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EA200400523A1 - Производные [[2-(амино-3,4-диоксо-1-циклобутен-1-ил)амино]алкил] кислоты, применяемые для лечения боли - Google Patents

Производные [[2-(амино-3,4-диоксо-1-циклобутен-1-ил)амино]алкил] кислоты, применяемые для лечения боли

Info

Publication number
EA200400523A1
EA200400523A1 EA200400523A EA200400523A EA200400523A1 EA 200400523 A1 EA200400523 A1 EA 200400523A1 EA 200400523 A EA200400523 A EA 200400523A EA 200400523 A EA200400523 A EA 200400523A EA 200400523 A1 EA200400523 A1 EA 200400523A1
Authority
EA
Eurasian Patent Office
Prior art keywords
alkyl
amino
dioxo
treatment
pain
Prior art date
Application number
EA200400523A
Other languages
English (en)
Other versions
EA009993B1 (ru
Inventor
Майкл Ричард Брандт
Маргарет Мария Залеска
Джон Аллен Мойер
Original Assignee
Уайт
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Уайт filed Critical Уайт
Publication of EA200400523A1 publication Critical patent/EA200400523A1/ru
Publication of EA009993B1 publication Critical patent/EA009993B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Настоящее изобретение относится к способу лечения боли у млекопитающего, который включает введение млекопитающему, нуждающемуся в таком лечении, эффективного для лечения боли количества соединения формулы (I), где Rпредставляет собой H, алкил или фенилалкил; Rпредставляет собой H, алкил, алкенил или фенилалкил; или Rи R, взятые вместе как Z, представляют собой -CHCH-, -CHC(R)(R)CH- или -CHC(R)(R)-C(R)(R)CH-, где R, Rи Rпредставляют собой, независимо, H, алкил или гидроксил и R, Rи Rпредставляют собой, независимо, H или алкил; A представляет собой алкилен или алкенилен; X представляет собой COR, P(O)(OR)(OR), 3,5-диоксо-1,2,4-оксадиазолидин-2-ил или 5-тетразолил, где R, Rи Rпредставляют собой, независимо, водород или алкил; или фармацевтических композиций для лечения боли, содержащих эффективное для лечения количество соединения формулы (I).Отчет о международном поиске был опубликован 2003.08.14.
EA200400523A 2001-10-10 2002-10-09 Производные [[2-(амино-3,4-диоксо-1-циклобутен-1-ил)амино]алкил]кислоты, применяемые для лечения боли EA009993B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32824501P 2001-10-10 2001-10-10
PCT/US2002/032252 WO2003031416A2 (en) 2001-10-10 2002-10-09 [[2-(amino-3,4-dioxo-1cyclobuten-1-yl)amino]alkyl]-acid derivatives for the treatment of pain

Publications (2)

Publication Number Publication Date
EA200400523A1 true EA200400523A1 (ru) 2004-08-26
EA009993B1 EA009993B1 (ru) 2008-06-30

Family

ID=23280159

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200400523A EA009993B1 (ru) 2001-10-10 2002-10-09 Производные [[2-(амино-3,4-диоксо-1-циклобутен-1-ил)амино]алкил]кислоты, применяемые для лечения боли

Country Status (26)

Country Link
US (2) US7098200B2 (ru)
EP (1) EP1434588B1 (ru)
JP (1) JP4350512B2 (ru)
KR (1) KR100922703B1 (ru)
CN (1) CN100448449C (ru)
AR (1) AR036764A1 (ru)
AT (1) ATE515266T1 (ru)
AU (1) AU2009201746A1 (ru)
BR (1) BR0213237A (ru)
CA (1) CA2461348C (ru)
CY (1) CY1111909T1 (ru)
DK (1) DK1434588T3 (ru)
EA (1) EA009993B1 (ru)
ES (1) ES2367356T3 (ru)
HU (1) HUP0401773A3 (ru)
IL (2) IL161275A0 (ru)
MX (1) MXPA04003354A (ru)
NO (1) NO20041378L (ru)
NZ (1) NZ532159A (ru)
PL (1) PL368863A1 (ru)
PT (1) PT1434588E (ru)
SI (1) SI1434588T1 (ru)
TW (1) TWI321472B (ru)
UA (1) UA78529C2 (ru)
WO (1) WO2003031416A2 (ru)
ZA (1) ZA200403406B (ru)

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DK1685829T3 (da) * 2002-11-22 2008-07-21 Gruenenthal Gmbh Anvendelse af (1RS,3RS,6RS)-6-dimethylaminomethyl-1-(3-methoxy-phenyl)-cyclohexan-1,3-diol til behandling af betændelsessmerte
CN1863810B (zh) 2003-04-09 2010-12-01 惠氏公司 [2-(8，9-二氧代-2，6-二氮杂二环[5.2.0]壬-1(7)-烯-2-基)烷基]膦酸衍生物及其作为n-甲基-d-天冬氨酸(nmda)受体拮抗剂的应用
BRPI0409088A (pt) * 2003-04-09 2006-04-11 Wyeth Corp composições farmacêuticas para administração intranasal de ácido [2-(8,9-dioxo-2,6-diazabiciclo [5.2.0]non-1(7)-en-2-il)alquil]-fosfÈnico e derivados e métodos de uso dos mesmos
US20050142192A1 (en) * 2003-10-15 2005-06-30 Wyeth Oral administration of [2-(8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1(7)-en-2-yl)alkyl] phosphonic acid and derivatives
TW200514775A (en) * 2003-10-22 2005-05-01 Wyeth Corp Methods for the preparation of {2-[(8,9)-dioxo-2,6-diaza-bicyclo[5.2.0]-non-1(7)-en-2-yl]ethyl} phosphonic acid and esters thereof
US7268123B2 (en) * 2004-10-08 2007-09-11 Wyeth Derivatives of [2-(8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1(7)-en-2-yl)alkyl]phosphonic acid and methods of making them
AU2008293622A1 (en) * 2007-08-27 2009-03-05 Wyeth Llc Compositions and methods employing NMDA antagonists for achieving an anesthetic-sparing effect
JP2012518007A (ja) * 2009-02-13 2012-08-09 アラーガン インコーポレイテッド （３‐（１‐（１ｈ‐イミダゾール‐４‐イル）エチル）‐２‐メチルフェニル）メタノールを含む医薬組成物
MX2011009716A (es) 2009-03-19 2011-10-17 Wyeth Llc Metodos para la preparacion de acido [2-(8,9-dioxo)-2,6-diazabicic lo[5.2.0]non-1(7)-en-2-il)etil]fosfonico y precursores de este.
US9095576B2 (en) 2011-11-21 2015-08-04 Allergan, Inc. Pharmaceutical compositions comprising 4-[1-(2,3-dimethylphenyl)ethyl]-3H-imidazole derivatives for treating retinal diseases
US10292989B2 (en) 2014-03-28 2019-05-21 University Of Virginia Patent Foundation General anesthetics that are not neurotoxic

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US5168103A (en) 1991-01-22 1992-12-01 American Home Products Corporation [[2-(amino-3,4-dioxo-1-cyclobuten-1-yl) amino]alkyl]-acid derivatives
US5124319A (en) 1991-10-11 1992-06-23 American Home Products Corporation Benzimidazole phosphono-amino acids
DK124393D0 (da) 1993-11-03 1993-11-03 Lundbeck & Co As H Compounds
AT400440B (de) * 1993-12-06 1995-12-27 Vianova Kunstharz Ag Verfahren zur herstellung von wasserverdünnbaren lackbindemitteln und deren verwendung
TW427904B (en) * 1995-12-07 2001-04-01 American Home Prod Neuroprotective agents
UA52698C2 (ru) * 1996-10-04 2003-01-15 Х. Луннбек А/С Производные(3-алкоксиизоксазол-4-ил)замещенных 2-аминокарбоновых кислот
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ATE232875T1 (de) 1997-08-01 2003-03-15 Wyeth Corp Verfahren zur herstellung von (2-((8,9-dioxo-2,6- diazabicyclo(5.2.0.)non-1(7)-en-2- yl)ethyl)phosphonsäure
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Also Published As

Publication number Publication date
US7759346B2 (en) 2010-07-20
BR0213237A (pt) 2004-09-28
AU2009201746A1 (en) 2009-05-28
WO2003031416A3 (en) 2003-08-14
EP1434588B1 (en) 2011-07-06
IL161275A0 (en) 2004-09-27
TWI321472B (en) 2010-03-11
JP2005508950A (ja) 2005-04-07
KR20050034604A (ko) 2005-04-14
SI1434588T1 (sl) 2011-10-28
IL161275A (en) 2009-09-01
NO20041378L (no) 2004-05-28
ES2367356T3 (es) 2011-11-02
DK1434588T3 (da) 2011-08-15
NZ532159A (en) 2006-02-24
PL368863A1 (en) 2005-04-04
CN100448449C (zh) 2009-01-07
US20030114444A1 (en) 2003-06-19
CA2461348C (en) 2011-02-15
KR100922703B1 (ko) 2009-10-22
HUP0401773A2 (hu) 2005-01-28
CY1111909T1 (el) 2015-11-04
HUP0401773A3 (en) 2005-06-28
JP4350512B2 (ja) 2009-10-21
EA009993B1 (ru) 2008-06-30
UA78529C2 (en) 2007-04-10
ZA200403406B (en) 2007-04-25
ATE515266T1 (de) 2011-07-15
HK1064609A1 (en) 2005-02-04
MXPA04003354A (es) 2004-09-28
PT1434588E (pt) 2011-09-05
CN1568189A (zh) 2005-01-19
CA2461348A1 (en) 2003-04-17
WO2003031416A2 (en) 2003-04-17
US20060205696A1 (en) 2006-09-14
EP1434588A2 (en) 2004-07-07
AR036764A1 (es) 2004-09-29
US7098200B2 (en) 2006-08-29

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Legal Events

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU