ZA200204351B - Indole derivatives as MCP-1 receptor antagonists. - Google Patents
Indole derivatives as MCP-1 receptor antagonists. Download PDFInfo
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- ZA200204351B ZA200204351B ZA200204351A ZA200204351A ZA200204351B ZA 200204351 B ZA200204351 B ZA 200204351B ZA 200204351 A ZA200204351 A ZA 200204351A ZA 200204351 A ZA200204351 A ZA 200204351A ZA 200204351 B ZA200204351 B ZA 200204351B
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- South Africa
- Prior art keywords
- sup
- hydrogen
- halo
- compound
- methoxy
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- JUJBNYBVVQSIOU-UHFFFAOYSA-M sodium;4-[2-(4-iodophenyl)-3-(4-nitrophenyl)tetrazol-2-ium-5-yl]benzene-1,3-disulfonate Chemical compound [Na+].C1=CC([N+](=O)[O-])=CC=C1N1[N+](C=2C=CC(I)=CC=2)=NC(C=2C(=CC(=CC=2)S([O-])(=O)=O)S([O-])(=O)=O)=N1 JUJBNYBVVQSIOU-UHFFFAOYSA-M 0.000 description 1
- 239000007901 soft capsule Substances 0.000 description 1
- 229960005078 sorbitan sesquioleate Drugs 0.000 description 1
- 235000019337 sorbitan trioleate Nutrition 0.000 description 1
- 229960000391 sorbitan trioleate Drugs 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 239000008347 soybean phospholipid Substances 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 239000011550 stock solution Substances 0.000 description 1
- QTENRWWVYAAPBI-YCRXJPFRSA-N streptomycin sulfate Chemical compound OS(O)(=O)=O.OS(O)(=O)=O.OS(O)(=O)=O.CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](N=C(N)N)[C@H](O)[C@@H](N=C(N)N)[C@H](O)[C@H]1O.CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](N=C(N)N)[C@H](O)[C@@H](N=C(N)N)[C@H](O)[C@H]1O QTENRWWVYAAPBI-YCRXJPFRSA-N 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 229910021653 sulphate ion Inorganic materials 0.000 description 1
- 239000001117 sulphuric acid Substances 0.000 description 1
- 235000011149 sulphuric acid Nutrition 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- DPKBAXPHAYBPRL-UHFFFAOYSA-M tetrabutylazanium;iodide Chemical compound [I-].CCCC[N+](CCCC)(CCCC)CCCC DPKBAXPHAYBPRL-UHFFFAOYSA-M 0.000 description 1
- 125000003831 tetrazolyl group Chemical group 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 239000012049 topical pharmaceutical composition Substances 0.000 description 1
- 229910052723 transition metal Inorganic materials 0.000 description 1
- 150000003624 transition metals Chemical class 0.000 description 1
- 231100000402 unacceptable toxicity Toxicity 0.000 description 1
- 239000013598 vector Substances 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 231100000747 viability assay Toxicity 0.000 description 1
- 238000003026 viability measurement method Methods 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 239000008096 xylene Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0000625.4A GB0000625D0 (en) | 2000-01-13 | 2000-01-13 | Chemical compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200204351B true ZA200204351B (en) | 2003-09-01 |
Family
ID=9883550
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200204351A ZA200204351B (en) | 2000-01-13 | 2002-05-30 | Indole derivatives as MCP-1 receptor antagonists. |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US6984657B1 (pt) |
| EP (1) | EP1268423B1 (pt) |
| JP (1) | JP2003519684A (pt) |
| KR (1) | KR20020064374A (pt) |
| CN (1) | CN1395564A (pt) |
| AT (1) | ATE318800T1 (pt) |
| AU (1) | AU779502B2 (pt) |
| BR (1) | BR0107405A (pt) |
| CA (1) | CA2393597A1 (pt) |
| DE (1) | DE60117517T2 (pt) |
| GB (1) | GB0000625D0 (pt) |
| IL (1) | IL150276A0 (pt) |
| MX (1) | MXPA02006612A (pt) |
| NO (1) | NO20023381L (pt) |
| NZ (1) | NZ519311A (pt) |
| WO (1) | WO2001051467A1 (pt) |
| ZA (1) | ZA200204351B (pt) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9716657D0 (en) | 1997-08-07 | 1997-10-15 | Zeneca Ltd | Chemical compounds |
| GB9902461D0 (en) | 1999-02-05 | 1999-03-24 | Zeneca Ltd | Chemical compounds |
| DE10022925A1 (de) * | 2000-05-11 | 2001-11-15 | Basf Ag | Substituierte Indole als PARP-Inhibitoren |
| US20080076120A1 (en) * | 2006-09-14 | 2008-03-27 | Millennium Pharmaceuticals, Inc. | Methods for the identification, evaluation and treatment of patients having CC-Chemokine receptor 2 (CCR-2) mediated disorders |
| WO2017163263A1 (en) | 2016-03-22 | 2017-09-28 | Council Of Scientific & Industrial Research | Indole derivatives, preparation and use thereof |
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| US3557142A (en) | 1968-02-20 | 1971-01-19 | Sterling Drug Inc | 4,5,6,7-tetrahydro-indole-lower-alkanoic acids and esters |
| US3776923A (en) | 1970-01-06 | 1973-12-04 | American Cyanamid Co | 2-nitro-4-oxo-4,5,6,7-tetrahydroindole |
| US3997557A (en) | 1974-04-23 | 1976-12-14 | American Hoechst Corporation | Substituted N-aminoalkylpyrroles |
| US4496742A (en) | 1981-10-13 | 1985-01-29 | The Upjohn Company | Analogs of 5,6-dihydro PGI2 |
| FR2537974A1 (fr) | 1982-12-16 | 1984-06-22 | Adir | Nouveaux derives de thieno (2,3-b) pyrrole, leur procede de preparation et les compositions pharmaceutiques les renfermant |
| US4529724A (en) | 1983-10-11 | 1985-07-16 | Mcneilab, Inc. | 6H-indolo[2,1-c][1,4]benzodiazepines and 12-oxo derivatives useful as antihypertensives |
| FR2565981B1 (fr) | 1984-06-15 | 1986-09-19 | Adir | Nouveaux derives de thieno (2,3-b) pyrrole, leur procede de preparation et les compositions pharmaceutiques les renfermant |
| AU581919B2 (en) | 1984-07-30 | 1989-03-09 | Schering Corporation | Process for the preparation of cis, endooctahydrocyclopenta (b) pyrrole-2-carboxylate |
| US4675332A (en) | 1984-12-10 | 1987-06-23 | Warner-Lambert Company | Acidic tetrazolyl substituted indole compounds and their use as antiallergy agents |
| EP0189690B1 (en) | 1984-12-12 | 1989-03-01 | Merck & Co. Inc. | Substituted aromatic sulfonamides, their preparation and ophthalmic compositions containing them |
| US4721725A (en) | 1986-01-27 | 1988-01-26 | E. R. Squibb & Sons, Inc. | Aryl-cycloalkyl[b]pyrrole derivatives |
| IL84796A (en) | 1986-12-17 | 1992-03-29 | Merck Frosst Canada Inc | Substituted n-benzyl-indoles and pharmaceutical compositions containing them |
| JPS63284177A (ja) | 1987-05-14 | 1988-11-21 | Sumitomo Chem Co Ltd | ホルミルピロロピロ−ル類およびその製造方法 |
| US4751231A (en) | 1987-09-16 | 1988-06-14 | Merck & Co., Inc. | Substituted thieno[2,3-b]pyrrole-5-sulfonamides as antiglaucoma agents |
| DE3907388A1 (de) | 1989-03-08 | 1990-09-13 | Kali Chemie Pharma Gmbh | Verfahren zur herstellung von indolcarbonsaeurederivaten |
| NZ234883A (en) | 1989-08-22 | 1995-01-27 | Merck Frosst Canada Inc | Quinolin-2-ylmethoxy indole derivatives, preparation and pharmaceutical compositions thereof |
| US5272145A (en) | 1989-08-22 | 1993-12-21 | Merck Frosst Canada, Inc. | (Quinolin-2-ylmethoxy)indoles as inhibitors of the biosynthesis of leukotrienes |
| DE3943225A1 (de) | 1989-12-23 | 1991-06-27 | Schering Ag | Neue ss-carboline, verfahren zu deren herstellung und deren verwendung in arzneimitteln |
| US5081145A (en) | 1990-02-01 | 1992-01-14 | Merck Frosst Canada, Inc. | Indole-2-alkanoic acids compositions of and anti allergic use thereof |
| AU8405691A (en) | 1990-09-04 | 1992-03-30 | Yamanouchi Pharmaceutical Co., Ltd. | Novel tetrahydrobenzazole derivative |
| US5260322A (en) | 1990-10-08 | 1993-11-09 | Merck & Co., Inc. | Angiotension II antagonists in the treatment of hyperuricemia |
| JPH04273857A (ja) | 1991-02-26 | 1992-09-30 | Taisho Pharmaceut Co Ltd | Ｎ−置換フェニルスルホニルインドール誘導体 |
| US5273980A (en) | 1991-09-30 | 1993-12-28 | Merck Frosst Canada Inc. | Bicyclic-azaarylmethoxy) indoles as inhibitors of leukotriene biosynthesis |
| US5290798A (en) | 1991-09-30 | 1994-03-01 | Merck Frosst Canada, Inc. | (hetero-arylmethoxy)indoles as inhibitors of leukotriene biosynthesis |
| US5389650A (en) | 1991-09-30 | 1995-02-14 | Merck Frosst Canada, Inc. | (Azaarylmethoxy)indoles as inhibitors of leukotriene biosynthesis |
| CA2079374C (en) | 1991-09-30 | 2003-08-05 | Merck Frosst Canada Incorporated | (bicyclic-azaarylmethoxy)indoles as inhibitors of leukotriene biosynthesis |
| US5190968A (en) | 1991-09-30 | 1993-03-02 | Merck Frosst Canada, Inc. | (Polycyclic-arylmethoxy) indoles as inhibitors of leukotriene biosynthesis |
| US5308850A (en) | 1991-09-30 | 1994-05-03 | Merck Frosst Canada, Inc. | (Bicyclic-hetero-arylmethoxy)indoles as inhibitors of leukotriene biosynthesis |
| US5318985A (en) | 1991-12-20 | 1994-06-07 | Merrell Dow Pharmaceuticals Inc. | Potentiation of NMDA antagonists |
| WO1993016069A1 (en) | 1992-02-13 | 1993-08-19 | Merck Frosst Canada Inc. | (azaaromaticalkoxy)indoles as inhibitors of leukotriene biosynthesis |
| ATE197051T1 (de) | 1992-04-03 | 2000-11-15 | Upjohn Co | Pharmazeutisch wirksame bicyclisch heterocyclische amine |
| US5334719A (en) | 1992-06-17 | 1994-08-02 | Merck Frosst Canada, Inc. | Bicyclic(azaaromatic)indoles as inhibitors of leukotriene bisynthesis |
| US5288743A (en) | 1992-11-20 | 1994-02-22 | Abbott Laboratories | Indole carboxylate derivatives which inhibit leukotriene biosynthesis |
| ZA939516B (en) | 1992-12-22 | 1994-06-06 | Smithkline Beecham Corp | Endothelin receptor antagonists |
| US5852046A (en) | 1993-08-03 | 1998-12-22 | Hoechst Aktiengesellschaft | Benzo-fused heterocyclic compounds having a 5-membered ring processes for their preparation their use as medicaments their use as diagnostic agents and medicaments containing them |
| EP0639573A1 (de) | 1993-08-03 | 1995-02-22 | Hoechst Aktiengesellschaft | Benzokondensierte 5-Ringheterocyclen, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament, ihre Verwendung als Diagnostikum, sowie sie enthaltendes Medikament |
| US5399699A (en) | 1994-01-24 | 1995-03-21 | Abbott Laboratories | Indole iminooxy derivatives which inhibit leukotriene biosynthesis |
| CZ24197A3 (en) | 1994-07-27 | 1997-08-13 | Sankyo Co | Heterocyclic compounds, usable as allosteric efectors in muscarine receptors |
| US5482960A (en) | 1994-11-14 | 1996-01-09 | Warner-Lambert Company | Nonpeptide endothelin antagonists |
| US5684032A (en) | 1994-12-13 | 1997-11-04 | Smithkline Beecham Corporation | Compounds |
| AU711968B2 (en) | 1995-04-04 | 1999-10-28 | Encysive Pharmaceuticals Inc. | Thienyl-, furyl-, pyrrolyl- and biphenylsulfonamides and derivatives thereof that modulate the activity of endothelin |
| IT1282797B1 (it) | 1995-04-21 | 1998-03-31 | Colla Paolo | Pirril-(indolil)-aril-sulfoni e relativo processo di produzione ed impiego nella terapia delle infezioni da virus dell'aids |
| US5604253A (en) | 1995-05-22 | 1997-02-18 | Merck Frosst Canada, Inc. | N-benzylindol-3-yl propanoic acid derivatives as cyclooxygenase inhibitors |
| US5639780A (en) | 1995-05-22 | 1997-06-17 | Merck Frosst Canada, Inc. | N-benzyl indol-3-yl butanoic acid derivatives as cyclooxygenase inhibitors |
| AU6966696A (en) | 1995-10-05 | 1997-04-28 | Warner-Lambert Company | Method for treating and preventing inflammation and atherosclerosis |
| TR199801665T2 (xx) | 1996-02-26 | 1998-12-21 | Advanced Research & Technology Institute | Makular �demin engellenmesi i�in karbonik anhidraz inhibit�rlerinin kullan�m�. |
| EP1021181A4 (en) | 1996-03-28 | 2002-06-26 | Smithkline Beecham Corp | INDOLCARBOXYLIC ACIDS AS CHEMOKIN INHIBITORS |
| US5859044A (en) | 1996-07-31 | 1999-01-12 | Pfizer Inc. | β-adrenergic agonists |
| WO1998006703A1 (en) | 1996-08-14 | 1998-02-19 | Warner-Lambert Company | 2-phenyl benzimidazole derivatives as mcp-1 antagonists |
| GB9716656D0 (en) | 1997-08-07 | 1997-10-15 | Zeneca Ltd | Chemical compounds |
| GB9716657D0 (en) * | 1997-08-07 | 1997-10-15 | Zeneca Ltd | Chemical compounds |
| TR200001954T2 (tr) | 1997-12-24 | 2000-12-21 | Hoechst Marion Roussel Deutschland Gmbh | Faktör XA'nın önleyicileri olarak indol türevleri. |
| GB9902461D0 (en) * | 1999-02-05 | 1999-03-24 | Zeneca Ltd | Chemical compounds |
-
2000
- 2000-01-13 GB GBGB0000625.4A patent/GB0000625D0/en not_active Ceased
-
2001
- 2001-01-09 IL IL15027601A patent/IL150276A0/xx unknown
- 2001-01-09 US US10/149,101 patent/US6984657B1/en not_active Expired - Fee Related
- 2001-01-09 MX MXPA02006612A patent/MXPA02006612A/es unknown
- 2001-01-09 CA CA002393597A patent/CA2393597A1/en not_active Abandoned
- 2001-01-09 CN CN01803643A patent/CN1395564A/zh active Pending
- 2001-01-09 AT AT01900197T patent/ATE318800T1/de not_active IP Right Cessation
- 2001-01-09 JP JP2001551849A patent/JP2003519684A/ja active Pending
- 2001-01-09 KR KR1020027009020A patent/KR20020064374A/ko not_active Application Discontinuation
- 2001-01-09 DE DE60117517T patent/DE60117517T2/de not_active Expired - Fee Related
- 2001-01-09 AU AU23874/01A patent/AU779502B2/en not_active Ceased
- 2001-01-09 NZ NZ519311A patent/NZ519311A/en unknown
- 2001-01-09 WO PCT/GB2001/000074 patent/WO2001051467A1/en active IP Right Grant
- 2001-01-09 EP EP01900197A patent/EP1268423B1/en not_active Expired - Lifetime
- 2001-01-09 BR BR0107405-9A patent/BR0107405A/pt not_active IP Right Cessation
-
2002
- 2002-05-30 ZA ZA200204351A patent/ZA200204351B/en unknown
- 2002-07-12 NO NO20023381A patent/NO20023381L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CN1395564A (zh) | 2003-02-05 |
| EP1268423A1 (en) | 2003-01-02 |
| NO20023381L (no) | 2002-09-09 |
| US6984657B1 (en) | 2006-01-10 |
| CA2393597A1 (en) | 2001-07-19 |
| JP2003519684A (ja) | 2003-06-24 |
| ATE318800T1 (de) | 2006-03-15 |
| BR0107405A (pt) | 2002-10-08 |
| AU779502B2 (en) | 2005-01-27 |
| NZ519311A (en) | 2004-05-28 |
| NO20023381D0 (no) | 2002-07-12 |
| GB0000625D0 (en) | 2000-03-01 |
| WO2001051467A1 (en) | 2001-07-19 |
| DE60117517D1 (de) | 2006-04-27 |
| MXPA02006612A (es) | 2002-09-30 |
| DE60117517T2 (de) | 2006-09-21 |
| AU2387401A (en) | 2001-07-24 |
| IL150276A0 (en) | 2002-12-01 |
| KR20020064374A (ko) | 2002-08-07 |
| EP1268423B1 (en) | 2006-03-01 |
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