CY1111909T1 - Παραγωγα [[2-(αμινο-3,4-διοξο-1-κυκλοβουτεν-1-υλ)amino] αλκυλ]-οξεος για τη θεραπεια του πονου - Google Patents
Παραγωγα [[2-(αμινο-3,4-διοξο-1-κυκλοβουτεν-1-υλ)amino] αλκυλ]-οξεος για τη θεραπεια του πονουInfo
- Publication number
- CY1111909T1 CY1111909T1 CY20111100744T CY111100744T CY1111909T1 CY 1111909 T1 CY1111909 T1 CY 1111909T1 CY 20111100744 T CY20111100744 T CY 20111100744T CY 111100744 T CY111100744 T CY 111100744T CY 1111909 T1 CY1111909 T1 CY 1111909T1
- Authority
- CY
- Cyprus
- Prior art keywords
- amino
- alkyl
- pain
- treatment
- dioxo
- Prior art date
Links
- 239000002253 acid Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 150000002431 hydrogen Chemical group 0.000 abstract 3
- -1 3,5-dioxo-1,2,4-oxadiazolidin-2-yl Chemical group 0.000 abstract 2
- 241000124008 Mammalia Species 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000003884 phenylalkyl group Chemical group 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000004450 alkenylene group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229940124583 pain medication Drugs 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Η εφεύρεση αυτή προσφέρει μια μέθοδο για τη θεραπεία του πόνου σε ένα θηλαστικό η οποία περιλαμβάνει τη χορήγηση σε ένα θηλαστικό που έχει ανάγκη μια τέτοια θεραπεία μιας αποτελεσματικής για τη θεραπεία του πόνου ποσότητας μιας χημικής ένωσης με τύπο (I): στον οποίο το R1 είναι υδρογόνο, αλκύλιο ή φαινυλαλκύλιο˙ το R2 είναι υδρογόνο, αλκύλιο, αλκενύλιο ή φαινυλαλκύλιο˙ ή τα R1 και R2 όταν ληφθούν μαζί ως Ζ, είναι -CH2CH2-, -CH2C(R6) (R7)CH2- ή -CH2C (R8) (R9)-C (R10) (R11) CH2- όπου τα R6, R8 και R10 είναι, ανεξάρτητα υδρογόνο, αλκύλιο ή υδροξύλιο και τα R7, R9 και R11 είναι, ανεξάρτητα υδρογόνο ή αλκύλιο˙ το Α είναι αλκυλένιο ή αλκενυλένιο˙ το Χ είναι CO2R3, Ρ (O) (OR4) (OR5), 3,5-διοξο-1,2,4-οξαδιαζολιδιv-2-ύλιο ή 5-τετραζολύλιο στα οποία τα R3, R4 και R5 είναι ανεξάρτητα υδρογόνο ή αλκύλιο ή φαρμακευτικές συνθέσεις για τη θεραπεία του πόνου που περιέχουν μια αποτελεσματική για τη θεραπεία του πόνου ποσότητα της χημικής ένωσης με τύπο (I).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32824501P | 2001-10-10 | 2001-10-10 | |
| EP02789180A EP1434588B1 (en) | 2001-10-10 | 2002-10-09 | 2-(amino-3,4-dioxo-1cyclobuten-1-yl)amino alkyl -acid derivatives for the treatment of pain |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1111909T1 true CY1111909T1 (el) | 2015-11-04 |
Family
ID=23280159
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20111100744T CY1111909T1 (el) | 2001-10-10 | 2011-08-02 | Παραγωγα [[2-(αμινο-3,4-διοξο-1-κυκλοβουτεν-1-υλ)amino] αλκυλ]-οξεος για τη θεραπεια του πονου |
Country Status (27)
| Country | Link |
|---|---|
| US (2) | US7098200B2 (el) |
| EP (1) | EP1434588B1 (el) |
| JP (1) | JP4350512B2 (el) |
| KR (1) | KR100922703B1 (el) |
| CN (1) | CN100448449C (el) |
| AR (1) | AR036764A1 (el) |
| AT (1) | ATE515266T1 (el) |
| AU (1) | AU2009201746A1 (el) |
| BR (1) | BR0213237A (el) |
| CA (1) | CA2461348C (el) |
| CY (1) | CY1111909T1 (el) |
| DK (1) | DK1434588T3 (el) |
| EA (1) | EA009993B1 (el) |
| ES (1) | ES2367356T3 (el) |
| HK (1) | HK1064609A1 (el) |
| HU (1) | HUP0401773A3 (el) |
| IL (2) | IL161275A0 (el) |
| MX (1) | MXPA04003354A (el) |
| NO (1) | NO20041378L (el) |
| NZ (1) | NZ532159A (el) |
| PL (1) | PL368863A1 (el) |
| PT (1) | PT1434588E (el) |
| SI (1) | SI1434588T1 (el) |
| TW (1) | TWI321472B (el) |
| UA (1) | UA78529C2 (el) |
| WO (1) | WO2003031416A2 (el) |
| ZA (1) | ZA200403406B (el) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1685829B1 (de) * | 2002-11-22 | 2008-04-09 | Grünenthal GmbH | Verwendung von (1RS,3RS,6RS)-6-dimethylaminomethyl-1-(3-methoxy-phenyl)-cyclohexan-1,3-diol zur Behandlung von Entzündungsschmerz |
| CN1802161A (zh) * | 2003-04-09 | 2006-07-12 | 惠氏公司 | [2－(8,9－二氧代－2,6－二氮杂双环[5.2.0]壬－1(7)－烯－2－基)烷基]－膦酸及其衍生物的鼻内给药药用组合物及用法 |
| CA2521313A1 (en) | 2003-04-09 | 2004-10-28 | Wyeth | Derivatives of 2-(8,9-dioxo-2,6-diazabicyclo(5.2.o)non-1(7)-3n-2-yl)-al kyl phosphonic acid and their use as n-methyl-d-aspartate (nmda) recetor antagonists |
| US20050142192A1 (en) * | 2003-10-15 | 2005-06-30 | Wyeth | Oral administration of [2-(8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1(7)-en-2-yl)alkyl] phosphonic acid and derivatives |
| TW200514775A (en) * | 2003-10-22 | 2005-05-01 | Wyeth Corp | Methods for the preparation of {2-[(8,9)-dioxo-2,6-diaza-bicyclo[5.2.0]-non-1(7)-en-2-yl]ethyl} phosphonic acid and esters thereof |
| AU2005294319A1 (en) * | 2004-10-08 | 2006-04-20 | Wyeth | Derivatives of [2-(8,9-dioxo-2,6-diazabicyclo[5.2.0)non-1(7)-en-2-yl)alkyl]phosphonic acid and method of making them |
| MX2010002191A (es) * | 2007-08-27 | 2010-03-17 | Wyeth Llc | Composiciones y metodos que emplean antagonistas nmda para lograr un efecto anestesico limitado. |
| WO2010093930A1 (en) * | 2009-02-13 | 2010-08-19 | Allergan, Inc. | Pharmaceutical compositions comprising (3-(1-(1h-imidazol-4-yl)ethyl)-2-methylphenyl)methanol |
| CA2754390A1 (en) | 2009-03-19 | 2010-09-23 | Wyeth Llc | Methods for the preparation of [2-(8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1(7)-en-2-yl)ethyl]phosphonic acid and precursors thereof |
| EP2782569A1 (en) | 2011-11-21 | 2014-10-01 | Allergan, Inc. | Pharmaceutical compositions comprising 4-[1-(2,3-dimethylphenyl)ethyl]-3h-imidazole derivatives for treating retinal diseases |
| WO2015149066A1 (en) * | 2014-03-28 | 2015-10-01 | University Of Virginia Patent Foundation | General anesthetics that are not neurotoxic |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5168103A (en) * | 1991-01-22 | 1992-12-01 | American Home Products Corporation | [[2-(amino-3,4-dioxo-1-cyclobuten-1-yl) amino]alkyl]-acid derivatives |
| US5124319A (en) * | 1991-10-11 | 1992-06-23 | American Home Products Corporation | Benzimidazole phosphono-amino acids |
| DK124393D0 (da) * | 1993-11-03 | 1993-11-03 | Lundbeck & Co As H | Compounds |
| AT400440B (de) * | 1993-12-06 | 1995-12-27 | Vianova Kunstharz Ag | Verfahren zur herstellung von wasserverdünnbaren lackbindemitteln und deren verwendung |
| TW427904B (en) * | 1995-12-07 | 2001-04-01 | American Home Prod | Neuroprotective agents |
| UA52698C2 (uk) * | 1996-10-04 | 2003-01-15 | Х. Луннбек А/С | Похідні (3-алкоксіізоксазол-4-іл)заміщеної 2-амінокарбонової кислоти та їх сірковмісні аналоги, фармацевтична композиція на їх основі |
| BR9811807A (pt) | 1997-08-01 | 2000-08-15 | American Home Prod | Processo para a preparação de ácido [2-(8,9)-dioxo-2,6-diazabiciclo-[5.2.0]-non-1(7)-en-2-il)-etil] fosfÈnico |
| US5990307A (en) * | 1997-08-01 | 1999-11-23 | American Home Products Corporation | Process for the preparation of [2-((8.9)-Dioxo-2,6-Diazabicyclo [5.2.0]-Non-1(7)-en-2yl) Ethyl]Phosphonic acid |
| US6362371B1 (en) | 1998-06-08 | 2002-03-26 | Advanced Medicine, Inc. | β2- adrenergic receptor agonists |
| US6225343B1 (en) * | 1999-06-16 | 2001-05-01 | Nastech Pharmaceutical Company, Inc. | Compositions and methods comprising morphine gluconate |
| US20030158254A1 (en) | 2002-01-24 | 2003-08-21 | Xenoport, Inc. | Engineering absorption of therapeutic compounds via colonic transporters |
| US20040082543A1 (en) * | 2002-10-29 | 2004-04-29 | Pharmacia Corporation | Compositions of cyclooxygenase-2 selective inhibitors and NMDA receptor antagonists for the treatment or prevention of neuropathic pain |
-
2002
- 2002-09-10 UA UA20040503402A patent/UA78529C2/uk unknown
- 2002-10-08 AR ARP020103791A patent/AR036764A1/es unknown
- 2002-10-09 HU HU0401773A patent/HUP0401773A3/hu unknown
- 2002-10-09 EA EA200400523A patent/EA009993B1/ru not_active IP Right Cessation
- 2002-10-09 SI SI200230959T patent/SI1434588T1/sl unknown
- 2002-10-09 CA CA2461348A patent/CA2461348C/en not_active Expired - Fee Related
- 2002-10-09 MX MXPA04003354A patent/MXPA04003354A/es active IP Right Grant
- 2002-10-09 EP EP02789180A patent/EP1434588B1/en not_active Expired - Lifetime
- 2002-10-09 US US10/267,159 patent/US7098200B2/en not_active Expired - Fee Related
- 2002-10-09 NZ NZ532159A patent/NZ532159A/en not_active IP Right Cessation
- 2002-10-09 PT PT02789180T patent/PT1434588E/pt unknown
- 2002-10-09 TW TW091123270A patent/TWI321472B/zh not_active IP Right Cessation
- 2002-10-09 AT AT02789180T patent/ATE515266T1/de active
- 2002-10-09 DK DK02789180.3T patent/DK1434588T3/da active
- 2002-10-09 KR KR1020047005298A patent/KR100922703B1/ko not_active IP Right Cessation
- 2002-10-09 BR BR0213237-0A patent/BR0213237A/pt not_active Application Discontinuation
- 2002-10-09 CN CNB028202430A patent/CN100448449C/zh not_active Expired - Fee Related
- 2002-10-09 IL IL16127502A patent/IL161275A0/xx unknown
- 2002-10-09 PL PL02368863A patent/PL368863A1/xx not_active IP Right Cessation
- 2002-10-09 JP JP2003534400A patent/JP4350512B2/ja not_active Expired - Fee Related
- 2002-10-09 ES ES02789180T patent/ES2367356T3/es not_active Expired - Lifetime
- 2002-10-09 WO PCT/US2002/032252 patent/WO2003031416A2/en active Application Filing
-
2004
- 2004-04-02 NO NO20041378A patent/NO20041378L/no unknown
- 2004-04-04 IL IL161275A patent/IL161275A/en not_active IP Right Cessation
- 2004-05-05 ZA ZA200403406A patent/ZA200403406B/en unknown
- 2004-10-05 HK HK04107633.4A patent/HK1064609A1/xx not_active IP Right Cessation
-
2006
- 2006-05-12 US US11/433,737 patent/US7759346B2/en not_active Expired - Fee Related
-
2009
- 2009-05-01 AU AU2009201746A patent/AU2009201746A1/en not_active Ceased
-
2011
- 2011-08-02 CY CY20111100744T patent/CY1111909T1/el unknown
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