6-diazabiciclo [5.2.0] non-1(7) -en-2-il) alquil- fosfonico] y metodos de uso del mismo.
AU2004230895B2 (en) *	2003-04-09	2010-09-09	Wyeth	Derivatives of 2-(8,9-dioxo-2,6-diazabicyclo(5.2.0)non-1(7)-en-2-yl)alkyl phosphonic acid and their use as N-methyl-D-aspartate (NMDA) receptor antagonists
US20050142192A1 (en) *	2003-10-15	2005-06-30	Wyeth	Oral administration of [2-(8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1(7)-en-2-yl)alkyl] phosphonic acid and derivatives
TW200514775A (en) *	2003-10-22	2005-05-01	Wyeth Corp	Methods for the preparation of {2-[(8,9)-dioxo-2,6-diaza-bicyclo[5.2.0]-non-1(7)-en-2-yl]ethyl} phosphonic acid and esters thereof
CA2583114A1 (en) *	2004-10-08	2006-04-20	Wyeth	Derivatives of [2-(8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1(7)-en-2-yl)alkyl]phosphonic acid and method of making them
JP2010537999A (ja) *	2007-08-27	2010-12-09	ワイス・エルエルシー	麻酔薬節約効果を得るためのｎｍｄａ拮抗薬を用いる組成物および方法
CA2752148A1 (en)	2009-02-13	2010-08-19	Daniel W. Gil	Pharmaceutical compositions comprising (3-(1-(1h-imidazol-4-yl)ethyl)-2-methylphenyl)methanol
BRPI1009900A2 (pt)	2009-03-19	2016-03-15	Wyeth Llc	métodos para a preparação de ácido [2-(8,9-dioxo-2,6-diazabiciclo[5.2.0]non-1(7)-en-2-il)etil]fosfônico e seus precursores
CA2856507C (en)	2011-11-21	2017-03-21	Allergan, Inc.	Pharmaceutical compositions comprising 4-[1-(2,3-dimethylphenyl)ethyl]-3h-imidazole derivatives for treating retinal diseases
US10292989B2 (en)	2014-03-28	2019-05-21	University Of Virginia Patent Foundation	General anesthetics that are not neurotoxic

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5168103A (en) *	1991-01-22	1992-12-01	American Home Products Corporation	[[2-(amino-3,4-dioxo-1-cyclobuten-1-yl) amino]alkyl]-acid derivatives
US5124319A (en) *	1991-10-11	1992-06-23	American Home Products Corporation	Benzimidazole phosphono-amino acids
DK124393D0 (da) *	1993-11-03	1993-11-03	Lundbeck & Co As H	Compounds
AT400440B (de) *	1993-12-06	1995-12-27	Vianova Kunstharz Ag	Verfahren zur herstellung von wasserverdünnbaren lackbindemitteln und deren verwendung
TW427904B (en) *	1995-12-07	2001-04-01	American Home Prod	Neuroprotective agents
UA52698C2 (uk) *	1996-10-04	2003-01-15	Х. Луннбек А/С	Похідні (3-алкоксіізоксазол-4-іл)заміщеної 2-амінокарбонової кислоти та їх сірковмісні аналоги, фармацевтична композиція на їх основі
AU746119B2 (en)	1997-08-01	2002-04-18	Wyeth	Process for the preparation of (2-((8,9)- dioxo-2,6-diazabicyclo (5.2.0)-non-1(7)-en-2-yl)-ethyl) phosphonic acid
US5990307A (en) *	1997-08-01	1999-11-23	American Home Products Corporation	Process for the preparation of [2-((8.9)-Dioxo-2,6-Diazabicyclo [5.2.0]-Non-1(7)-en-2yl) Ethyl]Phosphonic acid
US6541669B1 (en)	1998-06-08	2003-04-01	Theravance, Inc.	β2-adrenergic receptor agonists
US6225343B1 (en) *	1999-06-16	2001-05-01	Nastech Pharmaceutical Company, Inc.	Compositions and methods comprising morphine gluconate
US20030158254A1 (en)	2002-01-24	2003-08-21	Xenoport, Inc.	Engineering absorption of therapeutic compounds via colonic transporters
US20040082543A1 (en) *	2002-10-29	2004-04-29	Pharmacia Corporation	Compositions of cyclooxygenase-2 selective inhibitors and NMDA receptor antagonists for the treatment or prevention of neuropathic pain

2002
- 2002-09-10 UA UA20040503402A patent/UA78529C2/uk unknown
- 2002-10-08 AR ARP020103791A patent/AR036764A1/es unknown
- 2002-10-09 EA EA200400523A patent/EA009993B1/ru not_active IP Right Cessation
- 2002-10-09 ES ES02789180T patent/ES2367356T3/es not_active Expired - Lifetime
- 2002-10-09 IL IL16127502A patent/IL161275A0/xx unknown
- 2002-10-09 US US10/267,159 patent/US7098200B2/en not_active Expired - Fee Related
- 2002-10-09 CN CNB028202430A patent/CN100448449C/zh not_active Expired - Fee Related
- 2002-10-09 AT AT02789180T patent/ATE515266T1/de active
- 2002-10-09 BR BR0213237-0A patent/BR0213237A/pt not_active Application Discontinuation
- 2002-10-09 PT PT02789180T patent/PT1434588E/pt unknown
- 2002-10-09 WO PCT/US2002/032252 patent/WO2003031416A2/en active Application Filing
- 2002-10-09 HU HU0401773A patent/HUP0401773A3/hu unknown
- 2002-10-09 KR KR1020047005298A patent/KR100922703B1/ko not_active Expired - Fee Related
- 2002-10-09 DK DK02789180.3T patent/DK1434588T3/da active
- 2002-10-09 NZ NZ532159A patent/NZ532159A/en not_active IP Right Cessation
- 2002-10-09 PL PL02368863A patent/PL368863A1/xx not_active IP Right Cessation
- 2002-10-09 SI SI200230959T patent/SI1434588T1/sl unknown
- 2002-10-09 TW TW091123270A patent/TWI321472B/zh not_active IP Right Cessation
- 2002-10-09 JP JP2003534400A patent/JP4350512B2/ja not_active Expired - Fee Related
- 2002-10-09 MX MXPA04003354A patent/MXPA04003354A/es active IP Right Grant
- 2002-10-09 CA CA2461348A patent/CA2461348C/en not_active Expired - Fee Related
- 2002-10-09 EP EP02789180A patent/EP1434588B1/en not_active Expired - Lifetime
2004
- 2004-04-02 NO NO20041378A patent/NO20041378L/no unknown
- 2004-04-04 IL IL161275A patent/IL161275A/en not_active IP Right Cessation
- 2004-05-05 ZA ZA200403406A patent/ZA200403406B/en unknown
- 2004-10-05 HK HK04107633.4A patent/HK1064609A1/xx not_active IP Right Cessation
2006
- 2006-05-12 US US11/433,737 patent/US7759346B2/en not_active Expired - Fee Related
2009
- 2009-05-01 AU AU2009201746A patent/AU2009201746A1/en not_active Ceased
2011
- 2011-08-02 CY CY20111100744T patent/CY1111909T1/el unknown

Also Published As

Publication number	Publication date
HK1064609A1 (en)	2005-02-04
EA200400523A1 (ru)	2004-08-26
NO20041378L (no)	2004-05-28
CN1568189A (zh)	2005-01-19
EP1434588B1 (en)	2011-07-06
HUP0401773A2 (hu)	2005-01-28
ES2367356T3 (es)	2011-11-02
WO2003031416A3 (en)	2003-08-14
SI1434588T1 (sl)	2011-10-28
US7098200B2 (en)	2006-08-29
EA009993B1 (ru)	2008-06-30
HUP0401773A3 (en)	2005-06-28
JP4350512B2 (ja)	2009-10-21
JP2005508950A (ja)	2005-04-07
US7759346B2 (en)	2010-07-20
US20060205696A1 (en)	2006-09-14
UA78529C2 (en)	2007-04-10
IL161275A (en)	2009-09-01
ATE515266T1 (de)	2011-07-15
AU2009201746A1 (en)	2009-05-28
TWI321472B (en)	2010-03-11
NZ532159A (en)	2006-02-24
MXPA04003354A (es)	2004-09-28
KR20050034604A (ko)	2005-04-14
DK1434588T3 (da)	2011-08-15
EP1434588A2 (en)	2004-07-07
PT1434588E (pt)	2011-09-05
PL368863A1 (en)	2005-04-04
KR100922703B1 (ko)	2009-10-22
CN100448449C (zh)	2009-01-07
CA2461348C (en)	2011-02-15
US20030114444A1 (en)	2003-06-19
CA2461348A1 (en)	2003-04-17
WO2003031416A2 (en)	2003-04-17
BR0213237A (pt)	2004-09-28
IL161275A0 (en)	2004-09-27
AR036764A1 (es)	2004-09-29
CY1111909T1 (el)	2015-11-04

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Tariot et al.	1997	Treating Alzheimer's disease: pharmacologic options now and in the near future
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AU2002353792A1 (en)	2003-04-22	((2-(amino-3,4-dioxo-1cyclobuten-1-YL)amino)alkyl)-acid derivatives for the treatment of pain
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