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BR0107405A - Derivados de indol que atuam como antagonistas do receptor mcp-1 - Google Patents

Derivados de indol que atuam como antagonistas do receptor mcp-1

Info

Publication number
BR0107405A
BR0107405A BR0107405-9A BR0107405A BR0107405A BR 0107405 A BR0107405 A BR 0107405A BR 0107405 A BR0107405 A BR 0107405A BR 0107405 A BR0107405 A BR 0107405A
Authority
BR
Brazil
Prior art keywords
sup
halo
hydrogen
methoxy
lower alkyl
Prior art date
Application number
BR0107405-9A
Other languages
English (en)
Inventor
Alan Wellington Faull
Jason Grant Kettle
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of BR0107405A publication Critical patent/BR0107405A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

"DERIVADOS DE INDOL QUE ATUAM COMO ANTAGONISTAS DO RECEPTOR MCP-1". A presente invenção se refere a um composto de fórmula (I): em que R^ 1^ é hidrogênio, halogênio, metila, etila ou metóxi; R^ 2^ é hidrogênio, halogênio, metila, etila ou metóxi; R^ 3^ é um grupo halo, alquila inferior, alquenila inferior, alquinila inferior, trifluorometila, nitro, ciano, trifluorometóxi, C(O)R^ 7^ ou S(O)~ n~R^ 7^ onde n é 0, 1 ou 2 e R^ 7^ é um grupo alquila; R^ 4^ é um grupo halo, trifluorometila, metiltio, metóxi, trifluorometóxi ou alquila inferior, alquenila inferior ou alquinila inferior; R^ 5^ é hidrogênio, halogênio, ciano, alquila inferior, alquenila inferior ou alquinila inferior ou COR^ 8^, onde R^ 8^ é alquila inferior; R^ 6^ é hidrogênio, halogênio, alquila inferior, alquinila inferior ou COR^ 9^, onde R^ 9^ é alquila inferior; desde que quando R^ 1^ for hidrogênio, halogênio ou metóxi, R^ 2^ será hidrogênio, halogênio, metila, etila ou metóxi, R^ 5^ e R^ 6^ serão ambos hidrogênio, e um de R^ 3^ e R^ 4^ for cloro, flúor ou trifluorometila, então o outro de R^ 3^ e R^ 4^ não será halogênio nem trifluorometila; ou um sal ou pró-droga farmaceuticamente aceitáveis dos mesmos. Esse compostos apresentam atividade útil no tratamento de doenças inflamatórias, especificamente ao antagonizar o efeito mediado pela MCP-1 em um animal de sangue quente, tal como o ser humano.
BR0107405-9A 2000-01-13 2001-01-09 Derivados de indol que atuam como antagonistas do receptor mcp-1 BR0107405A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0000625.4A GB0000625D0 (en) 2000-01-13 2000-01-13 Chemical compounds
PCT/GB2001/000074 WO2001051467A1 (en) 2000-01-13 2001-01-09 Indole derivatives as mcp-1 receptor antagonists

Publications (1)

Publication Number Publication Date
BR0107405A true BR0107405A (pt) 2002-10-08

Family

ID=9883550

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0107405-9A BR0107405A (pt) 2000-01-13 2001-01-09 Derivados de indol que atuam como antagonistas do receptor mcp-1

Country Status (17)

Country Link
US (1) US6984657B1 (pt)
EP (1) EP1268423B1 (pt)
JP (1) JP2003519684A (pt)
KR (1) KR20020064374A (pt)
CN (1) CN1395564A (pt)
AT (1) ATE318800T1 (pt)
AU (1) AU779502B2 (pt)
BR (1) BR0107405A (pt)
CA (1) CA2393597A1 (pt)
DE (1) DE60117517T2 (pt)
GB (1) GB0000625D0 (pt)
IL (1) IL150276A0 (pt)
MX (1) MXPA02006612A (pt)
NO (1) NO20023381L (pt)
NZ (1) NZ519311A (pt)
WO (1) WO2001051467A1 (pt)
ZA (1) ZA200204351B (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9716657D0 (en) 1997-08-07 1997-10-15 Zeneca Ltd Chemical compounds
GB9902461D0 (en) 1999-02-05 1999-03-24 Zeneca Ltd Chemical compounds
DE10022925A1 (de) * 2000-05-11 2001-11-15 Basf Ag Substituierte Indole als PARP-Inhibitoren
US20080076120A1 (en) * 2006-09-14 2008-03-27 Millennium Pharmaceuticals, Inc. Methods for the identification, evaluation and treatment of patients having CC-Chemokine receptor 2 (CCR-2) mediated disorders
WO2017163263A1 (en) 2016-03-22 2017-09-28 Council Of Scientific & Industrial Research Indole derivatives, preparation and use thereof

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Also Published As

Publication number Publication date
WO2001051467A1 (en) 2001-07-19
DE60117517D1 (de) 2006-04-27
DE60117517T2 (de) 2006-09-21
ATE318800T1 (de) 2006-03-15
CA2393597A1 (en) 2001-07-19
MXPA02006612A (es) 2002-09-30
ZA200204351B (en) 2003-09-01
GB0000625D0 (en) 2000-03-01
IL150276A0 (en) 2002-12-01
CN1395564A (zh) 2003-02-05
EP1268423A1 (en) 2003-01-02
NZ519311A (en) 2004-05-28
AU2387401A (en) 2001-07-24
AU779502B2 (en) 2005-01-27
JP2003519684A (ja) 2003-06-24
NO20023381D0 (no) 2002-07-12
NO20023381L (no) 2002-09-09
US6984657B1 (en) 2006-01-10
KR20020064374A (ko) 2002-08-07
EP1268423B1 (en) 2006-03-01

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE 6A., 7A. E 8A. ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 DA RPI 2012 DE 28/07/2009.