ZA200110179B - Process for the preparation of pure citalopram. - Google Patents

Process for the preparation of pure citalopram.

Info

Publication number: ZA200110179B
Authority: ZA; South Africa
Prior art keywords: preparation; pure citalopram; citalopram; pure
Prior art date: 2000-12-22

Application number

ZA200110179A

Other languages

English (en)

Inventor

Marco Villa

Federico Sbrogio

Robert Dancer

Original Assignee

Lundbeck & Co As H

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-12-22

Filing date

2001-12-11

Publication date

2002-12-11

2001-12-11 Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H

2002-12-11 Publication of ZA200110179B publication Critical patent/ZA200110179B/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Psychiatry (AREA)
Medicinal Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Pain & Pain Management (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

ZA200110179A 2000-12-22 2001-12-11 Process for the preparation of pure citalopram. ZA200110179B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DKPA200001929		2000-12-22

Publications (1)

Publication Number	Publication Date
ZA200110179B true ZA200110179B (en)	2002-12-11

Family

ID=8159922

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA200110179A ZA200110179B (en)	2000-12-22	2001-12-11	Process for the preparation of pure citalopram.

Country Status (43)

Country	Link
US (1)	US6455710B1 (uk)
EP (2)	EP1462447A3 (uk)
JP (1)	JP3798982B2 (uk)
KR (1)	KR100439329B1 (uk)
CN (1)	CN1282648C (uk)
AR (1)	AR030056A1 (uk)
AT (2)	ATE277920T1 (uk)
AU (2)	AU3920101A (uk)
BE (2)	BE1013212A6 (uk)
BG (1)	BG65131B1 (uk)
BR (1)	BR0106272A (uk)
CA (1)	CA2360303C (uk)
CH (1)	CH691535A5 (uk)
CZ (1)	CZ292200B6 (uk)
DE (2)	DE60105926T2 (uk)
DK (1)	DK1181713T3 (uk)
EA (1)	EA003581B1 (uk)
ES (2)	ES2228824T3 (uk)
FI (2)	FI108639B (uk)
FR (1)	FR2812877B1 (uk)
GB (1)	GB2357763B (uk)
GR (1)	GR1003874B (uk)
HK (1)	HK1048812B (uk)
HR (1)	HRP20020004A2 (uk)
HU (2)	HU0101029D0 (uk)
IE (1)	IES20010254A2 (uk)
IL (1)	IL147226A (uk)
IS (1)	IS2060B (uk)
IT (1)	ITMI20010602A1 (uk)
MX (1)	MXPA01013151A (uk)
NL (2)	NL1017525C1 (uk)
NO (1)	NO20011271A (uk)
NZ (1)	NZ516298A (uk)
PL (1)	PL205724B1 (uk)
PT (1)	PT1181713E (uk)
SE (1)	SE517623C2 (uk)
SG (1)	SG167655A1 (uk)
SI (1)	SI1181713T1 (uk)
SK (2)	SK284428B6 (uk)
TR (1)	TR200201166T1 (uk)
UA (1)	UA71634C2 (uk)
WO (1)	WO2001045483A2 (uk)
ZA (1)	ZA200110179B (uk)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AR022329A1 (es)	1999-01-29	2002-09-04	Lundbeck & Co As H	Metodo para la preparacion de 5-cianoftalida
JP3798940B2 (ja) *	1999-04-14	2006-07-19	ハー・ルンドベック・アクチエゼルスカベット	シタロプラムの製造方法
ITMI991579A1 (it)	1999-06-25	2001-01-15	Lundbeck & Co As H	Metodo per la preparazione di citalopram
ITMI991581A1 (it) *	1999-06-25	2001-01-15	Lundbeck & Co As H	Metodo per la preparazione di citalopram
SK287139B6 (sk)	1999-10-25	2010-01-07	H. Lundbeck A/S	Spôsob prípravy citalopramu
CZ20022213A3 (cs)	1999-12-28	2002-09-11	H. Lundbeck A/S	Způsob výroby citalopramu
IL150367A0 (en)	1999-12-30	2002-12-01	Lundbeck & Co As H	Method for the preparation of citalopram
ES2206177T3 (es)	2000-01-14	2004-05-16	H. Lundbeck A/S	Metodo para la preparacion de 5-cianoftalida.
NL1017417C1 (nl)	2000-03-03	2001-03-16	Lundbeck & Co As H	Werkwijze voor de bereiding van Citalopram.
MXPA02008869A (es)	2000-03-13	2003-02-10	Lundbeck & Co As H	Metodo para la preparacion de citalopram.
KR20020080485A (ko)	2000-03-13	2002-10-23	하. 룬트벡 아크티에 셀스카브	5-치환 1-(4-플루오로페닐)-1,3-디히드로이소벤조푸란의단계적 알킬화
NL1017500C1 (nl)	2000-03-13	2001-04-26	Lundbeck & Co As H	Werkwijze voor de bereiding van Citalopram.
DE60101786T2 (de)	2000-03-14	2004-07-15	H. Lundbeck A/S, Valby	Verfahren zur herstellung von citalopram
SK14812002A3 (sk) *	2000-03-16	2003-02-04	H. Lundbeck A/S	Spôsob prípravy 5-kyano-1-(4-fluórfenyl)-1,3-dihydrobenzofuránov a antidepresívny farmaceutický prostriedok
AR032455A1 (es)	2000-05-12	2003-11-12	Lundbeck & Co As H	Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva
IL144816A (en)	2000-08-18	2005-09-25	Lundbeck & Co As H	Method for the preparation of citalopram
ES2181663T3 (es)	2000-12-28	2003-03-01	Lundbeck & Co As H	Procedimiento para la preparacion de citalopram puro.
GB0105627D0 (en) *	2001-03-07	2001-04-25	Cipla Ltd	Preparation of phthalanes
RU2003130073A (ru) *	2001-03-09	2005-04-10	Ранбакси Лабораторис Лимитед (In)	Способ получения циталопрама
US6967259B2 (en) *	2001-09-24	2005-11-22	Pharmachem Technologies Limited	Process for the preparation of Citalopram intermediate
CA2465186A1 (en) *	2001-11-08	2003-05-15	Sepracor, Inc.	Methods for treating depression and other cns disorders using enantiomerically enriched desmethyl- and didesmethyl-metabolites of citalopram
US7148364B2 (en) *	2002-01-07	2006-12-12	Sun Pharmaceutical Industries	Process for the preparation of 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofuran carbonitrile
GB0204607D0 (en) *	2002-02-27	2002-04-10	Matrix Lab Ltd	Process
ATE431817T1 (de) *	2002-11-15	2009-06-15	Akzo Nobel Nv	Behandlung zur reinigung/entfärbung von fettsäurenitrilen
TR200504022T1 (tr) *	2003-03-24	2006-08-21	Hetero Drugs Limited	(S)-sitalopram oksalatın yeni sıvı kristal formları.
US7019153B2 (en) *	2003-06-10	2006-03-28	Sun Pharmaceutical Industries Limited	Process for hydrogenolysis of [1-(3-dimethylamino)propyl)]-1-(4-fluorophenyl)-1,3-dihydro-5-halo-isobenzofuran acetamido-3-substituted-3-cephem-4-carboxylic acid
BR0318581A (pt) *	2003-10-28	2006-10-10	Wockhardt Ltd	processo melhorando para fabriacação de bromidrato de citalopram
CN100569765C (zh)	2003-12-19	2009-12-16	杭州民生药业集团有限公司	西酞普兰中间体晶体碱
TWI347942B (en) *	2005-06-22	2011-09-01	Lundbeck & Co As H	Crystalline base of escitalopram and orodispersible tablets comprising escitalopram base
CN114763343A (zh) *	2021-01-14	2022-07-19	浙江华海药业股份有限公司	一种西酞普兰或s-西酞普兰的纯化方法

Family Cites Families (32)

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DE536169C (de) *	1926-08-21	1931-10-20	British Dyestuffs Corp Ltd	Verfahren zur Gewinnung von tertiaeren aromatischen Aminen aus ihren Gemischen mit sekundaeren und primaeren aromatischen Aminen
US1992111A (en) *	1931-06-20	1935-02-19	Du Pont	Separation of secondary and tertiary amines
DE1032261B (de) *	1955-03-08	1958-06-19	Leda Chemicals Ltd	Verfahren zur Abtrennung sekundaerer Amine aus einer primaeres und sekundaeres Amin enthaltenden Mischung
GB1143702A (uk)	1965-03-18
GB1526331A (en) *	1976-01-14	1978-09-27	Kefalas As	Phthalanes
US4302399A (en) *	1978-09-28	1981-11-24	Dynapol	Acetylation of crude reaction products containing polymeric colorants
GB8419963D0 (en)	1984-08-06	1984-09-12	Lundbeck & Co As H	Intermediate compound and method
US4943591A (en)	1984-10-17	1990-07-24	Glaxo Group Limited	Dichloroaniline derivatives
DE3926765A1 (de)	1989-08-12	1991-02-14	Hoechst Ag	Verfahren zur verminderung von primaerem und sekundaerem amin in einem tertiaeren amin
DK213290D0 (da) *	1990-09-06	1990-09-06	Lundbeck & Co As H	Treatment of cerebrovascular disorders
US5296507A (en)	1990-09-06	1994-03-22	H.Lundbeck A/S	Treatment of cerbrovascular disorders
DE19626659A1 (de)	1996-07-03	1998-01-08	Basf Ag	Verfahren zur Herstellung von Phthaliden
DE19627697A1 (de)	1996-07-10	1998-01-15	Basf Ag	Verfahren zur Herstellung von Phthaliden
AU4655597A (en) *	1997-06-30	1999-01-19	Beloit Technologies, Inc.	Method and apparatus for the high speed application of coating to a traveling paper web
CZ291440B6 (cs)	1997-07-08	2003-03-12	H. Lundbeck A/S	Způsob výroby citalopramu
UA62985C2 (en)	1997-11-10	2004-01-15	Lunnbeck As H	A method for the preparation of citalopram
CN1286687A (zh)	1997-11-11	2001-03-07	H·隆德贝克有限公司	制备西酞普兰的方法
SK285719B6 (sk)	1998-10-20	2007-07-06	H. Lundbeck A/S	Spôsob prípravy citalopramu a medziprodukty
PT1140886E (pt)	1998-12-23	2003-08-29	Lundbeck & Co As H	Metodo para a preparacao de 5- cianoftalida
AR022329A1 (es)	1999-01-29	2002-09-04	Lundbeck & Co As H	Metodo para la preparacion de 5-cianoftalida
JP3798940B2 (ja)	1999-04-14	2006-07-19	ハー・ルンドベック・アクチエゼルスカベット	シタロプラムの製造方法
ITMI991579A1 (it) *	1999-06-25	2001-01-15	Lundbeck & Co As H	Metodo per la preparazione di citalopram
ITMI991581A1 (it) *	1999-06-25	2001-01-15	Lundbeck & Co As H	Metodo per la preparazione di citalopram
ITMI991486A1 (it) *	1999-07-06	2001-01-06	Vis Farmaceutici S P A	Processo per la sintesi di citalopram
SK287139B6 (sk)	1999-10-25	2010-01-07	H. Lundbeck A/S	Spôsob prípravy citalopramu
US6310222B1 (en)	1999-11-01	2001-10-30	Sumika Fine Chemicals Co., Ltd.	Production method of 5-phthalancarbonitrile compound, intermediate therefor and production method of the intermediate
IES20010143A2 (en)	2000-02-24	2001-07-25	Lundbeck & Co As H	Method for the preparation of citalopram
NL1017415C1 (nl)	2000-02-24	2001-05-18	Lundbeck & Co As H	Werkwijze voor de bereiding van Citalopram.
GB0005477D0 (en)	2000-03-07	2000-04-26	Resolution Chemicals Limited	Process for the preparation of citalopram
GB2357762B (en) *	2000-03-13	2002-01-30	Lundbeck & Co As H	Crystalline base of citalopram
IL144816A (en)	2000-08-18	2005-09-25	Lundbeck & Co As H	Method for the preparation of citalopram
ES2181663T3 (es)	2000-12-28	2003-03-01	Lundbeck & Co As H	Procedimiento para la preparacion de citalopram puro.

2001
- 2001-03-07 SG SG200504030-8A patent/SG167655A1/en unknown
- 2001-03-07 JP JP2001546230A patent/JP3798982B2/ja not_active Expired - Fee Related
- 2001-03-07 AU AU39201/01A patent/AU3920101A/en active Pending
- 2001-03-07 AT AT01913726T patent/ATE277920T1/de not_active IP Right Cessation
- 2001-03-07 ES ES01913726T patent/ES2228824T3/es not_active Expired - Lifetime
- 2001-03-07 PT PT01913726T patent/PT1181713E/pt unknown
- 2001-03-07 CA CA002360303A patent/CA2360303C/en not_active Expired - Fee Related
- 2001-03-07 EP EP04004482A patent/EP1462447A3/en not_active Withdrawn
- 2001-03-07 AU AU2001100405A patent/AU2001100405B4/en not_active Ceased
- 2001-03-07 SK SK1848-2001A patent/SK284428B6/sk not_active IP Right Cessation
- 2001-03-07 IL IL147226A patent/IL147226A/en not_active IP Right Cessation
- 2001-03-07 NL NL1017525A patent/NL1017525C1/nl not_active IP Right Cessation
- 2001-03-07 SK SK4-2005A patent/SK286283B6/sk not_active IP Right Cessation
- 2001-03-07 MX MXPA01013151A patent/MXPA01013151A/es active IP Right Grant
- 2001-03-07 DK DK01913726T patent/DK1181713T3/da active
- 2001-03-07 BR BR0106272-7A patent/BR0106272A/pt not_active Application Discontinuation
- 2001-03-07 KR KR10-2001-7016686A patent/KR100439329B1/ko not_active IP Right Cessation
- 2001-03-07 EP EP01913726A patent/EP1181713B1/en not_active Expired - Lifetime
- 2001-03-07 CN CNB018011225A patent/CN1282648C/zh not_active Expired - Lifetime
- 2001-03-07 TR TR2002/01166T patent/TR200201166T1/xx unknown
- 2001-03-07 PL PL353398A patent/PL205724B1/pl not_active IP Right Cessation
- 2001-03-07 WO PCT/DK2001/000147 patent/WO2001045483A2/en active Application Filing
- 2001-03-07 DE DE60105926T patent/DE60105926T2/de not_active Expired - Lifetime
- 2001-03-07 EA EA200200018A patent/EA003581B1/ru not_active IP Right Cessation
- 2001-03-07 SI SI200130238T patent/SI1181713T1/xx unknown
- 2001-03-09 IS IS5883A patent/IS2060B/xx unknown
- 2001-03-09 HU HU0101029A patent/HU0101029D0/hu unknown
- 2001-03-12 CZ CZ2001890A patent/CZ292200B6/cs not_active IP Right Cessation
- 2001-03-12 GB GB0105983A patent/GB2357763B/en not_active Revoked
- 2001-03-13 FI FI20010500A patent/FI108639B/fi not_active IP Right Cessation
- 2001-03-13 NO NO20011271A patent/NO20011271A/no not_active IP Right Cessation
- 2001-03-14 FR FR0103455A patent/FR2812877B1/fr not_active Expired - Fee Related
- 2001-03-15 AR ARP010101209A patent/AR030056A1/es not_active Application Discontinuation
- 2001-03-15 IE IE20010254A patent/IES20010254A2/en not_active IP Right Cessation
- 2001-03-16 DE DE10112829A patent/DE10112829C1/de not_active Expired - Fee Related
- 2001-03-16 GR GR20010100132A patent/GR1003874B/el not_active IP Right Cessation
- 2001-03-21 AT AT0020801U patent/AT4367U1/de not_active IP Right Cessation
- 2001-03-22 BE BE2001/0188A patent/BE1013212A6/fr not_active IP Right Cessation
- 2001-03-22 CH CH00545/01A patent/CH691535A5/de not_active IP Right Cessation
- 2001-03-22 IT IT2001MI000602A patent/ITMI20010602A1/it unknown
- 2001-06-22 NL NL1018360A patent/NL1018360C1/nl not_active IP Right Cessation
- 2001-06-26 BE BE2001/0435A patent/BE1013213A6/fr not_active IP Right Cessation
- 2001-07-03 UA UA2002021552A patent/UA71634C2/uk unknown
- 2001-07-05 HU HU0102817A patent/HUP0102817A3/hu unknown
- 2001-07-26 FI FI20011577A patent/FI20011577A0/fi unknown
- 2001-07-27 ES ES200101762A patent/ES2170732B2/es not_active Expired - Fee Related
- 2001-09-14 SE SE0103045A patent/SE517623C2/sv not_active IP Right Cessation
- 2001-12-10 BG BG106203A patent/BG65131B1/bg unknown
- 2001-12-11 ZA ZA200110179A patent/ZA200110179B/xx unknown
- 2001-12-20 NZ NZ516298A patent/NZ516298A/xx unknown
2002
- 2002-01-04 HR HR20020004A patent/HRP20020004A2/hr not_active Application Discontinuation
- 2002-01-08 US US10/046,126 patent/US6455710B1/en not_active Expired - Fee Related
2003
- 2003-02-10 HK HK03100966.7A patent/HK1048812B/zh not_active IP Right Cessation

Also Published As

Publication number	Publication date
CH691535A5 (de)	2001-08-15
HK1048812A1 (en)	2003-04-17
EP1462447A2 (en)	2004-09-29
SE517623C2 (sv)	2002-06-25
FR2812877A1 (fr)	2002-02-15
JP2003517484A (ja)	2003-05-27
ES2170732A1 (es)	2002-08-01
UA71634C2 (uk)	2004-12-15
BE1013213A6 (fr)	2001-10-02
CZ2001890A3 (cs)	2002-08-14
SK284428B6 (sk)	2005-04-01
DE60105926D1 (de)	2004-11-04
IS2060B (is)	2005-11-15
US6455710B1 (en)	2002-09-24
EP1462447A3 (en)	2004-11-17
CA2360303C (en)	2003-08-12
HU0101029D0 (en)	2001-05-28
SG167655A1 (en)	2011-01-28
SK286283B6 (sk)	2008-06-06
HUP0102817A3 (en)	2003-07-28
CN1282648C (zh)	2006-11-01
BG106203A (en)	2002-08-30
SK18482001A3 (sk)	2002-05-09
US20020120005A1 (en)	2002-08-29
KR20020065345A (ko)	2002-08-13
DE10112829C1 (de)	2002-07-25
EA003581B1 (ru)	2003-06-26
JP3798982B2 (ja)	2006-07-19
HUP0102817A2 (hu)	2001-12-28
AU2001100405A4 (en)	2001-11-01
MXPA01013151A (es)	2002-08-12
CA2360303A1 (en)	2001-06-28
SE0103045L (sv)	2002-06-23
AT4367U1 (de)	2001-06-25
IS5883A (is)	2001-06-20
EA200200018A1 (ru)	2002-04-25
GB2357763B (en)	2002-01-16
GB2357763A (en)	2001-07-04
PL353398A1 (en)	2003-11-17
NO20011271D0 (no)	2001-03-13
FI20010500A0 (fi)	2001-03-13
IES20010254A2 (en)	2002-03-06
SI1181713T1 (en)	2005-02-28
PT1181713E (pt)	2005-02-28
AU2001100405B4 (en)	2002-03-21
ATE277920T1 (de)	2004-10-15
NO312462B1 (no)	2002-05-13
BG65131B1 (bg)	2007-03-30
GR1003874B (el)	2002-04-24
GB0105983D0 (en)	2001-05-02
ES2170732B2 (es)	2003-09-16
ITMI20010602A1 (it)	2002-09-22
ES2228824T3 (es)	2005-04-16
NL1017525C1 (nl)	2001-04-26
CN1366525A (zh)	2002-08-28
IL147226A (en)	2006-04-10
DE60105926T2 (de)	2005-11-24
TR200201166T1 (tr)	2002-10-21
ITMI20010602A0 (it)	2001-03-22
SE0103045D0 (sv)	2001-09-14
FI20011577A0 (fi)	2001-07-26
WO2001045483A2 (en)	2001-06-28
AR030056A1 (es)	2003-08-13
DK1181713T3 (da)	2005-01-31
WO2001045483A3 (en)	2001-12-27
PL205724B1 (pl)	2010-05-31
NZ516298A (en)	2002-12-20
NO20011271A (no)	2002-05-13
BR0106272A (pt)	2004-06-15
BE1013212A6 (fr)	2001-10-02
IL147226A0 (en)	2002-08-14
CZ292200B6 (cs)	2003-08-13
HK1048812B (zh)	2007-06-01
EP1181713A2 (en)	2002-02-27
AU3920101A (en)	2001-07-03
FI108639B (fi)	2002-02-28
KR100439329B1 (ko)	2004-07-07
EP1181713B1 (en)	2004-09-29
NL1018360C1 (nl)	2001-10-04
FR2812877B1 (fr)	2003-04-04
HU0102817D0 (en)	2001-09-28
HRP20020004A2 (en)	2003-04-30

Publication	Publication Date	Title
ZA200110179B (en)	2002-12-11	Process for the preparation of pure citalopram.
GB2356199B (en)	2001-10-03	Process for the preparation of pure citalopram
HU0103291D0 (en)	2001-10-28	Process for the preparation of citalopram
ZA200206699B (en)	2003-11-21	Method for the preparation of citalopram.
IL151059A0 (en)	2003-04-10	Method for the preparation of citalopram
IL161026A0 (en)	2004-08-31	Process for the preparation of citalopram
MXPA03001800A (es)	2003-06-24	Proceso para la preparacion de fenilacetonitrilos sustituidos.
HUP0300060A3 (en)	2005-02-28	Method for the preparation of citalopram
HK1056171A1 (en)	2004-02-06	Method for the preparation of citalopram
IL151490A0 (en)	2003-04-10	Method for the preparation of citalopram
HK1040984A1 (zh)	2002-06-28	製備d，l-薄荷醇的方法
IL148525A0 (en)	2002-09-12	Method for the preparation of citalopram
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