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MXPA04003354A - Derivados de acido [[2-(amino-3,4-dioxo-1-ciclobuten-1-il)amino]alquilico] para tratamiento de dolor. - Google Patents

Derivados de acido [[2-(amino-3,4-dioxo-1-ciclobuten-1-il)amino]alquilico] para tratamiento de dolor.

Info

Publication number
MXPA04003354A
MXPA04003354A MXPA04003354A MXPA04003354A MXPA04003354A MX PA04003354 A MXPA04003354 A MX PA04003354A MX PA04003354 A MXPA04003354 A MX PA04003354A MX PA04003354 A MXPA04003354 A MX PA04003354A MX PA04003354 A MXPA04003354 A MX PA04003354A
Authority
MX
Mexico
Prior art keywords
alkyl
amino
pain
dioxo
treatment
Prior art date
Application number
MXPA04003354A
Other languages
English (en)
Inventor
Maria Zaleska Margaret
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of MXPA04003354A publication Critical patent/MXPA04003354A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Esta invencion proporciona un metodo para tratar el dolor en un mamifero que incluye administrar a un mamifero en necesidad de tal tratamiento una cantidad efectiva para tratar el dolor de un compuesto de la formula (I): donde R1 es H, alquilo o fenilalquilo; R2 es H, alquilo, alquenilo o fenilalquilo; o R1 y R2, tomados conjuntamente como Z, son -CH2CH2-, -CH2C(R6)(R7)CH2- o -CH2C(R8)(R9)-C(R10)(R11)CH2-, donde R6, R8 y R10 son, independientemente, H, alquilo o hidroxilo y R7, R9 R11 son, independientemente, H, o alquilo; A es alquileno o alquenileno; X es CO2R3, P(O)(OR4)(OR5), 3,5 dioxo-1,2,4-oxadiazolidin-2-ilo o 5-tetrazolilo, en los cuales R3, R4 y R5 son, independientemente, H o alquilo; o composiciones farmaceuticas para tratar el dolor que contienen una cantidad efectiva para tratar el dolor del compuesto de la formula (I).
MXPA04003354A 2001-10-10 2002-10-09 Derivados de acido [[2-(amino-3,4-dioxo-1-ciclobuten-1-il)amino]alquilico] para tratamiento de dolor. MXPA04003354A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32824501P 2001-10-10 2001-10-10
PCT/US2002/032252 WO2003031416A2 (en) 2001-10-10 2002-10-09 [[2-(amino-3,4-dioxo-1cyclobuten-1-yl)amino]alkyl]-acid derivatives for the treatment of pain

Publications (1)

Publication Number Publication Date
MXPA04003354A true MXPA04003354A (es) 2004-09-28

Family

ID=23280159

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA04003354A MXPA04003354A (es) 2001-10-10 2002-10-09 Derivados de acido [[2-(amino-3,4-dioxo-1-ciclobuten-1-il)amino]alquilico] para tratamiento de dolor.

Country Status (26)

Country Link
US (2) US7098200B2 (es)
EP (1) EP1434588B1 (es)
JP (1) JP4350512B2 (es)
KR (1) KR100922703B1 (es)
CN (1) CN100448449C (es)
AR (1) AR036764A1 (es)
AT (1) ATE515266T1 (es)
AU (1) AU2009201746A1 (es)
BR (1) BR0213237A (es)
CA (1) CA2461348C (es)
CY (1) CY1111909T1 (es)
DK (1) DK1434588T3 (es)
EA (1) EA009993B1 (es)
ES (1) ES2367356T3 (es)
HU (1) HUP0401773A3 (es)
IL (2) IL161275A0 (es)
MX (1) MXPA04003354A (es)
NO (1) NO20041378L (es)
NZ (1) NZ532159A (es)
PL (1) PL368863A1 (es)
PT (1) PT1434588E (es)
SI (1) SI1434588T1 (es)
TW (1) TWI321472B (es)
UA (1) UA78529C2 (es)
WO (1) WO2003031416A2 (es)
ZA (1) ZA200403406B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1685829T3 (da) * 2002-11-22 2008-07-21 Gruenenthal Gmbh Anvendelse af (1RS,3RS,6RS)-6-dimethylaminomethyl-1-(3-methoxy-phenyl)-cyclohexan-1,3-diol til behandling af betændelsessmerte
CN1863810B (zh) 2003-04-09 2010-12-01 惠氏公司 [2-(8，9-二氧代-2，6-二氮杂二环[5.2.0]壬-1(7)-烯-2-基)烷基]膦酸衍生物及其作为n-甲基-d-天冬氨酸(nmda)受体拮抗剂的应用
BRPI0409088A (pt) * 2003-04-09 2006-04-11 Wyeth Corp composições farmacêuticas para administração intranasal de ácido [2-(8,9-dioxo-2,6-diazabiciclo [5.2.0]non-1(7)-en-2-il)alquil]-fosfÈnico e derivados e métodos de uso dos mesmos
US20050142192A1 (en) * 2003-10-15 2005-06-30 Wyeth Oral administration of [2-(8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1(7)-en-2-yl)alkyl] phosphonic acid and derivatives
TW200514775A (en) * 2003-10-22 2005-05-01 Wyeth Corp Methods for the preparation of {2-[(8,9)-dioxo-2,6-diaza-bicyclo[5.2.0]-non-1(7)-en-2-yl]ethyl} phosphonic acid and esters thereof
US7268123B2 (en) * 2004-10-08 2007-09-11 Wyeth Derivatives of [2-(8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1(7)-en-2-yl)alkyl]phosphonic acid and methods of making them
AU2008293622A1 (en) * 2007-08-27 2009-03-05 Wyeth Llc Compositions and methods employing NMDA antagonists for achieving an anesthetic-sparing effect
JP2012518007A (ja) * 2009-02-13 2012-08-09 アラーガン インコーポレイテッド （３‐（１‐（１ｈ‐イミダゾール‐４‐イル）エチル）‐２‐メチルフェニル）メタノールを含む医薬組成物
MX2011009716A (es) 2009-03-19 2011-10-17 Wyeth Llc Metodos para la preparacion de acido [2-(8,9-dioxo)-2,6-diazabicic lo[5.2.0]non-1(7)-en-2-il)etil]fosfonico y precursores de este.
US9095576B2 (en) 2011-11-21 2015-08-04 Allergan, Inc. Pharmaceutical compositions comprising 4-[1-(2,3-dimethylphenyl)ethyl]-3H-imidazole derivatives for treating retinal diseases
US10292989B2 (en) 2014-03-28 2019-05-21 University Of Virginia Patent Foundation General anesthetics that are not neurotoxic

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5168103A (en) 1991-01-22 1992-12-01 American Home Products Corporation [[2-(amino-3,4-dioxo-1-cyclobuten-1-yl) amino]alkyl]-acid derivatives
US5124319A (en) 1991-10-11 1992-06-23 American Home Products Corporation Benzimidazole phosphono-amino acids
DK124393D0 (da) 1993-11-03 1993-11-03 Lundbeck & Co As H Compounds
AT400440B (de) * 1993-12-06 1995-12-27 Vianova Kunstharz Ag Verfahren zur herstellung von wasserverdünnbaren lackbindemitteln und deren verwendung
TW427904B (en) * 1995-12-07 2001-04-01 American Home Prod Neuroprotective agents
UA52698C2 (uk) * 1996-10-04 2003-01-15 Х. Луннбек А/С Похідні (3-алкоксіізоксазол-4-іл)заміщеної 2-амінокарбонової кислоти та їх сірковмісні аналоги, фармацевтична композиція на їх основі
US5990307A (en) 1997-08-01 1999-11-23 American Home Products Corporation Process for the preparation of [2-((8.9)-Dioxo-2,6-Diazabicyclo [5.2.0]-Non-1(7)-en-2yl) Ethyl]Phosphonic acid
ATE232875T1 (de) 1997-08-01 2003-03-15 Wyeth Corp Verfahren zur herstellung von (2-((8,9-dioxo-2,6- diazabicyclo(5.2.0.)non-1(7)-en-2- yl)ethyl)phosphonsäure
US6362371B1 (en) 1998-06-08 2002-03-26 Advanced Medicine, Inc. β2- adrenergic receptor agonists
US6225343B1 (en) 1999-06-16 2001-05-01 Nastech Pharmaceutical Company, Inc. Compositions and methods comprising morphine gluconate
US20030158254A1 (en) 2002-01-24 2003-08-21 Xenoport, Inc. Engineering absorption of therapeutic compounds via colonic transporters
US20040082543A1 (en) 2002-10-29 2004-04-29 Pharmacia Corporation Compositions of cyclooxygenase-2 selective inhibitors and NMDA receptor antagonists for the treatment or prevention of neuropathic pain

Also Published As

Publication number Publication date
US7759346B2 (en) 2010-07-20
BR0213237A (pt) 2004-09-28
AU2009201746A1 (en) 2009-05-28
WO2003031416A3 (en) 2003-08-14
EP1434588B1 (en) 2011-07-06
IL161275A0 (en) 2004-09-27
TWI321472B (en) 2010-03-11
JP2005508950A (ja) 2005-04-07
KR20050034604A (ko) 2005-04-14
SI1434588T1 (sl) 2011-10-28
IL161275A (en) 2009-09-01
NO20041378L (no) 2004-05-28
ES2367356T3 (es) 2011-11-02
DK1434588T3 (da) 2011-08-15
NZ532159A (en) 2006-02-24
PL368863A1 (en) 2005-04-04
CN100448449C (zh) 2009-01-07
US20030114444A1 (en) 2003-06-19
CA2461348C (en) 2011-02-15
KR100922703B1 (ko) 2009-10-22
HUP0401773A2 (hu) 2005-01-28
CY1111909T1 (el) 2015-11-04
HUP0401773A3 (en) 2005-06-28
JP4350512B2 (ja) 2009-10-21
EA009993B1 (ru) 2008-06-30
UA78529C2 (en) 2007-04-10
ZA200403406B (en) 2007-04-25
ATE515266T1 (de) 2011-07-15
HK1064609A1 (en) 2005-02-04
PT1434588E (pt) 2011-09-05
CN1568189A (zh) 2005-01-19
CA2461348A1 (en) 2003-04-17
EA200400523A1 (ru) 2004-08-26
WO2003031416A2 (en) 2003-04-17
US20060205696A1 (en) 2006-09-14
EP1434588A2 (en) 2004-07-07
AR036764A1 (es) 2004-09-29
US7098200B2 (en) 2006-08-29

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