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ZA200108364B - Preparation of biologically active molecules. - Google Patents

Preparation of biologically active molecules. Download PDF

Info

Publication number
ZA200108364B
ZA200108364B ZA200108364A ZA200108364A ZA200108364B ZA 200108364 B ZA200108364 B ZA 200108364B ZA 200108364 A ZA200108364 A ZA 200108364A ZA 200108364 A ZA200108364 A ZA 200108364A ZA 200108364 B ZA200108364 B ZA 200108364B
Authority
ZA
South Africa
Prior art keywords
caspase
protease
proll
biologically active
human
Prior art date
Application number
ZA200108364A
Other languages
English (en)
Inventor
Menachem Rubinstein
Bianling Liu
Daniela Novick
Charles Dinarello
Pierre Graber
Original Assignee
Yeda Res & Dev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yeda Res & Dev filed Critical Yeda Res & Dev
Publication of ZA200108364B publication Critical patent/ZA200108364B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6472—Cysteine endopeptidases (3.4.22)
    • C12N9/6475—Interleukin 1-beta convertase-like enzymes (3.4.22.10; 3.4.22.36; 3.4.22.63)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/545—IL-1

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • Toxicology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Steroid Compounds (AREA)
ZA200108364A 1999-04-13 2001-10-11 Preparation of biologically active molecules. ZA200108364B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IL12942799A IL129427A0 (en) 1999-04-13 1999-04-13 Preparation of biologically active molecules

Publications (1)

Publication Number Publication Date
ZA200108364B true ZA200108364B (en) 2002-10-11

Family

ID=11072700

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200108364A ZA200108364B (en) 1999-04-13 2001-10-11 Preparation of biologically active molecules.

Country Status (24)

Country Link
US (1) US7098002B1 (no)
EP (1) EP1169460B1 (no)
JP (1) JP4822587B2 (no)
KR (1) KR100682185B1 (no)
CN (1) CN1324140C (no)
AR (1) AR023468A1 (no)
AT (1) ATE326536T1 (no)
AU (1) AU781342B2 (no)
BR (1) BR0009782A (no)
CA (1) CA2368994C (no)
DE (1) DE60028022T2 (no)
DK (1) DK1169460T3 (no)
EA (1) EA006825B1 (no)
EE (1) EE05591B1 (no)
ES (1) ES2259287T3 (no)
HK (1) HK1044351A1 (no)
IL (3) IL129427A0 (no)
MX (1) MXPA01010487A (no)
NO (1) NO329525B1 (no)
PT (1) PT1169460E (no)
SI (1) SI1169460T1 (no)
UA (1) UA73940C2 (no)
WO (1) WO2000061768A2 (no)
ZA (1) ZA200108364B (no)

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AU1336701A (en) * 1999-10-20 2001-04-30 Scios Inc. Functional cloning of genes encoding proteins/enzymes involved in proteolytic cleavage
US7273722B2 (en) * 2000-11-29 2007-09-25 Allergan, Inc. Neurotoxins with enhanced target specificity
US7524488B2 (en) 2001-03-08 2009-04-28 Ares Trading S.A. Interleukin-18 mutants
IL142246A0 (en) * 2001-03-26 2002-03-10 Applied Research Systems Method and kit for quantitation of polypeptides
JP2005523001A (ja) 2002-02-11 2005-08-04 ザイモジェネティクス，インコーポレイティド 二量体増殖因子を調製するための材料と方法
NZ541551A (en) * 2003-02-21 2007-02-23 Biotecnol Sa Use of caspase enzymes for maturation of engineered recombinant polypeptide fusions
AU2004265613B2 (en) * 2003-08-06 2010-12-09 University Of Maryland, College Park Engineered proteases for affinity purification and processing of fusion proteins
EP1689877A1 (en) * 2003-11-24 2006-08-16 Novo Nordisk A/S Fusion proteins and methods of cleavage of such proteins
US7381794B2 (en) 2004-03-08 2008-06-03 Zymogenetics, Inc. Dimeric fusion proteins and materials and methods for producing them
ATE463506T1 (de) * 2005-09-19 2010-04-15 Allergan Inc Mit clostriedientoxin aktivierbare clostridientoxine
CA2649800C (en) 2006-04-20 2016-09-20 Kringle Pharma Inc. Hgf precursor protein variant and active protein thereof
DE102007008596B4 (de) * 2007-02-15 2010-09-02 Friedrich-Schiller-Universität Jena Biologisch wirksame Moleküle auf Grundlage von PNA und siRNA, Verfahren zu deren zellspezifischen Aktivierung sowie Applikationskit zur Verabreichung
EP2190861A4 (en) 2007-08-22 2011-03-30 Univ California ACTIVE BINDING POLYPEPTIDES AND METHOD FOR THEIR IDENTIFICATION AND USE
KR100980315B1 (ko) * 2007-10-01 2010-09-07 한국생명공학연구원 대장균시스템을 이용한 인위적 활성화가 가능한 카스파제전구체 대량생산 및 활성화 방법
DE102009043743B4 (de) 2009-03-13 2016-10-13 Friedrich-Schiller-Universität Jena Zellspezifisch wirksame Moleküle auf Grundlage von siRNA sowie Applikationskits zu deren Herstellung und Verwendung
EP2385955B1 (en) 2009-01-12 2020-08-12 CytomX Therapeutics, Inc. Modified antibody compositions, methods of making and using thereof
JP5861223B2 (ja) * 2009-02-23 2016-02-16 サイトムエックス セラピューティクス, インク.CytomX Therapeutics, Inc. プロタンパク質およびその使用方法
CN103923897B (zh) * 2013-01-11 2016-06-01 中国人民解放军军事医学科学院生物工程研究所 caspase重组酶原及其编码基因与应用
CN103388001B (zh) * 2013-07-16 2016-01-20 中国人民解放军第四军医大学 一种含凝血酶切割位点gst膜型表达载体及转染阳性细胞的方法
KR20160098277A (ko) 2013-12-20 2016-08-18 에프. 호프만-라 로슈 아게 개선된 재조합 폴리펩티드 제조 방법
MX392776B (es) 2015-03-30 2025-03-11 Greenlight Biosciences Inc Produccion de acido ribonucleico libre de celulas.
EP3313879B1 (en) 2015-06-24 2022-01-05 F. Hoffmann-La Roche AG Anti-transferrin receptor antibodies with tailored affinity
AR106189A1 (es) 2015-10-02 2017-12-20 Hoffmann La Roche ANTICUERPOS BIESPECÍFICOS CONTRA EL A-b HUMANO Y EL RECEPTOR DE TRANSFERRINA HUMANO Y MÉTODOS DE USO
AU2016333512B2 (en) 2015-10-02 2022-11-17 F. Hoffmann-La Roche Ag Bispecific anti-human CD20/human transferrin receptor antibodies and methods of use
RU2018138975A (ru) 2016-04-06 2020-05-12 Гринлайт Байосайенсис, Инк. Бесклеточная продукция рибонуклеиновой кислоты
AU2018347405B2 (en) 2017-10-11 2022-02-03 Greenlight Biosciences, Inc. Methods and compositions for nucleoside triphosphate and ribonucleic acid production
KR20200080749A (ko) * 2018-12-27 2020-07-07 주식회사 폴루스 N-말단의 메티오닌이 절단된 목적 단백질 발현용 유전자 발현 카세트 및 이를 이용하여 n-말단의 메티오닌이 절단된 목적 단백질을 생산하는 방법
CA3150818A1 (en) * 2019-08-13 2021-02-18 King's College London Immunoresponsive cells armoured with spatiotemporally restricted activity of cytokines of the il-1 superfamily

Family Cites Families (11)

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US5824297A (en) * 1990-06-25 1998-10-20 Oncogene Science, Inc. Tissue-derived tumor growth inhibitors, methods of preparation and uses thereof
WO1992000318A1 (en) * 1990-06-25 1992-01-09 Oncogene Science, Inc. Tissue-derived tumor growth inhibitors, methods for preparation and uses thereof
EP0533350B1 (en) * 1991-08-16 1999-05-26 Merck & Co. Inc. DNA encoding precursor interleukin 1B converting enzyme
AU683834B2 (en) * 1991-12-31 1997-11-27 Zymogenetics Inc. Methods for producing thrombin
JPH06125784A (ja) * 1992-01-17 1994-05-10 Takeda Chem Ind Ltd モノクローナル抗体，ハイブリドーマ，その製造法および用途
US6303369B1 (en) * 1993-09-30 2001-10-16 Carl Spana Protein expression system
WO1997024441A1 (en) 1995-12-29 1997-07-10 Incyte Pharmaceuticals, Inc. Nucleic acids encoding interferon gamma inducing factor-2
JP4059941B2 (ja) * 1996-08-26 2008-03-12 社団法人芝蘭会 Ｒｈｏ標的タンパク質ｐ１４０ｍＤｉａ
AT405516B (de) * 1997-02-27 1999-09-27 Immuno Ag Faktor x-analoge mit modifizierter proteasespaltstelle
JPH10327872A (ja) * 1997-05-30 1998-12-15 Otsuka Pharmaceut Co Ltd Ｂｃｌ−２相互作用蛋白遺伝子ｂｉｓ
CA2295957C (en) * 1997-08-07 2009-09-22 Toray Industries, Inc. Canine interleukin 18, canine interleukin 1.beta. converting enzyme, dna sequences encoding these, interleukin 18 production method and canine immune disease remedy

Also Published As

Publication number Publication date
EP1169460A2 (en) 2002-01-09
EP1169460B1 (en) 2006-05-17
EE05591B1 (et) 2012-10-15
IL129427A0 (en) 2000-02-17
EA006825B1 (ru) 2006-04-28
DE60028022T2 (de) 2006-09-28
UA73940C2 (uk) 2005-10-17
WO2000061768A3 (en) 2001-02-08
US7098002B1 (en) 2006-08-29
IL145842A0 (en) 2002-07-25
IL145842A (en) 2008-06-05
WO2000061768A2 (en) 2000-10-19
DK1169460T3 (da) 2006-09-18
AU3985100A (en) 2000-11-14
AU781342B2 (en) 2005-05-19
HK1044351A1 (en) 2002-10-18
SI1169460T1 (sl) 2006-08-31
KR100682185B1 (ko) 2007-02-12
NO20014966D0 (no) 2001-10-12
AR023468A1 (es) 2002-09-04
BR0009782A (pt) 2002-01-08
JP2002541813A (ja) 2002-12-10
KR20020007365A (ko) 2002-01-26
EE200100530A (et) 2002-12-16
JP4822587B2 (ja) 2011-11-24
DE60028022D1 (de) 2006-06-22
CN1324140C (zh) 2007-07-04
CN1353761A (zh) 2002-06-12
EA200101078A1 (ru) 2002-04-25
CA2368994C (en) 2010-03-09
ES2259287T3 (es) 2006-10-01
CA2368994A1 (en) 2000-10-19
NO329525B1 (no) 2010-11-01
ATE326536T1 (de) 2006-06-15
PT1169460E (pt) 2006-07-31
MXPA01010487A (es) 2002-05-06
NO20014966L (no) 2001-12-11

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