NO20023381D0 - Indolderivater som MCP-1-reseptoragonister - Google Patents
Indolderivater som MCP-1-reseptoragonisterInfo
- Publication number
- NO20023381D0 NO20023381D0 NO20023381A NO20023381A NO20023381D0 NO 20023381 D0 NO20023381 D0 NO 20023381D0 NO 20023381 A NO20023381 A NO 20023381A NO 20023381 A NO20023381 A NO 20023381A NO 20023381 D0 NO20023381 D0 NO 20023381D0
- Authority
- NO
- Norway
- Prior art keywords
- sup
- halo
- hydrogen
- methoxy
- lower alkyl
- Prior art date
Links
- 102000004497 CCR2 Receptors Human genes 0.000 title 1
- 108010017312 CCR2 Receptors Proteins 0.000 title 1
- 229940054051 antipsychotic indole derivative Drugs 0.000 title 1
- 150000002475 indoles Chemical class 0.000 title 1
- 239000000018 receptor agonist Substances 0.000 title 1
- 229940044601 receptor agonist Drugs 0.000 title 1
- 125000005843 halogen group Chemical group 0.000 abstract 8
- 125000000217 alkyl group Chemical group 0.000 abstract 6
- 229910052739 hydrogen Inorganic materials 0.000 abstract 6
- 239000001257 hydrogen Substances 0.000 abstract 6
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 6
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 4
- 125000003342 alkenyl group Chemical group 0.000 abstract 3
- 125000000304 alkynyl group Chemical group 0.000 abstract 3
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 3
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 3
- -1 C(O)R<SUP>7</SUP> Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 2
- 102100021943 C-C motif chemokine 2 Human genes 0.000 abstract 1
- 101710155857 C-C motif chemokine 2 Proteins 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 230000003042 antagnostic effect Effects 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0000625.4A GB0000625D0 (en) | 2000-01-13 | 2000-01-13 | Chemical compounds |
| PCT/GB2001/000074 WO2001051467A1 (en) | 2000-01-13 | 2001-01-09 | Indole derivatives as mcp-1 receptor antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20023381D0 true NO20023381D0 (no) | 2002-07-12 |
| NO20023381L NO20023381L (no) | 2002-09-09 |
Family
ID=9883550
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20023381A NO20023381L (no) | 2000-01-13 | 2002-07-12 | Indolderivater som MCP-1-reseptoragonister |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US6984657B1 (no) |
| EP (1) | EP1268423B1 (no) |
| JP (1) | JP2003519684A (no) |
| KR (1) | KR20020064374A (no) |
| CN (1) | CN1395564A (no) |
| AT (1) | ATE318800T1 (no) |
| AU (1) | AU779502B2 (no) |
| BR (1) | BR0107405A (no) |
| CA (1) | CA2393597A1 (no) |
| DE (1) | DE60117517T2 (no) |
| GB (1) | GB0000625D0 (no) |
| IL (1) | IL150276A0 (no) |
| MX (1) | MXPA02006612A (no) |
| NO (1) | NO20023381L (no) |
| NZ (1) | NZ519311A (no) |
| WO (1) | WO2001051467A1 (no) |
| ZA (1) | ZA200204351B (no) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9716657D0 (en) | 1997-08-07 | 1997-10-15 | Zeneca Ltd | Chemical compounds |
| GB9902461D0 (en) | 1999-02-05 | 1999-03-24 | Zeneca Ltd | Chemical compounds |
| DE10022925A1 (de) * | 2000-05-11 | 2001-11-15 | Basf Ag | Substituierte Indole als PARP-Inhibitoren |
| US20080076120A1 (en) * | 2006-09-14 | 2008-03-27 | Millennium Pharmaceuticals, Inc. | Methods for the identification, evaluation and treatment of patients having CC-Chemokine receptor 2 (CCR-2) mediated disorders |
| WO2017163263A1 (en) | 2016-03-22 | 2017-09-28 | Council Of Scientific & Industrial Research | Indole derivatives, preparation and use thereof |
Family Cites Families (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3557142A (en) | 1968-02-20 | 1971-01-19 | Sterling Drug Inc | 4,5,6,7-tetrahydro-indole-lower-alkanoic acids and esters |
| US3776923A (en) | 1970-01-06 | 1973-12-04 | American Cyanamid Co | 2-nitro-4-oxo-4,5,6,7-tetrahydroindole |
| US3997557A (en) | 1974-04-23 | 1976-12-14 | American Hoechst Corporation | Substituted N-aminoalkylpyrroles |
| US4496742A (en) | 1981-10-13 | 1985-01-29 | The Upjohn Company | Analogs of 5,6-dihydro PGI2 |
| FR2537974A1 (fr) | 1982-12-16 | 1984-06-22 | Adir | Nouveaux derives de thieno (2,3-b) pyrrole, leur procede de preparation et les compositions pharmaceutiques les renfermant |
| US4529724A (en) | 1983-10-11 | 1985-07-16 | Mcneilab, Inc. | 6H-indolo[2,1-c][1,4]benzodiazepines and 12-oxo derivatives useful as antihypertensives |
| FR2565981B1 (fr) | 1984-06-15 | 1986-09-19 | Adir | Nouveaux derives de thieno (2,3-b) pyrrole, leur procede de preparation et les compositions pharmaceutiques les renfermant |
| AU581919B2 (en) | 1984-07-30 | 1989-03-09 | Schering Corporation | Process for the preparation of cis, endooctahydrocyclopenta (b) pyrrole-2-carboxylate |
| US4675332A (en) | 1984-12-10 | 1987-06-23 | Warner-Lambert Company | Acidic tetrazolyl substituted indole compounds and their use as antiallergy agents |
| EP0189690B1 (en) | 1984-12-12 | 1989-03-01 | Merck & Co. Inc. | Substituted aromatic sulfonamides, their preparation and ophthalmic compositions containing them |
| US4721725A (en) | 1986-01-27 | 1988-01-26 | E. R. Squibb & Sons, Inc. | Aryl-cycloalkyl[b]pyrrole derivatives |
| IL84796A (en) | 1986-12-17 | 1992-03-29 | Merck Frosst Canada Inc | Substituted n-benzyl-indoles and pharmaceutical compositions containing them |
| JPS63284177A (ja) | 1987-05-14 | 1988-11-21 | Sumitomo Chem Co Ltd | ホルミルピロロピロ−ル類およびその製造方法 |
| US4751231A (en) | 1987-09-16 | 1988-06-14 | Merck & Co., Inc. | Substituted thieno[2,3-b]pyrrole-5-sulfonamides as antiglaucoma agents |
| DE3907388A1 (de) | 1989-03-08 | 1990-09-13 | Kali Chemie Pharma Gmbh | Verfahren zur herstellung von indolcarbonsaeurederivaten |
| NZ234883A (en) | 1989-08-22 | 1995-01-27 | Merck Frosst Canada Inc | Quinolin-2-ylmethoxy indole derivatives, preparation and pharmaceutical compositions thereof |
| US5272145A (en) | 1989-08-22 | 1993-12-21 | Merck Frosst Canada, Inc. | (Quinolin-2-ylmethoxy)indoles as inhibitors of the biosynthesis of leukotrienes |
| DE3943225A1 (de) | 1989-12-23 | 1991-06-27 | Schering Ag | Neue ss-carboline, verfahren zu deren herstellung und deren verwendung in arzneimitteln |
| US5081145A (en) | 1990-02-01 | 1992-01-14 | Merck Frosst Canada, Inc. | Indole-2-alkanoic acids compositions of and anti allergic use thereof |
| AU8405691A (en) | 1990-09-04 | 1992-03-30 | Yamanouchi Pharmaceutical Co., Ltd. | Novel tetrahydrobenzazole derivative |
| US5260322A (en) | 1990-10-08 | 1993-11-09 | Merck & Co., Inc. | Angiotension II antagonists in the treatment of hyperuricemia |
| JPH04273857A (ja) | 1991-02-26 | 1992-09-30 | Taisho Pharmaceut Co Ltd | Ｎ−置換フェニルスルホニルインドール誘導体 |
| US5273980A (en) | 1991-09-30 | 1993-12-28 | Merck Frosst Canada Inc. | Bicyclic-azaarylmethoxy) indoles as inhibitors of leukotriene biosynthesis |
| US5290798A (en) | 1991-09-30 | 1994-03-01 | Merck Frosst Canada, Inc. | (hetero-arylmethoxy)indoles as inhibitors of leukotriene biosynthesis |
| US5389650A (en) | 1991-09-30 | 1995-02-14 | Merck Frosst Canada, Inc. | (Azaarylmethoxy)indoles as inhibitors of leukotriene biosynthesis |
| CA2079374C (en) | 1991-09-30 | 2003-08-05 | Merck Frosst Canada Incorporated | (bicyclic-azaarylmethoxy)indoles as inhibitors of leukotriene biosynthesis |
| US5190968A (en) | 1991-09-30 | 1993-03-02 | Merck Frosst Canada, Inc. | (Polycyclic-arylmethoxy) indoles as inhibitors of leukotriene biosynthesis |
| US5308850A (en) | 1991-09-30 | 1994-05-03 | Merck Frosst Canada, Inc. | (Bicyclic-hetero-arylmethoxy)indoles as inhibitors of leukotriene biosynthesis |
| US5318985A (en) | 1991-12-20 | 1994-06-07 | Merrell Dow Pharmaceuticals Inc. | Potentiation of NMDA antagonists |
| WO1993016069A1 (en) | 1992-02-13 | 1993-08-19 | Merck Frosst Canada Inc. | (azaaromaticalkoxy)indoles as inhibitors of leukotriene biosynthesis |
| ATE197051T1 (de) | 1992-04-03 | 2000-11-15 | Upjohn Co | Pharmazeutisch wirksame bicyclisch heterocyclische amine |
| US5334719A (en) | 1992-06-17 | 1994-08-02 | Merck Frosst Canada, Inc. | Bicyclic(azaaromatic)indoles as inhibitors of leukotriene bisynthesis |
| US5288743A (en) | 1992-11-20 | 1994-02-22 | Abbott Laboratories | Indole carboxylate derivatives which inhibit leukotriene biosynthesis |
| ZA939516B (en) | 1992-12-22 | 1994-06-06 | Smithkline Beecham Corp | Endothelin receptor antagonists |
| US5852046A (en) | 1993-08-03 | 1998-12-22 | Hoechst Aktiengesellschaft | Benzo-fused heterocyclic compounds having a 5-membered ring processes for their preparation their use as medicaments their use as diagnostic agents and medicaments containing them |
| EP0639573A1 (de) | 1993-08-03 | 1995-02-22 | Hoechst Aktiengesellschaft | Benzokondensierte 5-Ringheterocyclen, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament, ihre Verwendung als Diagnostikum, sowie sie enthaltendes Medikament |
| US5399699A (en) | 1994-01-24 | 1995-03-21 | Abbott Laboratories | Indole iminooxy derivatives which inhibit leukotriene biosynthesis |
| CZ24197A3 (en) | 1994-07-27 | 1997-08-13 | Sankyo Co | Heterocyclic compounds, usable as allosteric efectors in muscarine receptors |
| US5482960A (en) | 1994-11-14 | 1996-01-09 | Warner-Lambert Company | Nonpeptide endothelin antagonists |
| US5684032A (en) | 1994-12-13 | 1997-11-04 | Smithkline Beecham Corporation | Compounds |
| AU711968B2 (en) | 1995-04-04 | 1999-10-28 | Encysive Pharmaceuticals Inc. | Thienyl-, furyl-, pyrrolyl- and biphenylsulfonamides and derivatives thereof that modulate the activity of endothelin |
| IT1282797B1 (it) | 1995-04-21 | 1998-03-31 | Colla Paolo | Pirril-(indolil)-aril-sulfoni e relativo processo di produzione ed impiego nella terapia delle infezioni da virus dell'aids |
| US5604253A (en) | 1995-05-22 | 1997-02-18 | Merck Frosst Canada, Inc. | N-benzylindol-3-yl propanoic acid derivatives as cyclooxygenase inhibitors |
| US5639780A (en) | 1995-05-22 | 1997-06-17 | Merck Frosst Canada, Inc. | N-benzyl indol-3-yl butanoic acid derivatives as cyclooxygenase inhibitors |
| AU6966696A (en) | 1995-10-05 | 1997-04-28 | Warner-Lambert Company | Method for treating and preventing inflammation and atherosclerosis |
| TR199801665T2 (xx) | 1996-02-26 | 1998-12-21 | Advanced Research & Technology Institute | Makular �demin engellenmesi i�in karbonik anhidraz inhibit�rlerinin kullan�m�. |
| EP1021181A4 (en) | 1996-03-28 | 2002-06-26 | Smithkline Beecham Corp | INDOLCARBOXYLIC ACIDS AS CHEMOKIN INHIBITORS |
| US5859044A (en) | 1996-07-31 | 1999-01-12 | Pfizer Inc. | β-adrenergic agonists |
| WO1998006703A1 (en) | 1996-08-14 | 1998-02-19 | Warner-Lambert Company | 2-phenyl benzimidazole derivatives as mcp-1 antagonists |
| GB9716656D0 (en) | 1997-08-07 | 1997-10-15 | Zeneca Ltd | Chemical compounds |
| GB9716657D0 (en) * | 1997-08-07 | 1997-10-15 | Zeneca Ltd | Chemical compounds |
| TR200001954T2 (tr) | 1997-12-24 | 2000-12-21 | Hoechst Marion Roussel Deutschland Gmbh | Faktör XA'nın önleyicileri olarak indol türevleri. |
| GB9902461D0 (en) * | 1999-02-05 | 1999-03-24 | Zeneca Ltd | Chemical compounds |
-
2000
- 2000-01-13 GB GBGB0000625.4A patent/GB0000625D0/en not_active Ceased
-
2001
- 2001-01-09 IL IL15027601A patent/IL150276A0/xx unknown
- 2001-01-09 US US10/149,101 patent/US6984657B1/en not_active Expired - Fee Related
- 2001-01-09 MX MXPA02006612A patent/MXPA02006612A/es unknown
- 2001-01-09 CA CA002393597A patent/CA2393597A1/en not_active Abandoned
- 2001-01-09 CN CN01803643A patent/CN1395564A/zh active Pending
- 2001-01-09 AT AT01900197T patent/ATE318800T1/de not_active IP Right Cessation
- 2001-01-09 JP JP2001551849A patent/JP2003519684A/ja active Pending
- 2001-01-09 KR KR1020027009020A patent/KR20020064374A/ko not_active Application Discontinuation
- 2001-01-09 DE DE60117517T patent/DE60117517T2/de not_active Expired - Fee Related
- 2001-01-09 AU AU23874/01A patent/AU779502B2/en not_active Ceased
- 2001-01-09 NZ NZ519311A patent/NZ519311A/en unknown
- 2001-01-09 WO PCT/GB2001/000074 patent/WO2001051467A1/en active IP Right Grant
- 2001-01-09 EP EP01900197A patent/EP1268423B1/en not_active Expired - Lifetime
- 2001-01-09 BR BR0107405-9A patent/BR0107405A/pt not_active IP Right Cessation
-
2002
- 2002-05-30 ZA ZA200204351A patent/ZA200204351B/en unknown
- 2002-07-12 NO NO20023381A patent/NO20023381L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CN1395564A (zh) | 2003-02-05 |
| EP1268423A1 (en) | 2003-01-02 |
| NO20023381L (no) | 2002-09-09 |
| ZA200204351B (en) | 2003-09-01 |
| US6984657B1 (en) | 2006-01-10 |
| CA2393597A1 (en) | 2001-07-19 |
| JP2003519684A (ja) | 2003-06-24 |
| ATE318800T1 (de) | 2006-03-15 |
| BR0107405A (pt) | 2002-10-08 |
| AU779502B2 (en) | 2005-01-27 |
| NZ519311A (en) | 2004-05-28 |
| GB0000625D0 (en) | 2000-03-01 |
| WO2001051467A1 (en) | 2001-07-19 |
| DE60117517D1 (de) | 2006-04-27 |
| MXPA02006612A (es) | 2002-09-30 |
| DE60117517T2 (de) | 2006-09-21 |
| AU2387401A (en) | 2001-07-24 |
| IL150276A0 (en) | 2002-12-01 |
| KR20020064374A (ko) | 2002-08-07 |
| EP1268423B1 (en) | 2006-03-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |