SG167655A1 - Method for the preparation of pure citalopram - Google Patents

Method for the preparation of pure citalopram

Info

Publication number: SG167655A1
Authority: SG; Singapore
Prior art keywords: citalopram; preparation; subjected; amide; purification
Prior art date: 2000-12-22

Application number

SG200504030-8A

Other languages

English (en)

Inventor

Marco Villa

Federico Sbrogio

Robert Dancer

Original Assignee

Lundbeck & Co As H

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-12-22

Filing date

2001-03-07

Publication date

2011-01-28

2001-03-07 Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H

2011-01-28 Publication of SG167655A1 publication Critical patent/SG167655A1/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Psychiatry (AREA)
Medicinal Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Pain & Pain Management (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

SG200504030-8A 2000-12-22 2001-03-07 Method for the preparation of pure citalopram SG167655A1 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DKPA200001929		2000-12-22

Publications (1)

Publication Number	Publication Date
SG167655A1 true SG167655A1 (en)	2011-01-28

Family

ID=8159922

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SG200504030-8A SG167655A1 (en)	2000-12-22	2001-03-07	Method for the preparation of pure citalopram

Country Status (43)

Country	Link
US (1)	US6455710B1 (uk)
EP (2)	EP1181713B1 (uk)
JP (1)	JP3798982B2 (uk)
KR (1)	KR100439329B1 (uk)
CN (1)	CN1282648C (uk)
AR (1)	AR030056A1 (uk)
AT (2)	ATE277920T1 (uk)
AU (2)	AU2001100405B4 (uk)
BE (2)	BE1013212A6 (uk)
BG (1)	BG65131B1 (uk)
BR (1)	BR0106272A (uk)
CA (1)	CA2360303C (uk)
CH (1)	CH691535A5 (uk)
CZ (1)	CZ292200B6 (uk)
DE (2)	DE60105926T2 (uk)
DK (1)	DK1181713T3 (uk)
EA (1)	EA003581B1 (uk)
ES (2)	ES2228824T3 (uk)
FI (2)	FI108639B (uk)
FR (1)	FR2812877B1 (uk)
GB (1)	GB2357763B (uk)
GR (1)	GR1003874B (uk)
HK (1)	HK1048812B (uk)
HR (1)	HRP20020004A2 (uk)
HU (2)	HU0101029D0 (uk)
IE (1)	IES20010254A2 (uk)
IL (1)	IL147226A (uk)
IS (1)	IS2060B (uk)
IT (1)	ITMI20010602A1 (uk)
MX (1)	MXPA01013151A (uk)
NL (2)	NL1017525C1 (uk)
NO (1)	NO20011271A (uk)
NZ (1)	NZ516298A (uk)
PL (1)	PL205724B1 (uk)
PT (1)	PT1181713E (uk)
SE (1)	SE517623C2 (uk)
SG (1)	SG167655A1 (uk)
SI (1)	SI1181713T1 (uk)
SK (2)	SK284428B6 (uk)
TR (1)	TR200201166T1 (uk)
UA (1)	UA71634C2 (uk)
WO (1)	WO2001045483A2 (uk)
ZA (1)	ZA200110179B (uk)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AR022329A1 (es)	1999-01-29	2002-09-04	Lundbeck & Co As H	Metodo para la preparacion de 5-cianoftalida
DE69907037T3 (de)	1999-04-14	2010-02-18	H. Lundbeck A/S	Verfahren zur herstellung von citalopram
ITMI991581A1 (it) *	1999-06-25	2001-01-15	Lundbeck & Co As H	Metodo per la preparazione di citalopram
ITMI991579A1 (it)	1999-06-25	2001-01-15	Lundbeck & Co As H	Metodo per la preparazione di citalopram
CH692421A5 (de)	1999-10-25	2002-06-14	Lundbeck & Co As H	Verfahren zur Herstellung von Citalopram.
IL150335A0 (en)	1999-12-28	2002-12-01	Lundbeck & Co As H	Method for the preparation of citalopram
CZ20022627A3 (cs)	1999-12-30	2002-10-16	H. Lundbeck A/S	Způsob výroby citalopramu
DK1254129T3 (da)	2000-01-14	2004-03-29	Lundbeck & Co As H	Fremgangsmåde til fremstilling af 5-cyanophthalid
IES20010157A2 (en)	2000-03-03	2002-03-06	Lundbeck & Co As H	Method for the preparation of citalopram
HUP0300274A2 (hu)	2000-03-13	2003-06-28	H. Lundbeck A/S	Eljárás citalopram előállítására
IES20010206A2 (en)	2000-03-13	2002-03-06	Lundbeck & Co As H	Method for the preparation of citalopram
IL151566A0 (en)	2000-03-13	2003-04-10	Lundbeck & Co As H	Stepwise alkylation of 5-substituted 1-(4-fluorophenyl)-1,3-dihydroisobenzofurans
SK14512002A3 (sk)	2000-03-14	2003-03-04	H. Lundbeck A/S	Spôsob výroby citalopramu, medziprodukt a citalopram výrobený týmto spôsobom
BR0109180A (pt) *	2000-03-16	2003-05-27	Lundbeck & Co As H	Método para a preparação de 5-ciano-1-(4-fluorofenil) -1,3- diidroisobenzofuranos e composição farmacêutica de antidepressivo
AR032455A1 (es)	2000-05-12	2003-11-12	Lundbeck & Co As H	Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva
FI20011622L (fi)	2000-08-18	2002-02-19	Lundbeck & Co As H	Menetelmä sitalopraamin valmistamiseksi
EP1181272B1 (en)	2000-12-28	2002-08-28	H. Lundbeck A/S	Process for the preparation of pure citalopram
GB0105627D0 (en) *	2001-03-07	2001-04-25	Cipla Ltd	Preparation of phthalanes
EP1370545A4 (en) *	2001-03-09	2005-03-16	Ranbaxy Lab Ltd	PROCESS FOR THE PREPARATION OF CITALOPRAM
US6967259B2 (en) *	2001-09-24	2005-11-22	Pharmachem Technologies Limited	Process for the preparation of Citalopram intermediate
CN1705654A (zh) *	2001-11-08	2005-12-07	塞普拉科公司	使用对映体富集的西酞普兰去甲基和二去甲基代谢产物治疗抑郁症以及其它中枢神经病症的方法
WO2003057132A2 (en) *	2002-01-07	2003-07-17	Sun Pharmaceutical Industries Limited	Process for the preparation of 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)- 1,3-dihydro-5-isobenzofuran carbonitrile
GB0204607D0 (en) *	2002-02-27	2002-04-10	Matrix Lab Ltd	Process
ES2327635T3 (es) *	2002-11-15	2009-11-02	Akzo Nobel N.V.	Tratamiento de purificacion/decoloracion de nitrilos grasos.
US20050154052A1 (en) *	2003-03-24	2005-07-14	Hetero Drugs Limited	Novel crystalline forms of (s)-citalopram oxalate
US7019153B2 (en) *	2003-06-10	2006-03-28	Sun Pharmaceutical Industries Limited	Process for hydrogenolysis of [1-(3-dimethylamino)propyl)]-1-(4-fluorophenyl)-1,3-dihydro-5-halo-isobenzofuran acetamido-3-substituted-3-cephem-4-carboxylic acid
EP1678122A4 (en) *	2003-10-28	2007-05-23	Wockhardt Ltd	IMPROVED PROCESS FOR THE PREPARATION OF CITALOPRAM HYDROBROMIDE
CN100569765C (zh)	2003-12-19	2009-12-16	杭州民生药业集团有限公司	西酞普兰中间体晶体碱
TWI358407B (en) *	2005-06-22	2012-02-21	Lundbeck & Co As H	Crystalline base of escitalopram and orodispersibl
CN114763343A (zh) *	2021-01-14	2022-07-19	浙江华海药业股份有限公司	一种西酞普兰或s-西酞普兰的纯化方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US1992111A (en) *	1931-06-20	1935-02-19	Du Pont	Separation of secondary and tertiary amines
DE1032261B (de) *	1955-03-08	1958-06-19	Leda Chemicals Ltd	Verfahren zur Abtrennung sekundaerer Amine aus einer primaeres und sekundaeres Amin enthaltenden Mischung
US4302399A (en) *	1978-09-28	1981-11-24	Dynapol	Acetylation of crude reaction products containing polymeric colorants
EP0413259A2 (de) *	1989-08-12	1991-02-20	Hoechst Aktiengesellschaft	Verfahren zur Verminderung von primärem und sekundärem Amin in einem tertiären Amin

Family Cites Families (28)

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Publication number	Priority date	Publication date	Assignee	Title
DE536169C (de) *	1926-08-21	1931-10-20	British Dyestuffs Corp Ltd	Verfahren zur Gewinnung von tertiaeren aromatischen Aminen aus ihren Gemischen mit sekundaeren und primaeren aromatischen Aminen
GB1143702A (uk)	1965-03-18
GB1526331A (en) *	1976-01-14	1978-09-27	Kefalas As	Phthalanes
GB8419963D0 (en)	1984-08-06	1984-09-12	Lundbeck & Co As H	Intermediate compound and method
US4943591A (en)	1984-10-17	1990-07-24	Glaxo Group Limited	Dichloroaniline derivatives
DK213290D0 (da) *	1990-09-06	1990-09-06	Lundbeck & Co As H	Treatment of cerebrovascular disorders
US5296507A (en)	1990-09-06	1994-03-22	H.Lundbeck A/S	Treatment of cerbrovascular disorders
DE19626659A1 (de)	1996-07-03	1998-01-08	Basf Ag	Verfahren zur Herstellung von Phthaliden
DE19627697A1 (de)	1996-07-10	1998-01-15	Basf Ag	Verfahren zur Herstellung von Phthaliden
AU4655597A (en) *	1997-06-30	1999-01-19	Beloit Technologies, Inc.	Method and apparatus for the high speed application of coating to a traveling paper web
NZ501737A (en)	1997-07-08	2001-10-26	H	Method for the preparation of citalopram using Grignard reagent 4-halogen-fluorophenyl and 3-halogen-N,N-dimethyl-propylamine
UA62985C2 (en)	1997-11-10	2004-01-15	Lunnbeck As H	A method for the preparation of citalopram
DE1042310T1 (de) *	1997-11-11	2001-04-19	Lundbeck & Co As H	Verfahren zur herstellung von citaloprame
PL199423B1 (pl) *	1998-10-20	2008-09-30	Lundbeck & Co As H	Sposób wytwarzania citalopramu
PT1140886E (pt)	1998-12-23	2003-08-29	Lundbeck & Co As H	Metodo para a preparacao de 5- cianoftalida
AR022329A1 (es)	1999-01-29	2002-09-04	Lundbeck & Co As H	Metodo para la preparacion de 5-cianoftalida
DE69907037T3 (de)	1999-04-14	2010-02-18	H. Lundbeck A/S	Verfahren zur herstellung von citalopram
ITMI991579A1 (it) *	1999-06-25	2001-01-15	Lundbeck & Co As H	Metodo per la preparazione di citalopram
ITMI991581A1 (it) *	1999-06-25	2001-01-15	Lundbeck & Co As H	Metodo per la preparazione di citalopram
ITMI991486A1 (it) *	1999-07-06	2001-01-06	Vis Farmaceutici S P A	Processo per la sintesi di citalopram
CH692421A5 (de)	1999-10-25	2002-06-14	Lundbeck & Co As H	Verfahren zur Herstellung von Citalopram.
US6310222B1 (en)	1999-11-01	2001-10-30	Sumika Fine Chemicals Co., Ltd.	Production method of 5-phthalancarbonitrile compound, intermediate therefor and production method of the intermediate
IES20010143A2 (en)	2000-02-24	2001-07-25	Lundbeck & Co As H	Method for the preparation of citalopram
FR2805812A1 (fr)	2000-02-24	2001-09-07	Lundbeck & Co As H	Procede de preparation du citalopram
GB0005477D0 (en)	2000-03-07	2000-04-26	Resolution Chemicals Limited	Process for the preparation of citalopram
GB2357762B (en) *	2000-03-13	2002-01-30	Lundbeck & Co As H	Crystalline base of citalopram
FI20011622L (fi)	2000-08-18	2002-02-19	Lundbeck & Co As H	Menetelmä sitalopraamin valmistamiseksi
EP1181272B1 (en)	2000-12-28	2002-08-28	H. Lundbeck A/S	Process for the preparation of pure citalopram

2001
- 2001-03-07 TR TR2002/01166T patent/TR200201166T1/xx unknown
- 2001-03-07 DE DE60105926T patent/DE60105926T2/de not_active Expired - Lifetime
- 2001-03-07 SK SK1848-2001A patent/SK284428B6/sk not_active IP Right Cessation
- 2001-03-07 SG SG200504030-8A patent/SG167655A1/en unknown
- 2001-03-07 CA CA002360303A patent/CA2360303C/en not_active Expired - Fee Related
- 2001-03-07 PT PT01913726T patent/PT1181713E/pt unknown
- 2001-03-07 MX MXPA01013151A patent/MXPA01013151A/es active IP Right Grant
- 2001-03-07 WO PCT/DK2001/000147 patent/WO2001045483A2/en active Application Filing
- 2001-03-07 NL NL1017525A patent/NL1017525C1/nl not_active IP Right Cessation
- 2001-03-07 AU AU2001100405A patent/AU2001100405B4/en not_active Ceased
- 2001-03-07 JP JP2001546230A patent/JP3798982B2/ja not_active Expired - Fee Related
- 2001-03-07 CN CNB018011225A patent/CN1282648C/zh not_active Expired - Lifetime
- 2001-03-07 EP EP01913726A patent/EP1181713B1/en not_active Expired - Lifetime
- 2001-03-07 EA EA200200018A patent/EA003581B1/ru not_active IP Right Cessation
- 2001-03-07 AT AT01913726T patent/ATE277920T1/de not_active IP Right Cessation
- 2001-03-07 AU AU39201/01A patent/AU3920101A/en active Pending
- 2001-03-07 SI SI200130238T patent/SI1181713T1/xx unknown
- 2001-03-07 KR KR10-2001-7016686A patent/KR100439329B1/ko not_active IP Right Cessation
- 2001-03-07 DK DK01913726T patent/DK1181713T3/da active
- 2001-03-07 EP EP04004482A patent/EP1462447A3/en not_active Withdrawn
- 2001-03-07 ES ES01913726T patent/ES2228824T3/es not_active Expired - Lifetime
- 2001-03-07 PL PL353398A patent/PL205724B1/pl not_active IP Right Cessation
- 2001-03-07 BR BR0106272-7A patent/BR0106272A/pt not_active Application Discontinuation
- 2001-03-07 IL IL147226A patent/IL147226A/en not_active IP Right Cessation
- 2001-03-07 SK SK4-2005A patent/SK286283B6/sk not_active IP Right Cessation
- 2001-03-09 HU HU0101029A patent/HU0101029D0/hu unknown
- 2001-03-09 IS IS5883A patent/IS2060B/xx unknown
- 2001-03-12 CZ CZ2001890A patent/CZ292200B6/cs not_active IP Right Cessation
- 2001-03-12 GB GB0105983A patent/GB2357763B/en not_active Revoked
- 2001-03-13 FI FI20010500A patent/FI108639B/fi not_active IP Right Cessation
- 2001-03-13 NO NO20011271A patent/NO20011271A/no not_active IP Right Cessation
- 2001-03-14 FR FR0103455A patent/FR2812877B1/fr not_active Expired - Fee Related
- 2001-03-15 IE IE20010254A patent/IES20010254A2/en not_active IP Right Cessation
- 2001-03-15 AR ARP010101209A patent/AR030056A1/es not_active Application Discontinuation
- 2001-03-16 DE DE10112829A patent/DE10112829C1/de not_active Expired - Fee Related
- 2001-03-16 GR GR20010100132A patent/GR1003874B/el not_active IP Right Cessation
- 2001-03-21 AT AT0020801U patent/AT4367U1/de not_active IP Right Cessation
- 2001-03-22 CH CH00545/01A patent/CH691535A5/de not_active IP Right Cessation
- 2001-03-22 BE BE2001/0188A patent/BE1013212A6/fr not_active IP Right Cessation
- 2001-03-22 IT IT2001MI000602A patent/ITMI20010602A1/it unknown
- 2001-06-22 NL NL1018360A patent/NL1018360C1/nl not_active IP Right Cessation
- 2001-06-26 BE BE2001/0435A patent/BE1013213A6/fr not_active IP Right Cessation
- 2001-07-03 UA UA2002021552A patent/UA71634C2/uk unknown
- 2001-07-05 HU HU0102817A patent/HUP0102817A3/hu unknown
- 2001-07-26 FI FI20011577A patent/FI20011577A0/fi unknown
- 2001-07-27 ES ES200101762A patent/ES2170732B2/es not_active Expired - Fee Related
- 2001-09-14 SE SE0103045A patent/SE517623C2/sv not_active IP Right Cessation
- 2001-12-10 BG BG106203A patent/BG65131B1/bg unknown
- 2001-12-11 ZA ZA200110179A patent/ZA200110179B/xx unknown
- 2001-12-20 NZ NZ516298A patent/NZ516298A/xx unknown
2002
- 2002-01-04 HR HR20020004A patent/HRP20020004A2/hr not_active Application Discontinuation
- 2002-01-08 US US10/046,126 patent/US6455710B1/en not_active Expired - Fee Related
2003
- 2003-02-10 HK HK03100966.7A patent/HK1048812B/zh not_active IP Right Cessation

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US1992111A (en) *	1931-06-20	1935-02-19	Du Pont	Separation of secondary and tertiary amines
DE1032261B (de) *	1955-03-08	1958-06-19	Leda Chemicals Ltd	Verfahren zur Abtrennung sekundaerer Amine aus einer primaeres und sekundaeres Amin enthaltenden Mischung
US4302399A (en) *	1978-09-28	1981-11-24	Dynapol	Acetylation of crude reaction products containing polymeric colorants
EP0413259A2 (de) *	1989-08-12	1991-02-20	Hoechst Aktiengesellschaft	Verfahren zur Verminderung von primärem und sekundärem Amin in einem tertiären Amin

Also Published As

Publication number	Publication date
HK1048812B (zh)	2007-06-01
ATE277920T1 (de)	2004-10-15
FI20010500A0 (fi)	2001-03-13
ZA200110179B (en)	2002-12-11
DE10112829C1 (de)	2002-07-25
PL205724B1 (pl)	2010-05-31
EA200200018A1 (ru)	2002-04-25
DE60105926D1 (de)	2004-11-04
KR100439329B1 (ko)	2004-07-07
FR2812877B1 (fr)	2003-04-04
GB2357763B (en)	2002-01-16
HU0101029D0 (en)	2001-05-28
FR2812877A1 (fr)	2002-02-15
JP3798982B2 (ja)	2006-07-19
CH691535A5 (de)	2001-08-15
NL1018360C1 (nl)	2001-10-04
IS5883A (is)	2001-06-20
JP2003517484A (ja)	2003-05-27
US20020120005A1 (en)	2002-08-29
BG106203A (en)	2002-08-30
CN1282648C (zh)	2006-11-01
HRP20020004A2 (en)	2003-04-30
ITMI20010602A1 (it)	2002-09-22
SK284428B6 (sk)	2005-04-01
SK18482001A3 (sk)	2002-05-09
GB0105983D0 (en)	2001-05-02
HUP0102817A3 (en)	2003-07-28
WO2001045483A3 (en)	2001-12-27
EP1181713B1 (en)	2004-09-29
IL147226A0 (en)	2002-08-14
TR200201166T1 (tr)	2002-10-21
BE1013212A6 (fr)	2001-10-02
DE60105926T2 (de)	2005-11-24
CZ292200B6 (cs)	2003-08-13
NO312462B1 (no)	2002-05-13
CA2360303C (en)	2003-08-12
ES2170732B2 (es)	2003-09-16
EA003581B1 (ru)	2003-06-26
ES2228824T3 (es)	2005-04-16
GB2357763A (en)	2001-07-04
US6455710B1 (en)	2002-09-24
FI108639B (fi)	2002-02-28
IL147226A (en)	2006-04-10
SE517623C2 (sv)	2002-06-25
GR1003874B (el)	2002-04-24
SI1181713T1 (en)	2005-02-28
BG65131B1 (bg)	2007-03-30
AR030056A1 (es)	2003-08-13
SE0103045D0 (sv)	2001-09-14
NZ516298A (en)	2002-12-20
NO20011271D0 (no)	2001-03-13
CZ2001890A3 (cs)	2002-08-14
HU0102817D0 (en)	2001-09-28
NO20011271A (no)	2002-05-13
CA2360303A1 (en)	2001-06-28
UA71634C2 (uk)	2004-12-15
BE1013213A6 (fr)	2001-10-02
MXPA01013151A (es)	2002-08-12
SK286283B6 (sk)	2008-06-06
WO2001045483A2 (en)	2001-06-28
AU2001100405A4 (en)	2001-11-01
IES20010254A2 (en)	2002-03-06
PT1181713E (pt)	2005-02-28
EP1462447A3 (en)	2004-11-17
AT4367U1 (de)	2001-06-25
AU2001100405B4 (en)	2002-03-21
PL353398A1 (en)	2003-11-17
SE0103045L (sv)	2002-06-23
EP1462447A2 (en)	2004-09-29
EP1181713A2 (en)	2002-02-27
FI20011577A0 (fi)	2001-07-26
ES2170732A1 (es)	2002-08-01
CN1366525A (zh)	2002-08-28
HK1048812A1 (en)	2003-04-17
AU3920101A (en)	2001-07-03
DK1181713T3 (da)	2005-01-31
KR20020065345A (ko)	2002-08-13
NL1017525C1 (nl)	2001-04-26
HUP0102817A2 (hu)	2001-12-28
IS2060B (is)	2005-11-15
ITMI20010602A0 (it)	2001-03-22
BR0106272A (pt)	2004-06-15

Publication	Publication Date	Title
SG167655A1 (en)	2011-01-28	Method for the preparation of pure citalopram
BG106219A (en)	2002-08-30	Process for the preparation of pure citalopram
DE69010375T2 (de)	1994-12-15	Protease-Hemmer.
JP2550369B2 (ja)	1996-11-06	二環式アミノカルボン酸誘導体
US5489708A (en)	1996-02-06	Synthesis of ioversol
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